Cartilage and Bone Development and Its Disorders: 4th ESPE Advanced Seminar in Developmental Endocrinology, Stockholm, June-July 2010Available to Purchase
In systemic childhood diseases, including cancer, gastrointestinal, pulmonary and cardiac disorders, childhood growth is severely impaired. In addition, almost 400 known genetic diseases inhibit the ability of the growth plate to form new bone, leaving affected children with growth failure and bony deformities which can severely impact their quality of life and may lead to morbidity and early mortality. This book provides a comprehensive review of bone and cartilage development, growth and disease. Focusing on novel treatment strategies, regulatory signals and molecular mechanisms are discussed in relation to the diseases affecting them. Furthermore, novel methodologies in bone and cartilage research based on recent advances in skeletal stem cell biology, cartilage tissue engineering and allele-specific gene silencing is covered. Providing insight into the basic mechanisms of bone growth, structure and metabolism, research methodology, as well as discussing the clinical management of related diseases, this book is of particular value to physicians with a special interest in bone and cartilage biology; in particular endocrinologists and pediatric endocrinologists that see patients with growth disorders, osteoporosis, osteogenesis imperfecta, and skeletal dysplasias.
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Table of Contents
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1 - 11: Chondrocyte Proliferation and DifferentiationByManuela Wuelling;Manuela WuellingCenter for Medical Biotechnology, Department of Developmental Biology, University Duisburg-Essen, Essen, GermanySearch for other works by this author on:Andrea VortkampAndrea VortkampCenter for Medical Biotechnology, Department of Developmental Biology, University Duisburg-Essen, Essen, GermanySearch for other works by this author on:
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12 - 22: Local Regulation of Growth Plate CartilageByStephan-Stanislaw Späth;Stephan-Stanislaw SpäthCenter for Molecular Medicine and Pediatric Endocrinology Unit, Q2:08, Department of Women’s and Children’s Health, Karolinska Institutet and University Hospital, Stockholm, SwedenSearch for other works by this author on:Anenisia C. Andrade;Anenisia C. AndradeCenter for Molecular Medicine and Pediatric Endocrinology Unit, Q2:08, Department of Women’s and Children’s Health, Karolinska Institutet and University Hospital, Stockholm, SwedenSearch for other works by this author on:Michael Chau;Michael ChauCenter for Molecular Medicine and Pediatric Endocrinology Unit, Q2:08, Department of Women’s and Children’s Health, Karolinska Institutet and University Hospital, Stockholm, SwedenSearch for other works by this author on:Ola NilssonOla NilssonCenter for Molecular Medicine and Pediatric Endocrinology Unit, Q2:08, Department of Women’s and Children’s Health, Karolinska Institutet and University Hospital, Stockholm, SwedenSearch for other works by this author on:
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23 - 29: Growth Plate Senescence and Catch-Up GrowthByJulian C. Lui;Julian C. LuiaDevelopmental Endocrinology Branch, Program in Developmental Endocrinology and Genetics, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Md., USA;Search for other works by this author on:Ola Nilsson;Ola NilssonbCenter for Molecular Medicine and Pediatric Endocrinology Unit Q2:08, Department of Women’s and Children’s Health, Karolinska Institutet and Karolinska University Hospital, Stockholm, SwedenSearch for other works by this author on:Jeffrey BaronJeffrey BaronaDevelopmental Endocrinology Branch, Program in Developmental Endocrinology and Genetics, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Md., USA;Search for other works by this author on:
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30 - 41: Endocrine Regulation of Longitudinal Bone GrowthByJan M. Wit;Jan M. WitaDepartment of Paediatrics, Leiden University Medical Center, Leiden, The Netherlands;Search for other works by this author on:Cecilia Camacho-HübnerCecilia Camacho-HübnerbDivision of Pediatric Endocrinology, Department of Women’s and Children’s Health, Karolinska Institutet, Stockholm, Sweden, andcPfizer Global Pharmaceuticals, New York, N.Y., USASearch for other works by this author on:
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42 - 51: Estrogen Signaling in Growth Plate CartilageByElham Karimian;Elham KarimianPediatric Endocrinology Unit, Q2:08, Department of Women’s and Children’s Health, Karolinska Institutet and University Hospital, Stockholm, SwedenSearch for other works by this author on:Lars SävendahlLars SävendahlPediatric Endocrinology Unit, Q2:08, Department of Women’s and Children’s Health, Karolinska Institutet and University Hospital, Stockholm, SwedenSearch for other works by this author on:
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52 - 66: Methods to Study Cartilage and Bone DevelopmentByAnenisia C. Andrade;Anenisia C. AndradeaDepartment of Women’s and Children’s Health, Karolinska Institutet, Stockholm, Sweden;Search for other works by this author on:Dionisios Chrysis;Dionisios ChrysisbDivision of Endocrinology, Department of Paediatrics, Medical School, University of Patras, Patras, Greece;Search for other works by this author on:Laura Audi;Laura AudicPaediatric Endocrinology Research Unit, Research Institute, Department of Paediatrics, Hospital Vall d’Hebron, Autonomous University, Centre for Biomedical Research Network on Rare Diseases, Instituto de Salud Carlos III, Barcelona, SpainSearch for other works by this author on:Ola NilssonOla NilssonaDepartment of Women’s and Children’s Health, Karolinska Institutet, Stockholm, Sweden;Search for other works by this author on:
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67 - 77: Fibroblast Growth Factor-23 and Phosphorus MetabolismByDov TiosanoDov TiosanoPediatric Endocrinology, Meyer Children’s Hospital, Rambam Medical Center, Rappaport Family Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, IsraelSearch for other works by this author on:
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78 - 84: Molecular Defects Causing Skeletal DysplasiasByOuti MäkitieOuti MäkitieHospital for Children and Adolescents, Pediatric Endocrinology and Metabolic Bone Diseases, Helsinki University Hospital and University of Helsinki, Helsinki, FinlandSearch for other works by this author on:
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85 - 90: Allele-Specific Gene Silencing in Osteogenesis ImperfectaByÖsten Ljunggren;Östen LjunggrenDepartment of Medical Sciences, Uppsala University, Uppsala, SwedenSearch for other works by this author on:Katarina Lindahl;Katarina LindahlDepartment of Medical Sciences, Uppsala University, Uppsala, SwedenSearch for other works by this author on:Carl-Johan Rubin;Carl-Johan RubinDepartment of Medical Sciences, Uppsala University, Uppsala, SwedenSearch for other works by this author on:Andreas KindmarkAndreas KindmarkDepartment of Medical Sciences, Uppsala University, Uppsala, SwedenSearch for other works by this author on:
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91 - 101: Stem Cells in Skeletal Physiology and Endocrine Diseases of BoneByPaolo Bianco;Paolo BiancoDepartment of Molecular Medicine, La Sapienza University, and Biomedical Science Park San Raffaele, Rome, ItalySearch for other works by this author on:Benedetto Sacchetti;Benedetto SacchettiDepartment of Molecular Medicine, La Sapienza University, and Biomedical Science Park San Raffaele, Rome, ItalySearch for other works by this author on:Mara RiminucciMara RiminucciDepartment of Molecular Medicine, La Sapienza University, and Biomedical Science Park San Raffaele, Rome, ItalySearch for other works by this author on:
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102 - 115: Cartilage Tissue EngineeringByLiliana S. Moreira-Teixeira;Liliana S. Moreira-TeixeiraDepartment of Tissue Regeneration, MIRA Institute for Biomedical Technology and Technical Medicine, University of Twente, Enschede, The NetherlandsSearch for other works by this author on:Nicole Georgi;Nicole GeorgiDepartment of Tissue Regeneration, MIRA Institute for Biomedical Technology and Technical Medicine, University of Twente, Enschede, The NetherlandsSearch for other works by this author on:Jeroen Leijten;Jeroen LeijtenDepartment of Tissue Regeneration, MIRA Institute for Biomedical Technology and Technical Medicine, University of Twente, Enschede, The NetherlandsSearch for other works by this author on:Ling Wu;Ling WuDepartment of Tissue Regeneration, MIRA Institute for Biomedical Technology and Technical Medicine, University of Twente, Enschede, The NetherlandsSearch for other works by this author on:Marcel KarperienMarcel KarperienDepartment of Tissue Regeneration, MIRA Institute for Biomedical Technology and Technical Medicine, University of Twente, Enschede, The NetherlandsSearch for other works by this author on: