Advances in Stem Cell Aging
Adult stem cells are present in most postnatal tissues of mammals. Tissues with high rates of cell turnover depend on the functional capacity of stem cells for lifelong maintenance of tissue homeostasis. Adult stem cells are also required for the regeneration of tissues in response to injury as in, for example, the regeneration of skeletal muscle. In addition to its function in tissue homeostasis and regeneration, adult stem cells can represent the cell type of origin of various types of cancers including leukemia and colorectal cancer. Stem cells are the most long-lived cells in the proliferative compartment of mammalian tissues. Therefore, stem cells have an increased risk of acquiring mutations that could ultimately lead to the transformation of tissue stem cells. This publication presents the current knowledge in the field of stem cell aging, which was discussed at the Else Kröner-Fresenius Symposium on Advances in Stem Cell Aging in 2011. It will be of special interest to scientists working on stem cell research, aging, regeneration, and cancer as well as physicians and scientists specializing in geriatric medicine, internal medicine, and surgery.
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Table of Contents
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1 - 1: IntroductionByK. Lenhard RudolphK. Lenhard RudolphInstitute of Molecular Medicine and Max Planck Research Group on Stem Cell Aging, University of Ulm, Ulm, GermanySearch for other works by this author on:
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2 - 17: Speakers at the SymposiumByMiwako MoritaMiwako MoritaInstitute of Molecular Medicine and Max Planck Research Group on Stem Cell Aging, University of Ulm, Ulm, GermanySearch for other works by this author on:
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18 - 26: Aging of the Niche and the Microenvironment and Its Role in Stem Cell AgingByHartmut GeigerHartmut GeigerDepartment of Dermatology and Allergic Diseases, University of Ulm, Ulm, GermanySearch for other works by this author on:
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27 - 35: Hematopoietic Stem Cell Aging and CancerByYulin Chen;Yulin ChenMax Planck Partner Group on Stem Cell Aging, Institute of Aging Research, Hangzhou Normal University School of Medicine, Hangzhou, PR ChinaSearch for other works by this author on:Zhenyu JuZhenyu JuMax Planck Partner Group on Stem Cell Aging, Institute of Aging Research, Hangzhou Normal University School of Medicine, Hangzhou, PR ChinaSearch for other works by this author on:
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36 - 47: DNA Damage, Checkpoint Responses, and Cell Cycle Control in Aging Stem CellsByKarin N. Kleinhans;Karin N. KleinhansInstitute of Molecular Medicine and Max Planck Research Group on Stem Cell Aging, University of Ulm, Ulm, GermanySearch for other works by this author on:Martin D. BurkhalterMartin D. BurkhalterInstitute of Molecular Medicine and Max Planck Research Group on Stem Cell Aging, University of Ulm, Ulm, GermanySearch for other works by this author on:
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48 - 73: Hematopoietic Stem Cell Aging and Fate DecisionByAnett Illing;Anett IllingInstitute of Molecular Medicine and Max Planck Research Group on Stem Cell Aging, University of Ulm, Ulm, GermanySearch for other works by this author on:Yohei MoritaYohei MoritaInstitute of Molecular Medicine and Max Planck Research Group on Stem Cell Aging, University of Ulm, Ulm, GermanySearch for other works by this author on:
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74 - 86: Stem Cell Therapy and Stress Response in Pancreas and IntestineByTobias Sperka;Tobias SperkaInstitute of Molecular Medicine and Max Planck Research Group on Stem Cell Aging, University of Ulm, Ulm, GermanySearch for other works by this author on:Omid OmraniOmid OmraniInstitute of Molecular Medicine and Max Planck Research Group on Stem Cell Aging, University of Ulm, Ulm, GermanySearch for other works by this author on:
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87 - 91: Niche-Stem Cell Interactions and Environmental InfluencesByDuozhuang TangDuozhuang TangInstitute of Molecular Medicine and Max Planck Research Group on Stem Cell Aging, University of Ulm, Ulm, GermanySearch for other works by this author on:
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92 - 99: Stem Cells and MetabolismByPavlos Missios;Pavlos MissiosInstitute of Molecular Medicine and Max Planck Research Group on Stem Cell Aging, University of Ulm, Ulm, GermanySearch for other works by this author on:Luis GuachallaLuis GuachallaInstitute of Molecular Medicine and Max Planck Research Group on Stem Cell Aging, University of Ulm, Ulm, GermanySearch for other works by this author on:
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100 - 111: Molecular Mechanisms of Muscle Stem Cell AgingByAli Hyder Baig;Ali Hyder BaigInstitute of Molecular Medicine and Max Planck Research Group on Stem Cell Aging, University of Ulm, Ulm, GermanySearch for other works by this author on:Stefan TümpelStefan TümpelInstitute of Molecular Medicine and Max Planck Research Group on Stem Cell Aging, University of Ulm, Ulm, GermanySearch for other works by this author on:
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112 - 120: Neural Stem Cells in Development and AgingByUta Schmidt-StraßburgerUta Schmidt-StraßburgerInstitute of Physiological Chemistry, University of Ulm, Ulm, GermanySearch for other works by this author on:
