Depression: From Psychopathology to Pharmacotherapy
Despite the availability of antidepressants for over 40 years, a substantial proportion of depressed patients do not respond adequately to treatment. Failure to respond effectively to treatment contributes to physical ill-health and psychiatric morbidity, often resulting in premature death of the depressed patient. The purpose of this volume is to consider the possible reasons for the limitations of the currently available antidepressants, to examine the advances in our understanding of the psychopathology of depression and how such knowledge may assist in the discovery of new methods of treatment. Leading international experts in this field discuss the possible underlying reasons for depression and limitations of current antidepressants. Opportunities for novel therapeutic approaches to dysfunctional circadian rhythms and mood disorders as well as current status and future perspectives for optimizing antidepressant management of depression are reviewed.
This publication illustrates the breadth of the latest research and is valuable reading for psychiatrists, neuroscientists and pharmacologists.
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Table of Contents
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1 - 19: Antidepressant Compounds: A Critical ReviewByS.W. Tang;S.W. TangaDepartment of Psychiatry, University of California, Irvine, Calif., USA;Search for other works by this author on:D.M. Helmeste;D.M. HelmesteaDepartment of Psychiatry, University of California, Irvine, Calif., USA;Search for other works by this author on:Brian E. LeonardBrian E. LeonardbDepartment of Pharmacology, National University of Ireland, Galway, IrelandSearch for other works by this author on:
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20 - 31: The Hypothalamic-Pituitary-Adrenal Axis in DepressionByMarcela Julio-Pieper;Marcela Julio-PieperaLaboratory of Neurogastroenterology, Alimentary Pharmabiotic Centre, andSearch for other works by this author on:Timothy G. DinanTimothy G. DinanbDepartment of Psychiatry, University College Cork, Cork, IrelandSearch for other works by this author on:
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32 - 52: Dysfunctional Circadian Rhythms and Mood Disorders: Opportunities for Novel Therapeutic ApproachesByTrevor R. NormanTrevor R. NormanDepartment of Psychiatry, University of Melbourne, Austin Hospital, Heidelberg, Vic., AustraliaSearch for other works by this author on:
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53 - 71: The Concept of Depression as a Dysfunction of the Immune SystemByBrian E. LeonardBrian E. LeonardPharmacology Department, National University of Ireland, Galway, Ireland; Department of Psychiatry and Psychotherapy, Ludwig Maximilian University, Munich, GermanySearch for other works by this author on:
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72 - 88: The Role of Polyunsaturated Fatty Acids in the Pathology and Treatment of DepressionByCai SongCai SongDepartment of Biomedical Science, University of Prince Edward Island, and Canada National Research Institute for Nutrisciences and Health, Charlottetown, P.E.I., CanadaSearch for other works by this author on:
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89 - 100: Overcoming Antidepressant Treatment Resistance: Focus on GlutamateByJames W. Murrough;James W. MurroughaDepartment of Psychiatry, Mount Sinai School of Medicine, New York, N.Y., andSearch for other works by this author on:Sanjay J. MathewSanjay J. MathewbMenninger Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston, Tex., USASearch for other works by this author on:
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101 - 123: Neuroimaging and the Pathophysiology and Treatment of Depression: Recent Advances and Future NeedsByDara M. CannonDara M. CannonDivision of Psychiatry, Clinical Science Institute, College of Medicine, Nursing & Health Sciences, National University of Ireland Galway, County Galway, IrelandSearch for other works by this author on:
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124 - 138: Animal Models of Depression – Where Are We Going?ByDavid A. Slattery;David A. SlatteryaDepartment of Behavioural and Molecular Neuroendocrinology, Institute of Zoology, University of Regensburg, Regensburg, Germany;Search for other works by this author on:John F. CryanJohn F. CryanbSchool of Pharmacy, Department of Pharmacology & Therapeutics, University College Cork, Cork, IrelandSearch for other works by this author on:
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139 - 154: Genetic Models of Depression and Antidepressant ResponseByIrwin LuckiIrwin LuckiDepartment of Psychiatry and Pharmacology, University of Pennsylvania, Philadelphia, Pa., USASearch for other works by this author on:
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155 - 181: The Role of 5-HT2C Receptors in the Antidepressant Response: A Critical ReviewByCédric B.P. Martin;Cédric B.P. MartinINSERM U894, Faculté de Médecine, Université Pierre et Marie Curie, Pitié-Salpêtrière, Paris, FranceSearch for other works by this author on:Michel Hamon;Michel HamonINSERM U894, Faculté de Médecine, Université Pierre et Marie Curie, Pitié-Salpêtrière, Paris, FranceSearch for other works by this author on:Laurence Lanfumey;Laurence LanfumeyINSERM U894, Faculté de Médecine, Université Pierre et Marie Curie, Pitié-Salpêtrière, Paris, FranceSearch for other works by this author on:Raymond MongeauRaymond MongeauINSERM U894, Faculté de Médecine, Université Pierre et Marie Curie, Pitié-Salpêtrière, Paris, FranceSearch for other works by this author on:
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182 - 198: Chromatin-Based Treatments for Affective Disorders – Insight or UtopiaByHerbert E. Covington III;Herbert E. Covington IIIaDepartment of Psychology and Neuroscience, Duke University, Durham, N.C., andSearch for other works by this author on:Olivier BertonOlivier BertonbDepartment of Psychiatry, University of Pennsylvania Medical School, Philadelphia, Pa., USASearch for other works by this author on:
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199 - 223: Neurotrophic Factors and Antidepressant Action: Recent AdvancesByOlivia F. O’Leary;Olivia F. O’LearyaSchool of Pharmacy, University College Cork, Cork, Ireland;Search for other works by this author on:Eero CastrénEero CastrénbNeuroscience Centre, University of Helsinki, Helsinki, FinlandSearch for other works by this author on:
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224 - 242: Neurogenic Basis of Antidepressant Action: Recent AdvancesByArnaud Tanti;Arnaud TantiINSERM U 930, Faculté des Sciences et Techniques, Université François Rabelais, Tours, FranceSearch for other works by this author on:Catherine BelzungCatherine BelzungINSERM U 930, Faculté des Sciences et Techniques, Université François Rabelais, Tours, FranceSearch for other works by this author on:
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243 - 253: The Nature and Treatment of Therapy-Resistant DepressionBySidney H. Kennedy;Sidney H. KennedyaDepartment of Psychiatry, University Health Network, and Departments ofbPsychiatry andSearch for other works by this author on:Sakina J. Rizvi;Sakina J. RizviaDepartment of Psychiatry, University Health Network, and Departments ofcPharmaceutical Sciences and Neuroscience, University of Toronto, Toronto, Ont., CanadaSearch for other works by this author on:Peter GiacobbePeter GiacobbeaDepartment of Psychiatry, University Health Network, and Departments ofbPsychiatry andSearch for other works by this author on:
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254 - 267: Optimizing Antidepressant Management of Depression: Current Status and Future PerspectivesByThomas L. Schwartz;Thomas L. SchwartzaPsychiatry Department, State University of New York Upstate Medical University, Syracuse, N.Y., andSearch for other works by this author on:Stephen M. StahlStephen M. StahlbNeuroscience Education Institute, University of California, San Diego, Calif, USA;cCambridge University, Cambridge, UKSearch for other works by this author on: