Microbial Host-Interaction: Tolerance versus Allergy: 64th Nestlé Nutrition Institute Workshop, Pediatric Program, Sydney, November 2008Available to Purchase
Most indigenous microbes occur in the intestinal tract, and their interactions with the host are largely unknown. Current understanding of host-microbe interactions links early microbial contact to the origin of disease, a theory that has its roots in the hygiene hypothesis. Modern life style appears to deprive the infant of conditions that provide adequate anti-inflammatory or tolerogenic stimuli upon antigen encounter. Thus, maturational signals from the environment and the diet are insufficient to adequately shape the immune system. This publication deals with the relationship between the gut microbiota as well as altered pattern of early microbial contact and the origin of human disease. New aspects of the original hygiene hypothesis are discussed in relation to disorders spanning from allergy and autoimmunity to obesity.The results presented suggest that all these disorders may be linked to aberrant antigen absorption and immune responses associated with dysfunction of mucosal defense. Researchers, clinicians and students interested in the interaction of the host with indigenous gut bacteria and the consequences for human health will find this publication of utmost interest.
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Table of Contents
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1 - 10: A Paradigm for Commensalism: The Role of a Specific Microbial Polysaccharide in Health and DiseaseByDennis L. KasperDennis L. KasperChanning Laboratory, Brigham and Women’s Hospital and Department of Microbiology and Molecular Genetics, Harvard Medical School, Boston, MA, USASearch for other works by this author on:
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11 - 22: The Hygiene Hypothesis: Do We Still Believe in It?ByBengt BjörksténBengt BjörksténInstitute of Environmental Medicine, Karolinska Institutet, Stockholm, SwedenSearch for other works by this author on:
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23 - 43: ‘ABC’ of Mucosal ImmunologyByPer BrandtzaegPer BrandtzaegLaboratory for Immunohistochemistry and Immunopathology, Institute and Division of Pathology, University of Oslo, Rikshospitalet University Hospital, Oslo, NorwaySearch for other works by this author on:
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45 - 61: Innate and Adaptive Immune Pathways to ToleranceByCatherine A. Thornton;Catherine A. ThorntonInstitute of Life Science, School of Medicine, Swansea University, Swansea, UKSearch for other works by this author on:Gareth MorganGareth MorganInstitute of Life Science, School of Medicine, Swansea University, Swansea, UKSearch for other works by this author on:
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63 - 74: Hitting the Mucosal Road in Tolerance InductionByUrsula WiedermannUrsula WiedermannDepartment of Specific Prophylaxis and Tropical Medicine, Medical University Vienna, Vienna, AustriaSearch for other works by this author on:
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75 - 89: Obesity – Extending the Hygiene HypothesisByErika Isolauri;Erika IsolauriDepartment of Pediatrics, Functional Foods Forum, and Department of Biochemistry and Food Chemistry, University of Turku, Turku, FinlandSearch for other works by this author on:Marko Kalliomäki;Marko KalliomäkiDepartment of Pediatrics, Functional Foods Forum, and Department of Biochemistry and Food Chemistry, University of Turku, Turku, FinlandSearch for other works by this author on:Samuli Rautava;Samuli RautavaDepartment of Pediatrics, Functional Foods Forum, and Department of Biochemistry and Food Chemistry, University of Turku, Turku, FinlandSearch for other works by this author on:Seppo Salminen;Seppo SalminenDepartment of Pediatrics, Functional Foods Forum, and Department of Biochemistry and Food Chemistry, University of Turku, Turku, FinlandSearch for other works by this author on:Kirsi LaitinenKirsi LaitinenDepartment of Pediatrics, Functional Foods Forum, and Department of Biochemistry and Food Chemistry, University of Turku, Turku, FinlandSearch for other works by this author on:
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91 - 104: Autoimmunity and DietByNadine Cerf-BensussanNadine Cerf-BensussanINSERM U793, Université Paris Descartes, Paris, FranceSearch for other works by this author on:
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105 - 120: Eosinophilic Esophagitis: Example of an Emerging Allergic Manifestation?ByRalf G. HeineRalf G. HeineDepartment of Gastroenterology and Clinical Nutrition, Royal Children’s Hospital; Department of Paediatrics, University of Melbourne, and Murdoch Children’s Research Institute, Melbourne, AustraliaSearch for other works by this author on:
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121 - 137: Microbial–Host Interactions in Inflammatory Bowel Diseases and Experimental ColitisByBalfour SartorBalfour SartorDepartments of Medicine, Microbiology and Immunology, University of North Carolina, Chapel Hill, NC, USASearch for other works by this author on:
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139 - 155: Development and Regulation of Immune Responses to Food Antigens in Pre- and Postnatal LifeByHarald Renz;Harald RenzDepartment of Clinical Chemistry and Molecular Diagnostics, Biomedical Research Center (BMFZ), Faculty of Medicine, Philipps University, Marburg, GermanySearch for other works by this author on:Petra Ina Pfefferle;Petra Ina PfefferleDepartment of Clinical Chemistry and Molecular Diagnostics, Biomedical Research Center (BMFZ), Faculty of Medicine, Philipps University, Marburg, GermanySearch for other works by this author on:René Teich;René TeichDepartment of Clinical Chemistry and Molecular Diagnostics, Biomedical Research Center (BMFZ), Faculty of Medicine, Philipps University, Marburg, GermanySearch for other works by this author on:Holger GarnHolger GarnDepartment of Clinical Chemistry and Molecular Diagnostics, Biomedical Research Center (BMFZ), Faculty of Medicine, Philipps University, Marburg, GermanySearch for other works by this author on:
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157 - 167: Novel Approaches in Treating Food Allergy Using AllergensByFabienne RancéFabienne RancéAllergologie – Pneumologie, Pôle Médico-Chirurgical de Pédiatrie, Hôpital des Enfants, Toulouse, FranceSearch for other works by this author on:
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169 - 184: Allergen Avoidance Approaches in Food Allergy ManagementBySibylle Koletzko;Sibylle KoletzkoDr. von Hauner Children’s Hospital, University of Munich Medical Center, Munich, GermanySearch for other works by this author on:Berthold KoletzkoBerthold KoletzkoDr. von Hauner Children’s Hospital, University of Munich Medical Center, Munich, GermanySearch for other works by this author on:
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185 - 200: Role of Dietary Immunomodulatory Factors in the Development of Immune ToleranceBySusan L. PrescottSusan L. PrescottSchool of Paediatrics and Child Health, University of Western Australia, Perth, W.A., AustraliaSearch for other works by this author on:
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201 - 217: Microbial–Host Interactions: Selecting the Right Probiotics and Prebiotics for InfantsBySeppo Salminen;Seppo SalminenaFunctional Foods Forum, andSearch for other works by this author on:Maria Carmen Collado;Maria Carmen ColladoaFunctional Foods Forum, andbInstituto de Agroquimica y Tecnologia de los Alimentos, Valencia, andSearch for other works by this author on:Erika Isolauri;Erika IsolauriaFunctional Foods Forum, andcDepartment of Pediatrics, University of Turku, Turku, Finland;Search for other works by this author on:Miguel GueimondeMiguel GueimondeaFunctional Foods Forum, anddInstituto de Productos Lácteos de Asturias, Villaviciosa, SpainSearch for other works by this author on:
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219 - 238: Probiotics and Prebiotics: Immunological and Clinical Effects in Allergic DiseaseByMimi L.K. TangMimi L.K. TangDepartment of Allergy and Immunology, Royal Children’s Hospital, Parkville, Vic., AustraliaSearch for other works by this author on:
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239 - 250: Modified Proteins in Allergy PreventionByAndrea von BergAndrea von BergChildren’s Department, Marien Hospital Wesel, Wesel, GermanySearch for other works by this author on: