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Advances in Oto-Rhino-Laryngology
Gene Therapy of Cochlear Deafness: Present Concepts and Future Aspects
Edited by
S.Karger AG
Volume
66
Status:
Available
ISBN electronic:
978-3-8055-9036-5
ISBN print:
978-3-8055-9035-8
Book Series:
Advances in Oto-Rhino-Laryngology
Publication date:
2009
Book Details
Gene therapy holds great potential for the treatment not only of genetic disorders, but also of many acquired diseases. This is as true for the inner ear as for any other organ. However, the technical challenges that must be overcome before gene therapy becomes more widely used are remarkable. In the inner ear the size, accessibility, delicacy and the involvement of many different cell types present unique conditions. This volume reviews current concepts and recent research findings of the application of gene therapy to the inner ear. Various forms of gene therapy, disorders that are potential targets for gene therapy, techniques for gene delivery, and mechanisms of gene targeting, and also obstacles that have yet to be overcome are discussed. This volume will be indispensable reading for otolaryngologists, hearing scientists, audiologists with a special interest in keeping up-to-date on gene therapy for inner ear disorders.
Gene Therapy of Cochlear Deafness: Present Concepts and Future Aspects
Edited by: A.F. Ryan
https://doi.org/10.1159/isbn.978-3-8055-9036-5
ISBN (print): 978-3-8055-9035-8
ISBN (electronic): 978-3-8055-9036-5
Publisher: S.Karger AG
Published: 2009
Download citation file:
Digital Version
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Print Version
Gene Therapy of Cochlear Deafness
$152.00
Table of Contents
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1 - 12: Gene Therapy for the Inner Ear: Challenges and PromisesByAllen F. Ryan;Allen F. RyanaDepartments of Surgery/Otolaryngology andbNeurosciences, UCSD School of Medicine and VA Medical Center, La Jolla, Calif., USA, andSearch for other works by this author on:Stefan DazertStefan DazertcDepartment of Otorhinolaryngology, School of Medicine, Ruhr University, Bochum, GermanySearch for other works by this author on:
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13 - 36: Therapeutic Regulation of Gene Expression in the Inner Ear using RNA InterferenceByYukihide Maeda;Yukihide MaedaaMolecular Otolaryngology Research Laboratories, Department of Otolaryngology, Head and Neck Surgery,Search for other works by this author on:Abraham M. Sheffield;Abraham M. SheffieldbMedical Scientist Training Program, andSearch for other works by this author on:Richard J.H. SmithRichard J.H. SmithaMolecular Otolaryngology Research Laboratories, Department of Otolaryngology, Head and Neck Surgery,bMedical Scientist Training Program, andcInterdepartmental PhD Genetics Program, University of Iowa, Iowa City, Iowa, USASearch for other works by this author on:
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37 - 51: Gene Therapy in the Inner Ear Using Adenovirus VectorsByJacob Husseman;Jacob HussemanaDivision of Otolaryngology-Head and Neck Surgery, University of California, San Diego, Calif., andSearch for other works by this author on:Yehoash RaphaelYehoash RaphaelbKresge Hearing Research Institute, Department of Otolaryngology, University of Michigan, Ann Arbor, Mich., USASearch for other works by this author on:
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52 - 63: Repair of the Vestibular System via Adenovector Delivery of Atoh1: A Potential Treatment for Balance DisordersByKim Baker;Kim BakeraUniversity of Maryland School of Medicine, Baltimore, Md.,Search for other works by this author on:Douglas E. Brough;Douglas E. BroughbGenVec Inc., Gaithersburg, Md., andSearch for other works by this author on:Hinrich StaeckerHinrich StaeckercUniversity of Kansas School of Medicine, Kansas City, Kans., USASearch for other works by this author on:
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64 - 86: Gene Therapy and Stem Cell Transplantation: Strategies for Hearing RestorationByBradley W. Kesser;Bradley W. KesseraDepartment of Otolaryngology-Head and Surgery, University of Virginia School of Medicine, Charlottesville, Va., andSearch for other works by this author on:Anil K. LalwaniAnil K. LalwanibDepartment of Otolaryngology, New York University School of Medicine, New York, N.Y, USASearch for other works by this author on:
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87 - 98: Adenoviral and AAV-Mediated Gene Transfer to the Inner Ear: Role of Serotype, Promoter, and Viral Load on In Vivo and In Vitro Infection EfficienciesByAnne E. Luebke;Anne E. LuebkeaDepartments of Neurobiology and Anatomy and Biomedical Engineering, University of Rochester Medical Center, Rochester, N.Y., andSearch for other works by this author on:Cherokee Rova;Cherokee RovabDepartment of Biomedical and Pharmaceutical Sciences, COBRE Center for Structural and Functional Neuroscience, University of Montana, Missoula, Mont., USASearch for other works by this author on:Peter G. Von Doersten;Peter G. Von DoerstenbDepartment of Biomedical and Pharmaceutical Sciences, COBRE Center for Structural and Functional Neuroscience, University of Montana, Missoula, Mont., USASearch for other works by this author on:David J. PoulsenDavid J. PoulsenbDepartment of Biomedical and Pharmaceutical Sciences, COBRE Center for Structural and Functional Neuroscience, University of Montana, Missoula, Mont., USASearch for other works by this author on:
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99 - 115: Cellular Targeting for Cochlear Gene TherapyByAllen F. Ryan;Allen F. RyanDepartments of Surgery/Otolaryngology and Neurosciences, UCSD School of Medicine, La Jolla, Calif., USASearch for other works by this author on:Lina M. Mullen;Lina M. MullenDepartments of Surgery/Otolaryngology and Neurosciences, UCSD School of Medicine, La Jolla, Calif., USASearch for other works by this author on:Joni K. DohertyJoni K. DohertyDepartments of Surgery/Otolaryngology and Neurosciences, UCSD School of Medicine, La Jolla, Calif., USASearch for other works by this author on:
