Diabetes and Cancer: Epidemiological Evidence and Molecular Links
The interdisciplinary work revealing varied roles in biological processes of chronic diseases has led to a new field of research concerning common molecular and clinical features of chronic diseases. Epidemiological literature suggests an association between the history of metabolic syndrome/diabetes mellitus type 2 and the risk of developing a variety of cancers. This book, at the forefront of experimental and clinical research, is the first to highlight the common molecular links between these two diseases. These tight links indicate a complex interdependency between both diseases on a cellular and hormonal basis, which is influenced by a variety of aspects (e.g. nutritional, social and neuro-immunological factors). Special attention has been given to the fundamental role of the switch from oxidative phosphorylation to glycolysis of cancer cells - the Warburg effect. Offering insights into the interdisciplinary approaches of tomorrow, this publication will encourage endocrinologists, oncologists, diabetologists, general practitioners, diabetic nurses and students of life sciences working separately on various aspects of diabetes and cancer to come together and combine therapies and strategies.
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Table of Contents
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1 - 18: Pathophysiology of Diabetes Mellitus Type 2: Roles of Obesity, Insulin Resistance and Β-Cell DysfunctionByF. ThévenodF. ThévenodDepartment of Physiology and Pathophysiology, University of Witten/Herdecke, Witten, GermanySearch for other works by this author on:
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19 - 29: In vivo Β-Cell Imaging in Diabetes, Β-Cell Hyperplasia, and InsulinomaByM. Gotthardt;M. GotthardtaDepartment of Nuclear Medicine, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands; b Department of Nuclear Medicine, University Hospital Giessen and Marburg, Campus Marburg, Marburg, Germany, and c Laboratoire d’Optique Biomédicale, Faculté des Sciences et Techniques de l’Ingénieur, Ecole Polytechnique Fédérale de Lausanne, Lausanne, SwitzerlandSearch for other works by this author on:M. Béhé;M. BéhéaDepartment of Nuclear Medicine, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands; b Department of Nuclear Medicine, University Hospital Giessen and Marburg, Campus Marburg, Marburg, Germany, and c Laboratoire d’Optique Biomédicale, Faculté des Sciences et Techniques de l’Ingénieur, Ecole Polytechnique Fédérale de Lausanne, Lausanne, SwitzerlandSearch for other works by this author on:T. LasserT. LasseraDepartment of Nuclear Medicine, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands; b Department of Nuclear Medicine, University Hospital Giessen and Marburg, Campus Marburg, Marburg, Germany, and c Laboratoire d’Optique Biomédicale, Faculté des Sciences et Techniques de l’Ingénieur, Ecole Polytechnique Fédérale de Lausanne, Lausanne, SwitzerlandSearch for other works by this author on:
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30 - 43: Incretin-Based Therapies for the Treatment of Type 2 Diabetes - DPP-4 Inhibitors and Incretin MimeticsByB. GallwitzB. GallwitzDepartment of Medicine IV, Eberhard Karls University, Tübingen, GermanySearch for other works by this author on:
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44 - 58: Janus Face of Glucose and Glucose-Regulating HormonesByK. MasurK. MasurInstitute of Immunology and Experimental Oncology, University of Witten/Herdecke, Witten, GermanySearch for other works by this author on:
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59 - 70: Role of Glucose Metabolism in Carcinogenesis and Cancer ProgressionByR. GatenbyR. GatenbyDepartment of Radiology, Moffitt Cancer Center, Tampa, Fla., USASearch for other works by this author on:
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71 - 83: Glucose Transporters: Their Abnormalities and Significance in Type 2 Diabetes and CancerByA. SchürmannA. SchürmannDepartment of Pharmacology, German Institute of Human Nutrition, Potsdam-Rehbrücke, Nuthetal, GermanySearch for other works by this author on:
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84 - 96: The Epidemiologic Relationship between Diabetes and CancerByK. ZänkerK. ZänkerInstitute of Immunology and Experimental Oncology, University of Witten/Herdecke, Witten, GermanySearch for other works by this author on:
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97 - 113: Diabetes Mellitus and Breast CancerByI. Wolf;I. WolfInstitute of Oncology, Chaim Sheba Medical Center, Ramat Gan, and Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, IsraelSearch for other works by this author on:T. RubinekT. RubinekInstitute of Oncology, Chaim Sheba Medical Center, Ramat Gan, and Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, IsraelSearch for other works by this author on:
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114 - 133: Nutrition, Diabetes, and CancerByJ. LaValleJ. LaValleLaValle Metabolic Institute, Cincinnati, Ohio, USASearch for other works by this author on:
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134 - 144: Diabetes and Cancer: The Road AheadByK. Masur;K. MasuraInstitute of Immunology and Experimental Oncology, and b Department of Physiology and Pathophysiology, University of Witten/Herdecke, Witten, GermanySearch for other works by this author on:F. Thévenod;F. ThévenodaInstitute of Immunology and Experimental Oncology, and b Department of Physiology and Pathophysiology, University of Witten/Herdecke, Witten, GermanySearch for other works by this author on:K. ZänkerK. ZänkeraInstitute of Immunology and Experimental Oncology, and b Department of Physiology and Pathophysiology, University of Witten/Herdecke, Witten, GermanySearch for other works by this author on:
