Disorders of the Human Adrenal Cortex
Substantial further advances in our understanding of adrenal development, steroid biosynthesis and adrenocortical disorders necessitate another look at this small but complex organ. In this volume, leaders in the fields of adrenal development, biochemistry and genetics review the most recent findings from bench and bedside research. New aspects of adrenal development and zonation and the novel ‘backdoor’ pathway to androgen synthesis are discussed. P450 oxidoreductase deficiency (a newly described form of congenital adrenal hyperplasia) and long-term outcome of prenatal treatment of 21-hydroxylase deficiency are examined. An update on ACTH resistance and adrenal Cushing’s syndrome is provided. Finally, the role of adrenal steroidogenesis in arterial hypertension and fetal programming of adrenal androgen excess as a possible explanation for polycystic ovary syndrome in later life are analyzed. This book will be of great interest to pediatric, adult and reproductive endocrinologists, clinical geneticists, developmental biologists and basic scientists working in the fields of endocrinology and steroidogenesis.
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Table of Contents
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1 - 18: Steroidogenic EnzymesByWalter L. MillerWalter L. MillerDivision of Endocrinology, Department of Pediatrics, University of California, San Francisco,Calif., USASearch for other works by this author on:
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19 - 32: Disorders of Adrenal DevelopmentByBruno Ferraz-de-Souza;Bruno Ferraz-de-SouzaDevelopmental Endocrinology Research Group, Clinical and Molecular Genetics Unit, UCL Institute of Child Health, University College London, London, UKSearch for other works by this author on:John C. AchermannJohn C. AchermannDevelopmental Endocrinology Research Group, Clinical and Molecular Genetics Unit, UCL Institute of Child Health, University College London, London, UKSearch for other works by this author on:
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33 - 54: Adrenal Androgens in Humans and Nonhuman Primates: Production, Zonation and RegulationByAnn D. Nguyen;Ann D. NguyenPopulation Health and Reproduction, School of Veterinary Medicine,University of California-Davis, Davis, Calif., USASearch for other works by this author on:Alan J. ConleyAlan J. ConleyPopulation Health and Reproduction, School of Veterinary Medicine,University of California-Davis, Davis, Calif., USASearch for other works by this author on:
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55 - 66: Clinical Implications of Androgen Synthesis via 5α-Reduced PrecursorsByHans K. Ghayee;Hans K. GhayeeDivision of Endocrinology and Metabolism, Department of Internal Medicine,University of Texas Southwestern Medical Center, Dallas, Tex., USASearch for other works by this author on:Richard J. AuchusRichard J. AuchusDivision of Endocrinology and Metabolism, Department of Internal Medicine,University of Texas Southwestern Medical Center, Dallas, Tex., USASearch for other works by this author on:
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67 - 81: P450 Oxidoreductase Deficiency – A New Form of Congenital Adrenal HyperplasiaByChrista E. Flück;Christa E. FlückaDivision of Pediatric Endocrinology and Diabetology, Department of Pediatrics, University of Bern, Bern, Switzerland;Search for other works by this author on:Amit V. Pandey;Amit V. PandeyaDivision of Pediatric Endocrinology and Diabetology, Department of Pediatrics, University of Bern, Bern, Switzerland;Search for other works by this author on:Ningwu Huang;Ningwu HuangbDepartment of Pediatrics, University of California San Francisco, San Francisco, Calif., USASearch for other works by this author on:Vishal Agrawal;Vishal AgrawalbDepartment of Pediatrics, University of California San Francisco, San Francisco, Calif., USASearch for other works by this author on:Walter L. MillerWalter L. MillerbDepartment of Pediatrics, University of California San Francisco, San Francisco, Calif., USASearch for other works by this author on:
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82 - 98: Long-Term Outcome of Prenatal Treatment of Congenital Adrenal HyperplasiaBySvetlana Lajic;Svetlana LajicDepartment of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, SwedenSearch for other works by this author on:Anna Nordenström;Anna NordenströmDepartment of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, SwedenSearch for other works by this author on:Tatja HirvikoskiTatja HirvikoskiDepartment of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, SwedenSearch for other works by this author on:
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99 - 116: Adrenocorticotropin Resistance SyndromesBySadani N. Cooray;Sadani N. CoorayCentre for Endocrinology, William Harvey Research Institute, Barts and the London,London, UKSearch for other works by this author on:Li Chan;Li ChanCentre for Endocrinology, William Harvey Research Institute, Barts and the London,London, UKSearch for other works by this author on:Lou Metherell;Lou MetherellCentre for Endocrinology, William Harvey Research Institute, Barts and the London,London, UKSearch for other works by this author on:Helen Storr;Helen StorrCentre for Endocrinology, William Harvey Research Institute, Barts and the London,London, UKSearch for other works by this author on:Adrian J.L. ClarkAdrian J.L. ClarkCentre for Endocrinology, William Harvey Research Institute, Barts and the London,London, UKSearch for other works by this author on:
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117 - 132: Cushing Syndrome Caused by Adrenocortical Tumors and Hyperplasias (Corticotropin- Independent Cushing Syndrome)ByConstantine A. StratakisConstantine A. StratakisSection on Endocrinology and Genetics, Program on Developmental Endocrinology and Genetics, National Institute of Child Health and Human Development,National Institutes of Health, Bethesda, Md., USASearch for other works by this author on:
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133 - 144: The Role of Adrenal Steroidogenesis in Arterial HypertensionByMarkus G. MohauptMarkus G. MohauptDivision of Hypertension, Department of Nephrology/Hypertension, University of Bern, Bern, SwitzerlandSearch for other works by this author on:
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145 - 158: Fetal Programming of Adrenal Androgen Excess: Lessons from a Nonhuman Primate Model of Polycystic Ovary SyndromeByDavid H. Abbott;David H. AbbottaDepartment of Obstetrics and Gynecology,b Wisconsin National Primate Research Center andc Endocrinology-Reproductive Physiology Training Program, University of Wisconsin, Madison, Wisc.,Search for other works by this author on:Rao Zhou;Rao ZhouaDepartment of Obstetrics and Gynecology,Search for other works by this author on:Ian M. Bird;Ian M. BirdaDepartment of Obstetrics and Gynecology,c Endocrinology-Reproductive Physiology Training Program, University of Wisconsin, Madison, Wisc.,Search for other works by this author on:Daniel A. Dumesic;Daniel A. Dumesicb Wisconsin National Primate Research Center andd Reproductive Medicine and Infertility Associates, Woodbury, Minn., andSearch for other works by this author on:Alan J. ConleyAlan J. ConleyePopulation Health and Reproduction, School of Veterinary Medicine, University of California-Davis, Davis, Calif., USASearch for other works by this author on: