Avian Influenza
Because of its high impact on both animal and human health, avian influenza has become a matter of increasing public concern and growing scientific interest within the last decade. This volume gives an overview of the most important results of these research efforts and provides information about the ecology and epidemiology of avian influenza with particular emphasis on recent H5N1 outbreaks in China, Siberia and Europe. Several articles deal with new vaccination strategies, the use of antivirals and other control measures to combat outbreaks of avian influenza. Further chapters illustrate that molecular biology, culminating in the generation of influenza viruses by recombinant DNA technology, was instrumental in unravelling the roles of the viral hemagglutinin and polymerase as well as cellular signalling pathways and innate immunity in pathogenesis and interspecies transmission. Finally, the threat of a pandemic originating from avian influenza viruses is illustrated by the example of the Spanish influenza of 1918. This comprehensive publication on avian influenza viruses and their relevance for human influenza will be of great value to all influenza virologists, molecular biologists, public health scientists, veterinary virologists, ecologists, and scientists engaged in drug design and vaccine development.
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Table of Contents
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1 - 10: Epidemiology of Avian InfluenzaByAlbert D.M.E. Osterhaus;Albert D.M.E. OsterhausDepartment of Virology, Erasmus MC, Rotterdam, The NetherlandsSearch for other works by this author on:Vincent J. Munster;Vincent J. MunsterDepartment of Virology, Erasmus MC, Rotterdam, The NetherlandsSearch for other works by this author on:Ron A.M. FouchierRon A.M. FouchierDepartment of Virology, Erasmus MC, Rotterdam, The NetherlandsSearch for other works by this author on:
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11 - 26: H5N1 in AsiaByHui-Ling Yen;Hui-Ling YenaSt. Jude Children’s Research Hospital, Department of Infectious Diseases, Division of Virology, Memphis, Tenn., USA, andSearch for other works by this author on:Yi Guan;Yi Guanb University of Hong Kong, Queen Mary Hospital Compound, Hong Kong, SAR, ChinaSearch for other works by this author on:Malik Peiris;Malik Peirisb University of Hong Kong, Queen Mary Hospital Compound, Hong Kong, SAR, ChinaSearch for other works by this author on:Robert G. WebsterRobert G. WebsteraSt. Jude Children’s Research Hospital, Department of Infectious Diseases, Division of Virology, Memphis, Tenn., USA, andSearch for other works by this author on:
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27 - 40: Epidemiology and Control of H5N1 Avian Influenza in ChinaByHualan Chen;Hualan ChenAnimal Influenza Laboratory of the Ministry of Agriculture and National Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, PR ChinaSearch for other works by this author on:Zhigao Bu;Zhigao BuAnimal Influenza Laboratory of the Ministry of Agriculture and National Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, PR ChinaSearch for other works by this author on:Jingfei WangJingfei WangAnimal Influenza Laboratory of the Ministry of Agriculture and National Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, PR ChinaSearch for other works by this author on:
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41 - 58: Avian Influenza in Northern EurasiaByDmitri K. Lvov;Dmitri K. LvovThe D.I. Ivanovsky Institute of Virology, RAMS, Moscow, RussiaSearch for other works by this author on:Nikolai V. KaverinNikolai V. KaverinThe D.I. Ivanovsky Institute of Virology, RAMS, Moscow, RussiaSearch for other works by this author on:
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59 - 70: Avian Influenza in Italy 1997–2006ByIlaria Capua;Ilaria CapuaNational OIE/FAO Reference Laboratory for Newcastle Disease and Avian Influenza,Istituto Zooprofilattico Sperimentale delle Venezie, Legnaro/Padova, ItalySearch for other works by this author on:Giovanni Cattoli;Giovanni CattoliNational OIE/FAO Reference Laboratory for Newcastle Disease and Avian Influenza,Istituto Zooprofilattico Sperimentale delle Venezie, Legnaro/Padova, ItalySearch for other works by this author on:Calogero Terregino;Calogero TerreginoNational OIE/FAO Reference Laboratory for Newcastle Disease and Avian Influenza,Istituto Zooprofilattico Sperimentale delle Venezie, Legnaro/Padova, ItalySearch for other works by this author on:Stefano MarangonStefano MarangonNational OIE/FAO Reference Laboratory for Newcastle Disease and Avian Influenza,Istituto Zooprofilattico Sperimentale delle Venezie, Legnaro/Padova, ItalySearch for other works by this author on:
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71 - 87: Avian Influenza Outbreaks in Germany – Development of New Avian VaccinesByOrtrud Werner;Ortrud WernerFriedrich-Loeffler-Institute, Federal Research Institute for Animal Health, Greifswald-Insel Riems, GermanySearch for other works by this author on:Timm Harder;Timm HarderFriedrich-Loeffler-Institute, Federal Research Institute for Animal Health, Greifswald-Insel Riems, GermanySearch for other works by this author on:Jutta Veits;Jutta VeitsFriedrich-Loeffler-Institute, Federal Research Institute for Animal Health, Greifswald-Insel Riems, GermanySearch for other works by this author on:Angela Römer-Oberdörfer;Angela Römer-OberdörferFriedrich-Loeffler-Institute, Federal Research Institute for Animal Health, Greifswald-Insel Riems, GermanySearch for other works by this author on:Walter Fuchs;Walter FuchsFriedrich-Loeffler-Institute, Federal Research Institute for Animal Health, Greifswald-Insel Riems, GermanySearch for other works by this author on:Martin Beer;Martin BeerFriedrich-Loeffler-Institute, Federal Research Institute for Animal Health, Greifswald-Insel Riems, GermanySearch for other works by this author on:Franz J. Conraths;Franz J. ConrathsFriedrich-Loeffler-Institute, Federal Research Institute for Animal Health, Greifswald-Insel Riems, GermanySearch for other works by this author on:Thomas C. MettenleiterThomas C. MettenleiterFriedrich-Loeffler-Institute, Federal Research Institute for Animal Health, Greifswald-Insel Riems, GermanySearch for other works by this author on:
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88 - 100: The Role of Pigs in Interspecies TransmissionByIan H. BrownIan H. BrownVeterinary Laboratories Agency-Weybridge, Addlestone, Surrey, UKSearch for other works by this author on:
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101 - 117: History of Research on Avian InfluenzaByChristoph ScholtissekChristoph ScholtissekLinden, GermanySearch for other works by this author on:
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118 - 133: Reverse Genetics of Influenza Viruses – Applications in Research and Vaccine DesignByGabriele Neumann;Gabriele NeumannaDepartment of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, Wisc., USA;Search for other works by this author on:Taisuke Horimoto;Taisuke Horimotob Division of Virology, Department of Microbiology and Immunology, International Research Center for Infectious Diseases, Institute of Medical Science, University of Tokyo, Tokyo, andSearch for other works by this author on:Yoshihiro KawaokaYoshihiro KawaokaaDepartment of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, Wisc., USA;b Division of Virology, Department of Microbiology and Immunology, International Research Center for Infectious Diseases, Institute of Medical Science, University of Tokyo, Tokyo, andc CREST, Japan Science and Technology Agency, Saitama, JapanSearch for other works by this author on:
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134 - 155: Receptor Specificity of Influenza Viruses and Its Alteration during Interspecies TransmissionByMikhail N. Matrosovich;Mikhail N. MatrosovichaInstitute of Virology, Philipps University, Marburg, Germany, andSearch for other works by this author on:Alexandra S. Gambaryan;Alexandra S. GambaryanbM.P. Chumakov Institute of Poliomyelitis and Viral Encephalitides, Moscow, RussiaSearch for other works by this author on:Hans-Dieter KlenkHans-Dieter KlenkbM.P. Chumakov Institute of Poliomyelitis and Viral Encephalitides, Moscow, RussiaSearch for other works by this author on:
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156 - 167: Cleavage Activation of the Influenza Virus Hemagglutinin and Its Role in PathogenesisByWolfgang Garten;Wolfgang GartenInstitute of Virology, Philipps University, Marburg, GermanySearch for other works by this author on:Hans-Dieter KlenkHans-Dieter KlenkInstitute of Virology, Philipps University, Marburg, GermanySearch for other works by this author on:
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168 - 186: Structure and Function of the Influenza A Virus Ribonucleoprotein: Transcription and ReplicationByJuan OrtínJuan OrtínCentro Nacional de Biotecnología (CSIC), Darwin 3, Cantoblanco, Madrid, SpainSearch for other works by this author on:
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187 - 194: Influenza A Virus Polymerase: A Determinant of Host Range and PathogenicityByJürgen StechJürgen StechFriedrich-Loeffler-Institute, Federal Research Institute for Animal Health,Institute of Molecular Biology, Greifswald-Insel Riems, GermanySearch for other works by this author on:
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195 - 209: Influenza A Virus Virulence and Innate Immunity: Recent Insights from New Mouse ModelsByOtto Haller;Otto HallerAbteilung Virologie, Institut für Medizinische Mikrobiologie und Hygiene,Universität Freiburg, Freiburg, GermanySearch for other works by this author on:Georg Kochs;Georg KochsAbteilung Virologie, Institut für Medizinische Mikrobiologie und Hygiene,Universität Freiburg, Freiburg, GermanySearch for other works by this author on:Peter StaeheliPeter StaeheliAbteilung Virologie, Institut für Medizinische Mikrobiologie und Hygiene,Universität Freiburg, Freiburg, GermanySearch for other works by this author on:
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210 - 224: Signaling to Life and Death: Influenza Viruses and Intracellular Signal Transduction CascadesByStephan Ludwig;Stephan LudwigaInstitute of Molecular Virology, Centre of Molecular Biology of Inflammation, Westfälische Wilhelms University, Münster;Search for other works by this author on:Oliver Planz;Oliver Planzb Institute of Immunology, Friedrich-Loeffler-Institute, Tübingen;Search for other works by this author on:Stephan Pleschka;Stephan Pleschkac Institute of Medical Virology, Justus Liebig University, Giessen, andSearch for other works by this author on:Thorsten WolffThorsten Wolffd Robert-Koch-Institute, Berlin, GermanySearch for other works by this author on:
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225 - 251: Cytokines in the Pathogenesis of Highly Virulent Influenza Viruses in HumansByKristien Van ReethKristien Van ReethLaboratory of Virology, Ghent University, Gent, BelgiumSearch for other works by this author on:
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252 - 271: Antivirals and ResistanceByAlan J. Hay;Alan J. HayaVirology Division, National Institute for Medical Research, London, andSearch for other works by this author on:Patrick J. Collins;Patrick J. CollinsaVirology Division, National Institute for Medical Research, London, andSearch for other works by this author on:Rupert J. RussellRupert J. Russellb Interdisciplinary Centre for Human and Avian Influenza Research, University of St Andrews, St Andrews, Fife, UKSearch for other works by this author on:
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272 - 286: The 1918 Influenza Pandemic: Lessons from the Past Raise Questions for the FutureByJohn Steel;John SteelDepartment of Microbiology, Mount Sinai School of Medicine, New York, N.Y., USASearch for other works by this author on:Peter PalesePeter PaleseDepartment of Microbiology, Mount Sinai School of Medicine, New York, N.Y., USASearch for other works by this author on: