Obesity and Metabolism
It has become increasingly difficult to keep up with the growing body of literature on the genetics, metabolic phenotype and treatment of obesity. This volume brings together an array of chapters from many of the foremost authorities and researchers in this area. Key advances in the genetics of obesity are summarized and the effects of obesity in pregnancy, childhood and old age explored. By scrutinizing the hormones and enzymes most recently implicated in the development, maintenance and consequences of obesity, the biochemical and physiological background of the abnormal metabolism of obesity is mapped out. Furthermore, a practical update on clinical approach and treatment of obesity is offered. Finally, the social aspects of obesity and the view of the obese body in art throughout the centuries are reflected.
A valuable overview of causes, metabolic disturbances and treatment options, this volume will appeal to those with an interest in clinical as well as pathophysiological and genetic aspects of obesity. Furthermore, it will provide useful reading for scientists and students who would like to broaden and update their knowledge in this area.
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Table of Contents
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1 - 11: Monogenic Human ObesityByI. Sadaf FarooqiI. Sadaf FarooqiMetabolic Research Laboratories, Institute of Metabolic Science, Addenbrooke’s Hospital, University of Cambridge,Cambridge, UKSearch for other works by this author on:
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12 - 36: Polygenic Contribution to Obesity: Genome-Wide Strategies Reveal New TargetsByAntje Körner;Antje KörneraUniversity Hospital for Children and Adolescents,Search for other works by this author on:Wieland Kiess;Wieland KiessaUniversity Hospital for Children and Adolescents,Search for other works by this author on:Michael Stumvoll;Michael Stumvollb Department of Internal Medicine III, andSearch for other works by this author on:Peter KovacsPeter Kovacsc Interdisciplinary Center for Clinical Research, University of Leipzig, Leipzig, GermanySearch for other works by this author on:
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37 - 60: Genetic Obesity SyndromesByAnthony P. Goldstone;Anthony P. GoldstoneaMRC Clinical Sciences Centre, Hammersmith Hospital, Imperial College LondonSearch for other works by this author on:Philip L. BealesPhilip L. BealesbMolecular Medicine Unit, UCL Institute of Child Health, London, UKSearch for other works by this author on:
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61 - 72: Fetal and Neonatal Pathways to ObesityByPeter D. Gluckman;Peter D. GluckmanaCentre for Human Evolution, Adaptation and Disease, Liggins Institute,c National Research Centre for Growth and Development, Auckland, New Zealand;Search for other works by this author on:Mark A. Hanson;Mark A. Hansond Institute of Developmental Sciences, University of Southampton, Southampton, UKSearch for other works by this author on:Alan S. Beedle;Alan S. BeedleaCentre for Human Evolution, Adaptation and Disease, Liggins Institute,Search for other works by this author on:David RaubenheimerDavid RaubenheimeraCentre for Human Evolution, Adaptation and Disease, Liggins Institute,b School of Biological Sciences, University of Auckland, andSearch for other works by this author on:
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73 - 84: Developmental Origins of Obesity and the Metabolic Syndrome: The Role of Maternal ObesityByJames Andrew Armitage;James Andrew ArmitageaDepartment of Anatomy and Developmental Biology, Monash University, Clayton, andbDivision of Cardiovascular Neuroscience, Baker Heart Research Institute, Melbourne, Australia;Search for other works by this author on:Lucilla Poston;Lucilla Postonc Maternal and Fetal Research Unit, Division of Reproductive Health, Endocrinology and Development, King’s College London, London, UKSearch for other works by this author on:Paul David TaylorPaul David Taylorc Maternal and Fetal Research Unit, Division of Reproductive Health, Endocrinology and Development, King’s College London, London, UKSearch for other works by this author on:
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85 - 96: Childhood ObesityByM.A. Sabin;M.A. SabinaRoyal Children’s Hospital and Murdoch Childrens Research Institute, Melbourne, Australia;b University of Bristol, Bristol, UKSearch for other works by this author on:J.P.H. ShieldJ.P.H. Shieldb University of Bristol, Bristol, UKSearch for other works by this author on:
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97 - 106: Obesity in Old AgeByIan McPhee ChapmanIan McPhee ChapmanDepartment of Medicine, Royal Adelaide Hospital, University of Adelaide, Adelaide, AustraliaSearch for other works by this author on:
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107 - 117: Models of ‘Obesity’ in Large Animals and BirdsByIain J. ClarkeIain J. ClarkeDepartment of Physiology, Monash University, Melbourne, AustraliaSearch for other works by this author on:
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118 - 134: The Β-Cell in Type 2 Diabetes and in ObesityByGuy A. Rutter;Guy A. RutteraDepartment of Cell Biology, Division of Medicine, Imperial College London, London, UK;Search for other works by this author on:Laura E. PartonLaura E. Partonb Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Mass., USASearch for other works by this author on:
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135 - 145: Role of the Endocannabinoid System in Energy Balance Regulation and ObesityByDaniela CotaDaniela CotaDepartment of Psychiatry, University of Cincinnati, Cincinnati, Ohio, USASearch for other works by this author on:
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146 - 164: 11Β-Hydroxysteroid Dehydrogenase Type 1 and ObesityByNicholas M. Morton;Nicholas M. MortonEndocrinology Unit, Centre for Cardiovascular Sciences, Queens Medical Research Institute,Edinburgh University, Edinburgh, UKSearch for other works by this author on:Jonathan R. SecklJonathan R. SecklEndocrinology Unit, Centre for Cardiovascular Sciences, Queens Medical Research Institute,Edinburgh University, Edinburgh, UKSearch for other works by this author on:
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165 - 181: Gut and Hormones and ObesityByAlison M. WrenAlison M. WrenDepartment of Endocrinology, Chelsea and Westminster Hospital NHS Foundation Trust, London, UKSearch for other works by this author on:
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182 - 197: Adipokines in ObesityByRexford S. Ahima;Rexford S. AhimaDivision of Endocrinology, Diabetes and Metabolism,Department of Medicine, University of Pennsylvania School of Medicine,Philadelphia, Pa., USASearch for other works by this author on:Suzette Y. OseiSuzette Y. OseiDivision of Endocrinology, Diabetes and Metabolism,Department of Medicine, University of Pennsylvania School of Medicine,Philadelphia, Pa., USASearch for other works by this author on:
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198 - 211: The Role of AMP-Activated Protein Kinase in ObesityByBlerina Kola;Blerina KolaDepartment of Endocrinology, Barts and the London, Queen Mary’s School of Medicine and Dentistry,University of London, London, UKSearch for other works by this author on:Ashley B. Grossman;Ashley B. GrossmanDepartment of Endocrinology, Barts and the London, Queen Mary’s School of Medicine and Dentistry,University of London, London, UKSearch for other works by this author on:Márta KorbonitsMárta KorbonitsDepartment of Endocrinology, Barts and the London, Queen Mary’s School of Medicine and Dentistry,University of London, London, UKSearch for other works by this author on:
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212 - 228: Classical Endocrine Diseases Causing ObesityByJolanta U. WeaverJolanta U. WeaverSchool of Clinical Medical Sciences, University of Newcastle, Newcastle upon Tyne, UKSearch for other works by this author on:
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229 - 259: Emerging Concepts in the Medical and Surgical Treatment of ObesityBySimon Aylwin;Simon AylwinDepartment of Endocrinology, King’s College Hospital NHS Foundation Trust, London, UKSearch for other works by this author on:Yayha Al-ZamanYayha Al-ZamanDepartment of Endocrinology, King’s College Hospital NHS Foundation Trust, London, UKSearch for other works by this author on:
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260 - 270: The Sociology of ObesityByAnnika Rosengren;Annika RosengrenaDepartment of Medicine, Sahlgrenska Universital Hospital/Ostra, and b Department of Public Health and Community Medicine, Sahlgrenska Academy at Göteborg University, Göteborg, SwedenSearch for other works by this author on:Lauren LissnerLauren LissneraDepartment of Medicine, Sahlgrenska Universital Hospital/Ostra, and b Department of Public Health and Community Medicine, Sahlgrenska Academy at Göteborg University, Göteborg, SwedenSearch for other works by this author on:
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271 - 286: Obesity in Art – A Brief OverviewByRosalind WoodhouseRosalind WoodhouseDepartment of Endocrinology, Barts and the London, Queen Mary’s School of Medicine and Dentistry,University of London, London, UKSearch for other works by this author on: