Development of the Pancreas and Neonatal Diabetes: 1st ESPE Advanced Seminar in Developmental Endocrinology, Paris, May 2007Available to Purchase
It is now clear that abnormal pancreas development can give rise to specific forms of diabetes. Thus, the study of human and animal pancreatic developmental biology, one of the main focuses of the current volume of 'Endocrine Development', is crucial - also in order to define new treatments for diabetes based on cell therapy or regenerative medicine.
This publication presents in vivo and in vitro techniques to investigate pancreas development and islet cell function. Besides, a series of reviews are included dealing with genetics. Amongst others, the transcription factors in pancreatic development are observed, and the distinct roles of HNF1beta, HNF1alpha, and HNF4alpha in regulating pancreas development, beta-cell function and growth are studied in detail. A further point under discussion is genomic imprinting and its impact on the pancreas. Special emphasis is placed on the investigation, management and treatment of neonatal diabetes.
This collection written by outstanding scientists and clinicians is a valuable reference for endocrinologists, geneticists and pancreatic developmental scientists alike.
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Table of Contents
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1 - 11: Pancreatic Development as a Basis for the Definition of New Therapies for DiabetesByRaphael ScharfmannRaphael ScharfmannINSERM U845, Necker Hospital, Faculty of Medicine, University Paris-Descartes, Paris , FranceSearch for other works by this author on:
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12 - 23: Overview of Neonatal DiabetesByJulian P. Hamilton-ShieldJulian P. Hamilton-ShieldUniversity of Bristol and Bristol Royal Hospital for Children, Bristol , UKSearch for other works by this author on:
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24 - 32: Transcription Factors in Pancreatic Development: Animal ModelsByMerce Martin;Merce MartinInserm U682, Development and Physiopathology of the Intestine and Pancreas,Université Louis Pasteur, Strasbourg , FranceSearch for other works by this author on:Viviane Hauer;Viviane HauerInserm U682, Development and Physiopathology of the Intestine and Pancreas,Université Louis Pasteur, Strasbourg , FranceSearch for other works by this author on:Mélanie Messmer;Mélanie MessmerInserm U682, Development and Physiopathology of the Intestine and Pancreas,Université Louis Pasteur, Strasbourg , FranceSearch for other works by this author on:Christophe Orvain;Christophe OrvainInserm U682, Development and Physiopathology of the Intestine and Pancreas,Université Louis Pasteur, Strasbourg , FranceSearch for other works by this author on:Gérard GradwohlGérard GradwohlInserm U682, Development and Physiopathology of the Intestine and Pancreas,Université Louis Pasteur, Strasbourg , FranceSearch for other works by this author on:
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33 - 45: Distinct Roles of HNF1 Β , HNF1 α , and HNF4 α in Regulating Pancreas Development, Β -Cell Function and GrowthByMiguel Angel Maestro;Miguel Angel MaestroGenomic Programming of Beta Cells Laboratory, Institut d’Investigacions Biomèdiques August Pi i Sunyer, Endocrinology, Hospital Clínic de Barcelona, Barcelona , SpainSearch for other works by this author on:Carina Cardalda;Carina CardaldaGenomic Programming of Beta Cells Laboratory, Institut d’Investigacions Biomèdiques August Pi i Sunyer, Endocrinology, Hospital Clínic de Barcelona, Barcelona , SpainSearch for other works by this author on:Sylvia F. Boj;Sylvia F. BojGenomic Programming of Beta Cells Laboratory, Institut d’Investigacions Biomèdiques August Pi i Sunyer, Endocrinology, Hospital Clínic de Barcelona, Barcelona , SpainSearch for other works by this author on:Reini F. Luco;Reini F. LucoGenomic Programming of Beta Cells Laboratory, Institut d’Investigacions Biomèdiques August Pi i Sunyer, Endocrinology, Hospital Clínic de Barcelona, Barcelona , SpainSearch for other works by this author on:Joan Marc Servitja;Joan Marc ServitjaGenomic Programming of Beta Cells Laboratory, Institut d’Investigacions Biomèdiques August Pi i Sunyer, Endocrinology, Hospital Clínic de Barcelona, Barcelona , SpainSearch for other works by this author on:Jorge FerrerJorge FerrerGenomic Programming of Beta Cells Laboratory, Institut d’Investigacions Biomèdiques August Pi i Sunyer, Endocrinology, Hospital Clínic de Barcelona, Barcelona , SpainSearch for other works by this author on:
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46 - 54: In vivo and in vitro Techniques to Study Pancreas Development and Islet Cell FunctionByBertrand Duvillié;Bertrand DuvilliéINSERM U845, Necker Hospital, Faculty of Medicine, University Paris-Descartes, Paris , FranceSearch for other works by this author on:Mylène Heinis;Mylène HeinisINSERM U845, Necker Hospital, Faculty of Medicine, University Paris-Descartes, Paris , FranceSearch for other works by this author on:Volodymyr StetsyukVolodymyr StetsyukINSERM U845, Necker Hospital, Faculty of Medicine, University Paris-Descartes, Paris , FranceSearch for other works by this author on:
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55 - 66: Functional Imaging of the Pancreas: The Role of [ 18 F]Fluoro- L -DOPA PET in the Diagnosis of Hyperinsulinism of InfancyByMaria-João Ribeiro;Maria-João RibeiroaLife Sciences Division, Biomedical Imaging Institute, Frédéric Joliot Hospital, CEA, Orsay , andSearch for other works by this author on:Nathalie Boddaert;Nathalie BoddaertbDepartments of Radiology, Pediatrics, Surgery and Pathology, Necker-Enfants Malades Hospital, AP-HP, Paris , FranceSearch for other works by this author on:Thierry Delzescaux;Thierry DelzescauxaLife Sciences Division, Biomedical Imaging Institute, Frédéric Joliot Hospital, CEA, Orsay , andSearch for other works by this author on:Vassili Valayannopoulos;Vassili ValayannopoulosbDepartments of Radiology, Pediatrics, Surgery and Pathology, Necker-Enfants Malades Hospital, AP-HP, Paris , FranceSearch for other works by this author on:Christine Bellanné-Chantelot;Christine Bellanné-ChantelotbDepartments of Radiology, Pediatrics, Surgery and Pathology, Necker-Enfants Malades Hospital, AP-HP, Paris , FranceSearch for other works by this author on:Francis Jaubert;Francis JaubertbDepartments of Radiology, Pediatrics, Surgery and Pathology, Necker-Enfants Malades Hospital, AP-HP, Paris , FranceSearch for other works by this author on:Virginie Verkarre;Virginie VerkarrebDepartments of Radiology, Pediatrics, Surgery and Pathology, Necker-Enfants Malades Hospital, AP-HP, Paris , FranceSearch for other works by this author on:Claire Nihoul-Fékété;Claire Nihoul-FékétébDepartments of Radiology, Pediatrics, Surgery and Pathology, Necker-Enfants Malades Hospital, AP-HP, Paris , FranceSearch for other works by this author on:Francis Brunelle;Francis BrunellebDepartments of Radiology, Pediatrics, Surgery and Pathology, Necker-Enfants Malades Hospital, AP-HP, Paris , FranceSearch for other works by this author on:Pascale De LonlayPascale De LonlaybDepartments of Radiology, Pediatrics, Surgery and Pathology, Necker-Enfants Malades Hospital, AP-HP, Paris , FranceSearch for other works by this author on:
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67 - 74: Insulin Pump Therapy in Neonatal DiabetesByNadia Tubiana-RufiNadia Tubiana-RufiDepartment of Endocrinology and Diabetology, Robert Debré Hospital, AP-HP, Paris , FranceSearch for other works by this author on:
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75 - 85: Generating New Candidate Genes for Neonatal Diabetes: Functional and Genetic Studies of Insulin Secretion in Type 2 DiabetesByGuy A. RutterGuy A. RutterDepartment of Cell Biology, Division of Medicine, Imperial College London, London , UKSearch for other works by this author on:
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86 - 98: Diabetes in Very Young Children and Mutations in the Insulin-Secreting Cell Potassium Channel Genes: Therapeutic ConsequencesByIsabelle Flechtner;Isabelle FlechtneraClinique des Maladies du Développement, Unité d’Endocrinologie, Diabétologie et Gynécologie Pédiatrique, Hôpital Necker-Enfants Malades,Search for other works by this author on:Martine Vaxillaire;Martine VaxillairedCentre National de la Recherche Scientifique UMR 8090, Institute of Biology, Pasteur Institute, Lille , France;Search for other works by this author on:Hélène Cavé;Hélène Cavéb Genetic biochemistry, Hôpital Robert-Debré, andSearch for other works by this author on:Raphael Scharfmann;Raphael Scharfmannc Unité INSERM U845, Université Paris-V, Paris , andSearch for other works by this author on:Philippe Froguel;Philippe FrogueldCentre National de la Recherche Scientifique UMR 8090, Institute of Biology, Pasteur Institute, Lille , France;e Imperial College, Hammersmith Hospital (PF), London , UKSearch for other works by this author on:Michel PolakMichel PolakaClinique des Maladies du Développement, Unité d’Endocrinologie, Diabétologie et Gynécologie Pédiatrique, Hôpital Necker-Enfants Malades,c Unité INSERM U845, Université Paris-V, Paris , andSearch for other works by this author on:
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99 - 112: Genomic Imprinting – Roles and Regulation in DevelopmentByGavin KelseyGavin KelseyLaboratory of Developmental Genetics and Imprinting, The Babraham Institute, Cambridge , UKSearch for other works by this author on:
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113 - 123: Imprinting in Human Disease with Special Reference to Transient Neonatal Diabetes and Beckwith-Wiedemann SyndromeByI. Karen TempleI. Karen TempleWessex Clinical Genetics Academic Group, Division of Human Genetics,University of Southampton, Southampton , UKSearch for other works by this author on:
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124 - 137: The Physiology and Clinical Management of Glucose Metabolism in the NewbornByKathryn Beardsall;Kathryn BeardsallDepartment of Paediatrics, University of Cambridge, Addenbrooke’s Hospital NHS Trust,Cambridge , UKSearch for other works by this author on:David DungerDavid DungerDepartment of Paediatrics, University of Cambridge, Addenbrooke’s Hospital NHS Trust,Cambridge , UKSearch for other works by this author on: