Skip Nav Destination
Drug HypersensitivityAvailable to Purchase
Edited by
S.Karger AG
Status:
Available
ISBN electronic:
978-3-318-01454-9
ISBN print:
978-3-8055-8269-8
Subject Area:
Dermatology
,
Further Areas
,
General Medicine
,
Immunology and Allergy
,
Nephrology
,
Pharmacology
Publication date:
2007
Book Details
Drug hypersensitivities are immune-mediated reactions characterized by exanthems, fever and internal organ involvement. They represent a challenging field of research: many different drugs can induce a variety of clinical symptoms through multiple mechanisms of drug-host interaction, many of which are poorly understood. This is the first book to approach the phenomenon of drug hypersensitivity in a comprehensive manner. Besides epidemiological aspects, it addresses the immunological mechanisms underlying these complicated reactions which go far beyond the IgE-mediated drug allergies also considered in the book. Furthermore, the book covers clinical manifestations and new diagnostic methods, and introduces some recently established animal models. Well-accepted and also completely new concepts are presented and discussed in detail. Many topics are treated from multiple perspectives, and the 33 chapters are thoroughly cross-referenced. This publication will be of immense value not only to allergologists, dermatologists and anyone prescribing medication, but also to scientists in a pharmaceutical industry challenged by the economic effects of failures in drug development or drug removal from the market. Elucidating the mechanisms of drug hypersensitivity will not only help to identify patients at risk but will also provide novel insights into the pathophysiology of numerous immune-mediated diseases. (A Karger "Publishing Highlights 1890–2015" title)
Drug Hypersensitivity
Edited by: W.J. Pichler
https://doi.org/10.1159/isbn.978-3-318-01454-9
ISBN (print): 978-3-8055-8269-8
ISBN (electronic): 978-3-318-01454-9
Publisher: S.Karger AG
Published: 2007
Download citation file:
Digital Version
Pay-Per-View Access
$322.00
Print Version
Drug Hypersensitivity
$322.00
Table of Contents
-
Epidemiology of Drug Allergies: Epidemiology and Causes of Drug HypersensitivityByPascal Demoly;Pascal DemolyaExploration des allergies et INSERM, Hôpital Arnaud de Villeneuve, University Hospital of Montpellier, Montpellier , France; bDepartment of Internal Medicine and Geriatrics, UCSC-Allergy Unit, Complesso Integrato Columbus, Rome , and c IRCCS Oasi Maria S.S., Troina , Italy; d Alergy Department, Hospital Maria Pia, Porto , PortugalSearch for other works by this author on:Marinella Viola;Marinella ViolaaExploration des allergies et INSERM, Hôpital Arnaud de Villeneuve, University Hospital of Montpellier, Montpellier , France; bDepartment of Internal Medicine and Geriatrics, UCSC-Allergy Unit, Complesso Integrato Columbus, Rome , and c IRCCS Oasi Maria S.S., Troina , Italy; d Alergy Department, Hospital Maria Pia, Porto , PortugalSearch for other works by this author on:Eva Rebelo Gomes;Eva Rebelo GomesaExploration des allergies et INSERM, Hôpital Arnaud de Villeneuve, University Hospital of Montpellier, Montpellier , France; bDepartment of Internal Medicine and Geriatrics, UCSC-Allergy Unit, Complesso Integrato Columbus, Rome , and c IRCCS Oasi Maria S.S., Troina , Italy; d Alergy Department, Hospital Maria Pia, Porto , PortugalSearch for other works by this author on:Antonino RomanoAntonino RomanoaExploration des allergies et INSERM, Hôpital Arnaud de Villeneuve, University Hospital of Montpellier, Montpellier , France; bDepartment of Internal Medicine and Geriatrics, UCSC-Allergy Unit, Complesso Integrato Columbus, Rome , and c IRCCS Oasi Maria S.S., Troina , Italy; d Alergy Department, Hospital Maria Pia, Porto , PortugalSearch for other works by this author on:
-
Epidemiology and Causes of Severe Cutaneous Adverse Reactions to DrugsByMaja MockenhauptMaja MockenhauptDokumentationszentrum schwerer Hautreaktionen, Department of Dermatology, University Medical Center Freiburg, Freiburg , GermanySearch for other works by this author on:
-
Pathomechanisms, Genetics and Animal Models: Chemical-Induced Contact Hypersensitivity in the Mouse ModelByStefan F. MartinStefan F. MartinAllergy Research Group, Department of Dermatology, University Medical Center Freiburg, Freiburg , GermanySearch for other works by this author on:
-
Lessons from Nickel Hypersensitivity: Structural FindingsByHans Ulrich WeltzienHans Ulrich WeltzienMax-Planck-Institut für Immunbiologie, Freiburg , GermanySearch for other works by this author on:
-
Drugs as Haptens, Antigens, and ImmunogensByB. Kevin Park;B. Kevin ParkDepartment of Pharmacology and Therapeutics, University of Liverpool, Liverpool , UKSearch for other works by this author on:Joseph P. Sanderson;Joseph P. SandersonDepartment of Pharmacology and Therapeutics, University of Liverpool, Liverpool , UKSearch for other works by this author on:Dean J. NaisbittDean J. NaisbittDepartment of Pharmacology and Therapeutics, University of Liverpool, Liverpool , UKSearch for other works by this author on:
-
The p-i Concept: Evidence and ImplicationsByBasil O. Gerber;Basil O. GerberDivision of Allergology, Clinic and Policlinic for Rheumatology and Clinical Immunology/Allergology, Inselspital, Bern , SwitzerlandSearch for other works by this author on:Werner J. PichlerWerner J. PichlerDivision of Allergology, Clinic and Policlinic for Rheumatology and Clinical Immunology/Allergology, Inselspital, Bern , SwitzerlandSearch for other works by this author on:
-
Tolerance Mechanisms to Small Molecular CompoundsByAndrea Cavani;Andrea CavaniLaboratory of Immunology and Allergology, IDI-IRCCS, Rome , ItalySearch for other works by this author on:Ornella De PitàOrnella De PitàLaboratory of Immunology and Allergology, IDI-IRCCS, Rome , ItalySearch for other works by this author on:
-
HIV and Drug HypersensitivityByMunir PirmohamedMunir PirmohamedDepartment of Pharmacology and Therapeutics, University of Liverpool, Liverpool , UKSearch for other works by this author on:
-
Abacavir HypersensitivityByDavid Nolan;David NolanCentre for Clinical Immunology and Biomedical Statistics, Royal Perth Hospital and Murdoch University, Perth , AustraliaSearch for other works by this author on:Coral-Ann Almeida;Coral-Ann AlmeidaCentre for Clinical Immunology and Biomedical Statistics, Royal Perth Hospital and Murdoch University, Perth , AustraliaSearch for other works by this author on:Elizabeth Phillips;Elizabeth PhillipsCentre for Clinical Immunology and Biomedical Statistics, Royal Perth Hospital and Murdoch University, Perth , AustraliaSearch for other works by this author on:Simon MallalSimon MallalCentre for Clinical Immunology and Biomedical Statistics, Royal Perth Hospital and Murdoch University, Perth , AustraliaSearch for other works by this author on:
-
Genetics of Severe Drug Hypersensitivity Reactions in Han ChineseByShuen-Iu Hung;Shuen-Iu HungaInstitute of Biomedical Sciences, Academia Sinica, and b Department of Dermatology, Chang Gung Memorial Hospital, Taipei , TaiwanSearch for other works by this author on:Wen-Hung Chung;Wen-Hung ChungaInstitute of Biomedical Sciences, Academia Sinica, and b Department of Dermatology, Chang Gung Memorial Hospital, Taipei , TaiwanSearch for other works by this author on:Yuan-Tsong ChenYuan-Tsong ChenaInstitute of Biomedical Sciences, Academia Sinica, and b Department of Dermatology, Chang Gung Memorial Hospital, Taipei , TaiwanSearch for other works by this author on:
-
Nevirapine HypersensitivityByJ.M. Shenton;J.M. Shentona Department of Pharmaceutical Sciences, University of Toronto, Toronto, Ont. , Canada; b Department of Immunotoxicology, Bristol-Myers Squibb Co., Syracuse, N.Y. , USA; c Department of Investigative Toxicology, Novartis Pharma AG, Basel , SwitzerlandSearch for other works by this author on:M. Popovic;M. Popovica Department of Pharmaceutical Sciences, University of Toronto, Toronto, Ont. , Canada; b Department of Immunotoxicology, Bristol-Myers Squibb Co., Syracuse, N.Y. , USA; c Department of Investigative Toxicology, Novartis Pharma AG, Basel , SwitzerlandSearch for other works by this author on:J.P. UetrechtJ.P. Uetrechta Department of Pharmaceutical Sciences, University of Toronto, Toronto, Ont. , Canada; b Department of Immunotoxicology, Bristol-Myers Squibb Co., Syracuse, N.Y. , USA; c Department of Investigative Toxicology, Novartis Pharma AG, Basel , SwitzerlandSearch for other works by this author on:
-
Animal Models of Toxic Epidermal NecrolysisByHiroaki Azukizawa;Hiroaki AzukizawaDepartments of a Dermatology and b Regenerative Dermatology, Osaka University, Graduate School of Medicine, Osaka , JapanSearch for other works by this author on:Satoshi ItamiSatoshi ItamiDepartments of a Dermatology and b Regenerative Dermatology, Osaka University, Graduate School of Medicine, Osaka , JapanSearch for other works by this author on:
-
Non-Clinical Testing Approaches for Drug Development: Possibilities and LimitationsByThomas T. Kawabata;Thomas T. KawabataDrug Safety R&D, Pfizer Global Research and Development, a Groton, Conn. and b Ann Arbor, Mich. , USASearch for other works by this author on:Joseph R. PiccottiJoseph R. PiccottiDrug Safety R&D, Pfizer Global Research and Development, a Groton, Conn. and b Ann Arbor, Mich. , USASearch for other works by this author on:
-
Adverse Side Effects to Biological AgentsByWerner J. Pichler;Werner J. Pichlera Department for Rheumatology and Clinical Immunology/Allergology, Inselspital, University of Bern, Bern , Switzerland; b Nuovo Ospedale San Giovanni di Dio, Florence , ItalySearch for other works by this author on:Paolo CampiPaolo Campia Department for Rheumatology and Clinical Immunology/Allergology, Inselspital, University of Bern, Bern , Switzerland; b Nuovo Ospedale San Giovanni di Dio, Florence , ItalySearch for other works by this author on:
-
Clinical Manifestations: Drug Hypersensitivity Reactions: Classification and Relationship to T-Cell ActivationByWerner J. PichlerWerner J. PichlerDivision of Allergology, Department for Rheumatology and Clinical Immunology/Allergology, Inselspital, University of Bern, Bern , SwitzerlandSearch for other works by this author on:
-
Urticaria and Anaphylaxis due to Betalactams (Penicillins and Cephalosporins)ByMaria José Torres;Maria José TorresAllergy Service and Research Unit for Allergic Diseases, Carlos Haya Hospital, Malaga , SpainSearch for other works by this author on:Cristobalina Mayorga;Cristobalina MayorgaAllergy Service and Research Unit for Allergic Diseases, Carlos Haya Hospital, Malaga , SpainSearch for other works by this author on:Miguel BlancaMiguel BlancaAllergy Service and Research Unit for Allergic Diseases, Carlos Haya Hospital, Malaga , SpainSearch for other works by this author on:
-
Perioperative AnaphylaxisByPascale DewachterPascale DewachterDepartment of Anesthesiology, College of Physicians and Surgeons, Columbia University, New York, N.Y. , USASearch for other works by this author on:
-
IgE-Mediated Allergy to Pyrazolones, Quinolones and Other Non- Β -Lactam AntibioticsByPaolo Campi;Paolo Campia Allergy Clinic and b Allergy Laboratory, Azienda Sanitaria di Firenze, Nuovo Ospedale San Giovanni di Dio, Florence , ItalySearch for other works by this author on:Mariangela Manfredi;Mariangela Manfredia Allergy Clinic and b Allergy Laboratory, Azienda Sanitaria di Firenze, Nuovo Ospedale San Giovanni di Dio, Florence , ItalySearch for other works by this author on:Maurizio SeverinoMaurizio Severinoa Allergy Clinic and b Allergy Laboratory, Azienda Sanitaria di Firenze, Nuovo Ospedale San Giovanni di Dio, Florence , ItalySearch for other works by this author on:
-
Hypersensitivity Reactions to Iodinated Contrast Media: An UpdateByCathrine ChristiansenCathrine ChristiansenResearch and Development, GE Healthcare, Oslo , NorwaySearch for other works by this author on:
-
Maculopapular Drug EruptionsByNikhil YawalkarNikhil YawalkarDepartment of Dermatology, University Hospital, Inselspital, Bern , SwitzerlandSearch for other works by this author on:
-
Drug-Induced Hypersensitivity Syndrome and Viral ReactivationByTetsuo Shiohara;Tetsuo ShioharaDepartment of Dermatology, Kyorin University School of Medicine, Tokyo , JapanSearch for other works by this author on:Ryo Takahashi;Ryo TakahashiDepartment of Dermatology, Kyorin University School of Medicine, Tokyo , JapanSearch for other works by this author on:Yoko KanoYoko KanoDepartment of Dermatology, Kyorin University School of Medicine, Tokyo , JapanSearch for other works by this author on:
-
Clinic and Pathogenesis of Severe Bullous Skin Reactions: Stevens-Johnson Syndrome, Toxic Epidermal NecrolysisByLaurence Allanore;Laurence AllanoreDepartment of Dermatology, Hôpital Henri Mondor, Université Paris XII, Créteil , FranceSearch for other works by this author on:Jean-Claude RoujeauJean-Claude RoujeauDepartment of Dermatology, Hôpital Henri Mondor, Université Paris XII, Créteil , FranceSearch for other works by this author on:
-
Drug Allergic Liver InjuryByAndreas Cerny;Andreas Cernya Pharmacovigilance Center and b Department of Medicine, Ospedale Regionale di Lugano, Lugano , SwitzerlandSearch for other works by this author on:Raffaela BertoliRaffaela Bertolia Pharmacovigilance Center and b Department of Medicine, Ospedale Regionale di Lugano, Lugano , SwitzerlandSearch for other works by this author on:
-
Drug-Induced Interstitial NephritisByMonika Keller;Monika KellerDivision of Allergology, Clinic of Rheumatology and Clinical Immunology/Allergology, Inselspital, Bern , SwitzerlandSearch for other works by this author on:Zoi Spanou;Zoi SpanouDivision of Allergology, Clinic of Rheumatology and Clinical Immunology/Allergology, Inselspital, Bern , SwitzerlandSearch for other works by this author on:Werner J. PichlerWerner J. PichlerDivision of Allergology, Clinic of Rheumatology and Clinical Immunology/Allergology, Inselspital, Bern , SwitzerlandSearch for other works by this author on:
-
Blood Dyscrasias Caused by Hypersensitivity to DrugsByRichard H. AsterRichard H. AsterBlood Research Institute, Blood Center of Wisconsin, and Medical College of Wisconsin, Milwaukee, Wisc. , USASearch for other works by this author on:
-
Allergy and Pseudoallergy to Drugs and Vaccines in ChildrenByClaude Ponvert;Claude PonvertRené Descartes-Paris V University, Paediatrics Department, Pulmonology, Allergology & Dermatology Unit, Sick Children’s Hospital, Paris , FranceSearch for other works by this author on:Smail Hadj-Rabia;Smail Hadj-RabiaRené Descartes-Paris V University, Paediatrics Department, Pulmonology, Allergology & Dermatology Unit, Sick Children’s Hospital, Paris , FranceSearch for other works by this author on:Pierre ScheinmannPierre ScheinmannRené Descartes-Paris V University, Paediatrics Department, Pulmonology, Allergology & Dermatology Unit, Sick Children’s Hospital, Paris , FranceSearch for other works by this author on:
-
Hypersensitivity to Aspirin and Other NSAIDs: Mechanisms, Clinical Presentation and ManagementByA. Szczeklik;A. SzczeklikDepartment of Medicine, Jagiellonian University School of Medicine, Kraków , PolandSearch for other works by this author on:E. Nizankowska-Mogilnicka;E. Nizankowska-MogilnickaDepartment of Medicine, Jagiellonian University School of Medicine, Kraków , PolandSearch for other works by this author on:M. SanakM. SanakDepartment of Medicine, Jagiellonian University School of Medicine, Kraków , PolandSearch for other works by this author on:
-
Diagnosis: Approach to the Patient with a Drug Hypersensitivity Reaction – Clinical PerspectivesByAndreas J. BircherAndreas J. BircherAllergy Unit, Department of Dermatology, University Hospital Basel, Basel , SwitzerlandSearch for other works by this author on:
-
Place of Drug Skin Tests in Investigating Systemic Cutaneous Drug ReactionsByAnnick BarbaudAnnick BarbaudDermatology Department, Fournier Hospital, Nancy , FranceSearch for other works by this author on:
-
In vitro Tests of T-Cell-Mediated Drug HypersensitivityByAndreas Beeler;Andreas BeelerDivision of Allergology, Department for Rheumatology and Clinical Immunology/Allergology, Inselspital, Bern , SwitzerlandSearch for other works by this author on:Werner J. PichlerWerner J. PichlerDivision of Allergology, Department for Rheumatology and Clinical Immunology/Allergology, Inselspital, Bern , SwitzerlandSearch for other works by this author on:
-
In vitro Tests: Basophil Activation TestsByMaría L. Sanz;María L. Sanza Department of Allergology and Clinical Immunology, University Clinic, School of Medicine, University of Navarra, Pamplona , and b Servicio de Alergia, Hospital Basurto, Bilbao , SpainSearch for other works by this author on:Pedro M. Gamboa;Pedro M. Gamboaa Department of Allergology and Clinical Immunology, University Clinic, School of Medicine, University of Navarra, Pamplona , and b Servicio de Alergia, Hospital Basurto, Bilbao , SpainSearch for other works by this author on:A.L. De WeckA.L. De Wecka Department of Allergology and Clinical Immunology, University Clinic, School of Medicine, University of Navarra, Pamplona , and b Servicio de Alergia, Hospital Basurto, Bilbao , SpainSearch for other works by this author on:
-
Desensitization with AntibioticsByRoland SolenskyRoland SolenskyDivision of Allergy and Immunology, The Corvallis Clinic, Corvallis, Oreg. , USASearch for other works by this author on:
-
Drug Desensitization in Oncology: Chemotherapy Agents and Monoclonal AntibodiesByMariana CastellsMariana CastellsHarvard Medical School, Boston, Mass. , USASearch for other works by this author on:
