Atherosclerosis, Large Arteries and Cardiovascular Risk
Arterial stiffness is now firmly established as an important and independent predictor of cardiovascular risk. The structural and functional changes of the large arteries may be age-related, but a number of conditions have been associated with accelerated arterial stiffening including the hypertensive diseases, atherosclerosis, end-stage renal disease, and traditional cardiovascular risk factors such as diabetes mellitus and smoking. This book presents the current thinking of international experts regarding the underlying mechanisms of cardiovascular risk, and the pathogenesis and pathophysiology of large arterial stiffness and reduced large arterial distensibility. It not only gives new insights into the relationship between arterial stiffness and atherosclerosis, but also establishes the possible interactions with age and other cardiovascular factors such as high blood pressure, diabetes and hyperlipidemia. Finally, the therapeutic means of approaching arterial stiffness are analyzed in detail and new perspectives for the treatment and prevention of cardiovascular diseases are developed. Authoritative and up-to-date, this book is a valuable resource for basic scientists interested in vascular physiology and pathophysiology, for clinicians in the areas of cardiology, diabetes and renal diseases, as well as for investigators in drug development.
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Table of Contents
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1 - 18: Arterial Stiffness: A Simplified Overview in Vascular MedicineByMichel E. SafarMichel E. SafarDiagnosis Center, Hôtel-Dieu Hospital, Paris , FranceSearch for other works by this author on:
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19 - 34: Aging and Arterial Structure-Function RelationsByJoseph L. Jr. Izzo;Joseph L. Jr. IzzoaState University of New York at Buffalo, Buffalo, N.Y. , andSearch for other works by this author on:Gary F. MitchellGary F. MitchellbCardiovascular Engineering, Inc., Waltham, Mass. , USASearch for other works by this author on:
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35 - 61: Local Elasticity Imaging of Vulnerable Atherosclerotic Coronary PlaquesByRadj A. Baldewsing;Radj A. BaldewsingaBiomedical Engineering, Thorax Center, Erasmus Medical Center, Rotterdam , andSearch for other works by this author on:Johannes A. Schaar;Johannes A. SchaaraBiomedical Engineering, Thorax Center, Erasmus Medical Center, Rotterdam , andSearch for other works by this author on:Frits Mastik;Frits MastikaBiomedical Engineering, Thorax Center, Erasmus Medical Center, Rotterdam , andSearch for other works by this author on:Antonius F.W. van der SteenAntonius F.W. van der SteenaBiomedical Engineering, Thorax Center, Erasmus Medical Center, Rotterdam , andbInteruniversity Cardiology Institute of the Netherlands, Utrecht , The NetherlandsSearch for other works by this author on:
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62 - 75: Endothelial Function, Mechanical Stress and AtherosclerosisByDaniel Hayoz;Daniel HayozDepartment of Medicine, Vascular Medicine, CHUV, Lausanne , SwitzerlandSearch for other works by this author on:Lucia MazzolaiLucia MazzolaiDepartment of Medicine, Vascular Medicine, CHUV, Lausanne , SwitzerlandSearch for other works by this author on:
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76 - 95: Arterial Stiffness and Extracellular MatrixByJavier DíezJavier DíezDivision of Cardiovascular Sciences, Centre for Applied Medical Research and University Clinic, School of Medicine, University of Navarra, Pamplona , SpainSearch for other works by this author on:
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96 - 116: Animal Models of Arterial StiffnessByJeffrey AtkinsonJeffrey AtkinsonPharmacology Laboratory, Pharmacy Faculty, UHP-Nancy, Nancy , FranceSearch for other works by this author on:
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117 - 124: Blood Pressure, Large Arteries and AtherosclerosisByEdward D. Frohlich;Edward D. FrohlichOchsner Clinic Foundation, New Orleans, La. , USASearch for other works by this author on:Dink SusicDink SusicOchsner Clinic Foundation, New Orleans, La. , USASearch for other works by this author on:
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125 - 138: Arterial Stiffness and Coronary Ischemic DiseaseByBronwyn A. Kingwell;Bronwyn A. KingwellBaker Heart Research Institute, Melbourne , AustraliaSearch for other works by this author on:Anna A. AhimastosAnna A. AhimastosBaker Heart Research Institute, Melbourne , AustraliaSearch for other works by this author on:
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139 - 149: Central Pulse Pressure and Atherosclerotic Alterations of Coronary ArteriesByNicolas Danchin;Nicolas DanchinaDepartment of Cardiology, Hôpital Européen Georges Pompidou, Paris , andSearch for other works by this author on:Jean-Jacques MouradJean-Jacques MouradbDepartment of Internal Medicine, Hôpital Avicenne, Bobigny , FranceSearch for other works by this author on:
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150 - 159: Does Brachial Pulse Pressure Predict Coronary Events?ByPaolo Verdecchia;Paolo VerdecchiaUnità di Ricerca Clinica, Cardiologia Preventiva, Struttura Complessa di Cardiologia, Ospedale R. Silvestrini, Perugia , ItalySearch for other works by this author on:Fabio AngeliFabio AngeliUnità di Ricerca Clinica, Cardiologia Preventiva, Struttura Complessa di Cardiologia, Ospedale R. Silvestrini, Perugia , ItalySearch for other works by this author on:
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160 - 172: Does Arterial Stiffness Predict Atherosclerotic Coronary Events?ByCarmel M. McEniery;Carmel M. McEnieryaClinical Pharmacology Unit, University of Cambridge, Addenbrooke’s Hospital, Cambridge , andSearch for other works by this author on:John R. CockcroftJohn R. CockcroftbWales Heart Research Institute, Cardiff University,University Hospital, Cardiff , UKSearch for other works by this author on:
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173 - 186: Carotid Atherosclerosis, Arterial Stiffness and Stroke EventsByEnrico Agabiti-Rosei;Enrico Agabiti-RoseiInternal Medicine, Department of Medical and Surgical Sciences,University of Brescia, Brescia , ItalySearch for other works by this author on:Maria Lorenza MuiesanMaria Lorenza MuiesanInternal Medicine, Department of Medical and Surgical Sciences,University of Brescia, Brescia , ItalySearch for other works by this author on:
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187 - 198: Atherosclerosis versus Arterial Stiffness in Advanced Renal FailureByA. Guerin;A. GuerinService de Néphrologie, Centre Hospitalier Manhes, Fleury Mérogis , FranceSearch for other works by this author on:B. Pannier;B. PannierService de Néphrologie, Centre Hospitalier Manhes, Fleury Mérogis , FranceSearch for other works by this author on:G. LondonG. LondonService de Néphrologie, Centre Hospitalier Manhes, Fleury Mérogis , FranceSearch for other works by this author on:
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199 - 211: Arterial Stiffness and Peripheral Arterial DiseaseByMichel E. SafarMichel E. SafarThe Diagnosis Center, Hôtel-Dieu Hospital, Paris , FranceSearch for other works by this author on:
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212 - 222: Cardiovascular Risk Factors, Atherosclerosis and Pulse PressureByJacques Amar;Jacques AmarService de Médecine Interne et d’hypertension artérielle, CHU Toulouse , FranceSearch for other works by this author on:Bernard ChamontinBernard ChamontinService de Médecine Interne et d’hypertension artérielle, CHU Toulouse , FranceSearch for other works by this author on:
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223 - 233: Pulse Pressure and Inflammatory Process in AtherosclerosisByJerome L. Abramson;Jerome L. AbramsonaDepartment of Epidemiology, Rollins School of Public Health, andSearch for other works by this author on:Viola VaccarinoViola VaccarinoaDepartment of Epidemiology, Rollins School of Public Health, andb Department of Medicine, Division of Cardiology, Emory University School of Medicine, Emory University, Atlanta, Ga. , USASearch for other works by this author on:
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234 - 244: Calcifications, Arterial Stiffness and AtherosclerosisByRachel H. Mackey;Rachel H. MackeyDepartment of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pa. , USASearch for other works by this author on:Lakshmi Venkitachalam;Lakshmi VenkitachalamDepartment of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pa. , USASearch for other works by this author on:Kim Sutton-TyrrellKim Sutton-TyrrellDepartment of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pa. , USASearch for other works by this author on:
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245 - 251: Diabetes and Arterial StiffeningByNathaniel Winer;Nathaniel WineraDivision of Endocrinology, Diabetes, and Hypertension, SUNY Downstate Medical Center, New York, N.Y. , andSearch for other works by this author on:James R. SowersJames R. SowersbUniversity of Missouri School of Medicine and Harry S. Truman Veterans Affairs Medical Center, Columbia, Mo. , USASearch for other works by this author on:
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252 - 260: Insulin Resistance, Arterial Stiffness and Wave ReflectionByHannele Yki-Järvinen;Hannele Yki-JärvinenDepartment of Medicine, Division of Diabetes, University of Helsinki,Helsinki , FinlandSearch for other works by this author on:Jukka WesterbackaJukka WesterbackaDepartment of Medicine, Division of Diabetes, University of Helsinki,Helsinki , FinlandSearch for other works by this author on:
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261 - 277: Cholesterol, Lipids and Arterial StiffnessByIan Wilkinson;Ian WilkinsonaClinical Pharmacology Unit, University of Cambridge, Addenbrooke’s Hospital, Cambridge , andSearch for other works by this author on:John R. CockcroftJohn R. CockcroftbDepartment of Cardiology, University of Wales College of Medicine, University Hospital, Cardiff , UKSearch for other works by this author on:
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278 - 301: Homocysteine and Large ArteriesByCoen van Guldener;Coen van GuldeneraDepartment of Internal Medicine, Amphia Hospital, Breda , andSearch for other works by this author on:Coen D.A. StehouwerCoen D.A. StehouwerbDepartment of Internal Medicine, Academic Hospital Maastricht and Cardiovascular Research Institute Maastricht, Maastricht University, Maastricht , The NetherlandsSearch for other works by this author on:
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302 - 314: Nitrates, Arterial Function, Wave Reflections and Coronary Heart DiseaseByHarold SmulyanHarold SmulyanDepartment of Medicine, Upstate Medical University, Syracuse, N.Y. , USASearch for other works by this author on:
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315 - 330: Modulation of Atherosclerosis, Blood Pressure and Arterial Elasticity by StatinsByAnjan K. Sinha;Anjan K. SinhaDivision of Cardiovascular Medicine, University of Arkansas for Medical Sciences and Central Arkansas Veterans Healthcare Center, Little Rock, Ark. , USASearch for other works by this author on:Jawahar L. MehtaJawahar L. MehtaDivision of Cardiovascular Medicine, University of Arkansas for Medical Sciences and Central Arkansas Veterans Healthcare Center, Little Rock, Ark. , USASearch for other works by this author on:
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331 - 351: Atherosclerosis, Arterial Stiffness and Antihypertensive Drug TherapyByMichel E. Safar;Michel E. SafaraThe Diagnosis Center, Hôtel-Dieu Hospital, Paris , France, andSearch for other works by this author on:Harold SmulyanHarold SmulyanbDepartment of Medicine, Upstate Medical University, Syracuse, N.Y. , USASearch for other works by this author on: