Alcohol, Tobacco and CancerAvailable to Purchase
Excessive alcohol consumption and smoking are among the major risk factors for cancer. Simultaneous indulgence further increases the risk for especially cancer of the upper aerodigestive tract due to the interaction of several metabolic and genetic factors. The first part of this book addresses in detail the correlations between alcohol and carcinogenicity, focusing on specific organs such as the upper aerodigestive tract, liver, colon, pancreas and breast. This includes the impairment of methionine-folate metabolism and DNA methylation by alcohol, as well as the use of s-adenosylmethionine to prevent cancer. Furthermore, the synergistic effects of reactive oxygen species and iron in producing liver cancer are addressed. The second part is dedicated to the role of tobacco in lung and digestive tract cancers and to their prevention, highlighting the role of phytochemicals. More specifically, the mutagenic, mitogenic, precarcinogenic, anti-apoptotic, and immunosuppressive properties of nicotine which are involved in the development of cancer, and the possible use of nicotine vaccine in the prevention of mortality associated with tobacco, are discussed. Highlighting general mechanisms leading to cancer and providing the latest information on the underlying mechanisms whereby alcohol consumption and tobacco use initiate and/or promote carcinogenesis, this book is a valuable source of information for all those interested in the topic.
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Table of Contents
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1 - 12: General Mechanisms of CancerByAnnie On On Chan;Annie On On ChanDepartment of Medicine, University of Hong Kong, Hong Kong, ChinaSearch for other works by this author on:Benjamin Chun Yu WongBenjamin Chun Yu WongDepartment of Medicine, University of Hong Kong, Hong Kong, ChinaSearch for other works by this author on:
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13 - 28: Epidemiology of Alcohol-Associated CancersByLinda Morris BrownLinda Morris BrownDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Md., USASearch for other works by this author on:
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29 - 47: Alcohol Metabolism,Tobacco and CancerBySamir ZakhariSamir ZakhariDivision of Metabolism and Health Effects, National Institute on Alcohol Abuse and Alcoholism, Bethesda, Md., USASearch for other works by this author on:
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48 - 62: Interaction of Alcohol and Tobacco in Upper Aerodigestive Tract and Stomach CancerByMikko Salaspuro;Mikko SalaspuroaResearch Unit of Substance Abuse Medicine, Biomedicum Helsinki, University of Helsinki, Helsinki, Finland;Search for other works by this author on:Ville Salaspuro;Ville SalaspuroaResearch Unit of Substance Abuse Medicine, Biomedicum Helsinki, University of Helsinki, Helsinki, Finland;Search for other works by this author on:Helmut K. SeitzHelmut K. SeitzbDepartment of Medicine, Salem Medical Center Heidelberg and Laboratory of Alcohol Research, Liver Disease and Nutrition, Heidelberg, GermanySearch for other works by this author on:
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63 - 77: Alcohol and Cancer of the Large IntestineByHelmut K. Seitz;Helmut K. SeitzaDepartment of Medicine, Salem Medical Centre and Laboratory of Alcohol Research, Liver Disease and Nutrition, Heidelberg, Germany;Search for other works by this author on:Gudrun Pöschl;Gudrun PöschlaDepartment of Medicine, Salem Medical Centre and Laboratory of Alcohol Research, Liver Disease and Nutrition, Heidelberg, Germany;Search for other works by this author on:Mikko SalaspuroMikko SalaspurobResearch Unit of Substance Abuse Medicine, Biomedicum Helsinki, University of Helsinki, Helsinki, FinlandSearch for other works by this author on:
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78 - 94: Acetaldehyde-DNA Adducts: Implications for the Molecular Mechanism of Alcohol-Related CarcinogenesisByP.J. Brooks;P.J. BrooksSection on Molecular Neurobiology, Laboratory of Neurogenetics,National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health,Bethesda, Md., USASearch for other works by this author on:Jacob A. TheruvathuJacob A. TheruvathuSection on Molecular Neurobiology, Laboratory of Neurogenetics,National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health,Bethesda, Md., USASearch for other works by this author on:
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95 - 108: Ethanol and Liver CancerByIain H. McKillop;Iain H. McKillopDepartment of Biology, University of North Carolina at Charlotte,Charlotte, N.C., USASearch for other works by this author on:Laura W. SchrumLaura W. SchrumDepartment of Biology, University of North Carolina at Charlotte,Charlotte, N.C., USASearch for other works by this author on:
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109 - 118: Alcohol, Reactive Oxygen Species, Pancreatitis and Pancreatic CancerByStephen J. Pandol;Stephen J. PandolaPancreatic Research Group,bVA Greater Los Angeles Health Care System andcUniversity of California, Los Angeles, Calif., USA;Search for other works by this author on:Mouad Edderkaoui;Mouad EdderkaouiaPancreatic Research Group,bVA Greater Los Angeles Health Care System andcUniversity of California, Los Angeles, Calif., USA;Search for other works by this author on:Jong Kyun Lee;Jong Kyun LeedSungkyunkwan University School of Medicine, Samsung Medical Center, Seoul, Korea;Search for other works by this author on:Richard Hu;Richard HuaPancreatic Research Group,bVA Greater Los Angeles Health Care System andcUniversity of California, Los Angeles, Calif., USA;Search for other works by this author on:Aurelia Lugea;Aurelia LugeaaPancreatic Research Group,bVA Greater Los Angeles Health Care System andcUniversity of California, Los Angeles, Calif., USA;Search for other works by this author on:James Sul;James SulaPancreatic Research Group,bVA Greater Los Angeles Health Care System andcUniversity of California, Los Angeles, Calif., USA;Search for other works by this author on:Minoti Apte;Minoti ApteeThe University of New South Wales, Sydney, Australia;Search for other works by this author on:Eva Vaquero;Eva Vaquerof Hospital General Vall d’Hebron, Barcelona, SpainSearch for other works by this author on:Izumi Ohno;Izumi OhnoaPancreatic Research Group,bVA Greater Los Angeles Health Care System andcUniversity of California, Los Angeles, Calif., USA;Search for other works by this author on:Ilya Gukovsky;Ilya GukovskyaPancreatic Research Group,bVA Greater Los Angeles Health Care System andcUniversity of California, Los Angeles, Calif., USA;Search for other works by this author on:Vay Liang W. Go;Vay Liang W. GoaPancreatic Research Group,Search for other works by this author on:Anna S. GukovskayaAnna S. GukovskayaaPancreatic Research Group,bVA Greater Los Angeles Health Care System andcUniversity of California, Los Angeles, Calif., USA;Search for other works by this author on:
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119 - 139: Alcohol and Breast Cancer RiskByRamona G. Dumitrescu;Ramona G. DumitrescuLombardi Comprehensive Cancer Center, Georgetown University Medical Center,Washington, D.C., USASearch for other works by this author on:Peter G. ShieldsPeter G. ShieldsLombardi Comprehensive Cancer Center, Georgetown University Medical Center,Washington, D.C., USASearch for other works by this author on:
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140 - 159: Alcohol and Tobacco Smoke in Retinoid Metabolism and Signaling: Implications for CarcinogenesisByHeather Mernitz;Heather MernitzNutrition and Cancer Biology Laboratory, Jean Mayer United States Department of Agriculture Human Nutrition Research Center on Aging at Tufts University,Boston, Mass., USASearch for other works by this author on:Xiang-Dong WangXiang-Dong WangNutrition and Cancer Biology Laboratory, Jean Mayer United States Department of Agriculture Human Nutrition Research Center on Aging at Tufts University,Boston, Mass., USASearch for other works by this author on:
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160 - 174: Role of S-Adenosyl-L-Methionine in Alcohol-Associated Liver CancerByShelly C. Lu;Shelly C. LuaUSC Research Center for Liver Diseases, USC-UCLA Research Center for Alcoholic Liver and Pancreatic Diseases, Keck School of Medicine USC, Los Angeles, Calif.,USA;Search for other works by this author on:José M. MatoJosé M. MatobCIC Biogune, Center for Cooperative Research in Biosciences, Parque Tecnológico de Bizkaia, Derio, SpainSearch for other works by this author on:
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175 - 188: Alcohol and Iron as Cofactors in Hepatocellular CarcinomaByDennis R. PetersenDennis R. PetersenDepartment of Pharmaceutical Sciences, University of Colorado Health Sciences Center, Denver, Colo., USASearch for other works by this author on:
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189 - 204: Tobacco Use and Cancer: An Epidemiologic PerspectiveByMichael J. ThunMichael J. ThunAmerican Cancer Society, Atlanta, Ga., USASearch for other works by this author on:
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205 - 228: Tobacco Associated Lung CancerByHildegard M. SchullerHildegard M. SchullerExperimental Oncology Laboratory, Department of Pathobiology, College of Veterinary Medicine, University of Tennessee, Knoxville, Tenn., USASearch for other works by this author on:
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229 - 236: Tobacco and Cancer in the Digestive TractByHelge L. Waldum;Helge L. WaldumNTNU, Department of Cancer Research and Molecular Medicine and Department of Medicine, St. Olavs Hospital, Trondheim University Hospital,Trondheim, NorwaySearch for other works by this author on:Tom C. MartinsenTom C. MartinsenNTNU, Department of Cancer Research and Molecular Medicine and Department of Medicine, St. Olavs Hospital, Trondheim University Hospital,Trondheim, NorwaySearch for other works by this author on:
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237 - 252: Modification of Experimental Carcinogenesis by Cigarette Smoke and its ConstituentsByAkiyoshi NishikawaAkiyoshi NishikawaDivision of Pathology, National Institute of Health Sciences,Kamiyoga, Setagaya-ku, Tokyo, JapanSearch for other works by this author on:
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253 - 267: Nicotine and CancerByWilliam Ka Kei Wu;William Ka Kei WuaDepartment of Pharmacology;Search for other works by this author on:Helen Pui Shan Wong;Helen Pui Shan WongaDepartment of Pharmacology;Search for other works by this author on:Chi Hin ChoChi Hin ChoaDepartment of Pharmacology;b Research Center of Infection and Immunology, Faculty of Medicine, The University of Hong Kong, Hong Kong, SAR, ChinaSearch for other works by this author on:
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268 - 287: Phytochemicals in the Prevention of Lung Cancer Induced by Tobacco CarcinogensByFung-Lung Chung;Fung-Lung ChungLombardi Comprehensive Cancer Center, Georgetown University Medical Center,Washington, D.C., USASearch for other works by this author on:Lixin MiLixin MiLombardi Comprehensive Cancer Center, Georgetown University Medical Center,Washington, D.C., USASearch for other works by this author on:
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288 - 304: Prevention of Tobacco Associated Morbidity and Mortality by a Vaccine against NicotineByLivia Franzini-Brunner;Livia Franzini-BrunnerbInstitut de Biochimie, Université de Lausanne, Lausanne,Search for other works by this author on:Thomas CernyThomas CernycDepartment of Oncology/Hematology, Kantonsspital St. Gallen, St. Gallen, SwitzerlandSearch for other works by this author on: