Infection and Inflammation: Impacts on Oncogenesis
The last two decades have shown that the local microenvironment plays a pivotal role in cancer progression. Cancer is not the result of mutation events in single cells, but of a complex interplay of tumor cells, inflammatory cells, stem cells, growth factors, cytokines, chemokines and DNA-damaging agents. This book provides an up-to-date overview of how infections and chronic inflammatory conditions can give rise to the onset of a malignant phenotype, a theory that was originally postulated by Rudolf Virchow as early as 1863. Internationally recognized experts discuss novel aspects such as the role of stem cells and the occurrence of aneuploidy in carcinogenesis. Several examples of pathogens and their correlation with specific cancer types are described, e.g. Helicobacter pylori and gastric neoplasia, and schistosomiasis and bladder cancer. The mechanisms of carcinogenesis are examined in detail as are the types of cells that can transform to a malignant phenotype, with special emphasis on stem cells which have recently been shown to give rise to cancer. Further chapters discuss the role of chemokines in directing metastasis and describe options for visualizing metastasis formation in 3-dimensional model systems and in the living body. Our increasing knowledge of the inflammatory microenvironment’s role in the carcinogenic process will be the basis for investigating new anti-inflammatory strategies to counter tumor formation and growth. Therefore, this book is essential reading for scientists and clinicians working in cancer research and prevention.
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Table of Contents
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1 - 15: In Memoriam of Rudolf Virchow: A Historical Retrospective Including Aspects of Inflammation, Infection and NeoplasiaByA. Schmidt;A. SchmidtaInstitute of Microbiology and Virology, University of Witten/Herdecke, Witten;Search for other works by this author on:O.F. WeberO.F. WeberbInstitute of Molecular Medicine and Experimental Immunology, University of Bonn, Bonn, GermanySearch for other works by this author on:
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16 - 44: Aneuploidy and Cancer: From Correlation to CausationByPeter Duesberg;Peter DuesbergaDepartment of Molecular and Cellular Biology, Donner Laboratory, UC Berkeley, Berkeley, Calif., USA;Search for other works by this author on:Ruhong Li;Ruhong LiaDepartment of Molecular and Cellular Biology, Donner Laboratory, UC Berkeley, Berkeley, Calif., USA;Search for other works by this author on:Alice Fabarius;Alice Fabariusb III. Medizinische Klinik Mannheim, University of Heidelberg at Mannheim, Mannheim, GermanySearch for other works by this author on:Ruediger HehlmannRuediger Hehlmannb III. Medizinische Klinik Mannheim, University of Heidelberg at Mannheim, Mannheim, GermanySearch for other works by this author on:
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45 - 65: Adult Stem Cell Theory of the Multi-Stage, Multi-Mechanism Theory of Carcinogenesis: Role of Inflammation on the Promotion of Initiated Stem CellsByJames E. Trosko;James E. TroskoDepartment of Pediatrics and Human Development,National Food Safety Toxicology Center, College of Human Medicine, Michigan State University, East Lansing, Mich., USASearch for other works by this author on:Mei-Hui TaiMei-Hui TaiDepartment of Pediatrics and Human Development,National Food Safety Toxicology Center, College of Human Medicine, Michigan State University, East Lansing, Mich., USASearch for other works by this author on:
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66 - 80: Helicobacter pylori and Gastric NeoplasiaByWai K. LeungWai K. LeungDepartment of Medicine and Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong KongSearch for other works by this author on:
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81 - 100: Schistosomiasis and NeoplasiaByAyman YosryAyman YosryTropical Medicine Department and Gastrointestinal Endoscopy and Liver Unit, Cairo University, Cairo, EgyptSearch for other works by this author on:
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101 - 117: Relevant Oncogenic Viruses in Veterinary Medicine: Original Pathogens and Animal Models for Human DiseaseByUwe Truyen;Uwe TruyenaInstitute for Animal Hygiene and Veterinary Public Health, University of Leipzig, Leipzig;Search for other works by this author on:Martin LöcheltMartin LöcheltbDepartment for Genome Modifications and Carcinogenesis, Focus Infection and Cancer, German Cancer Research Center (DKFZ), Heidelberg, GermanySearch for other works by this author on:
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118 - 137: The Inflammatory Tumor Microenvironment and Its Impact on Cancer DevelopmentByKarin E. de Visser;Karin E. de VisseraDepartment of Molecular Biology, The Netherlands Cancer Institute, Amsterdam, The Netherlands;Search for other works by this author on:Lisa M. CoussensLisa M. Coussensb Cancer Research Institute,cDepartment of Pathology, anddComprehensive Cancer Center, University of California, San Francisco, Calif., USASearch for other works by this author on:
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138 - 155: Co-Opting Macrophage Traits in Cancer Progression: A Consequence of Tumor Cell Fusion?ByJohn Pawelek;John PawelekaDepartments of Dermatology,dYale Cancer Center, Yale University School of Medicine, New Haven, Conn., andSearch for other works by this author on:Ashok Chakraborty;Ashok ChakrabortyaDepartments of Dermatology,dYale Cancer Center, Yale University School of Medicine, New Haven, Conn., andSearch for other works by this author on:Rossita Lazova;Rossita LazovaaDepartments of Dermatology,dYale Cancer Center, Yale University School of Medicine, New Haven, Conn., andSearch for other works by this author on:Yesim Yilmaz;Yesim Yilmazb Genetics,dYale Cancer Center, Yale University School of Medicine, New Haven, Conn., andSearch for other works by this author on:Dennis Cooper;Dennis CoopercSection of Medical Oncology, anddYale Cancer Center, Yale University School of Medicine, New Haven, Conn., andSearch for other works by this author on:Douglas Brash;Douglas Brashb Genetics,dYale Cancer Center, Yale University School of Medicine, New Haven, Conn., andSearch for other works by this author on:Tamara HandersonTamara HandersoneDepartment of Pathology, University of Massachusetts School of Medicine, Worchester, Mass., USASearch for other works by this author on:
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156 - 169: Carcinogenesis Driven by Bone Marrow-Derived Stem CellsByThomas Dittmar;Thomas DittmarInstitute of Immunology, University of Witten/Herdecke, Witten, GermanySearch for other works by this author on:Jeanette Seidel;Jeanette SeidelInstitute of Immunology, University of Witten/Herdecke, Witten, GermanySearch for other works by this author on:Kurt S. Zaenker;Kurt S. ZaenkerInstitute of Immunology, University of Witten/Herdecke, Witten, GermanySearch for other works by this author on:Bernd NiggemannBernd NiggemannInstitute of Immunology, University of Witten/Herdecke, Witten, GermanySearch for other works by this author on:
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170 - 190: Chemokine-Directed MetastasisByBrigitte N. Gomperts;Brigitte N. GompertsaDepartments of Pediatrics,Search for other works by this author on:Robert M. StrieterRobert M. Strieterb Medicine, andc Pathology, University of California, Los Angeles, School of Medicine, Los Angeles, Calif., USASearch for other works by this author on:
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191 - 199: Involvement of Chemokine Receptors in Organ-Specific MetastasisByAlbert ZlotnikAlbert ZlotnikDepartment of Molecular Medicine, Neurocrine Biosciences,San Diego, Calif., USASearch for other works by this author on:
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200 - 208: Visualization of Tumor Cell ExtravasationByChristoph Heyder;Christoph HeyderaInstitute of Immunology andSearch for other works by this author on:Eva Gloria-Maercker;Eva Gloria-MaerckeraInstitute of Immunology andSearch for other works by this author on:Wolfgang Hatzmann;Wolfgang Hatzmannb Department of Gynaecology, Marien-Hospital Witten, University of Witten/Herdecke, Witten, GermanySearch for other works by this author on:Kurt S. Zaenker;Kurt S. ZaenkeraInstitute of Immunology andSearch for other works by this author on:Thomas DittmarThomas DittmaraInstitute of Immunology andSearch for other works by this author on:
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209 - 231: Options for Visualizing Metastatic Disease in the Living BodyByMike W. Helms;Mike W. HelmsaInstitute of Pathology, University of Muenster, Muenster,Search for other works by this author on:Burkhard H. Brandt;Burkhard H. BrandtbInstitute of Tumor Biology,University Hospital Hamburg-Eppendorf, Hamburg, Germany;Search for other works by this author on:Christopher H. ContagChristopher H. Contagc Stanford University, School of Medicine, Stanford, Calif., USASearch for other works by this author on:
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232 - 239: Infection, Inflammation and Neoplasia: An Interdisciplinary ChallengeByKurt S. ZaenkerKurt S. ZaenkerInstitute of Immunology, University of Witten/Herdecke, Witten, GermanySearch for other works by this author on: