Parasites and Allergy
The inverse correlation between allergic diseases and helminth infections has been debated for over 30 years. It was initially assumed that the underlying mechanism is an imbalance between Th1 and Th2 responses that, as a result of reduced exposure to Th1-inducing infectious pathogens, has tipped to allergic Th2 responses. It has only recently been clearly demonstrated that helminth infections have negative effects on allergic disease manifestation. This was shown to be consistent with the activity of regulatory cell populations, which control the effector mechanisms of both Th1 and Th2. In this book, international experts in the field discuss the various roles of the cell populations involved in allergic reactions and helminth infections such as regulatory T and B cells, natural killer T cells, mast cells and basophils. Essential for specialists and students in the field, the contributions to this volume pave the way to new directions of research for the successful immunization against helminths and the prevention of inflammatory responses in allergic and autoimmune diseases.
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Table of Contents
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1 - 13: Helminth-Induced Immunoregulation of an Allergic Response to FoodByCathryn Nagler-AndersonCathryn Nagler-AndersonMucosal Immunology Laboratory, Massachusetts General Hospital,Charlestown, Mass., USASearch for other works by this author on:
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14 - 28: The Mutual Influence of Nematode Infection and AllergyByDeborah Negrão-Corrêa;Deborah Negrão-CorrêaaDepartments of Parasitologia andSearch for other works by this author on:Mauro M. TeixeiraMauro M. Teixeirab Bioquímica e Imunologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, MG, BrazilSearch for other works by this author on:
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29 - 44: Human Schistosomiasis Decreases Immune Responses to Allergens and Clinical Manifestations of AsthmaByMaria Ilma Araujo;Maria Ilma AraujoServiço de Imunologia, Hospital Universitário Prof. Edgard Santos, Universidade Federal da Bahia, and Escola Bahiana de Medicina e Saúde Pública, Salvador, BA, BrazilSearch for other works by this author on:Edgar M. de CarvalhoEdgar M. de CarvalhoServiço de Imunologia, Hospital Universitário Prof. Edgard Santos, Universidade Federal da Bahia, and Escola Bahiana de Medicina e Saúde Pública, Salvador, BA, BrazilSearch for other works by this author on:
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45 - 64: Proteases in Helminth- and Allergen- Induced Inflammatory ResponsesBySheila Donnelly;Sheila DonnellyaInstitute for the Biotechnology of Infectious Diseases, Westbourne Street, Gore Hill,Sydney, andSearch for other works by this author on:John P. Dalton;John P. DaltonaInstitute for the Biotechnology of Infectious Diseases, Westbourne Street, Gore Hill,Sydney, andSearch for other works by this author on:Alex LoukasAlex LoukasbDivision of Infectious Disease and Immunology, Australian Centre for International and Tropical Health and Nutrition, Queensland Institute of Medical Research, Brisbane, AustraliaSearch for other works by this author on:
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65 - 81: Mechanisms Underlying Helminth- Induced Th2 Polarization: Default, Negative or Positive Pathways?ByDragana Jankovic;Dragana JankovicLaboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Md., USASearch for other works by this author on:Svenja Steinfelder;Svenja SteinfelderLaboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Md., USASearch for other works by this author on:Marika C. Kullberg;Marika C. KullbergLaboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Md., USASearch for other works by this author on:Alan SherAlan SherLaboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Md., USASearch for other works by this author on:
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82 - 90: Regulation of Dendritic Cell Function by Pathogen-Derived Molecules Plays a Key Role in Dictating the Outcome of the Adaptive Immune ResponseByEdward J. Pearce;Edward J. PearceDepartment of Pathobiology, School of Veterinary Medicine,University of Pennsylvania, Philadelphia, Pa., USASearch for other works by this author on:Colleen M. Kane;Colleen M. KaneDepartment of Pathobiology, School of Veterinary Medicine,University of Pennsylvania, Philadelphia, Pa., USASearch for other works by this author on:Jie SunJie SunDepartment of Pathobiology, School of Veterinary Medicine,University of Pennsylvania, Philadelphia, Pa., USASearch for other works by this author on:
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91 - 112: Glycans Modulate Immune Responses in Helminth Infections and AllergyByIrma van Die;Irma van DieaGlycoimmunology Group, Department of Molecular Cell Biology and Immunology, VU University Medical Center, Amsterdam, The Netherlands;Search for other works by this author on:Richard D. CummingsRichard D. CummingsbDepartment of Biochemistry and Molecular Biology, Oklahoma Center for Medical Glycobiology, University of Oklahoma Health Sciences Center, Oklahoma City, Okla., USASearch for other works by this author on:
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113 - 127: Role of the Natural Killer T Lymphocytes in Th2 Responses during Allergic Asthma and Helminth Parasitic DiseasesByFrançois Trottein;François TrotteinaInstitut National de la Santé et de la Recherche Médicale, Unité 547, Institut Pasteur de Lille, Lille, andSearch for other works by this author on:Thierry Mallevaey;Thierry MallevaeyaInstitut National de la Santé et de la Recherche Médicale, Unité 547, Institut Pasteur de Lille, Lille, andSearch for other works by this author on:Christelle Faveeuw;Christelle FaveeuwaInstitut National de la Santé et de la Recherche Médicale, Unité 547, Institut Pasteur de Lille, Lille, andSearch for other works by this author on:Monique Capron;Monique CapronaInstitut National de la Santé et de la Recherche Médicale, Unité 547, Institut Pasteur de Lille, Lille, andSearch for other works by this author on:Maria Leite-de-MoraesMaria Leite-de-MoraesbCentre National de la Recherche Scientifique, UMA 8147, Hôpital Necker, Paris, FranceSearch for other works by this author on:
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128 - 140: The Mast Cell and Gut Nematodes: Damage and DefenceByJoanne L. Pennock;Joanne L. PennockFaculty of Life Sciences, The University of Manchester, Manchester, UKSearch for other works by this author on:Richard K. GrencisRichard K. GrencisFaculty of Life Sciences, The University of Manchester, Manchester, UKSearch for other works by this author on:
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141 - 156: Basophils, Basophilia and Helminth InfectionsByEdward Mitre;Edward MitreLaboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Md., USASearch for other works by this author on:Thomas B. NutmanThomas B. NutmanLaboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Md., USASearch for other works by this author on:
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157 - 175: Innate, Adaptive and Regulatory Responses in Schistosomiasis: Relationship to AllergyByFranca C. Hartgers;Franca C. HartgersaDepartment of Parasitology, Leiden University Medical Center, Leiden, andSearch for other works by this author on:Hermelijn H. Smits;Hermelijn H. SmitsaDepartment of Parasitology, Leiden University Medical Center, Leiden, andSearch for other works by this author on:Desiree van der Kleij;Desiree van der KleijbTNO, Defence, Safety and Security, Rijswijk, The NetherlandsSearch for other works by this author on:Maria YazdanbakhshMaria YazdanbakhshaDepartment of Parasitology, Leiden University Medical Center, Leiden, andSearch for other works by this author on:
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176 - 195: Regulatory T Cells Induced by Parasites and the Modulation of Allergic ResponsesByMark S. Wilson;Mark S. WilsonInstitute of Immunology and Infection Research, University of Edinburgh, Edinburgh, UKSearch for other works by this author on:Rick M. MaizelsRick M. MaizelsInstitute of Immunology and Infection Research, University of Edinburgh, Edinburgh, UKSearch for other works by this author on: