IGF-I and IGF Binding Proteins: Basic Research and Clinical ManagementAvailable to Purchase
The IGF system pervades the fields of development, linear and cellular growth and metabolism. Not only is the functional integrity of the IGF system crucial for normal linear growth and metabolism, it is also of fundamental importance for normal fetal development. This book consists of a compilation of chapters based on presentations at a symposium entitled ‘IGFs and IGFBPs: Assessment and Therapeutic Benefit’. Highly qualified basic scientists and endocrinologists report new advances in the broad field of IGF physiology and pathophysiology, related to clinical medicine. New and topical areas of the IGF field are covered, focussing particularly on clinically relevant topics related to growth, pediatric and adult growth hormone deficiency, metabolic disorders, diabetes mellitus and neurology. Molecular and developmental defects are discussed, as are the contributions to clinical diagnosis and management of measurement of IGFs and IGFBPs. The therapeutic potential of recombinant human IGFs and IGFBPs in a range of disorders is also covered. The present volume of Endocrine Development will be of particular interest to scientists and clinicians working in IGF and IGF-related fields and to clinicians working in both pediatric and adult endocrinology and metabolism.
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Table of Contents
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1 - 10: The IGF System: New Developments Relevant to Pediatric PracticeByRon G. RosenfeldRon G. RosenfeldLucile Packard Foundation for Children’s Health,Palo Alto, Calif., USASearch for other works by this author on:
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11 - 16: Clinical Relevance of Systemic and Local IGF-IByShoshana Yakar;Shoshana YakarDiabetes Branch, NIDDK, NIH MSC, Bethesda, Md., USASearch for other works by this author on:Patricia Pennisi;Patricia PennisiDiabetes Branch, NIDDK, NIH MSC, Bethesda, Md., USASearch for other works by this author on:Yiping Wu;Yiping WuDiabetes Branch, NIDDK, NIH MSC, Bethesda, Md., USASearch for other works by this author on:Hong Zhao;Hong ZhaoDiabetes Branch, NIDDK, NIH MSC, Bethesda, Md., USASearch for other works by this author on:Derek LeRoithDerek LeRoithDiabetes Branch, NIDDK, NIH MSC, Bethesda, Md., USASearch for other works by this author on:
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17 - 30: Cartilage Disorders: Potential Therapeutic Use of Mesenchymal Stem CellsByAnna Spagnoli;Anna SpagnoliaDepartments of Pediatrics andb Cancer Biology, Vanderbilt University Medical Center, T-0107 Medical Center North, Nashville, Tenn., USASearch for other works by this author on:Lara Longobardi;Lara LongobardiaDepartments of Pediatrics andSearch for other works by this author on:Lynda O’RearLynda O’RearaDepartments of Pediatrics andSearch for other works by this author on:
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31 - 43: Treatment in Animal ModelsByJ. Guan;J. GuanThe Liggins Institute, Department of Physiology and Departments of Paediatrics and Obstetrics and Gynaecology, Faculty of Medicine and Health Sciences, The University of Auckland, Auckland, New ZealandSearch for other works by this author on:L. Bennet;L. BennetThe Liggins Institute, Department of Physiology and Departments of Paediatrics and Obstetrics and Gynaecology, Faculty of Medicine and Health Sciences, The University of Auckland, Auckland, New ZealandSearch for other works by this author on:P.D. Gluckman;P.D. GluckmanThe Liggins Institute, Department of Physiology and Departments of Paediatrics and Obstetrics and Gynaecology, Faculty of Medicine and Health Sciences, The University of Auckland, Auckland, New ZealandSearch for other works by this author on:A.J. GunnA.J. GunnThe Liggins Institute, Department of Physiology and Departments of Paediatrics and Obstetrics and Gynaecology, Faculty of Medicine and Health Sciences, The University of Auckland, Auckland, New ZealandSearch for other works by this author on:
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44 - 54: Insulin-Like Growth Factor-I and Risk of Type 2 Diabetes and Coronary Heart Disease: Molecular EpidemiologyByManjinder S. SandhuManjinder S. SandhuDepartment of Public Health and Primary Care,Institute of Public Health, University of Cambridge,Strangeways Research Laboratory, Cambridge, UKSearch for other works by this author on:
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55 - 65: Quantitative Measurement of IGF-I and Its Use in Diagnosing and Monitoring Treatment of Disorders of Growth Hormone SecretionByDavid R. ClemmonsDavid R. ClemmonsDivision of Endocrinology, Department of Medicine,University of North Carolina School of Medicine, Chapel Hill, N.C., USASearch for other works by this author on:
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66 - 75: IGF-I and IGFBP-3 Assessment in the Management of Childhood Onset Growth Hormone DeficiencyByS. Cianfarani;S. CianfaraniRina Balducci Center of Pediatric Endocrinology,Department of Public Health and Cell Biology,Tor Vergata University, Rome, ItalySearch for other works by this author on:A. Liguori,;A. Liguori,Rina Balducci Center of Pediatric Endocrinology,Department of Public Health and Cell Biology,Tor Vergata University, Rome, ItalySearch for other works by this author on:D. GermaniD. GermaniRina Balducci Center of Pediatric Endocrinology,Department of Public Health and Cell Biology,Tor Vergata University, Rome, ItalySearch for other works by this author on:
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76 - 88: IGFs and IGFBPs in Adult Growth Hormone DeficiencyByGianluca Aimaretti;Gianluca AimarettiDivision of Endocrinology and Metabolism, Department of Internal Medicine, University of Turin, Turin, ItalySearch for other works by this author on:Roberto Baldelli;Roberto BaldelliDivision of Endocrinology and Metabolism, Department of Internal Medicine, University of Turin, Turin, ItalySearch for other works by this author on:Ginevra Corneli;Ginevra CorneliDivision of Endocrinology and Metabolism, Department of Internal Medicine, University of Turin, Turin, ItalySearch for other works by this author on:Chiara Croce,;Chiara Croce,Division of Endocrinology and Metabolism, Department of Internal Medicine, University of Turin, Turin, ItalySearch for other works by this author on:Silvia Rovere;Silvia RovereDivision of Endocrinology and Metabolism, Department of Internal Medicine, University of Turin, Turin, ItalySearch for other works by this author on:Claudia Baffoni;Claudia BaffoniDivision of Endocrinology and Metabolism, Department of Internal Medicine, University of Turin, Turin, ItalySearch for other works by this author on:Simonetta Bellone;Simonetta BelloneDivision of Endocrinology and Metabolism, Department of Internal Medicine, University of Turin, Turin, ItalySearch for other works by this author on:SValentina Gasco;SValentina GascoDivision of Endocrinology and Metabolism, Department of Internal Medicine, University of Turin, Turin, ItalySearch for other works by this author on:Riccarda Granata;Riccarda GranataDivision of Endocrinology and Metabolism, Department of Internal Medicine, University of Turin, Turin, ItalySearch for other works by this author on:Silvia Grottoli;Silvia GrottoliDivision of Endocrinology and Metabolism, Department of Internal Medicine, University of Turin, Turin, ItalySearch for other works by this author on:Ezio GhigoEzio GhigoDivision of Endocrinology and Metabolism, Department of Internal Medicine, University of Turin, Turin, ItalySearch for other works by this author on:
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89 - 99: Monitoring of Insulin-Like Growth Factors during Growth Hormone Treatment: Adulthood Growth Hormone DeficiencyByJohn P. MonsonJohn P. MonsonCentre for Clinical Endocrinology, William Harvey Research Institute, St Bartholomew’s and The Royal London Hospital, Queen Mary’s School of Medicine and Dentistry, University of London, London, UKSearch for other works by this author on:
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100 - 106: IGFs and IGFBPs in GH InsensitivityByM.O. Savage;M.O. SavageaDepartment of Endocrinology, St Bartholomew’s Hospital, London, UK;Search for other works by this author on:J.C. Blair;J.C. BlairaDepartment of Endocrinology, St Bartholomew’s Hospital, London, UK;Search for other works by this author on:A.J. Jorge;A.J. JorgeaDepartment of Endocrinology, St Bartholomew’s Hospital, London, UK;Search for other works by this author on:M.E. Street;M.E. StreetbChildren’s Hospital, Parma, Italy, andSearch for other works by this author on:M.B. Ranke;M.B. RankecUniversity Children’s Hospital,Tubingen, GermanySearch for other works by this author on:C. Camacho-HübnerC. Camacho-HübneraDepartment of Endocrinology, St Bartholomew’s Hospital, London, UK;Search for other works by this author on:
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107 - 120: Childhood and Adolescent DiabetesByDavid B. Dunger;David B. DungerDepartment of Paediatrics, Addenbrooke’s Hospital, University of Cambridge, Cambridge, UKSearch for other works by this author on:Fiona M. Regan;Fiona M. ReganDepartment of Paediatrics, Addenbrooke’s Hospital, University of Cambridge, Cambridge, UKSearch for other works by this author on:Carlo L. AceriniCarlo L. AceriniDepartment of Paediatrics, Addenbrooke’s Hospital, University of Cambridge, Cambridge, UKSearch for other works by this author on:
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121 - 134: Insulin Resistance and Type 2 Diabetes mellitus: Is There a Therapeutic Role for IGF-1?ByAlan C. MosesAlan C. MosesNovo Nordisk Pharmaceuticals, Inc., Princeton, N.J., USASearch for other works by this author on:
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135 - 159: Insulin-Like Growth Factors in the Treatment of Neurological DiseaseByGina M. Leinninger;Gina M. LeinningeraNeuroscience Program andSearch for other works by this author on:Eva L. FeldmanEva L. FeldmanaNeuroscience Program andb Department of Neurology, University of Michigan,Ann Arbor, Mich., USASearch for other works by this author on:
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160 - 169: Insulin-Like Growth Factor System in Amyotrophic Lateral SclerosisByNadine Wilczak;Nadine WilczakDepartment of Neurology, Academic Hospital Groningen, Groningen, The NetherlandsSearch for other works by this author on:Jacques de KeyserJacques de KeyserDepartment of Neurology, Academic Hospital Groningen, Groningen, The NetherlandsSearch for other works by this author on: