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Gerontological Aspects of Genome Peptide Regulation
S.Karger AG
Status:
Available
ISBN electronic:
978-3-318-01193-7
ISBN print:
978-3-8055-7895-0
Subject Area:
Further Areas
,
Genetics
,
Geriatrics and Gerontology
,
Pathology and Cell Biology
,
Pharmacology
,
Public Health
Publication date:
2005
Book Details
This monograph highlights the gerontological aspects of the peptide regulation of gene expression. It focuses on the mechanisms of the geroprotective action of peptides related to chromatin activation, increase in telomerase enzyme activity, and elongation of telomeres in different cells. A key role in the initiation of the biological activity of peptide is its interaction with DNA which provides genetic stability and a normalization of the age-related metabolic shifts. Study of the genetic mechanisms of peptide action suggests a new concept which most comprehensively reflects on the evolutionary biological role peptide plays in the organism. The impact of peptides on the expression and structure of genes opens a new gate for the prevention of premature aging and age-related pathology which appears to be most promising in pharmacogenomics.
This monograph narrates not only the theoretical aspects and experimental data, but also outlines new approaches to the prevention of aging and age-related pathology, thus addressing a wide readership of gerontologists, geneticists, molecular biologists, biochemists, and pharmacologists alike.
Gerontological Aspects of Genome Peptide Regulation
By: V.K. Khavinson, V.V. Malinin
https://doi.org/10.1159/isbn.978-3-318-01193-7
ISBN (print): 978-3-8055-7895-0
ISBN (electronic): 978-3-318-01193-7
Publisher: S.Karger AG
Published: 2005
Download citation file:
Digital Version
Pay-Per-View Access
$139.00
Print Version
Gerontological Aspects of Genome Peptide Regulation
$139.00
Table of Contents
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1 - 10: Anti-Aging Mechanisms of PeptidesByV.V. Malinin;V.V. MalininSaint Petersburg Institute of Bio regulation and Gerontology,North-Western Branch of the Russian Academy of Medical Sciences, Saint Petersburg, RussiaSearch for other works by this author on:V.Kh. KhavinsonV.Kh. KhavinsonSaint Petersburg Institute of Bio regulation and Gerontology,North-Western Branch of the Russian Academy of Medical Sciences, Saint Petersburg, RussiaSearch for other works by this author on:
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11 - 20: Estimation of Peptides Effect on Gene Expression in Mouse Heart Using DNA-Microarray TechnologyByV.V. Malinin;V.V. MalininSaint Petersburg Institute of Bio regulation and Gerontology,North-Western Branch of the Russian Academy of Medical Sciences, Saint Petersburg, Russia.Search for other works by this author on:V.Kh. KhavinsonV.Kh. KhavinsonSaint Petersburg Institute of Bio regulation and Gerontology,North-Western Branch of the Russian Academy of Medical Sciences, Saint Petersburg, Russia.Search for other works by this author on:
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21 - 29: Effect of Peptides on IL-2 Gene ExpressionByV.V. Malinin;V.V. MalininSaint Petersburg Institute of Bio regulation and Gerontology,North-Western Branch of the Russian Academy of Medical Sciences, Saint Petersburg, RussiaSearch for other works by this author on:V.Kh. KhavinsonV.Kh. KhavinsonSaint Petersburg Institute of Bio regulation and Gerontology,North-Western Branch of the Russian Academy of Medical Sciences, Saint Petersburg, RussiaSearch for other works by this author on:
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30 - 37: Effect of Peptides on c-fos Gene Expression in StressByV.V. Malinin;V.V. MalininSaint Petersburg Institute of Bio regulation and Gerontology,North-Western Branch of the Russian Academy of Medical Sciences, Saint Petersburg, Russia.Search for other works by this author on:V. Kh. KhavinsonV. Kh. KhavinsonSaint Petersburg Institute of Bio regulation and Gerontology,North-Western Branch of the Russian Academy of Medical Sciences, Saint Petersburg, Russia.Search for other works by this author on:
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38 - 39: Effect of Peptides on Carcinogenesis inTransgenic MiceByV.V. Malinin;V.V. MalininSaint Petersburg Institute of Bio regulation and Gerontology,North-Western Branch of the Russian Academy of Medical Sciences, Saint Petersburg, RussiaSearch for other works by this author on:V. Kh. KhavinsonV. Kh. KhavinsonSaint Petersburg Institute of Bio regulation and Gerontology,North-Western Branch of the Russian Academy of Medical Sciences, Saint Petersburg, RussiaSearch for other works by this author on:
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40 - 51: Effect of Peptides on ChromosomesByV.V. Malinin;V.V. MalininSaint Petersburg Institute of Bio regulation and Gerontology,North-Western Branch of the Russian Academy of Medical Sciences, Saint Petersburg, RussiaSearch for other works by this author on:V. Kh. KhavinsonV. Kh. KhavinsonSaint Petersburg Institute of Bio regulation and Gerontology,North-Western Branch of the Russian Academy of Medical Sciences, Saint Petersburg, RussiaSearch for other works by this author on:
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52 - 57: Effect of Epitalon on Telomerase Activity,Telomere Elongation and Proliferative Potential in Human Somatic CellsByV.V. Malinin;V.V. MalininSaint Petersburg Institute of Bio regulation and Gerontology,North-Western Branch of the Russian Academy of Medical Sciences, Saint Petersburg, RussiaSearch for other works by this author on:V. Kh. KhavinsonV. Kh. KhavinsonSaint Petersburg Institute of Bio regulation and Gerontology,North-Western Branch of the Russian Academy of Medical Sciences, Saint Petersburg, RussiaSearch for other works by this author on:
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58 - 63: Effect of Peptides on DNA SynthesisByV.V. Malinin;V.V. MalininSaint Petersburg Institute of Bio regulation and Gerontology,North-Western Branch of the Russian Academy of Medical Sciences, Saint Petersburg, RussiaSearch for other works by this author on:V. Kh. KhavinsonV. Kh. KhavinsonSaint Petersburg Institute of Bio regulation and Gerontology,North-Western Branch of the Russian Academy of Medical Sciences, Saint Petersburg, RussiaSearch for other works by this author on:
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64 - 87: Interaction between Small Peptides and DNA Double HelixByV.V. Malinin;V.V. MalininSaint Petersburg Institute of Bio regulation and Gerontology,North-Western Branch of the Russian Academy of Medical Sciences, Saint Petersburg, RussiaSearch for other works by this author on:V. Kh. KhavinsonV. Kh. KhavinsonSaint Petersburg Institute of Bio regulation and Gerontology,North-Western Branch of the Russian Academy of Medical Sciences, Saint Petersburg, RussiaSearch for other works by this author on:
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88 - 91: From Anti-Aging Peptide Regulation to PharmacogenomicsByV.V. Malinin;V.V. MalininSaint Petersburg Institute of Bio regulation and Gerontology,North-Western Branch of the Russian Academy of Medical Sciences, Saint Petersburg, RussiaSearch for other works by this author on:V.Kh. KhavinsonV.Kh. KhavinsonSaint Petersburg Institute of Bio regulation and Gerontology,North-Western Branch of the Russian Academy of Medical Sciences, Saint Petersburg, RussiaSearch for other works by this author on:
