Current Research in Head and Neck Cancer: Molecular Pathways, Novel Therapeutic Targets, and Prognostic Factors
The development of head and neck cancer is a multistep process in which genetic as well as epigenetic alterations interfere with the regular functions of proto-oncogenes and tumor suppressor genes. In addition, carcinogenesis is promoted by the impairment of mechanisms responsible for the maintenance of genetic stability. The accumulation of crucial events such as evasion of apoptosis, lack of senescence, deregulated proliferation, invasion and metastasis, as well as neoangiogenesis eventually determines the malignant phenotype.
The 16 articles of this volume span from advances in the understanding of underlying molecular pathways (conditional mouse model, folate activity, DNA repair, genomic heterogeneity, p53 family members, human papillomavirus), to preclinical and clinical studies investigating potential novel therapeutic targets (epidermal growth factor receptor, nuclear factor-kappaB, vascular endothelial growth factor, chemokine receptors, P53-based immunotherapy, virus-modified tumor vaccination), and biometric considerations on the evaluation of prognostic factors.
This state-of-the-art publication is recommended reading not only for ENT specialists and oncologists, but also for molecular biologists and other subspecialists interested in head and neck cancer research.
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1 - 11: Development of a Conditional Mouse Model for Head and Neck Squamous Cell CarcinomaByE.M.J. Bindels;E.M.J. BindelsDepartment of Otolaryngology, The Netherlands Cancer Institute,Amsterdam, The NetherlandsSearch for other works by this author on:M.W.M. van den BrekelM.W.M. van den BrekelDepartment of Otolaryngology, The Netherlands Cancer Institute,Amsterdam, The NetherlandsSearch for other works by this author on:
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12 - 24: Hypofolatemia as a Risk Factor for Head and Neck CancerByGaetano Paludetti;Gaetano PaludettiInstitute of Otolaryngology, Università Cattolica del Sacro Cuore,Roma, ItalySearch for other works by this author on:Giovanni Almadori;Giovanni AlmadoriInstitute of Otolaryngology, Università Cattolica del Sacro Cuore,Roma, ItalySearch for other works by this author on:Francesco Bussu;Francesco BussuInstitute of Otolaryngology, Università Cattolica del Sacro Cuore,Roma, ItalySearch for other works by this author on:Jacopo Galli;Jacopo GalliInstitute of Otolaryngology, Università Cattolica del Sacro Cuore,Roma, ItalySearch for other works by this author on:Gabriella Cadoni;Gabriella CadoniInstitute of Otolaryngology, Università Cattolica del Sacro Cuore,Roma, ItalySearch for other works by this author on:Maurizio MauriziMaurizio MauriziInstitute of Otolaryngology, Università Cattolica del Sacro Cuore,Roma, ItalySearch for other works by this author on:
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25 - 37: Reduced DNA Repair Capacity in Laryngeal Cancer Subjects: A Comparison of Phenotypic and Genotypic ResultsByMarzena Gajecka;Marzena GajeckaaInstitute of Human Genetics, Polish Academy of Sciences, andSearch for other works by this author on:Malgorzata Rydzanicz;Malgorzata RydzaniczaInstitute of Human Genetics, Polish Academy of Sciences, andSearch for other works by this author on:Renata Jaskula-Sztul;Renata Jaskula-SztulaInstitute of Human Genetics, Polish Academy of Sciences, andSearch for other works by this author on:Martgorzata Wierzbicka;Martgorzata WierzbickabDepartment of Otolaryngology, K. Marcinkowski University of Medical Sciences, Poznan, PolandSearch for other works by this author on:Witold Szyfter;Witold SzyfterbDepartment of Otolaryngology, K. Marcinkowski University of Medical Sciences, Poznan, PolandSearch for other works by this author on:Krzysztof SzyfterKrzysztof SzyfteraInstitute of Human Genetics, Polish Academy of Sciences, andbDepartment of Otolaryngology, K. Marcinkowski University of Medical Sciences, Poznan, PolandSearch for other works by this author on:
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38 - 48: Intratumoral Genomic Heterogeneity in Advanced Head and Neck Cancer Detected by Comparative Genomic HybridizationByKarl Götte;Karl GötteaDepartment of Otolaryngology, Head and Neck Surgery, University Hospital Mannheim, MannheimSearch for other works by this author on:Susanne C. Tremmel;Susanne C. TremmelbInstitute of Human Genetics, University of HeidelbergSearch for other works by this author on:Susanne Popp;Susanne PoppbInstitute of Human Genetics, University of HeidelbergcDeutsches Krebsforschungszentrum, Division of Genetics of Skin Carcinogenesis, Heidelberg, GermanySearch for other works by this author on:Susanne Weber;Susanne WeberbInstitute of Human Genetics, University of HeidelbergSearch for other works by this author on:Karl Hörmann;Karl HörmannaDepartment of Otolaryngology, Head and Neck Surgery, University Hospital Mannheim, MannheimSearch for other works by this author on:Claus R. Bartram;Claus R. BartrambInstitute of Human Genetics, University of HeidelbergSearch for other works by this author on:Anna JauchAnna JauchbInstitute of Human Genetics, University of HeidelbergSearch for other works by this author on:
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49 - 57: Function and Importance of p63 in Normal Oral Mucosa and Squamous Cell Carcinoma of the Head and NeckByNiklas Thurfjell;Niklas ThurfjellaDepartment of Medical Biosciences/Pathology, Umeå UniversitySearch for other works by this author on:Philip J. Coates;Philip J. CoatescDivision of Pathology and Neurosciences, University of Dundee, Ninewells Hospital and Medical School, Dundee, UKSearch for other works by this author on:Linda Boldrup;Linda BoldrupaDepartment of Medical Biosciences/Pathology, Umeå UniversitySearch for other works by this author on:Britta Lindgren;Britta LindgrenaDepartment of Medical Biosciences/Pathology, Umeå UniversitySearch for other works by this author on:Bodil Bäcklund;Bodil BäcklundaDepartment of Medical Biosciences/Pathology, Umeå UniversitySearch for other works by this author on:Tony Uusitalo;Tony UusitaloaDepartment of Medical Biosciences/Pathology, Umeå UniversitySearch for other works by this author on:David Mahani;David MahaniaDepartment of Medical Biosciences/Pathology, Umeå UniversitySearch for other works by this author on:Erik Dabelsteen;Erik DabelsteendDepartment of Oral Diagnostics, Dental School, University of Copenhagen, Copenhagen, DenmarkSearch for other works by this author on:Åke Dahlqvist;Åke DahlqvistbDepartment of Clinical Sciences/Otorhinolaryngology, Umeå University Hospital, Umeå , SwedenSearch for other works by this author on:Björn Sjöström;Björn SjöströmbDepartment of Clinical Sciences/Otorhinolaryngology, Umeå University Hospital, Umeå , SwedenSearch for other works by this author on:Göran Roos;Göran RoosaDepartment of Medical Biosciences/Pathology, Umeå UniversitySearch for other works by this author on:Borek Vojtesek;Borek VojtesekeDepartment of Cellular and Molecular Oncology, Masaryk Memorial Cancer InstituteSearch for other works by this author on:Rudolf Nenutil;Rudolf NenutilfDepartment of Pathology, Maternity Hospital, Brno, Czech RepublicSearch for other works by this author on:Karin NylanderKarin NylanderaDepartment of Medical Biosciences/Pathology, Umeå UniversitySearch for other works by this author on:
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58 - 71: p53, p63 and p73 Expression in Squamous Cell Carcinomas of the Head and Neck and Their Response to Cisplatin ExposureByVera Balz;Vera BalzDepartment of Otorhinolaryngology/Head and Neck Surgery, Heinrich Heine University, Düsseldorf, GermanySearch for other works by this author on:Kathrin Scheckenbach;Kathrin ScheckenbachDepartment of Otorhinolaryngology/Head and Neck Surgery, Heinrich Heine University, Düsseldorf, GermanySearch for other works by this author on:Henning Bier;Henning BierDepartment of Otorhinolaryngology/Head and Neck Surgery, Heinrich Heine University, Düsseldorf, GermanySearch for other works by this author on:Christian GwosdzChristian GwosdzDepartment of Otorhinolaryngology/Head and Neck Surgery, Heinrich Heine University, Düsseldorf, GermanySearch for other works by this author on:
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72 - 80: Expression of p16 Protein Is Associated with Human Papillomavirus Status in Tonsillar Carcinomas and Has Implications on SurvivalByClaus Wittekindt;Claus WittekindtaDepartment of Oto-Rhino-Laryngology, Head and Neck SurgerySearch for other works by this author on:Elif Gültekin;Elif GültekindDepartment of Oral Pathology, Faculty of Dentistry, Gazi University, Ankara, TurkeySearch for other works by this author on:Soenke J. Weissenborn;Soenke J. WeissenbornbInstitute of Virology andSearch for other works by this author on:Hans P. Dienes;Hans P. DienescDepartment of Pathology, University of Cologne, Cologne GermanySearch for other works by this author on:Herbert J. Pfister;Herbert J. PfisterbInstitute of Virology andSearch for other works by this author on:Jens P. KlussmannJens P. KlussmannaDepartment of Oto-Rhino-Laryngology, Head and Neck SurgerySearch for other works by this author on:
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81 - 91: EGFR-Antibody-Supplemented TPF Chemotherapy: Preclinical Investigations to a Novel Approach for Head and Neck Cancer Induction TreatmentByRainald Knecht;Rainald KnechtaDepartments of Otorhinolaryngology andSearch for other works by this author on:Silke Peters;Silke PetersaDepartments of Otorhinolaryngology andSearch for other works by this author on:Markus Hambek;Markus HambekaDepartments of Otorhinolaryngology andSearch for other works by this author on:Christine Solbach;Christine SolbachbGynecology and Obstetrics, School of Medicine, J.W. Goethe University, Frankfurt, GermanySearch for other works by this author on:Mehran Baghi;Mehran BaghiaDepartments of Otorhinolaryngology andSearch for other works by this author on:Wolfgang Gstöttner;Wolfgang GstöttneraDepartments of Otorhinolaryngology andSearch for other works by this author on:Markus HambekMarkus HambekaDepartments of Otorhinolaryngology andSearch for other works by this author on:
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92 - 102: Nuclear Factor-KB as a Common Target and Activator of Oncogenes in Head and Neck Squamous Cell CarcinomaByAngela A. Chang;Angela A. ChangaNational Institutes of Health Clinical Research Training Program andSearch for other works by this author on:Carter van WaesCarter van WaesbHead and Neck Surgery Branch, National Institute on Deafness and Other Communication Disorders, Bethesda, Md., USASearch for other works by this author on:
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103 - 120: Antiangiogenic Therapy of Head and Neck Squamous Cell Carcinoma by Vascular Endothelial Growth Factor Antisense TherapyByFrank Riedel;Frank RiedelaDepartment of Otolaryngology, Head and Neck Surgery, University Hospital Mannheim, Mannheim, Germany;Search for other works by this author on:Karl Götte;Karl GötteaDepartment of Otolaryngology, Head and Neck Surgery, University Hospital Mannheim, Mannheim, Germany;Search for other works by this author on:Karl Hörmann;Karl HörmannaDepartment of Otolaryngology, Head and Neck Surgery, University Hospital Mannheim, Mannheim, Germany;Search for other works by this author on:Jennifer Rubin GrandisJennifer Rubin GrandisbUniversity of Pittsburgh Cancer Institute,University of Pittsburgh, Pittsburgh Pa., USASearch for other works by this author on:
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121 - 133: Chemokine Receptors 6 and 7 Identify a Metastatic Expression Pattern in Squamous Cell Carcinoma of the Head and NeckByJun Wang;Jun WangaDepartments of Otolaryngology and Immunology, University of Pittsburgh School of Medicine, Hillman Cancer Center,Search for other works by this author on:Liqiang Xi;Liqiang XibDepartment of Surgery, Cancer Institute, University of Pittsburgh School of Medicine,cUniversity of Pittsburgh Cancer Institute andSearch for other works by this author on:William Gooding;William GoodingdDepartment of Biostatistics, University of Pittsburgh Cancer Institute, Pittsburgh, Pa., USASearch for other works by this author on:Tony E. Godfrey;Tony E. GodfreybDepartment of Surgery, Cancer Institute, University of Pittsburgh School of Medicine,cUniversity of Pittsburgh Cancer Institute andSearch for other works by this author on:Robert L. FerrisRobert L. FerrisaDepartments of Otolaryngology and Immunology, University of Pittsburgh School of Medicine, Hillman Cancer Center,cUniversity of Pittsburgh Cancer Institute andSearch for other works by this author on:
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134 - 150: p53-Based Immunotherapy of CancerByAlbert B. De LeoAlbert B. De LeoUniversity of Pittsburgh Cancer Institute, Division of Basic Research and Department of Pathology, University of Pittsburgh School of Medicine,Pittsburgh, Pa., USASearch for other works by this author on:
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151 - 160: p53 as an Immunotherapeutic Target in Head and Neck Cancer: Approaches to Reversing Unresponsiveness of T Lymphocytes and Preventing Tumor EscapeByThomas K. Hoffmann;Thomas K. HoffmannaDepartment of Otorhinolaryngology, Heinrich Heine University, Düsseldorf, Germany;bUniversity of Pittsburgh Cancer Institute and Departments ofSearch for other works by this author on:Henning Bier;Henning BieraDepartment of Otorhinolaryngology, Heinrich Heine University, Düsseldorf, Germany;Search for other works by this author on:Albert D. Donnenberg;Albert D. DonnenbergbUniversity of Pittsburgh Cancer Institute and Departments ofcMedicine,Search for other works by this author on:Theresa L. Whiteside;Theresa L. WhitesidebUniversity of Pittsburgh Cancer Institute and Departments ofdPathology andeOtolaryngology, University of Pittsburgh School of Medicine, Pittsburgh, Pa., USASearch for other works by this author on:Albert B. De LeoAlbert B. De LeobUniversity of Pittsburgh Cancer Institute and Departments ofdPathology andSearch for other works by this author on:
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161 - 172: Imbalance in Absolute Counts of T Lymphocyte Subsets in Patients with Head and Neck Cancer and Its Relation to Disease1ByB. Hathaway,;B. Hathaway,University of Pittsburgh Cancer Institute, Pittsburgh, Pa., USASearch for other works by this author on:R.L. Ferris,;R.L. Ferris,University of Pittsburgh Cancer Institute, Pittsburgh, Pa., USASearch for other works by this author on:W. Gooding,;W. Gooding,University of Pittsburgh Cancer Institute, Pittsburgh, Pa., USASearch for other works by this author on:T.L. Whiteside;T.L. WhitesideUniversity of Pittsburgh Cancer Institute, Pittsburgh, Pa., USASearch for other works by this author on:I. Kuss,I. Kuss,University of Pittsburgh Cancer Institute, Pittsburgh, Pa., USASearch for other works by this author on:
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173 - 183: Antitumor Immunization of Head and Neck Squamous Cell Carcinoma Patients with a Virus-Modified Autologous Tumor Cell VaccineByChristel Herold-Mende;Christel Herold-MendeaMolecular Cell Biology Group, Department of Head and Neck Surgery, andbMolecular Biology Laboratory, Department of Neurosurgery, University of Heidelberg, andSearch for other works by this author on:Jochen Karcher;Jochen KarcherdHNO-Klinik der Caritasklinik St. Theresia, Saarbrücken, GermanySearch for other works by this author on:Gerhard Dyckhoff;Gerhard DyckhoffaMolecular Cell Biology Group, Department of Head and Neck Surgery, andSearch for other works by this author on:Volker SchirrmacherVolker SchirrmachercDivision of Cellular Immunology, German Cancer Research Center, Heidelberg, andSearch for other works by this author on:
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184 - 200: Prognostic Factors: Confusion Caused by Bad Quality of Design,Analysis and Reporting of Many StudiesByWilli SauerbreiWilli SauerbreiaAbteilung Medizinische Biometrie und Statistik, Institut für Medizinische Biometrie und Medizinische Informatik, Universitätsklinikum Freiburg, Freiburg, DeutschlandSearch for other works by this author on: