Principles of Molecular Neurosurgery
The future of neurosurgery will be characterized by less invasive, molecular technologies that promise to revolutionize the field of neurosurgery and impact the treatment of additional neurological disorders, including neurometabolic diseases, stroke, dementias, affective and psychiatric diseases, movement disorders, epilepsy, and others. This book encompasses developing an understanding of the principles underlying the advent of novel molecular approaches to neurological and neurosurgical diseases. It Identifies key principles that will allow dramatic improvement in the treatment and outcomes of patients suffering from a varity of disorders affecting the central nervous system and spinal axis. This volume gives neurosurgeons an excellent understanding of the development of novel molecular and cellular technologies that will markedly change the way neurosurgery is practiced in the near future. It is also of special interest to neurologists, psychiatrists, physiatrists, spinal orthopeadic surgeons, neurobiologists and gene therapy research scientists.
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Table of Contents
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1 - 4: IntroductionByAndrew Freese;Andrew FreeseaDepartment of Neurosurgery, University of Minnesota School of Medicine MMC 96, Minneapolis, Minn.,Search for other works by this author on:Christopher Janson;Christopher JansonbCell and Gene Therapy Center,UMDNJ-Robert Wood Johnson Medical School, Division of Neurosurgery, Camden, N.J.,Search for other works by this author on:Paola Leone;Paola LeonebCell and Gene Therapy Center,UMDNJ-Robert Wood Johnson Medical School, Division of Neurosurgery, Camden, N.J.,Search for other works by this author on:Frederick A. SimeoneFrederick A. SimeonecDepartment of Neurosurgery, University of Pennsylvania, Philadelphia, Pa., USASearch for other works by this author on:
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5 - 29: The Molecular Basis of Intervertebral Disc DegenerationByBrian M. Leo;Brian M. LeoaDepartment of Orthopaedic Surgery, University of Virginia, Charlottesville, VA.,Search for other works by this author on:Matthew H. Walker;Matthew H. WalkeraDepartment of Orthopaedic Surgery, University of Virginia, Charlottesville, VA.,Search for other works by this author on:D. Greg AndersonD. Greg AndersonbDepartment of Orthopaedic Surgery, Thomas Jefferson University, Philadelphia, PA., USASearch for other works by this author on:
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30 - 36: Genetics of Degenerative Disc DiseaseByShekar N. Kurpad;Shekar N. KurpadDepartment of Neurosurgery, Medical College of Wisconsin,Milwaukee, Wisc., USASearch for other works by this author on:Jason LifshutzJason LifshutzDepartment of Neurosurgery, Medical College of Wisconsin,Milwaukee, Wisc., USASearch for other works by this author on:
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37 - 51: Gene Therapy for Degenerative Disc DiseaseByJoseph Kim;Joseph KimDepartment of Orthopaedic Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA, USASearch for other works by this author on:Lars G. Gilbertson;Lars G. GilbertsonDepartment of Orthopaedic Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA, USASearch for other works by this author on:James D. KangJames D. KangDepartment of Orthopaedic Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA, USASearch for other works by this author on:
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52 - 64: Bone Morphogenetic Proteins: Spinal Fusion ApplicationsByDavid A. Bomback;David A. BombackDepartment of Orthopaedics and Rehabilitation, Yale University School of Medicine, New Haven, CT, USASearch for other works by this author on:Jonathan N. GrauerJonathan N. GrauerDepartment of Orthopaedics and Rehabilitation, Yale University School of Medicine, New Haven, CT, USASearch for other works by this author on:
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65 - 103: Cellular and Gene Therapy Approaches to Spinal Cord InjuryByMichael P. Steinmetz;Michael P. SteinmetzDepartment of Neurosurgery S31, Cleveland Clinic Foundation,Cleveland, Ohio, USASearch for other works by this author on:James K. Liu;James K. LiuDepartment of Neurosurgery S31, Cleveland Clinic Foundation,Cleveland, Ohio, USASearch for other works by this author on:Nicholas M. BoulisNicholas M. BoulisDepartment of Neurosurgery S31, Cleveland Clinic Foundation,Cleveland, Ohio, USASearch for other works by this author on:
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104 - 123: Neural Stem Cell Transplantation for Spinal Cord RepairByAkio Iwanami;Akio IwanamiaDepartments of Physiology andb Orthopaedic Surgery, Keio University School of Medicine, Shinjuku, Tokyo,cCore Research for Evolutional Science and Technology, Japan Science and Technology Corporation, Osaka andSearch for other works by this author on:Yuto Ogawa;Yuto OgawaaDepartments of Physiology andb Orthopaedic Surgery, Keio University School of Medicine, Shinjuku, Tokyo,cCore Research for Evolutional Science and Technology, Japan Science and Technology Corporation, Osaka andSearch for other works by this author on:Masaya Nakamura;Masaya Nakamurab Orthopaedic Surgery, Keio University School of Medicine, Shinjuku, Tokyo,cCore Research for Evolutional Science and Technology, Japan Science and Technology Corporation, Osaka andSearch for other works by this author on:Shinjiro Kaneko;Shinjiro KanekoaDepartments of Physiology andb Orthopaedic Surgery, Keio University School of Medicine, Shinjuku, Tokyo,cCore Research for Evolutional Science and Technology, Japan Science and Technology Corporation, Osaka andSearch for other works by this author on:Kazunobu Sawamoto;Kazunobu SawamotocCore Research for Evolutional Science and Technology, Japan Science and Technology Corporation, Osaka anddDepartment of Neuroanatomy, Osaka University Graduate School of Medicine, Suita, Osaka, JapanSearch for other works by this author on:Hirotaka James Okano;Hirotaka James OkanoaDepartments of Physiology andcCore Research for Evolutional Science and Technology, Japan Science and Technology Corporation, Osaka andSearch for other works by this author on:Yoshiaki Toyama;Yoshiaki Toyamab Orthopaedic Surgery, Keio University School of Medicine, Shinjuku, Tokyo,cCore Research for Evolutional Science and Technology, Japan Science and Technology Corporation, Osaka andSearch for other works by this author on:Hideyuki OkanoHideyuki OkanoaDepartments of Physiology andcCore Research for Evolutional Science and Technology, Japan Science and Technology Corporation, Osaka anddDepartment of Neuroanatomy, Osaka University Graduate School of Medicine, Suita, Osaka, JapanSearch for other works by this author on:
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124 - 145: Contemporary Applications of Functional and Stereotactic Techniques for Molecular NeurosurgeryByPaul A. House;Paul A. HouseDepartment of Neurological Surgery, University of Utah Medical Center, Salt Lake City, Utah, USASearch for other works by this author on:Ganesh Rao;Ganesh RaoDepartment of Neurological Surgery, University of Utah Medical Center, Salt Lake City, Utah, USASearch for other works by this author on:William CouldwellWilliam CouldwellDepartment of Neurological Surgery, University of Utah Medical Center, Salt Lake City, Utah, USASearch for other works by this author on:
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146 - 153: Xeno-NeurotransplantationByJames M. SchumacherJames M. SchumacherCenter for Movement Disorders, University of Miami School of Medicine, Miami, Fla., USASearch for other works by this author on:
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154 - 168: Adeno-Associated Viral Vectors for Clinical Gene Therapy in the BrainByR. Jude Samulski;R. Jude SamulskiGene Therapy Center, Department of Pharmacology, University of North Carolina at Chapel Hill, N.C., USASearch for other works by this author on:Jennifer GilesJennifer GilesGene Therapy Center, Department of Pharmacology, University of North Carolina at Chapel Hill, N.C., USASearch for other works by this author on:
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169 - 201: Molecular Mechanisms of Epilepsy and Gene TherapyByAlbert Telfeian;Albert TelfeianaDivision of Neurosurgery, Texas Tech University Medical Center, Lubbock, Tex.,Search for other works by this author on:Juanita Celix;Juanita CelixbDepartment of Neurosurgery, University of Washington, Seattle, Wash.,Search for other works by this author on:Marc DichterMarc DichtercDepartment of Neurology, University of Pennsylvania, Philadelphia, Pa., USASearch for other works by this author on:
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202 - 212: Emerging Treatment of Neurometabolic DisordersByRoscoe O. Brady;Roscoe O. BradyDevelopmental and Metabolic Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Md., USASearch for other works by this author on:Roscoe O. Brady Jr.Roscoe O. Brady Jr.Developmental and Metabolic Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Md., USASearch for other works by this author on:
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213 - 245: Gene Therapy for Parkinson’s DiseaseByPiotr Hadaczek;Piotr HadaczekMolecular Therapy Laboratory, Department of Neurological Surgery,University of California, San Francisco, Calif., USASearch for other works by this author on:Marcel Daadi;Marcel DaadiMolecular Therapy Laboratory, Department of Neurological Surgery,University of California, San Francisco, Calif., USASearch for other works by this author on:Krystof BankiewiczKrystof BankiewiczMolecular Therapy Laboratory, Department of Neurological Surgery,University of California, San Francisco, Calif., USASearch for other works by this author on:
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246 - 257: Simplifying Complex Neurodegenerative Diseases by Gene Chip AnalysisByClemens R. Scherzer;Clemens R. ScherzeraLaboratory for Functional Genomics, Center for Neurologic Diseases, Harvard Medical School, Brigham and Women’s Hospital, Cambridge, Mass., andSearch for other works by this author on:Steven R. Gullans;Steven R. GullansaLaboratory for Functional Genomics, Center for Neurologic Diseases, Harvard Medical School, Brigham and Women’s Hospital, Cambridge, Mass., andSearch for other works by this author on:Roderick V. JensenRoderick V. JensenbDepartment of Physics, Wesleyan University, Middletown, Conn., USASearch for other works by this author on:
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258 - 269: Molecular Pathology of Dementia: Emerging Treatment StrategiesByGunnar K. GourasGunnar K. GourasDepartment of Neurology and Neuroscience, Laboratory of Alzheimer’s Disease Neurobiology, Weill Medical College of Cornell University, New York, N.Y., USASearch for other works by this author on:
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270 - 283: Expanding the Role of Deep Brain Stimulation from Movement Disorders to Other Neurological DiseasesByMassimo Leone;Massimo LeoneIstituto Nazionale Neurologico Carlo Besta, Milano, ItalySearch for other works by this author on:Angelo Franzini;Angelo FranziniIstituto Nazionale Neurologico Carlo Besta, Milano, ItalySearch for other works by this author on:Giovanni Broggi;Giovanni BroggiIstituto Nazionale Neurologico Carlo Besta, Milano, ItalySearch for other works by this author on:Gennaro BussoneGennaro BussoneIstituto Nazionale Neurologico Carlo Besta, Milano, ItalySearch for other works by this author on:
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284 - 321: Molecular Mediators of PainByPriya Chaudhary;Priya ChaudharyDepartment of Neurological Surgery, L472,Oregon Health & Science University, Portland, Oreg., USASearch for other works by this author on:Kim BurchielKim BurchielDepartment of Neurological Surgery, L472,Oregon Health & Science University, Portland, Oreg., USASearch for other works by this author on:
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322 - 335: Gene Transfer in the Treatment of PainByDavid Fink;David FinkaDepartment of Neurology, University of Michigan and VA Ann Arbor Healthcare System, Ann Arbor, Mich., andSearch for other works by this author on:Marina Mata;Marina MataaDepartment of Neurology, University of Michigan and VA Ann Arbor Healthcare System, Ann Arbor, Mich., andSearch for other works by this author on:Joseph C. GloriosoJoseph C. Gloriosob Department of Molecular Genetics and Biochemistry, University of Pittsburgh, Pittsburgh, Pa., USASearch for other works by this author on:
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336 - 376: Gene Discovery Underlying StrokeByFrank C. Barone;Frank C. BaroneaHigh Throughput Biology, GlaxoSmithKline, King of Prussia, Pa., USA,Search for other works by this author on:Simon J. ReadSimon J. ReadbRIRA, Astra Zeneca, Mereside, Alderley Park, Macclesfield, Cheshire, UKSearch for other works by this author on:
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377 - 412: Molecular Mediators of Hemorrhagic StrokeByR. Loch MacdonaldR. Loch MacdonaldDepartment of Neurosurgery, University of Chicago Medical Center, Chicago, Ill., USASearch for other works by this author on:
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413 - 438: Advances towards Cerebrovascular Gene TherapyByYoshimasa Watanabe;Yoshimasa WatanabeDepartments of Internal Medicine and Pharmacology, University of Iowa College of Medicine, Cardiovascular Center, and Veterans Affairs Medical Center, Iowa City, Iowa, USASearch for other works by this author on:Donald D. HeistadDonald D. HeistadDepartments of Internal Medicine and Pharmacology, University of Iowa College of Medicine, Cardiovascular Center, and Veterans Affairs Medical Center, Iowa City, Iowa, USASearch for other works by this author on:
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439 - 457: Ex vivo Gene Therapy and Cell Therapy for StrokeByDouglas Kondziolka;Douglas KondziolkaaDepartment of Neurological Surgery, University of Pittsburgh, Pittsburgh, Pa.,Search for other works by this author on:Jason Sheehan;Jason SheehanbDepartment of Neurological Surgery, University of Virginia, Charlottesville, Va., USASearch for other works by this author on:Ajay NiranjanAjay NiranjanaDepartment of Neurological Surgery, University of Pittsburgh, Pittsburgh, Pa.,Search for other works by this author on:
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458 - 498: Neurosurgical Applications for Polymeric Drug Delivery SystemsByPaul P. Wang;Paul P. WangaDepartments of Neurological Surgery andSearch for other works by this author on:Henry BremHenry BremaDepartments of Neurological Surgery andbOncology, The Johns Hopkins Hospital, Baltimore, Md., USASearch for other works by this author on:
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499 - 520: Immunotherapy Strategies for Treatment of Malignant GliomasByLarry Harshyne;Larry HarshyneaDepartment of Neurosurgery andSearch for other works by this author on:Phyllis Flomenberg;Phyllis Flomenbergb Department of Internal Medicine, Thomas Jefferson University, Philadelphia, Pa., USASearch for other works by this author on:David W. AndrewsDavid W. AndrewsaDepartment of Neurosurgery andSearch for other works by this author on:
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521 - 556: Glioma-Genesis: Signaling Pathways for the Development of Molecular OncotherapyByGurpreet S. Kapoor;Gurpreet S. KapooraDepartments of Neurosurgery andSearch for other works by this author on:Donald M. O’RourkeDonald M. O’RourkeaDepartments of Neurosurgery andb Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pa., USASearch for other works by this author on:
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557 - 579: Oncolytic Viral Therapy for GliomaByMartine L.M. Lamfers;Martine L.M. LamfersaMolecular Neuro-Oncology Laboratories, Neurosurgery Service, Massachusetts General Hospital, Harvard Medical School, Charlestown, Mass.,Search for other works by this author on:Therese Visted;Therese VistedaMolecular Neuro-Oncology Laboratories, Neurosurgery Service, Massachusetts General Hospital, Harvard Medical School, Charlestown, Mass.,Search for other works by this author on:E. Antonio ChioccaE. Antonio ChioccabDepartment of Neurological Surgery, The Ohio State University Medical Center, James Cancer Hospital and Solove Research Institute, Columbus, Ohio, USASearch for other works by this author on:
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580 - 623: Molecular Neurosurgery in the Pituitary Gland: Gene Transfer as an Adjunctive Treatment StrategyByMaria G. Castro;Maria G. CastroaGene Therapeutics Research Institute, Cedars-Sinai Medical Center, Research Pavilion,bDepartment of Medicine, UCLA David Geffen School of Medicine,Search for other works by this author on:Nelson Jovel;Nelson JovelaGene Therapeutics Research Institute, Cedars-Sinai Medical Center, Research Pavilion,bDepartment of Medicine, UCLA David Geffen School of Medicine,Search for other works by this author on:Shyam Goverdhana;Shyam GoverdhanaaGene Therapeutics Research Institute, Cedars-Sinai Medical Center, Research Pavilion,bDepartment of Medicine, UCLA David Geffen School of Medicine,Search for other works by this author on:Jinwei Hu;Jinwei HuaGene Therapeutics Research Institute, Cedars-Sinai Medical Center, Research Pavilion,bDepartment of Medicine, UCLA David Geffen School of Medicine,Search for other works by this author on:John Yu;John YucMaxine Dunitz Neurosurgical Institute, Cedars-Sinai Medical Center, Los Angeles, Calif., USASearch for other works by this author on:Moneeb Ehtesham;Moneeb EhteshamcMaxine Dunitz Neurosurgical Institute, Cedars-Sinai Medical Center, Los Angeles, Calif., USASearch for other works by this author on:Xiangpeng Yuan;Xiangpeng YuanaGene Therapeutics Research Institute, Cedars-Sinai Medical Center, Research Pavilion,bDepartment of Medicine, UCLA David Geffen School of Medicine,Search for other works by this author on:Diana Greengold;Diana GreengoldaGene Therapeutics Research Institute, Cedars-Sinai Medical Center, Research Pavilion,bDepartment of Medicine, UCLA David Geffen School of Medicine,Search for other works by this author on:Weidong Xiong;Weidong XiongaGene Therapeutics Research Institute, Cedars-Sinai Medical Center, Research Pavilion,bDepartment of Medicine, UCLA David Geffen School of Medicine,Search for other works by this author on:Pedro R. LowensteinPedro R. LowensteinaGene Therapeutics Research Institute, Cedars-Sinai Medical Center, Research Pavilion,bDepartment of Medicine, UCLA David Geffen School of Medicine,Search for other works by this author on:
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624 - 644: Stem Cells for Targeting CNS MalignancyByStephen Yip;Stephen YipaDivision of Neuropathology, Department of Pathology and Laboratory Medicine,Vancouver General Hospital, University of British Columbia, Vancouver, Canada;Search for other works by this author on:Richard L. Sidman;Richard L. SidmanbDepartment of Neurology, Harvard Medical School, Harvard Institutes of Medicine,Beth Israel-Deaconess Medical Center & Children’s Hospital, Boston, Mass., andSearch for other works by this author on:Evan Y. SnyderEvan Y. SnyderbDepartment of Neurology, Harvard Medical School, Harvard Institutes of Medicine,Beth Israel-Deaconess Medical Center & Children’s Hospital, Boston, Mass., andcThe Burnham Institute, Program in Developmental & Regenerative Cell Biology,a Jolla, Calif., USASearch for other works by this author on: