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Frontiers in Diabetes
Glucokinase and Glycemic Disease: From Basics to Novel Therapeutics
S.Karger AG
Volume
16
Status:
Available
ISBN electronic:
978-3-318-01080-0
ISBN print:
978-3-8055-7744-1
Book Series:
Frontiers in Diabetes
Publication date:
2004
Book Details
The glucose-phosphorylating enzyme glucokinase (also known as hexokinase IV) plays a preeminent role as a glucose sensor and regulatory metabolic enzyme. The implications of this central position of glucokinase for the understanding and treatment of diabetes mellitus are far reaching.
This book addresses the molecular and human genetic, as well as the physiological-chemical and pharmacological aspects of the role glucokinase plays in glucose homeostasis and diseases of glucose metabolism, and how the enzyme serves as the drug target for the treatment of diabetes mellitus.
The collection of assays by a team of internationally renowned authors includes basic science chapters dealing with the enzymology, structure and the kinetics of hexokinases, essays describing the biochemical genetics of glucokinase-linked hypo- and hyperglycemia syndromes, and papers that discuss the diverse roles of the enzyme in a variety of tissues. Finally, the book contains the latest information on the recently discovered class of weight drugs that activate glucokinase (i.e. glucokinase activators or GKAs).
This volume is of great interest to basic and clinical diabetes researchers, geneticists, biochemists, physiologists and pharmacologists.
Glucokinase and Glycemic Disease: From Basics to Novel Therapeutics
Edited by: F.M. Matschinsky, M.A. Magnuson
https://doi.org/10.1159/isbn.978-3-318-01080-0
ISBN (print): 978-3-8055-7744-1
ISBN (electronic): 978-3-318-01080-0
Publisher: S.Karger AG
Published: 2004
Download citation file:
Digital Version
Pay-Per-View Access
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Print Version
Glucokinase and Glycemic Disease: From Basics to Novel Therapeutics
$304.00
Table of Contents
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1 - 17: Glucokinase as a Glucose Sensor: Past, Present and FutureByM.A. Magnuson;M.A. MagnusonaDepartment of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, Tenn., andSearch for other works by this author on:F.M. MatschinskyF.M. MatschinskybDepartment of Biochemistry and Biophysics and the Diabetes Research Center, University of Pennsylvania School of Medicine, Philadelphia, Pa., USASearch for other works by this author on:
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18 - 30: The Hexokinase Gene FamilyByJ.E. WilsonJ.E. WilsonDepartment of Biochemistry and Molecular Biology, Michigan State University, East Lansing, Mich., USASearch for other works by this author on:
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31 - 41: Comparative Biochemistry of GlucokinaseByM.L. CárdenasM.L. CárdenasInstitut Fédératif ‘Biologie Structurale et Microbiologie’, Bioénergétique et Ingénierie des Protéines, Centre National de la Recherche Scientifique, Marseille, FranceSearch for other works by this author on:
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42 - 64: Maturity Onset Diabetes of the Young Type 2ByP. Froguel;P. FroguelbInstitute of Biology-CNRS 8090, Pasteur Institute, Lille, France;cHammersmith Genome Centre, Imperial College, London, andSearch for other works by this author on:A. Gloyn;A. GloyndDiabetes and Vascular Medicine, Peninsula Medical School, Exeter, UKSearch for other works by this author on:A. HattersleyA. HattersleydDiabetes and Vascular Medicine, Peninsula Medical School, Exeter, UKSearch for other works by this author on:
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65 - 74: Permanent Neonatal Diabetes mellitus due to Glucokinase DeficiencyByP.R. Njolstad;P.R. NjolstadaDivision of Pediatrics, Department of Clinical Medicine, University of Bergen and Haukeland University Hospital, Bergen, Norway;Search for other works by this author on:O. Sovik;O. SovikaDivision of Pediatrics, Department of Clinical Medicine, University of Bergen and Haukeland University Hospital, Bergen, Norway;Search for other works by this author on:F.M. Matschinsky;F.M. MatschinskybDepartment of Biochemistry and Biophysics and Diabetes Research Center, University of Pennsylvania School of Medicine, Philadelphia, Pa., andSearch for other works by this author on:G.I. BellG.I. BellcDepartments of Biochemistry and Molecular Biology, Medicine and Human Genetics, The University of Chicago, Chicago, Ill., USASearch for other works by this author on:
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75 - 91: Glucokinase-Linked Hypoglycemia: Clinical Aspects of Activating Glucokinase MutationsByH.B.T. Christesen;H.B.T. ChristesenDepartment of Pediatrics, Odense University Hospital, Odense, Denmark; College of Physicians and Surgeons, Columbia University, N.Y., USA; Department of Pediatric Endocrinology, University Children’s Hospital, Nijmegen, The Netherlands; Diabetes and Vascular Medicine, Peninsula Medical School, Exeter, UKSearch for other works by this author on:K. Herold;K. HeroldDepartment of Pediatrics, Odense University Hospital, Odense, Denmark; College of Physicians and Surgeons, Columbia University, N.Y., USA; Department of Pediatric Endocrinology, University Children’s Hospital, Nijmegen, The Netherlands; Diabetes and Vascular Medicine, Peninsula Medical School, Exeter, UKSearch for other works by this author on:K. Noordam;K. NoordamDepartment of Pediatrics, Odense University Hospital, Odense, Denmark; College of Physicians and Surgeons, Columbia University, N.Y., USA; Department of Pediatric Endocrinology, University Children’s Hospital, Nijmegen, The Netherlands; Diabetes and Vascular Medicine, Peninsula Medical School, Exeter, UKSearch for other works by this author on:A.L. GloynA.L. GloynDepartment of Pediatrics, Odense University Hospital, Odense, Denmark; College of Physicians and Surgeons, Columbia University, N.Y., USA; Department of Pediatric Endocrinology, University Children’s Hospital, Nijmegen, The Netherlands; Diabetes and Vascular Medicine, Peninsula Medical School, Exeter, UKSearch for other works by this author on:
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92 - 109: Glucokinase and the Regulation of Blood Sugar: A Mathematical Model Predicts the Threshold for Glucose Stimulated Insulin Release for GCK Gene Mutations that Cause Hyper- and HypoglycemiaByA.L. Gloyn;A.L. GloynaDiabetes and Vascular Medicine, Peninsula Medical School, Exeter, UK;Search for other works by this author on:S. Odili;S. OdilibDepartment of Biochemistry and Biophysics and the Diabetes Research Center, University of Pennsylvania School of Medicine, Philadelphia, Pa., USA;Search for other works by this author on:C. Buettger;C. BuettgerbDepartment of Biochemistry and Biophysics and the Diabetes Research Center, University of Pennsylvania School of Medicine, Philadelphia, Pa., USA;Search for other works by this author on:P.R. Njolstad;P.R. NjolstadcInstitute for Clinical Medicine and Molecular Medicine, Department of Paediatrics, Haukeland University Hospital, University of Bergen, Bergen, Norway;Search for other works by this author on:C. Shiota;C. ShiotadDepartment of Molecular Physiology and Biophysics, Vanderbilt University Medical School, Nashville, Tenn., USASearch for other works by this author on:M.A. Magnuson;M.A. MagnusondDepartment of Molecular Physiology and Biophysics, Vanderbilt University Medical School, Nashville, Tenn., USASearch for other works by this author on:F.M. MatschinskyF.M. MatschinskybDepartment of Biochemistry and Biophysics and the Diabetes Research Center, University of Pennsylvania School of Medicine, Philadelphia, Pa., USA;Search for other works by this author on:
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110 - 124: Glucokinase/Glutamate Dehydrogenase Interactions in the GDH form of Congenital HyperinsulinismByA. Kelly;A. KellyDivision of Endocrinology, The Children’s Hospital of Philadelphia, Philadelphia, Pa., USASearch for other works by this author on:C. Li;C. LiDivision of Endocrinology, The Children’s Hospital of Philadelphia, Philadelphia, Pa., USASearch for other works by this author on:C.A. StanleyC.A. StanleyDivision of Endocrinology, The Children’s Hospital of Philadelphia, Philadelphia, Pa., USASearch for other works by this author on:
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125 - 134: Glucokinase: A Monomeric Enzyme with Positive CooperativityByA. Cornish-Bowden;A. Cornish-BowdenInstitut Fédératif ‘Biologie Structurale et Microbiologie’, Bioénergétique et Ingénierie des Protéines, Centre National de la Recherche Scientifique, Marseille, FranceSearch for other works by this author on:M.L. CárdenasM.L. CárdenasInstitut Fédératif ‘Biologie Structurale et Microbiologie’, Bioénergétique et Ingénierie des Protéines, Centre National de la Recherche Scientifique, Marseille, FranceSearch for other works by this author on:
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135 - 144: Molecular Models of Human Glucokinase and the Implications for Glycemic DiseasesByR.W. Harrison;R.W. HarrisonaDepartments of Biology, andbComputer Science, andSearch for other works by this author on:I.T. WeberI.T. WeberaDepartments of Biology, andcChemistry, Georgia State University, Atlanta, Ga., USASearch for other works by this author on:
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145 - 154: Crystal Structure of Human Liver Glucokinase Bound to a Small Molecule Allosteric Activator: Insights into the Activating MutationsByW. Levin;W. LevincRoche Discovery Technologies, Hoffmann-La Roche, Nutley, N.J.;Search for other works by this author on:L. Reik;L. ReikcRoche Discovery Technologies, Hoffmann-La Roche, Nutley, N.J.;Search for other works by this author on:M.A. Magnuson;M.A. MagnusondDepartment of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, Tenn., andSearch for other works by this author on:F.M. Matschinsky;F.M. MatschinskyeDepartment of Biochemistry and Diabetes Center, University of Pennsylvania School of Medicine, Philadelphia, Pa., USASearch for other works by this author on:J.F. GrippoJ.F. GrippobMetabolic Diseases, andSearch for other works by this author on:
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155 - 168: Molecular Biology of Glucokinase RegulationByP.B. IynedjianP.B. IynedjianDivision of Clinical Biochemistry and Diabetes Research, University of Geneva School of Medicine, Geneva, SwitzerlandSearch for other works by this author on:
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169 - 179: Role of the Transcription Factor Sterol Regulatory Element Binding Protein-1c in Hepatic Glucokinase Gene RegulationByF. Foufelle;F. FoufelleINSERM Unit 465, Les Cordeliers, Paris, FranceSearch for other works by this author on:P. FerréP. FerréINSERM Unit 465, Les Cordeliers, Paris, FranceSearch for other works by this author on:
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180 - 192: Regulation of Hepatic Glucokinase Gene ExpressionByC. Postic;C. PosticDépartement d’Endocrinologie, Institut Cochin, Paris, FranceSearch for other works by this author on:J.-F. Decaux;J.-F. DecauxDépartement d’Endocrinologie, Institut Cochin, Paris, FranceSearch for other works by this author on:J. GirardJ. GirardDépartement d’Endocrinologie, Institut Cochin, Paris, FranceSearch for other works by this author on:
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193 - 207: Discovery and Role of Glucokinase Regulatory ProteinByE. van Schaftingen;E. van SchaftingenLaboratoire de Chimie Physiologique, Christian de Duve Institute of Cellular Pathology (ICP), and Université Catholique de Louvain (UCL), Brussels, BelgiumSearch for other works by this author on:M. Veiga da CunhaM. Veiga da CunhaLaboratoire de Chimie Physiologique, Christian de Duve Institute of Cellular Pathology (ICP), and Université Catholique de Louvain (UCL), Brussels, BelgiumSearch for other works by this author on:
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208 - 221: GKRP/GK: Control of Metabolic Fluxes in HepatocytesByL. Agius;L. AgiusDepartment of Diabetes, SCMS, University of Newcastle, Newcastle, UKSearch for other works by this author on:S. Aiston;S. AistonDepartment of Diabetes, SCMS, University of Newcastle, Newcastle, UKSearch for other works by this author on:M. Mukhtar;M. MukhtarDepartment of Diabetes, SCMS, University of Newcastle, Newcastle, UKSearch for other works by this author on:N. de la IglesiaN. de la IglesiaDepartment of Diabetes, SCMS, University of Newcastle, Newcastle, UKSearch for other works by this author on:
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222 - 239: Regulation of Glucokinase as Islets Adapt to PregnancyByR.L. Sorenson;R.L. SorensonDepartment of Genetics Cell Biology and Development, University of Minnesota Medical School, Minneapolis, Minn., USASearch for other works by this author on:A.J. Weinhaus;A.J. WeinhausDepartment of Genetics Cell Biology and Development, University of Minnesota Medical School, Minneapolis, Minn., USASearch for other works by this author on:T.C. BreljeT.C. BreljeDepartment of Genetics Cell Biology and Development, University of Minnesota Medical School, Minneapolis, Minn., USASearch for other works by this author on:
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240 - 248: Regulation of Glucokinase by Vitamins and HormonesByC. Fernandez-Mejia;C. Fernandez-MejiaaNutrition Genetics Unit, Biomedical Research Institute, National Autonomous University of Mexico and the National Institute of Pediatrics, Mexico City, Mexico;Search for other works by this author on:M.S. GermanM.S. GermanbDepartment of Medicine, University of California San Francisco/Diabetes Center, Hormone Research Institute, San Francisco, Calif., USASearch for other works by this author on:
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249 - 261: Regulation of β-Cell GK Gene Transcription by InsulinByB. Leibiger;B. LeibigerThe Rolf Luft Center for Diabetes Research, Department of Molecular Medicine, Karolinska Institutet, Stockholm, SwedenSearch for other works by this author on:P.-O. Berggren;P.-O. BerggrenThe Rolf Luft Center for Diabetes Research, Department of Molecular Medicine, Karolinska Institutet, Stockholm, SwedenSearch for other works by this author on:I.B. LeibigerI.B. LeibigerThe Rolf Luft Center for Diabetes Research, Department of Molecular Medicine, Karolinska Institutet, Stockholm, SwedenSearch for other works by this author on:
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262 - 274: Interaction of GK with the Bifunctional Enzyme 6-Phosphofructo-2-Kinase/Fructose-2,6-Bisphosphatase (6PF2K/F26P2ase)ByS. Baltrusch;S. BaltruschaInstitute of Clinical Biochemistry, Hannover Medical School, Hannover, Germany;Search for other works by this author on:C. Wu;C. WubDepartment of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, Minn., USASearch for other works by this author on:D.A. Okar;D.A. OkarbDepartment of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, Minn., USASearch for other works by this author on:M. Tiedge;M. TiedgeaInstitute of Clinical Biochemistry, Hannover Medical School, Hannover, Germany;Search for other works by this author on:A.J. LangeA.J. LangebDepartment of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, Minn., USASearch for other works by this author on:
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275 - 288: Role of Sulfhydril Groups in GK Catalysis for GK FunctionByM. Tiedge;M. TiedgeInstitute of Clinical Biochemistry, Hannover Medical School, Hannover, GermanySearch for other works by this author on:S. Baltrusch;S. BaltruschInstitute of Clinical Biochemistry, Hannover Medical School, Hannover, GermanySearch for other works by this author on:S. LenzenS. LenzenInstitute of Clinical Biochemistry, Hannover Medical School, Hannover, GermanySearch for other works by this author on:
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289 - 300: Mouse Models of Altered Glucokinase Gene ExpressionByM.A. Magnuson;M.A. MagnusonDepartment of Molecular Physiology and Biophysics, Vanderbilt University Medical School, Nashville, Tenn., USASearch for other works by this author on:K.-A. KimK.-A. KimDepartment of Molecular Physiology and Biophysics, Vanderbilt University Medical School, Nashville, Tenn., USASearch for other works by this author on:
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301 - 312: Anatomy, Physiology and Regulation of Glucokinase as a Brain GlucosensorByB.E. Levin;B.E. LevinaDepartments of Neurosciences andcNeurology Service of the VA Medical Center, E. Orange, N.J., USASearch for other works by this author on:V. Routh;V. RouthbPharmacology and Physiology, New Jersey Medical School, Newark, N.J., andSearch for other works by this author on:A. Dunn-MeynellA. Dunn-MeynellaDepartments of Neurosciences andcNeurology Service of the VA Medical Center, E. Orange, N.J., USASearch for other works by this author on:
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313 - 326: A Glucokinase/AP-1 Glucose Transduction Mechanism in the Ventromedial Hypothalamic Satiety CenterByX.-j. Yang;X.-j. YangaFishberg Center for Neurobiology, Neurobiology of Aging Laboratories, and Department of Geriatrics Mount Sinai School of Medicine, New York, N.Y., USA;Search for other works by this author on:T. Funabashi;T. FunabashibDepartment of Physiology, Yokohama City University School of Medicine, Yokohama, Japan;Search for other works by this author on:L.-M. Kow;L.-M. KowcDepartment of Neurobiology and Behavior, Rockefeller University, New York, N.Y., USASearch for other works by this author on:C.V. MobbsC.V. MobbsaFishberg Center for Neurobiology, Neurobiology of Aging Laboratories, and Department of Geriatrics Mount Sinai School of Medicine, New York, N.Y., USA;Search for other works by this author on:
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327 - 338: The Hepatoportal Glucose Sensor: Mechanisms of Glucose Sensing and Signal TransductionByB. ThorensB. ThorensInstitute of Pharmacology and Toxicology and Institute of Physiology, University of Lausanne, Lausanne, SwitzerlandSearch for other works by this author on:
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339 - 349: Linear Relationship between Glucokinase Expression, Metabolic Redox State and Insulin SecretionByD.W. Piston;D.W. PistonDepartment of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, Tenn., USASearch for other works by this author on:G.H. PattersonG.H. PattersonDepartment of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, Tenn., USASearch for other works by this author on:
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350 - 359: Glucokinase in β-Cell Insulin-Secretory GranulesByI. Miwa;I. MiwaaDepartment of Pathobiochemistry, Faculty of Pharmacy, Meijo University, Nagoya, andSearch for other works by this author on:Y. Toyoda;Y. ToyodaaDepartment of Pathobiochemistry, Faculty of Pharmacy, Meijo University, Nagoya, andSearch for other works by this author on:S. YoshieS. YoshiebDepartment of Oral Anatomy, Nippon Dental University School of Dentistry at Niigata, Niigata, JapanSearch for other works by this author on:
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360 - 378: Discovery and Actions of Glucokinase ActivatorsByJ. Grimsby;J. GrimsbyaDepartment of Metabolic Diseases, Hoffmann-La Roche, Nutley, N.J., andSearch for other works by this author on:F.M. Matschinsky;F.M. MatschinskybDepartment of Biochemistry and Diabetes Center, University of Pennsylvania School of Medicine, Philadelphia, Pa., USASearch for other works by this author on:J.F. GrippoJ.F. GrippoaDepartment of Metabolic Diseases, Hoffmann-La Roche, Nutley, N.J., andSearch for other works by this author on:
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379 - 397: Balancing Hepatic Glucose Disposal and Production: Key Regulatory Genes and Therapeutic OpportunitiesByR. Yang;R. YangSarah W. Stedman Nutrition and Metabolism Center, Departments of Pharmacology & Cancer Biology, Biochemistry, and Medicine, Duke University Medical Center, Durham, N.C., USASearch for other works by this author on:C.B. NewgardC.B. NewgardSarah W. Stedman Nutrition and Metabolism Center, Departments of Pharmacology & Cancer Biology, Biochemistry, and Medicine, Duke University Medical Center, Durham, N.C., USASearch for other works by this author on:
