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Current Directions in Autoimmunity
Complement in Autoimmunity
Edited by
S.Karger AG
Volume
7
Status:
Available
ISBN electronic:
978-3-318-01024-4
ISBN print:
978-3-8055-7646-8
Discontinued Book Series:
Current Directions in Autoimmunity
Subject Area:
Further Areas
,
Genetics
,
Hematology
,
Immunology and Allergy
,
Nephrology
,
Pathology and Cell Biology
Published online:
2004
Published in print:
2003
Book Details
Complement protein expression and activation control central aspects of the normal B cell response. Imbalances in these processes invariably lead to autoimmune disease. Complement activation causes tissue damage in a number of ways and may by itself lead to autoimmune disease. Although the use of complement activation inhibitors in the treatment of complement-mediated tissue injury and disease is largely in pre-clinical trials, the expectations that they will be of significant clinical value are high.
This volume contains a series of review articles that address the role of complement in the pathogenesis of autoimmune disease and the ensuing tissue damage. Topics include structural and functional aspects of the CD19/CD21/CD81 complex, role of the complement system in the expression of systemic lupus erythematosus (SLE) and antiphospholipid antibody syndrome. Also featured is the role of complement activation in ischemia/reperfusion and autoimmune disease injury. Finally, in-depth reviews about complement activation in the development of glomerulonephritis in autoimmune disease and the function of membrane-bound complement regulatory proteins in autoimmunity are presented.
Students as well as basic and clinical researchers in immunology who wish to understand the role of complement in the pathogenesis of autoimmune disease will value this comprehensive and up-to-date publication.
Complement in Autoimmunity
Edited by: G.C. Tsokos
https://doi.org/10.1159/isbn.978-3-318-01024-4
ISBN (print): 978-3-8055-7646-8
ISBN (electronic): 978-3-318-01024-4
Publisher: S.Karger AG
Published: 2003
Download citation file:
Digital Version
Pay-Per-View Access
$233.00
Print Version
Complement in Autoimmunity
$233.00
Table of Contents
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1 - 3: IntroductionByG.C. TsokosG.C. TsokosDepartment of Cellular Injury, Walter Reed Army Institute of Research, Silver Spring, Md., USASearch for other works by this author on:
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4 - 32: Signaling by the CD19/CD21 Complex on B CellsByR.H. Carter;R.H. CarteraUniversity of Alabama at Birmingham, Birmingham, Ala. andSearch for other works by this author on:R.A. BarringtonR.A. Barringtonbthe Center for Blood Research, Boston, Mass., USASearch for other works by this author on:
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33 - 48: Complement Receptor 2 and AutoimmunityByV.M. Holers;V.M. HolersDepartments of Medicine and Immunology, University of Colorado Health Sciences Center, Denver, Colo., USASearch for other works by this author on:S.A. BoackleS.A. BoackleDepartments of Medicine and Immunology, University of Colorado Health Sciences Center, Denver, Colo., USASearch for other works by this author on:
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49 - 86: Apoptosis, Complement and Systemic Lupus Erythematosus: A Mechanistic ViewByC.-C. Liu;C.-C. LiuDivision of Rheumatology and Clinical Immunology, Department of Medicine, University of Pittsburgh School of Medicine, Lupus Center of Excellence, University of Pittsburgh Schools of the Health Sciences, Pittsburgh, Pa., USASearch for other works by this author on:J.S. Navratil;J.S. NavratilDivision of Rheumatology and Clinical Immunology, Department of Medicine, University of Pittsburgh School of Medicine, Lupus Center of Excellence, University of Pittsburgh Schools of the Health Sciences, Pittsburgh, Pa., USASearch for other works by this author on:J.M. Sabatine;J.M. SabatineDivision of Rheumatology and Clinical Immunology, Department of Medicine, University of Pittsburgh School of Medicine, Lupus Center of Excellence, University of Pittsburgh Schools of the Health Sciences, Pittsburgh, Pa., USASearch for other works by this author on:J.M. AhearnJ.M. AhearnDivision of Rheumatology and Clinical Immunology, Department of Medicine, University of Pittsburgh School of Medicine, Lupus Center of Excellence, University of Pittsburgh Schools of the Health Sciences, Pittsburgh, Pa., USASearch for other works by this author on:
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87 - 97: Role of C1q and C1q Receptors in the Pathogenesis of Systemic Lupus ErythematosusByB. Ghebrehiwet;B. GhebrehiwetaDepartment of Medicine, State University of New York, Stony Brook, N.Y., andSearch for other works by this author on:E.I.B. PeerschkeE.I.B. PeerschkebDepartment of Pathology, Weill Medical College of Cornell University, New York, N.Y., USASearch for other works by this author on:
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98 - 132: The Intricate Role of Complement Component C4 in Human Systemic Lupus ErythematosusByY. Yang;Y. YangaCenter for Molecular and Human genetics, Columbus Children’s Research Institute,bDepartment of Molecular Virology, Immunology and Medical Genetics,Search for other works by this author on:E.K. Chung;E.K. ChungaCenter for Molecular and Human genetics, Columbus Children’s Research Institute,bDepartment of Molecular Virology, Immunology and Medical Genetics,Search for other works by this author on:B. Zhou;B. ZhouaCenter for Molecular and Human genetics, Columbus Children’s Research Institute,Search for other works by this author on:K. Lhotta;K. LhottaeDivision of Clinical Nephrology, Innsbruck University Hospital, Innsbruck, AustriaSearch for other works by this author on:L.A. Hebert;L.A. HebertcDivision of Nephrology, Department of Internal Medicine, andSearch for other works by this author on:D.J. Birmingham;D.J. BirminghamcDivision of Nephrology, Department of Internal Medicine, andSearch for other works by this author on:B.H. Rovin;B.H. RovincDivision of Nephrology, Department of Internal Medicine, andSearch for other works by this author on:Y. YuY. YuaCenter for Molecular and Human genetics, Columbus Children’s Research Institute,bDepartment of Molecular Virology, Immunology and Medical Genetics,dDepartment of Pediatrics, The Ohio State University, Columbus, Ohio, USA, andSearch for other works by this author on:
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133 - 148: The Role of Complement in the Antiphospholipid SyndromeByJ.E. Salmon;J.E. SalmonDepartment of Medicine, Hospital for Special Surgery-Weill Medical College of Cornell University, New York, N.Y., USASearch for other works by this author on:G. GirardiG. GirardiDepartment of Medicine, Hospital for Special Surgery-Weill Medical College of Cornell University, New York, N.Y., USASearch for other works by this author on:
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149 - 164: Autoimmunity, Complement Activation, Tissue Injury and Reciprocal EffectsByG.C. Tsokos;G.C. TsokosDepartment of Cellular Injury, Walter Reed Army Institute of Research, Silver Spring, Md., USASearch for other works by this author on:S.D. FlemingS.D. FlemingDepartment of Cellular Injury, Walter Reed Army Institute of Research, Silver Spring, Md., USASearch for other works by this author on:
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165 - 180: Complement and Autoimmune Glomerular DiseasesByR.J. QuiggR.J. QuiggUniversity of Chicago, Section of Nephrology, Chicago, Ill., USASearch for other works by this author on:
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181 - 199: Membrane Complement Regulatory Proteins in Autoimmune and Inflammatory Tissue InjuryByW.-C. SongW.-C. SongCenter for Experimental Therapeutics and Department of Pharmacology, University of Pennsylvania School of Medicine, Philadelphia, Pa., USASearch for other works by this author on:
