Proteomics and Metabolomics in Psychiatry
This publication compiles data generated by proteomics and metabolomics about psychiatric disorders. Leading researchers in these fields review the basic principles of proteomics and metabolomics and propose the new directions to be followed in molecular psychiatry. The chapters divided into two sections - Schizophrenia/Psychotic Disorders and Mood Disorders - deal with findings in diverse tissues from human and preclinical models in order to unravel the biology and biochemistry behind the establishment and course of these illnesses as well as potential biomarkers for clinical applications. More than an update, this publication indicates the next steps to discover biomarkers and understand psychiatric disorders more comprehensively. This publication is valuable reading for psychiatrists, neuroscientists and analytical chemists interested in the basics of proteomics and metabolomics, psychiatric definitions and the most advanced hypotheses about the pathobiology of schizophrenia, depression and bipolar disorder.
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1 - 15: Proteomic Characterization of the Brain and Cerebrospinal Fluid of Schizophrenia PatientsByCecília C. Café-Mendes;Cecília C. Café-MendesaDepartment of Physiology and Biophysics, Institute of Biomedical Sciences andcMax Planck Institute of Psychiatry, andSearch for other works by this author on:Wagner F. Gattaz;Wagner F. GattazbLaboratory of Neurosciences (LIM-27), Institute of Psychiatry, University of São Paulo, São Paulo, Brazil;Search for other works by this author on:Andrea Schmitt;Andrea SchmittbLaboratory of Neurosciences (LIM-27), Institute of Psychiatry, University of São Paulo, São Paulo, Brazil;dDepartment of Psychiatry and Psychotherapy, Ludwig Maximilian University of Munich, Munich, Germany;Search for other works by this author on:Luiz R.G. Britto;Luiz R.G. BrittoaDepartment of Physiology and Biophysics, Institute of Biomedical Sciences andSearch for other works by this author on:Daniel Martins-de-SouzaDaniel Martins-de-SouzabLaboratory of Neurosciences (LIM-27), Institute of Psychiatry, University of São Paulo, São Paulo, Brazil;cMax Planck Institute of Psychiatry, anddDepartment of Psychiatry and Psychotherapy, Ludwig Maximilian University of Munich, Munich, Germany;eLaboratory of Neuroproteomics, Department of Biochemistry, Institute of Biology University of Campinas (UNICAMP), Campinas, BrazilSearch for other works by this author on:
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16 - 26: Peripheral Biomarker Candidates in SchizophreniaByJohannes Thome;Johannes ThomeaClinic and Policlinic for Psychiatry and Psychotherapy, University of Rostock, Rostock, Germany;Search for other works by this author on:Agnieszka Bratek;Agnieszka BratekbDepartment of Psychiatry and Psychotherapy, Medical University of Silesia, Katowice, PolandSearch for other works by this author on:Krzysztof KrystaKrzysztof KrystabDepartment of Psychiatry and Psychotherapy, Medical University of Silesia, Katowice, PolandSearch for other works by this author on:
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27 - 44: Schizophrenia: Blood-Serum-Plasma MetabolomicsBySimone Lista;Simone ListaDepartment of Psychiatry, Psychotherapy and Psychosomatics, Martin Luther University of Halle-Wittenberg, Halle, GermanySearch for other works by this author on:Ina Giegling;Ina GieglingDepartment of Psychiatry, Psychotherapy and Psychosomatics, Martin Luther University of Halle-Wittenberg, Halle, GermanySearch for other works by this author on:Dan RujescuDan RujescuDepartment of Psychiatry, Psychotherapy and Psychosomatics, Martin Luther University of Halle-Wittenberg, Halle, GermanySearch for other works by this author on:
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45 - 55: Proteomic and Metabolomic Evidence for Glial Alterations in SchizophreniaByClare L. Beasley;Clare L. BeasleyaDepartment of Psychiatry, University of British Columbia, Vancouver, B.C., andSearch for other works by this author on:Vilte E. BarakauskasVilte E. BarakauskasbDepartment of Laboratory Medicine and Pathology, University of Alberta, Edmonton, Alta., CanadaSearch for other works by this author on:
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56 - 73: Insights from Proteomic Studies on Schizophrenia Preclinical Models: What Can We Learn for Drug Discovery?ByLorna A. Farrelly;Lorna A. FarrellyDepartment of Psychiatry, Royal College of Surgeons in Ireland, Smurfit Education and Research Centre, Beaumont Hospital, Dublin, IrelandSearch for other works by this author on:Melanie Föcking;Melanie FöckingDepartment of Psychiatry, Royal College of Surgeons in Ireland, Smurfit Education and Research Centre, Beaumont Hospital, Dublin, IrelandSearch for other works by this author on:David R. CotterDavid R. CotterDepartment of Psychiatry, Royal College of Surgeons in Ireland, Smurfit Education and Research Centre, Beaumont Hospital, Dublin, IrelandSearch for other works by this author on:
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74 - 80: Metabolomics to Study Psychotic Disorders and Their Metabolic ComorbiditiesByMatej OrešičMatej OrešičVTT Technical Research Center of Finland, Espoo, FinlandSearch for other works by this author on:
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81 - 91: Peripheral Biomarkers for Depression by Plasma and Serum ProteomicsByEnrico DomeniciEnrico DomeniciNeurosciences Discovery and Translational Area, F. Hoffman-La Roche, Basel, SwitzerlandSearch for other works by this author on:
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92 - 102: Proteomics of Preclinical Models of DepressionByLucia CarboniLucia CarboniDepartment of Pharmacy and Biotechnology, Alma Mater Studiorum University of Bologna, Bologna, ItalySearch for other works by this author on:
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103 - 115: Antidepressant Response MetabonomicsByXuemei Qin;Xuemei QinModern Research Center for Traditional Chinese Medicine of Shanxi University, Taiyuan, PR ChinaSearch for other works by this author on:Xiaoxia Gao;Xiaoxia GaoModern Research Center for Traditional Chinese Medicine of Shanxi University, Taiyuan, PR ChinaSearch for other works by this author on:Yarong Qiao;Yarong QiaoModern Research Center for Traditional Chinese Medicine of Shanxi University, Taiyuan, PR ChinaSearch for other works by this author on:Yuzhi Zhou;Yuzhi ZhouModern Research Center for Traditional Chinese Medicine of Shanxi University, Taiyuan, PR ChinaSearch for other works by this author on:Junsheng Tian;Junsheng TianModern Research Center for Traditional Chinese Medicine of Shanxi University, Taiyuan, PR ChinaSearch for other works by this author on:Zhenyu LiZhenyu LiModern Research Center for Traditional Chinese Medicine of Shanxi University, Taiyuan, PR ChinaSearch for other works by this author on:
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116 - 127: Proteomics and Metabolomics of Bipolar DisorderByAlessandra SussuliniAlessandra SussuliniaUniversidade Estadual de Campinas, Campinas, Brazil;bMax-Planck-Institut für Experimentelle Medizin, Göttingen, GermanySearch for other works by this author on:
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128 - 138: Use of Metabolomics and Proteomics to Reveal Pathophysiological Pathways in Anxiety DisordersByElisabeth Altmaier;Elisabeth AltmaieraInstitutes of Genetic Epidemiology andSearch for other works by this author on:Rebecca T. EmenyRebecca T. EmenybEpidemiology II, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, GermanySearch for other works by this author on: