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Frontiers in Diabetes
Genetics in Diabetes: Type 2 Diabetes and Related Traits
Edited by
S.Karger AG
Volume
23
Status:
Available
ISBN electronic:
978-3-318-02700-6
ISBN print:
978-3-318-02699-3
Book Series:
Frontiers in Diabetes
Publication date:
2014
Book Details
Over the past decade, there has been unprecedented progress in our understanding of the genetic basis of type 2 diabetes driven largely by technological advances which have facilitated genome-wide studies. Bringing together comprehensive synopses written by leaders in the field, this book discusses the recent progress in defining the genetic basis for type 2 diabetes and related traits.
The opening section focuses on the impact of genome-wide association studies on our understanding of the genetic landscape of type 2 diabetes, whilst later chapters explore how variants affecting relevant metabolic traits influence diabetes susceptibility. The impact of next-generation sequencing on gene discovery efforts in both type 2 diabetes and mendelian forms of diabetes and insulin resistance is covered in detail. Particular attention is also given to efforts to increase our understanding of sequence annotation in diabetes-relevant tissues and how this can be harnessed to leverage molecular mechanisms for genetic association signals. Finally, efforts to translate this improved knowledge into both molecular mechanisms and clinical care are discussed. Providing a comprehensive overview of the current knowledge of the genetic basis for type 2 diabetes and related traits, this book is essential reading for researchers with an interest in the etiology of diabetes and human genetics.
Genetics in Diabetes: Type 2 Diabetes and Related Traits
Edited by: A.L. Gloyn, M.I. McCarthy
https://doi.org/10.1159/isbn.978-3-318-02700-6
ISBN (print): 978-3-318-02699-3
ISBN (electronic): 978-3-318-02700-6
Publisher: S.Karger AG
Published: 2014
Download citation file:
Digital Version
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Print Version
Genetics in Diabetes
$233.00
Table of Contents
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1 - 13: Genome-Wide Association Studies in Type 2 DiabetesByNicola L. Beer;Nicola L. BeeraOxford Centre for Diabetes, Endocrinology & Metabolism, andSearch for other works by this author on:Mark I. McCarthyMark I. McCarthyaOxford Centre for Diabetes, Endocrinology & Metabolism, andbWellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UKSearch for other works by this author on:
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14 - 28: Fine Mapping Type 2 Diabetes Susceptibility LociByAndrew P. MorrisAndrew P. MorrisWellcome Trust Centre for Human Genetics, University of Oxford, Oxford, and Department of Biostatistics, University of Liverpool, Liverpool, UKSearch for other works by this author on:
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29 - 41: Whole Genome and Exome Sequencing of Type 2 DiabetesByKyle Gaulton;Kyle GaultonaWellcome Trust Centre for Human Genetics, Oxford, UK;Search for other works by this author on:Jason Flannick;Jason FlannickbBroad Institute of Harvard and MIT, Cambridge, Mass., andSearch for other works by this author on:Christian FuchsbergerChristian FuchsbergercUniversity of Michigan, Ann Arbor, Mich., USASearch for other works by this author on:
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42 - 57: Genome-Wide Association Studies of Glycaemic Traits: A MAGICal JourneyByJose C. Florez;Jose C. FlorezaProgram in Medical and Population Genetics, Broad Institute, Cambridge, Mass.,bCenter for Human Genetic Research, andcDiabetes Research Center, Diabetes Unit, Massachusetts General Hospital, anddDepartment of Medicine, Harvard Medical School, Boston, Mass., USA;Search for other works by this author on:Inês BarrosoInês BarrosoeWellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, andfNIHR Cambridge Biomedical Research Centre and University of Cambridge Metabolic Research Laboratories, Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, UKSearch for other works by this author on:
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58 - 70: Genome-Wide Association Studies of Obesity and Related TraitsByKaren L. Mohlke;Karen L. MohlkeaDepartment of Genetics, University of North Carolina, Chapel Hill, N.C., USA;Search for other works by this author on:Cecilia M. LindgrenCecilia M. LindgrenbWellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UKSearch for other works by this author on:
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71 - 86: Next-Generation Sequencing for the Diagnosis of Monogenic Diabetes and Discovery of Novel AetiologiesBySian Ellard;Sian EllardInstitute of Biomedical and Clinical Science, University of Exeter Medical School, Exeter, UKSearch for other works by this author on:Elisa De FrancoElisa De FrancoInstitute of Biomedical and Clinical Science, University of Exeter Medical School, Exeter, UKSearch for other works by this author on:
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87 - 101: Whole-Exome Sequencing of Patients with Severe Disorders of Insulin ActionByRobert Semple;Robert SempleaNIHR Cambridge Biomedical Research Centre and University of Cambridge Metabolic Research Laboratories, Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, andSearch for other works by this author on:Inês BarrosoInês BarrosoaNIHR Cambridge Biomedical Research Centre and University of Cambridge Metabolic Research Laboratories, Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, andbWellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, UKSearch for other works by this author on:
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102 - 110: Epigenetic Modifications and Type 2 Diabetes in HumansByCharlotte LingCharlotte LingEpigenetics and Diabetes Unit, Lund University Diabetes Center, Department of Clinical Sciences, Lund University, Scania University Hospital, Malmö, SwedenSearch for other works by this author on:
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111 - 121: Insights into β-Cell Biology and Type 2 Diabetes Pathogenesis from Studies of the Islet TranscriptomeByMartijn van de Bunt;Martijn van de BuntaOxford Centre for Diabetes, Endocrinology & Metabolism,bWellcome Trust Centre for Human Genetics, University of Oxford, Oxford, andSearch for other works by this author on:Ignasi Morán;Ignasi MoráncDepartment of Medicine, Imperial College, London, UK;dGenomic Programming of Beta Cells Laboratory, Institut d'Investigacions Biomèdiques August Pi i Sunyer, Barcelona, SpainSearch for other works by this author on:Jorge Ferrer;Jorge FerrercDepartment of Medicine, Imperial College, London, UK;dGenomic Programming of Beta Cells Laboratory, Institut d'Investigacions Biomèdiques August Pi i Sunyer, Barcelona, SpainSearch for other works by this author on:Mark I. McCarthyMark I. McCarthyaOxford Centre for Diabetes, Endocrinology & Metabolism,bWellcome Trust Centre for Human Genetics, University of Oxford, Oxford, andSearch for other works by this author on:
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122 - 132: Genomics of Adipose TissueByKatherine E. Pinnick;Katherine E. PinnickaOxford Centre for Diabetes, Endocrinology & Metabolism, University of Oxford, Churchill Hospital, andSearch for other works by this author on:Fredrik KarpeFredrik KarpeaOxford Centre for Diabetes, Endocrinology & Metabolism, University of Oxford, Churchill Hospital, andbNIHR Oxford Biomedical Research Centre, Oxford University Hospital Trust, Churchill Hospital, Oxford, UKSearch for other works by this author on:
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133 - 145: Translating Genetic Association Signals for Diabetes and Metabolic Traits into Molecular Mechanisms for DiseaseByMatthew G. Rees;Matthew G. ReesaOxford Centre for Diabetes, Endocrinology & Metabolism, University of Oxford, Oxford, andcNational Human Genome Research Institute, National Institutes of Health, Bethesda, Md., USASearch for other works by this author on:Anna L. GloynAnna L. GloynaOxford Centre for Diabetes, Endocrinology & Metabolism, University of Oxford, Oxford, andbNIHR Oxford Biomedical Research Centre, Oxford University Hospital Trust, Churchill Hospital, Oxford, UK;Search for other works by this author on:
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146 - 157: Understanding Molecular Mechanisms for Diabetes and Obesity through Mouse ModelsByMyrte Merkestein;Myrte MerkesteinaHenry Wellcome Centre for Gene Function, Department of Physiology, Anatomy, and Genetics, University of Oxford, Oxford, andSearch for other works by this author on:Roger Cox;Roger CoxbMRC Harwell, Mammalian Genetics Unit, Harwell Science and Innovation Campus, Harwell, UKSearch for other works by this author on:Frances AshcroftFrances AshcroftaHenry Wellcome Centre for Gene Function, Department of Physiology, Anatomy, and Genetics, University of Oxford, Oxford, andSearch for other works by this author on:
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158 - 172: Genetics of Drug Response in DiabetesByEwan R. Pearson;Ewan R. PearsonaDivision of Cardiovascular and Diabetes Medicine, Medical Research Institute, University of Dundee, Dundee, UK;Search for other works by this author on:Jose C. FlorezJose C. FlorezbCenter for Human Genetic Research and Diabetes Research Center (Diabetes Unit, Department of Medicine), Massachusetts General Hospital,cDepartment of Medicine, Harvard Medical School, Boston, Mass., anddProgram in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, Mass., USASearch for other works by this author on:
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173 - 186: Translating Advances in Our Understanding of the Genetics of Diabetes into the ClinicByDaphne S. Gardner;Daphne S. GardneraOxford Centre for Diabetes, Endocrinology & Metabolism, University of Oxford, andcDepartment of Endocrinology, Singapore General Hospital, Singapore, SingaporeSearch for other works by this author on:Katharine R. Owen;Katharine R. OwenaOxford Centre for Diabetes, Endocrinology & Metabolism, University of Oxford, andbNIHR Oxford Biomedical Research Centre, Oxford University Hospital Trust, Churchill Hospital, Oxford, UK;Search for other works by this author on:Anna L. GloynAnna L. GloynaOxford Centre for Diabetes, Endocrinology & Metabolism, University of Oxford, andbNIHR Oxford Biomedical Research Centre, Oxford University Hospital Trust, Churchill Hospital, Oxford, UK;Search for other works by this author on:
