Cancer and Aging: From Bench to Clinics
Cancer is clearly an age-related disease. Recent research in both aging and cancer has demonstrated the complex interaction between the two phenomena. This affects a wide spectrum of research and practice, anywhere from basic research to health care organization. Core examples of these close associations are addressed in this book. Starting with basic research, the first chapters cover cancer development, mTOR inhibition, senescent cells altering the tumor microenvironment, and immune senescence affecting cancer vaccine response. Taking into account the multidisciplinarity of geriatric oncology, several chapters focus on geriatric and oncologic aspects in patient assessment, treatment options, nursing and exercise programs. The book is rounded off by a discussion on the impact of the metabolic syndrome illustrating the interactions between comorbidity and cancer and a chapter on frailty. This book provides the reader with insights that will hopefully foster his or her reflection in their own research and practice to further the development of this most exciting field. Given the aging of the population worldwide and the high prevalence of cancer, it is essential reading not only for oncologists and geriatricians but for all health practitioners.
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Table of Contents
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1 - 16: Chronic Mechanistic Target of Rapamycin Inhibition: Preventing Cancer to Delay Aging, or Vice Versa?ByZelton Dave Sharp;Zelton Dave SharpaDepartment of Molecular Medicine, Institute of Biotechnology,cBarshop Institute for Longevity and Aging Studies, anddCancer Therapy and Research Center, The University of Texas Health Science Center at San Antonio, San Antonio, Tex., USASearch for other works by this author on:Tyler Jay Curiel;Tyler Jay CurielbDepartment of Medicine/Hematology and Medical Oncology,cBarshop Institute for Longevity and Aging Studies, anddCancer Therapy and Research Center, The University of Texas Health Science Center at San Antonio, San Antonio, Tex., USASearch for other works by this author on:Carolina Becker LiviCarolina Becker LiviaDepartment of Molecular Medicine, Institute of Biotechnology,cBarshop Institute for Longevity and Aging Studies, anddCancer Therapy and Research Center, The University of Texas Health Science Center at San Antonio, San Antonio, Tex., USASearch for other works by this author on:
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17 - 27: Senescent Cells and Their Secretory Phenotype as Targets for Cancer TherapyByMichael C. Velarde;Michael C. VelardeaBuck Institute for Research on Aging, Novato, Calif., andSearch for other works by this author on:Marco Demaria;Marco DemariaaBuck Institute for Research on Aging, Novato, Calif., andSearch for other works by this author on:Judith CampisiJudith CampisiaBuck Institute for Research on Aging, Novato, Calif., andbLawrence Berkeley National Laboratory, Berkeley, Calif., USASearch for other works by this author on:
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28 - 37: Cancer Vaccination at Older AgeByClaudia GravekampClaudia GravekampDepartment of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, N.Y., USASearch for other works by this author on:
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38 - 48: Immunology of Aging and Cancer DevelopmentByAnis Larbi;Anis LarbicSingapore Immunology Network (SIgN), Biopolis, A*STAR, Singapore, andSearch for other works by this author on:Rami Kotb;Rami KotbbDivision of Haematology, Department of Medicine, Faculty of Medicine, University of Sherbrooke, Sherbrooke, Canada;Search for other works by this author on:Graham PawelecGraham PawelecdCenter for Medical Research, University of Tuebingen, Tuebingen, GermanySearch for other works by this author on:
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49 - 60: Metabolic Syndrome and Cancer: From Bedside to Bench and BackByMartine ExtermannMartine ExtermannSenior Adult Oncology Program, H. Lee Moffitt Cancer Center and Research Institute, University of South Florida, Tampa, Fla., USASearch for other works by this author on:
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61 - 72: Frailty: A Common Pathway in Aging and CancerByLodovico BalducciLodovico BalducciSenior Adult Oncology Program, H. Lee Moffitt Cancer Center and Research Institute, University of South Florida, Tampa, Fla., USASearch for other works by this author on:
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73 - 84: Targeting Age-Related Changes in the Biology of Acute Myeloid Leukemia: Is the Patient Seeing the Progress?ByNorbert VeyNorbert VeyInstitut Paoli-Calmettes and Aix-Marseille Université, Marseille, FranceSearch for other works by this author on:
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85 - 103: Comprehensive Geriatric Assessment in OncologyBySupriya G. Mohile;Supriya G. MohileSchool of Medicine and Dentistry, University of Rochester Medical Center, Rochester, N.Y., USASearch for other works by this author on:Allison MagnusonAllison MagnusonSchool of Medicine and Dentistry, University of Rochester Medical Center, Rochester, N.Y., USASearch for other works by this author on:
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104 - 123: Pharmacology of Aging and Cancer: How Useful Are Pharmacokinetic Tests?ByStuart M. LichtmanStuart M. LichtmanMemorial Sloan-Kettering Cancer Center, Commack, N.Y. and Weill Cornell Medical College, New York, N.Y., USASearch for other works by this author on:
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124 - 131: Surgery in Older Cancer Patients – Recent Results and New Techniques: Worth the Investment?ByBarbara L. van Leeuwen;Barbara L. van LeeuwenaDepartment of Surgery, University Medical Center Groningen, Groningen University, Groningen, The Netherlands;Search for other works by this author on:Monique G. Huisman;Monique G. HuismanaDepartment of Surgery, University Medical Center Groningen, Groningen University, Groningen, The Netherlands;Search for other works by this author on:Riccardo A. AudisioRiccardo A. AudisiobSt. Helens Teaching Hospital, University of Liverpool, St. Helens, UKSearch for other works by this author on:
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132 - 138: Organizing the Geriatrician/Oncologist Partnership: One Size Fits All? Practical SolutionsByHolly M. Holmes;Holly M. HolmesaDepartment of General Internal Medicine, University of Texas MD Anderson Cancer Center, Houston, Tex., USA, andSearch for other works by this author on:Gilles AlbrandGilles AlbrandbProgramme Lyonnais d’Onco-gériatrie (PROLOG), Hôpital Geriatrique Antoine Charial, Hospices Civils de Lyon, Francheville, FranceSearch for other works by this author on:
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139 - 145: Geriatric Oncology Nursing: Beyond Standard CareByJanine OvercashJanine OvercashThe Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute, Columbus, Ohio, USASearch for other works by this author on:
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146 - 157: Exercise for Older Cancer Patients: Feasible and Helpful?ByHeidi D. Klepin;Heidi D. KlepinaWake Forest School of Medicine, Winston-Salem, N.C.,Search for other works by this author on:Supriya G. Mohile;Supriya G. MohilebSchool of Medicine and Dentistry, University of Rochester Medical Center, Rochester, N.Y., andSearch for other works by this author on:Shannon MihalkoShannon MihalkocWake Forest University, Winston-Salem, N.C., USASearch for other works by this author on:
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158 - 164: Aging and Cancer – Addressing a Nation’s ChallengeByJeanne-Marie Bréchot;Jeanne-Marie BréchotInstitut National du Cancer, Boulogne-Billancourt, FranceSearch for other works by this author on:Martine Le Quellec-Nathan;Martine Le Quellec-NathanInstitut National du Cancer, Boulogne-Billancourt, FranceSearch for other works by this author on:Agnès BuzynAgnès BuzynInstitut National du Cancer, Boulogne-Billancourt, FranceSearch for other works by this author on: