Aging in Nonhuman Primates
As the number of elderly people in human populations increases, the study of normal aging, age-related disorders, and enhanced longevity is taking on new urgency. Fundamental research will provide means of preventing and effectively treating the most debilitating and distressing aspects of advanced age. Considerations of aging in non-human life forms do not aim at life extension, but at an increasing appreciation for the biological role of the aging process in populations, in addition to developing a more comprehensive understanding of the mechanisms of aging. The present volume focuses on primate aging because human characteristics that evolved during their evolution are homologous with those of other primates. Therefore, the research on nonhuman primates will decidedly also contribute to our understanding of the process of human aging. The topics of this volume include brain aging and neurodegenerative diseases, social behavior, cognition and aging, skeletal aging in natural and captive conditions, and consequences of caloric restriction for life and health extension. The great variety of contributions aim at providing a survey of the relevant work in progress and increasing the understanding of normal and pathological aging and life-span enhancement in a variety of nonhuman primate species.
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1 - 21: One Gerontology: Advancing Understanding of Aging through Studies of Great Apes and Other PrimatesByJ.M. Erwin;J.M. ErwinaDivision of Neurobiology, Behavior, and Genetics, BIOQUAL, Inc. andbFoundation for Comparative and Conservation Biology, Rockville, Md., andSearch for other works by this author on:P.R. Hof;P.R. HofbFoundation for Comparative and Conservation Biology, Rockville, Md., andcKastor Neurobiology of Aging Laboratories and Fishberg Research Center for Neurobiology andSearch for other works by this author on:J.J. Ely;J.J. ElyaDivision of Neurobiology, Behavior, and Genetics, BIOQUAL, Inc. andbFoundation for Comparative and Conservation Biology, Rockville, Md., andSearch for other works by this author on:D.P. PerlD.P. PerlbFoundation for Comparative and Conservation Biology, Rockville, Md., andcKastor Neurobiology of Aging Laboratories and Fishberg Research Center for Neurobiology anddDepartment of Pathology (Neuropathology), Mount Sinai School of Medicine, New York, N.Y., USASearch for other works by this author on:
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22 - 31: Skeletal and Dental Evidence of Aging in Captive Western Lowland Gorillas: A Preliminary ReportByK.A. Nichols;K.A. NicholsaDepartment of Anthropology, CB233, University of Colorado at Boulder, Colo., andSearch for other works by this author on:A.L. ZihlmanA.L. ZihlmanbSocial Science I, Department of Anthropology, University of California at Santa Cruz, Calif., USASearch for other works by this author on:
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32 - 47: Skeletal Aging in Macaque MonkeysByR.J. Colman;R.J. ColmanaWisconsin Regional Primate Research Center andSearch for other works by this author on:N. BinkleyN. BinkleyaWisconsin Regional Primate Research Center andbInstitute on Aging, University of Wisconsin, Madison, Wisc., USASearch for other works by this author on:
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48 - 62: Getting Old at Gombe: Skeletal Aging in Wild-Ranging ChimpanzeesByM.E. Morbeck;M.E. MorbeckaDepartments of Anthropology and Cell Biology and Anatomy, University of Arizona, Tucson, Ariz.,Search for other works by this author on:A. Galloway;A. GallowaybDepartment of Anthropology, University of California, Santa Cruz, Calif., andSearch for other works by this author on:D. Richman SumnerD. Richman SumnercDepartments of Anatomy and Orthopedic Surgery, Rush Medical College, Chicago, Ill., USASearch for other works by this author on:
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63 - 75: Nutritional Modulation of Aging by Caloric RestrictionByJ.A. Mattison;J.A. MattisonIntramural Research Program, Gerontology Research Center, Baltimore, Md., USASearch for other works by this author on:D.K. Ingram;D.K. IngramIntramural Research Program, Gerontology Research Center, Baltimore, Md., USASearch for other works by this author on:G.S. Roth;G.S. RothIntramural Research Program, Gerontology Research Center, Baltimore, Md., USASearch for other works by this author on:M.A. LaneM.A. LaneIntramural Research Program, Gerontology Research Center, Baltimore, Md., USASearch for other works by this author on:
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76 - 101: Methodological Considerations when Studying the Aging Process in the Nonhuman Primate BrainByJ.I.H. Keuker;J.I.H. KeukeraDivision of Neurobiology, German Primate Center andcDepartment of Animal Physiology, University of Groningen, andSearch for other works by this author on:T. Michaelis;T. MichaelisbBiomedizinische NMR Forschungs GmbH, Max-Planck-Institute for Biophysical Chemistry, Göttingen, Germany;Search for other works by this author on:G. de Biurrun;G. de BiurrunaDivision of Neurobiology, German Primate Center andbBiomedizinische NMR Forschungs GmbH, Max-Planck-Institute for Biophysical Chemistry, Göttingen, Germany;Search for other works by this author on:P.G.M. Luiten;P.G.M. LuitencDepartment of Animal Physiology, University of Groningen, andSearch for other works by this author on:M.P. Witter;M.P. WitterdDepartment of Anatomy, Vrije Universiteit, Amsterdam, The NetherlandsSearch for other works by this author on:E. FuchsE. FuchsaDivision of Neurobiology, German Primate Center andSearch for other works by this author on:
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102 - 117: Nigrostriatal Function in Aged Nonhuman PrimatesByM.E. Emborg;M.E. EmborgResearch Center for Brain Repair and Department of Neurological Sciences, Rush University, Chicago, Ill., USASearch for other works by this author on:J.H. KordowerJ.H. KordowerResearch Center for Brain Repair and Department of Neurological Sciences, Rush University, Chicago, Ill., USASearch for other works by this author on:
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118 - 129: The Brain of the Aging Baboon: A Nonhuman Primate Model for Neuronal and Glial Tau PathologyByC. Schultz;C. SchultzaDepartment of Clinical Neuroanatomy, Johann Wolfgang Goethe University, Frankfurt am Main, Germany;Search for other works by this author on:K. del Tredici;K. del TrediciaDepartment of Clinical Neuroanatomy, Johann Wolfgang Goethe University, Frankfurt am Main, Germany;Search for other works by this author on:U. Rüb;U. RübaDepartment of Clinical Neuroanatomy, Johann Wolfgang Goethe University, Frankfurt am Main, Germany;Search for other works by this author on:E. Braak;E. BraakaDepartment of Clinical Neuroanatomy, Johann Wolfgang Goethe University, Frankfurt am Main, Germany;†DeceasedSearch for other works by this author on:G.B. Hubbard;G.B. HubbardbDepartment of Laboratory Animal Medicine, Southwest Foundation for Biomedical Research, San Antonio, Tex., USASearch for other works by this author on:H. BraakH. BraakaDepartment of Clinical Neuroanatomy, Johann Wolfgang Goethe University, Frankfurt am Main, Germany;Search for other works by this author on:
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130 - 154: Comparative Neuropathology of Brain Aging in PrimatesByP.R. Hof;P.R. HofaKastor Neurobiology of Aging Laboratories and Fishberg Research Center for Neurobiology, Departments ofbGeriatrics and Adult Development,gNew York Consortium in Evolutionary Primatology, New York, N.Y.,iFoundation for Comparative and Conservation Biology, Rockville, Md., USA;Search for other works by this author on:E.P. Gilissen;E.P. GilissenjDepartment of Anatomical Sciences, University of the Witwatersrand, Parktown, South AfricaSearch for other works by this author on:C.C. Sherwood;C.C. SherwoodaKastor Neurobiology of Aging Laboratories and Fishberg Research Center for Neurobiology, Departments offDepartment of Anthropology, Columbia University,gNew York Consortium in Evolutionary Primatology, New York, N.Y.,Search for other works by this author on:H. Duan;H. DuanaKastor Neurobiology of Aging Laboratories and Fishberg Research Center for Neurobiology, Departments ofSearch for other works by this author on:P.W.H. Lee;P.W.H. LeeaKastor Neurobiology of Aging Laboratories and Fishberg Research Center for Neurobiology, Departments ofSearch for other works by this author on:P.J. Gannon;P.J. GannondOtolaryngology andgNew York Consortium in Evolutionary Primatology, New York, N.Y.,Search for other works by this author on:D.P. Perl;D.P. PerlaKastor Neurobiology of Aging Laboratories and Fishberg Research Center for Neurobiology, Departments ofePathology, Mount Sinai School of Medicine,iFoundation for Comparative and Conservation Biology, Rockville, Md., USA;Search for other works by this author on:J.M. ErwinJ.M. ErwinhDivision of Neurobiology, Behavior, and Genetics, Bioqual Inc., Rockville, Md., andiFoundation for Comparative and Conservation Biology, Rockville, Md., USA;Search for other works by this author on:
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155 - 177: The Aged Rhesus Macaque in Neuroscience Research: Importance of the Nonhuman Primate ModelByJ.A. RobertsJ.A. RobertsCalifornia Regional Primate Research Center, University of California, Davis, Calif., USASearch for other works by this author on:
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178 - 195: The Rhesus Monkey Model as a Heuristic Resource in Cognitive Aging ResearchByJ.G. Herndon;J.G. HerndonDivision of Neuroscience, Yerkes Regional Primate Research Center, Emory University, Atlanta, Ga., USASearch for other works by this author on:A. LacreuseA. LacreuseDivision of Neuroscience, Yerkes Regional Primate Research Center, Emory University, Atlanta, Ga., USASearch for other works by this author on:
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196 - 208: Comparative Models of Cognitive Decline in Aging Great ApesByL.J. Martin;L.J. MartinbDepartment of Psychology, The Ohio State University, Columbus, Ohio, USASearch for other works by this author on:S.T. BoysenS.T. BoysenbDepartment of Psychology, The Ohio State University, Columbus, Ohio, USASearch for other works by this author on:
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209 - 231: The Behavior of Aged Great ApesByL.R. Tarou;L.R. TarouaSmithsonian National Zoological Park,bGeorgia Institute of Technology, School of Psychology,Search for other works by this author on:M.A. Bloomsmith;M.A. BloomsmithaSmithsonian National Zoological Park,cYerkes Regional Primate Research Center, Emory University, Atlanta, Ga.,Search for other works by this author on:M.P. Hoff;M.P. HoffdDalton State College, Division of Social Sciences, Dalton, Ga.,Search for other works by this author on:J.M. Erwin;J.M. ErwineDivision of Neurobiology, Behavior and Genetics, BIOQUAL, Inc., Rockville, Md., USASearch for other works by this author on:T.L. MapleT.L. MapleaSmithsonian National Zoological Park,bGeorgia Institute of Technology, School of Psychology,Search for other works by this author on: