Animal Testing in Infectiology
Animal testing has a long history, and the resulting knowledge has brought about a significant contribution to the improvement of health and welfare of mankind and animals. Federal regulations concerning the performance of animal testing have become more restrictive worldwide over the last few decades, thus ensuring that only significant tests with a minimum of animal suffering are carried out. Apart from fundamental in vitro studies and clinical trials, animal testing is still indispensable for research on infectious diseases. It offers the opportunity to study the parasitic forms of infectious agents in a complex infection process including the assessment of specific host-defense mechanisms. Another important setting is the in vivo evaluation of substances in infection models for the development of new anti-infective agents. The aim of this book is to provide a comprehensive overview of animal testing in the four major fields of infectiology - bacteriology, virology, mycology and parasitology - as well as in the development of vaccines. New and innovative techniques are introduced and their efficacies critically discussed. In addition, the book shows ways to refine, reduce and replace animal tests in infectiological research and considers ethical aspects of their use. A valuable source of information, this publication will be of interest to research scientists, regulatory agencies, veterinarians supervising experimental animals, breeders and anyone involved in the public debate on animal testing.
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Table of Contents
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1 - 14: Animal Models in BacteriologyByJ.D. Knudsen;J.D. KnudsenDepartment of Clinical Microbiology, Statens Serum Institut, Copenhagen, DenmarkSearch for other works by this author on:N. Frimodt-MollerN. Frimodt-MollerDepartment of Clinical Microbiology, Statens Serum Institut, Copenhagen, DenmarkSearch for other works by this author on:
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15 - 30: Animal Models in VirologyByO.F. WeberO.F. WeberBayer Corp., West Haven, Conn., USASearch for other works by this author on:
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31 - 44: Animal Models in ParasitologyByB. GottsteinB. GottsteinInstitute of Parasitology, Faculty of Veterinary Medicine and Faculty of Medicine, University of Bern, SwitzerlandSearch for other works by this author on:
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45 - 57: Animal Models in MycologyByK. Kamei;K. KameiResearch Center of Pathogenic Fungi and Microbial Toxicoses, Chiba University, Chiba, JapanSearch for other works by this author on:M. MiyajiM. MiyajiResearch Center of Pathogenic Fungi and Microbial Toxicoses, Chiba University, Chiba, JapanSearch for other works by this author on:
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58 - 70: The Use of Animal Models in the Development of Classical VaccinesByU. MethnerU. MethnerFederal Institute for Health Protection of Consumers and Veterinary Medicine, Jena Branch, Jena, GermanySearch for other works by this author on:
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71 - 88: Revealing the Spatiotemporal Patterns of Bacterial Infectious Diseases Using Bioluminescent Pathogens and Whole Body ImagingByK.P. Francis;K.P. FranciscXenogen Corp., Alameda, Calif., USASearch for other works by this author on:L.D. Shortliffe;L.D. ShortliffebUrology, Stanford University Medical Center, Stanford University, Stanford, Calif., andSearch for other works by this author on:P.R. Contag;P.R. ContagaDepartments of Pediatrics andcXenogen Corp., Alameda, Calif., USASearch for other works by this author on:C.H. ContagC.H. ContagaDepartments of Pediatrics andSearch for other works by this author on:
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89 - 117: Alternatives to Animal Testing in Microbiology and InfectiologyByK. Bottrill;K. BottrillFRAME – Fund for the Replacement of Animals in Medical Experiments, Nottingham, UKSearch for other works by this author on:R.D. CombesR.D. CombesFRAME – Fund for the Replacement of Animals in Medical Experiments, Nottingham, UKSearch for other works by this author on:
