Frailty: Pathophysiology, Phenotype and Patient Care: 83rd Nestlé Nutrition Institute Workshop, Barcelona, March 2014
The demographic shift in the average age of the population worldwide calls for careful attention to the nutritional and health needs of the elderly. Frailty has been associated with increased disability, postsurgical complications and increased mortality; in a frail state, older adults are at greater risk for adverse outcomes, including falls and admissions to hospital and nursing homes. Despite the strong associations between frailty and subsequent poor outcomes, limited attention to this common geriatric condition has been paid in clinical settings. Emerging evidence suggests that both behavioral (nutrition and physical activity) and pharmacologic interventions may be effective in the treatment and prevention of the frailty syndrome. The papers in this book address our current understanding of the biological basis, clinical presentation and therapeutic interventions that target frailty. They highlight the transitional nature of research on the frailty syndrome and identified key unmet needs and areas for future investigation in this expanding field.
Download citation file:
Digital Version
Print Version
Table of Contents
-
1 - 10: Connecting Age-Related Biological Decline to Frailty and Late-Life VulnerabilityByJeremy D. WalstonJeremy D. WalstonDivision of Geriatric Medicine and Gerontology, Department of Medicine, Older Americans Independence Center, Johns Hopkins University School of Medicine, Baltimore, MD, USASearch for other works by this author on:
-
11 - 18: Cellular Senescence and the Biology of Aging, Disease, and FrailtyByNathan K. LeBrasseur;Nathan K. LeBrasseuraRobert and Arlene Kogod Center on Aging, andbDepartment of Physical Medicine and Rehabilitation, Mayo Clinic, Rochester, MN, USASearch for other works by this author on:Tamara Tchkonia;Tamara TchkoniaaRobert and Arlene Kogod Center on Aging, andSearch for other works by this author on:James L. KirklandJames L. KirklandaRobert and Arlene Kogod Center on Aging, andSearch for other works by this author on:
-
19 - 28: The Role of Genome Instability in Frailty: Mitochondria versus NucleusByArnold Y. Seo;Arnold Y. SeoaDepartment of Aging and Geriatric Research, College of Medicine, University of Florida, Gainesville, FL, andbCell Biology and Metabolism Program, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, USASearch for other works by this author on:Christiaan LeeuwenburghChristiaan LeeuwenburghaDepartment of Aging and Geriatric Research, College of Medicine, University of Florida, Gainesville, FL, andSearch for other works by this author on:
-
29 - 40: Determinants of Frailty and Longevity: Are They the Same Ones?ByLeocadio Rodríguez MañasLeocadio Rodríguez MañasServicio de Geriatría, Hospital Universitario de Getafe, Getafe, SpainSearch for other works by this author on:
-
41 - 44: A Summary of the Biological Basis of FrailtyByRoger A. FieldingRoger A. FieldingNutrition, Exercise Physiology and Sarcopenia Laboratory, Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Boston, MA, USASearch for other works by this author on:
-
45 - 54: Psychological Frailty in the Aging PatientByL. Jaime FittenL. Jaime FittenDepartment of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine at UCLA, and VA Greater Los Angeles Healthcare System, Sepulveda Campus, Los Angeles, CA, USASearch for other works by this author on:
-
55 - 64: Frailty Clinical Phenotype: A Physical and Cognitive Point of ViewByMylene Aubertin-Leheudre;Mylene Aubertin-LeheudreaDepartment of Kinanthropology, Faculty of Science, GRAPA, University of Quebec at Montreal, andbResearch Centre, Montreal Geriatric University Institute, Montreal, QC, Canada;cDepartment of Aging and Geriatric Research andSearch for other works by this author on:Adam J. Woods;Adam J. WoodscDepartment of Aging and Geriatric Research anddCognitive Aging and Memory Clinical Translational Research Program, Institute on Aging, University of Florida, Gainesville, FL, USASearch for other works by this author on:Stephen Anton;Stephen AntoncDepartment of Aging and Geriatric Research andSearch for other works by this author on:Ronald Cohen;Ronald CohencDepartment of Aging and Geriatric Research anddCognitive Aging and Memory Clinical Translational Research Program, Institute on Aging, University of Florida, Gainesville, FL, USASearch for other works by this author on:Marco PahorMarco PahorcDepartment of Aging and Geriatric Research andSearch for other works by this author on:
-
65 - 70: Overlaps between Frailty and Sarcopenia DefinitionsByTommy CederholmTommy CederholmDepartment of Geriatric Medicine, Uppsala University Hospital and Public Health and Caring Sciences, Clinical Nutrition and Metabolism, Uppsala University, Uppsala, SwedenSearch for other works by this author on:
-
71 - 82: Recovery after Hip Fracture: Interventions and Their Timing to Address Deficits and Desired Outcomes - Evidence from the Baltimore Hip StudiesByJay Magaziner;Jay MagazinerDepartment of Epidemiology and Public Health, School of Medicine, University of Maryland, Baltimore, MD, USASearch for other works by this author on:Nancy Chiles;Nancy ChilesDepartment of Epidemiology and Public Health, School of Medicine, University of Maryland, Baltimore, MD, USASearch for other works by this author on:Denise OrwigDenise OrwigDepartment of Epidemiology and Public Health, School of Medicine, University of Maryland, Baltimore, MD, USASearch for other works by this author on:
-
83 - 92: Physical Exercise as Therapy for FrailtyByLina E. Aguirre;Lina E. AguirreaNew Mexico VA Health Care System,bBiomedical Research Institute of New Mexico, andSearch for other works by this author on:Dennis T. VillarealDennis T. VillarealaNew Mexico VA Health Care System,cCenter for Translational Research on Inflammatory Disease (CTRID), Michael E. DeBakey VA Medical Center and Baylor College of Medicine, Houston, Tex., USASearch for other works by this author on:
-
93 - 98: Frailty in Clinical PracticeByMatteo Cesari;Matteo CesariGérontopole, Centre Hospitalier Universitaire de Toulouse, and INSERM UMR1027, Université de Toulouse III Paul Sabatier, Toulouse, FranceSearch for other works by this author on:Bruno VellasBruno VellasGérontopole, Centre Hospitalier Universitaire de Toulouse, and INSERM UMR1027, Université de Toulouse III Paul Sabatier, Toulouse, FranceSearch for other works by this author on:
-
99 - 104: Integrating Frailty into Clinical Practice to Prevent the Risk of Dependency in the ElderlyByBruno VellasBruno VellasGérontopôle, Centre Hospitalier Universitaire de Toulouse, and INSERM UMR1027, Université de Toulouse III Paul Sabatier, Toulouse, FranceSearch for other works by this author on: