Neuroendocrine Tumors: A Multidisciplinary Approach
The term ‘carcinoid’ entered medical literature over 100 years ago to describe a peculiar intestinal epithelial neoplasm. Since then, a large body of literature has expanded the concept of carcinoid, later replaced by the term ‘NeuroEndocrine Tumor’ (NET), defining a wide spectrum of peculiar tumors, potentially affecting all organs and tissues, originating from neuroendocrine cells, sharing, but, at the same time, keeping, pathognomonic pathological, radiological and clinical features. This book provides an authoritative overview of the epidemiological, clinical, genetic, molecular and pathological characteristics of NETs and highlights the most relevant controversial issues in the classification, diagnosis and therapy. Furthermore the new frontiers in the field of medical therapies are presented, through a multidisciplinary and translational approach. Considering the fact that NETs have been recently demonstrated less rare as considered so far, 'Neuroendocrine Tumors: A Multidisciplinary Approach' is a must read for endocrinologists, gastroenterologists, endocrine surgeons, as well as pathologists, nuclear medicine physicians and radiologists focused on NET.
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Table of Contents
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1 - 23: Epidemiology of Neuroendocrine TumorsByMerav Fraenkel;Merav FraenkelaEndocrinology Unit, Soroka University Medical Center and The Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer Sheva, Israel;Search for other works by this author on:Antongiulio Faggiano;Antongiulio FaggianobDepartment of Molecular and Clinical Endocrinology and Metabolism, Federico II University of Naples, Napoli, Italy;Search for other works by this author on:Gerlof D. ValkGerlof D. ValkcDepartment of Internal Medicine, University Medical Center Utrecht, Utrecht, The NetherlandsSearch for other works by this author on:
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24 - 39: Biochemical Testing in Patients with Neuroendocrine TumorsByDan GranbergDan GranbergDepartment of Medical Sciences, Uppsala University, Uppsala, SwedenSearch for other works by this author on:
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40 - 57: Clinical Syndromes Related to Gastrointestinal Neuroendocrine NeoplasmsByGeorgios Boutzios;Georgios BoutziosEndocrine Unit, Department of Pathophysiology, National University of Athens, Athens, GreeceSearch for other works by this author on:Gregory KaltsasGregory KaltsasEndocrine Unit, Department of Pathophysiology, National University of Athens, Athens, GreeceSearch for other works by this author on:
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58 - 72: Radiological Imaging: Computed Tomography, Magnetic Resonance Imaging and UltrasonographyByAnders Sundin;Anders SundinaDepartment of Radiology, Section for Molecular Imaging, Uppsala University Hospital, Uppsala, Sweden;Search for other works by this author on:Mark Wills;Mark WillsbSalisbury NHS Foundation Trust, Salisbury, Wiltshire;Search for other works by this author on:Andrea RockallAndrea RockallcDepartment of Radiology, Imperial College Healthcare NHS Trust, London, UKSearch for other works by this author on:
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73 - 87: Nuclear Medicine Imaging of Neuroendocrine TumorsByTessa Brabander;Tessa BrabanderaDepartments of Nuclear Medicine andSearch for other works by this author on:Dik J. Kwekkeboom;Dik J. KwekkeboomaDepartments of Nuclear Medicine andSearch for other works by this author on:Richard A. Feelders;Richard A. FeeldersbInternal Medicine, Division of Endocrinology, Erasmus Medical Centre, Rotterdam, andSearch for other works by this author on:Adrienne H. Brouwers;Adrienne H. BrouwerscDepartment of Nuclear Medicine and Molecular Imaging, University of Groningen, University Medical Centre Groningen, Groningen, The NetherlandsSearch for other works by this author on:Jaap J.M. TeunissenJaap J.M. TeunissenaDepartments of Nuclear Medicine andSearch for other works by this author on:
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88 - 103: Endoscopy and Endoscopic Ultrasound in Assessing and Managing Neuroendocrine NeoplasmsByDermot O'Toole;Dermot O'TooleaNational Neuroendocrine Tumour Service, St. Vincent's University Hospital,bDepartment of Gastroenterology, St James's Hospital, andcTrinity College, Dublin, Ireland;Search for other works by this author on:Laurent PalazzoLaurent PalazzodService d'Endoscopie, Clinique du Trocadero, Paris, FranceSearch for other works by this author on:
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104 - 114: Pathology: Classification and ImmunoprofileByAnnika Blank;Annika BlankInstitute of Pathology, University of Bern, SwitzerlandSearch for other works by this author on:Anja Schmitt;Anja SchmittInstitute of Pathology, University of Bern, SwitzerlandSearch for other works by this author on:Aurel PerrenAurel PerrenInstitute of Pathology, University of Bern, SwitzerlandSearch for other works by this author on:
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115 - 138: Genetics and Epigenetics of Pancreatic Neuroendocrine Tumors and Pulmonary CarcinoidsByKoen M.A. Dreijerink;Koen M.A. DreijerinkaDepartment of Endocrine Oncology, University Medical Centre Utrecht, Utrecht, and Departments ofSearch for other works by this author on:Ivana Cataldo;Ivana CataldodDepartment of Pathology and Diagnostics, University and Hospital Trust of Verona, Verona, ItalySearch for other works by this author on:Aldo Scarpa;Aldo ScarpadDepartment of Pathology and Diagnostics, University and Hospital Trust of Verona, Verona, ItalySearch for other works by this author on:Gerlof D. Valk;Gerlof D. ValkaDepartment of Endocrine Oncology, University Medical Centre Utrecht, Utrecht, and Departments ofSearch for other works by this author on:Ernst-Jan M. SpeelErnst-Jan M. SpeelcPathology, GROW-School of Oncology and Developmental Biology, Maastricht University Medical Centre, Maastricht, The Netherlands;Search for other works by this author on:
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139 - 148: Pancreatic SurgeryByAngela Maurizi;Angela MauriziPancreatic Surgery Unit, AOUI Ospedali Riuniti - Università Politecnica delle Marche, Ancona, ItalySearch for other works by this author on:Stefano Partelli;Stefano PartelliPancreatic Surgery Unit, AOUI Ospedali Riuniti - Università Politecnica delle Marche, Ancona, ItalySearch for other works by this author on:Massimo FalconiMassimo FalconiPancreatic Surgery Unit, AOUI Ospedali Riuniti - Università Politecnica delle Marche, Ancona, ItalySearch for other works by this author on:
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149 - 163: Gastrointestinal Surgery of Neuroendocrine NeoplasmsByCarsten Palnæs Hansen;Carsten Palnæs HansenaDepartments of Surgical Gastroenterology andSearch for other works by this author on:Ingrid Holst Olsen;Ingrid Holst OlsenaDepartments of Surgical Gastroenterology andbEndocrinology, Neuroendocrine Tumor Centre of Excellence, Rigshospitalet, Copenhagen University Hospital, Faculty of Health Sciences, University of Copenhagen, Copenhagen, DenmarkSearch for other works by this author on:Ulrich KniggeUlrich KniggeaDepartments of Surgical Gastroenterology andbEndocrinology, Neuroendocrine Tumor Centre of Excellence, Rigshospitalet, Copenhagen University Hospital, Faculty of Health Sciences, University of Copenhagen, Copenhagen, DenmarkSearch for other works by this author on:
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164 - 176: Transplantation and Debulking Procedures for Neuroendocrine TumorsByA. Frilling;A. FrillingaDepartments of Surgery and Cancer andSearch for other works by this author on:A. Al-Nahhas;A. Al-NahhasbImaging (Nuclear Medicine) andSearch for other works by this author on:A.K. CliftA.K. CliftcSchool of Medicine, Imperial College London, London, UKSearch for other works by this author on:
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177 - 192: A 25-Year Experience of Gastroenteropancreatic Neuroendocrine Tumors and Somatostatin (Congeners) Analogs: From Symptom Control to Antineoplastic TherapyByThomas M. O'Dorisio;Thomas M. O'DorisioaDepartment of Internal Medicine, Division of Endocrinology and Metabolism, Holden NCI Designated Comprehensive Cancer Center, University of Iowa, Iowa City, Iowa, andSearch for other works by this author on:Lowell B. AnthonyLowell B. AnthonybDepartment of Internal Medicine, Division of Medical Oncology, Markey NCI Designated Comprehensive Cancer Center, University of Kentucky, Lexington, Ky., USASearch for other works by this author on:
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193 - 197: Medical Therapy of Pulmonary Neuroendocrine Neoplasms: Targeted, Symptomatic and ChemotherapyByPiero FerollaPiero FerollaMultidisciplinary Group for Diagnosis and Therapy of Neuroendocrine Tumors, ENETS Center of Excellence, Umbria Regional Cancer Network, Perugia, ItalySearch for other works by this author on:
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198 - 215: Peptide Receptor Radionuclide Therapy of Neuroendocrine TumorsByLisa Bodei;Lisa BodeiaDivision of Nuclear Medicine, European Institute of Oncology, Milan, Italy;Search for other works by this author on:Mark Kidd;Mark KiddbDepartment of Gastroenterological Surgery, Yale School of Medicine, New Haven, Conn., USA;Search for other works by this author on:Vikas Prasad;Vikas PrasadcDepartment of Nuclear Medicine, Campus Virchow-Klinikum, Charité University Hospital, Berlin, GermanySearch for other works by this author on:Irvin M. ModlinIrvin M. ModlinbDepartment of Gastroenterological Surgery, Yale School of Medicine, New Haven, Conn., USA;Search for other works by this author on:
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216 - 238: Hormone and Receptor Candidates for Target and Biotherapy of Neuroendocrine TumorsByLeo J. Hofland;Leo J. HoflandaDepartment of Internal Medicine, Division of Endocrinology, Erasmus Medical Center, Rotterdam, The Netherlands;Search for other works by this author on:Timon Vandamme;Timon VandammeaDepartment of Internal Medicine, Division of Endocrinology, Erasmus Medical Center, Rotterdam, The Netherlands;bDepartment of Oncology, University of Antwerp, Antwerp, Belgium;Search for other works by this author on:Manuela Albertelli;Manuela AlbertellicSection of Endocrinology, Department of Internal Medicine and Medical Specialties and Center of Excellence for Biomedical Research, IRCCS AOU San Martino-IST, University of Genoa, Genoa, ItalySearch for other works by this author on:Diego FeroneDiego FeronecSection of Endocrinology, Department of Internal Medicine and Medical Specialties and Center of Excellence for Biomedical Research, IRCCS AOU San Martino-IST, University of Genoa, Genoa, ItalySearch for other works by this author on:
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239 - 247: The Role of Chemotherapy in Well-Differentiated Gastroenteropancreatic Neuroendocrine TumorsByJonathan Strosberg;Jonathan StrosbergaMoffitt Cancer Center and Research Institute, andSearch for other works by this author on:Jamie Goldman;Jamie GoldmanbUniversity of South Florida, Tampa, Fla., USA;Search for other works by this author on:Frederico Costa;Frederico CostacCentro de Oncologia, Hospital Sírio Libanês, São Paulo, Brazil;Search for other works by this author on:Marianne PavelMarianne PaveldCharité University Medicine Berlin, Berlin, GermanySearch for other works by this author on:
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248 - 262: Other Novel Therapies: Biomarkers, microRNAs and microRNA Inhibitors, DNA Methylation, Epigenetics, Immunotherapy and VirotherapyByValeria Giandomenico;Valeria GiandomenicoaDepartments of Medical Sciences, Endocrine Oncology, andSearch for other works by this author on:Chrissie Thirlwell;Chrissie ThirlwellcCancer Research UK, Medical Genomics Laboratory, UCL Cancer Institute, London, UKSearch for other works by this author on:Magnus EssandMagnus EssandbImmunology, Genetics and Pathology, Clinical Immunology, Rudbeck Laboratory, Uppsala University, Uppsala, Sweden;Search for other works by this author on: