Development and Applications of Vaccines and Gene Therapy in AIDS: International Workshop, Naples, Italy, June 1995
This publication is an overview of the exciting discoveries in the field of AIDS which were discussed at the workshop ‘Development and Applications of Vaccines and Gene Therapy in AIDS’ (Naples, June 1995). Various articles present the latest advances in the development of vaccines, focusing on the analysis of immunogenetic epitopes and models of expression and/or administration. Some contributions describe the results of recent vaccine trials with animal models while others concentrate on human clinical trials. Furthermore, articles on new approaches in the field of gene therapy are included. The data compiled in this outstanding volume is essential not only for biomedical scientists but also for all researchers interested in the latest developments in the field of HIV/AIDS.
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1 - 3: Importance of the Collaboration between Research and Public Health Institutions from Developing and Industrialized Nations in the Development of Efficient Preventive Measures for AIDS, Particularly through VaccinesByJames G. S. MakumbiJames G. S. MakumbiMinister of Public Health, Republic of Uganda, Entebbe, UgandaSearch for other works by this author on:
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4 - 12: Host Factors in the Pathogenesis of HIV DiseaseByAnthony S. FauciAnthony S. FauciNational Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda,Md., USASearch for other works by this author on:
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13 - 20: Questions about CD8+ Anti-HIV Lymphocytes in the Control of HIV InfectionByJean Paul LevyJean Paul LevyInstitut Cochin de Génétique Moléculaire, Paris, FranceSearch for other works by this author on:
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21 - 29: Mucosal Receptors and T- and B-Cell Immunity1ByThomas Lehner;Thomas LehnerDepartment of Immunology, United Medical and Dental Schools at Guy’s Hospital, London, UKSearch for other works by this author on:Lesley Bergmeier;Lesley BergmeierDepartment of Immunology, United Medical and Dental Schools at Guy’s Hospital, London, UKSearch for other works by this author on:Louisa Tao;Louisa TaoDepartment of Immunology, United Medical and Dental Schools at Guy’s Hospital, London, UKSearch for other works by this author on:Roger Brookes;Roger BrookesDepartment of Immunology, United Medical and Dental Schools at Guy’s Hospital, London, UKSearch for other works by this author on:Luma Hussain;Luma HussainDepartment of Immunology, United Medical and Dental Schools at Guy’s Hospital, London, UKSearch for other works by this author on:Linda Klavinskis;Linda KlavinskisDepartment of Immunology, United Medical and Dental Schools at Guy’s Hospital, London, UKSearch for other works by this author on:Elaine MitchellElaine MitchellDepartment of Immunology, United Medical and Dental Schools at Guy’s Hospital, London, UKSearch for other works by this author on:
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30 - 38: HIV-1 Genetic Variability: Implications for the Development of HIV VaccinesBySaladin Osmanov;Saladin OsmanovVaccine Development Unit, Division of Research and Intervention Development, Global Program on AIDS, World Health Organization, Geneva, SwitzerlandSearch for other works by this author on:William L. Heyward;William L. HeywardVaccine Development Unit, Division of Research and Intervention Development, Global Program on AIDS, World Health Organization, Geneva, SwitzerlandSearch for other works by this author on:José EsparzaJosé EsparzaVaccine Development Unit, Division of Research and Intervention Development, Global Program on AIDS, World Health Organization, Geneva, SwitzerlandSearch for other works by this author on:
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39 - 48: V3 Region Genotyping of HIV Isolates in Northern Uganda: Heteroduplex Mobility Assay, Nucleotide Sequence and Phylogenese AnalysisByFranco M. Buonaguro;Franco M. Buonaguroa Division of Viral Oncology, Istituto Nazionale Tumori, ‘Fondazione G. Pascale’ (INT), Naples,Search for other works by this author on:Luigi Buonaguro;Luigi Buonaguroa Division of Viral Oncology, Istituto Nazionale Tumori, ‘Fondazione G. Pascale’ (INT), Naples,Search for other works by this author on:Elena Del Gaudio;Elena Del Gaudioa Division of Viral Oncology, Istituto Nazionale Tumori, ‘Fondazione G. Pascale’ (INT), Naples,Search for other works by this author on:Maria Lina Tornesello;Maria Lina Torneselloa Division of Viral Oncology, Istituto Nazionale Tumori, ‘Fondazione G. Pascale’ (INT), Naples,Search for other works by this author on:Mario Monaco;Mario Monacoa Division of Viral Oncology, Istituto Nazionale Tumori, ‘Fondazione G. Pascale’ (INT), Naples,Search for other works by this author on:Donato Greco;Donato Grecob Laboratory of Epidemiology, Istituto Superiore di Sanità, Rome, Italy;Search for other works by this author on:Piero Corti;Piero Cortic St. Mary’s Lacor Hospital, Gulu, UgandaSearch for other works by this author on:Lucille Teasdale Corti;Lucille Teasdale Cortic St. Mary’s Lacor Hospital, Gulu, UgandaSearch for other works by this author on:Elke Beth-Giraldo;Elke Beth-Giraldoa Division of Viral Oncology, Istituto Nazionale Tumori, ‘Fondazione G. Pascale’ (INT), Naples,Search for other works by this author on:Gaetano Giraldo;Gaetano Giraldoa Division of Viral Oncology, Istituto Nazionale Tumori, ‘Fondazione G. Pascale’ (INT), Naples,Search for other works by this author on:and the Italian-Ugandan Cooperation AIDS Programand the Italian-Ugandan Cooperation AIDS ProgramSearch for other works by this author on:
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49 - 55: HIV-1 Biological Phenotype Varies with Severity of Infection across HIV-1 Genetic SubtypesByEva Maria FenyöEva Maria FenyöMicrobiology and Tumorbiology Center, Karolinska Institute, Stockholm, SwedenSearch for other works by this author on:
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56 - 62: Immunotyping HIV-1 in the 1990sByPeter L. Nara;Peter L. NaraVirus Biology Section, LTCB, BCP, DCE, NCI-FCRDC, NIH, Frederick, Md., USASearch for other works by this author on:and the WHO Collaborating Networkand the WHO Collaborating NetworkSearch for other works by this author on:
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63 - 67: Overview of HIV Vaccine DevelopmentByDani P. BolognesiDani P. BolognesiDepartment of Surgery, Duke University Medical Center, Durham, N.C., USASearch for other works by this author on:
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68 - 83: A Recombinant HIV-1 Virus-Like Particle Vaccine: From Concepts to a Field StudyByRalf Wagner;Ralf Wagnera Institute of Medical Microbiology and Hygiene, University of Regensburg, Germany,Search for other works by this author on:Ludwig Deml;Ludwig Demla Institute of Medical Microbiology and Hygiene, University of Regensburg, Germany,Search for other works by this author on:Vera Teeuwsen;Vera Teeuwsenb Laboratory of Viral Pathogenesis, Biomedical Primate Research Center, Rijswijk, The Netherlands, andSearch for other works by this author on:Jonathan Heeney;Jonathan Heeneyb Laboratory of Viral Pathogenesis, Biomedical Primate Research Center, Rijswijk, The Netherlands, andSearch for other works by this author on:Shao Yiming;Shao Yimingc Chinese Academy of Preventive Medicine, Beijing, Republic of ChinaSearch for other works by this author on:Hans WolfHans Wolfa Institute of Medical Microbiology and Hygiene, University of Regensburg, Germany,Search for other works by this author on:
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84 - 91: Role of Adjuvants in HIV Vaccine DesignByFrederick R. VogelFrederick R. VogelVaccine and Prevention Research Program, Division of AIDS, National Institute of Allergy and Infectious Diseases, Bethesda, Md., USASearch for other works by this author on:
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92 - 99: Relative Importance and Functional Role of Genetic Elements Targeted for a Live Attenuated AIDS VaccineBySabine M. Lang;Sabine M. LangNew England Regional Primate Research Center, Harvard Medical School, Southborough, Mass., USASearch for other works by this author on:Ronald C. DesrosiersRonald C. DesrosiersNew England Regional Primate Research Center, Harvard Medical School, Southborough, Mass., USASearch for other works by this author on:
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100 - 104: Vaccination of Mice and Nonhuman Primates using HIV-Gene-Containing DNAByMargaret A. Liu;Margaret A. Liua Department of Virus and Cell Biology, Merck Research Laboratories, West Point, Pa., USA;Search for other works by this author on:Yasuhiro Yasutomi;Yasuhiro Yasutomib Harvard Medical School, Beth Israel Hospital, Boston, Mass., USASearch for other works by this author on:Mary-Ellen Davies;Mary-Ellen Daviesa Department of Virus and Cell Biology, Merck Research Laboratories, West Point, Pa., USA;Search for other works by this author on:Helen C. Perry;Helen C. Perrya Department of Virus and Cell Biology, Merck Research Laboratories, West Point, Pa., USA;Search for other works by this author on:Daniel C. Freed;Daniel C. Freeda Department of Virus and Cell Biology, Merck Research Laboratories, West Point, Pa., USA;Search for other works by this author on:Norman L. Letvin;Norman L. Letvinb Harvard Medical School, Beth Israel Hospital, Boston, Mass., USASearch for other works by this author on:John W. ShiverJohn W. Shivera Department of Virus and Cell Biology, Merck Research Laboratories, West Point, Pa., USA;Search for other works by this author on:
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105 - 112: Immune Responses to the HIV rev Regulatory GeneByB. Wahren;B. Wahrena Microbiology and Tumor Biology Center, Karolinska Institute, andb Swedish Institute for Infectious Disease Control, Stockholm, SwedenSearch for other works by this author on:M. Maria Brytting;M. Maria Bryttingb Swedish Institute for Infectious Disease Control, Stockholm, SwedenSearch for other works by this author on:Gunnel Engström;Gunnel Engströmb Swedish Institute for Infectious Disease Control, Stockholm, SwedenSearch for other works by this author on:Jorma Hinkula;Jorma Hinkulaa Microbiology and Tumor Biology Center, Karolinska Institute, andb Swedish Institute for Infectious Disease Control, Stockholm, SwedenSearch for other works by this author on:Michael Levi;Michael Levia Microbiology and Tumor Biology Center, Karolinska Institute, andb Swedish Institute for Infectious Disease Control, Stockholm, SwedenSearch for other works by this author on:Ewa Ljungdahl Ståhle;Ewa Ljungdahl Ståhleb Swedish Institute for Infectious Disease Control, Stockholm, SwedenSearch for other works by this author on:Staffan Ohlsson;Staffan Ohlssona Microbiology and Tumor Biology Center, Karolinska Institute, andb Swedish Institute for Infectious Disease Control, Stockholm, SwedenSearch for other works by this author on:Ulla Rudén;Ulla Rudénb Swedish Institute for Infectious Disease Control, Stockholm, SwedenSearch for other works by this author on:Stefan SchwartzStefan Schwartza Microbiology and Tumor Biology Center, Karolinska Institute, andSearch for other works by this author on:
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113 - 120: HIV-2 Vaccine Trials in Cynomolgus MonkeysByGunnel Biberfeld;Gunnel BiberfeldKarolinska Institute and Swedish Institute for Infectious Disease Control, Stockholm, SwedenSearch for other works by this author on:Rigmor Thorstensson;Rigmor ThorstenssonKarolinska Institute and Swedish Institute for Infectious Disease Control, Stockholm, SwedenSearch for other works by this author on:Per PutkonenPer PutkonenKarolinska Institute and Swedish Institute for Infectious Disease Control, Stockholm, SwedenSearch for other works by this author on:
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121 - 124: Vaccination of Chimpanzees against HIV-1ByFrançoise Barré-Sinoussi;Françoise Barré-Sinoussia Institut Pasteur, Paris, France andSearch for other works by this author on:Elna van der Ryst;Elna van der Rysta Institut Pasteur, Paris, France andSearch for other works by this author on:Patricia Fultz;Patricia Fultzb University of Alabama, Birmingham, Ala., USASearch for other works by this author on:Marc GirardMarc Girarda Institut Pasteur, Paris, France andSearch for other works by this author on:
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125 - 130: Evaluation of Protective Immunity to HIV-1 in Human PBL-SCID MiceByDonald E. MosierDonald E. MosierDepartment of Immunology, Scripps Research Institute, La Jolla, Calif., USASearch for other works by this author on:
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131 - 138: Vaccination of Cynomolgus Monkeys with Whole Inactivated or Live-Attenuated Simian Immunodeficiency VirusByFausto Titti;Fausto Tittia Laboratory of Virology, Istituto Superiore di Sanità, Rome,Search for other works by this author on:Leonardo Sernicola;Leonardo Sernicolaa Laboratory of Virology, Istituto Superiore di Sanità, Rome,Search for other works by this author on:Franco Corrias;Franco Corriasa Laboratory of Virology, Istituto Superiore di Sanità, Rome,Search for other works by this author on:Alessandra Borsetti;Alessandra Borsettia Laboratory of Virology, Istituto Superiore di Sanità, Rome,Search for other works by this author on:Maria Teresa Maggiorella;Maria Teresa Maggiorellaa Laboratory of Virology, Istituto Superiore di Sanità, Rome,Search for other works by this author on:Gianluca Panzini;Gianluca Panzinia Laboratory of Virology, Istituto Superiore di Sanità, Rome,Search for other works by this author on:Andrea Geraci;Andrea Geracia Laboratory of Virology, Istituto Superiore di Sanità, Rome,Search for other works by this author on:Rita Zamarchi;Rita Zamarchib Department of Oncology, University of Padua, ItalySearch for other works by this author on:Alberto Amadori;Alberto Amadorib Department of Oncology, University of Padua, ItalySearch for other works by this author on:Luigi Chieco-Bianchi;Luigi Chieco-Bianchib Department of Oncology, University of Padua, ItalySearch for other works by this author on:Paola VeraniPaola Verania Laboratory of Virology, Istituto Superiore di Sanità, Rome,Search for other works by this author on:
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139 - 144: Establishment of WHO-Sponsored Field Sites for HIV Vaccine Evaluation in Developing CountriesByWilliam L. Heyward;William L. HeywardVaccine Development Unit, Division of Research and Intervention Development, Global Programme on AIDS, World Health Organization, Geneva, SwitzerlandSearch for other works by this author on:Saladin Osmanov;Saladin OsmanovVaccine Development Unit, Division of Research and Intervention Development, Global Programme on AIDS, World Health Organization, Geneva, SwitzerlandSearch for other works by this author on:Jose EsparzaJose EsparzaVaccine Development Unit, Division of Research and Intervention Development, Global Programme on AIDS, World Health Organization, Geneva, SwitzerlandSearch for other works by this author on:
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145 - 146: Combination Strategies for Vaccination against HIVByStanley A. PlotkinStanley A. PlotkinPasteur Mérieux Connaught, Marnes-la-Coquette, FranceSearch for other works by this author on:
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147 - 154: Immunological Aspects of Patients with HIV-1 Disease following Immunization with Recombinant gp160 (VaxSyn)ByEmma Guerra;Emma Guerraa Department of Allergy and Clinical Immunology, University of Rome ‘La Sapienza’, andSearch for other works by this author on:Giovanni Ricci;Giovanni Riccia Department of Allergy and Clinical Immunology, University of Rome ‘La Sapienza’, andSearch for other works by this author on:Maurizio Carlesimo;Maurizio Carlesimoa Department of Allergy and Clinical Immunology, University of Rome ‘La Sapienza’, andSearch for other works by this author on:Anna Rita Varani;Anna Rita Varania Department of Allergy and Clinical Immunology, University of Rome ‘La Sapienza’, andSearch for other works by this author on:Oscar Pontesilli;Oscar Pontesillia Department of Allergy and Clinical Immunology, University of Rome ‘La Sapienza’, andSearch for other works by this author on:Enrico Scala;Enrico Scalaa Department of Allergy and Clinical Immunology, University of Rome ‘La Sapienza’, andSearch for other works by this author on:Ivano Mezzaroma;Ivano Mezzaromaa Department of Allergy and Clinical Immunology, University of Rome ‘La Sapienza’, andSearch for other works by this author on:Marina Pierdominici;Marina Pierdominicia Department of Allergy and Clinical Immunology, University of Rome ‘La Sapienza’, andSearch for other works by this author on:Franco Pandolfi;Franco Pandolfia Department of Allergy and Clinical Immunology, University of Rome ‘La Sapienza’, andSearch for other works by this author on:Andrea Antinori;Andrea Antinorib Department of Infectious Diseases, Catholic University, Rome, ItalySearch for other works by this author on:Andrea De Luca;Andrea De Lucab Department of Infectious Diseases, Catholic University, Rome, ItalySearch for other works by this author on:Rita Murri;Rita Murrib Department of Infectious Diseases, Catholic University, Rome, ItalySearch for other works by this author on:Adriana Ammassari;Adriana Ammassarib Department of Infectious Diseases, Catholic University, Rome, ItalySearch for other works by this author on:Luigi Ortona;Luigi Ortonab Department of Infectious Diseases, Catholic University, Rome, ItalySearch for other works by this author on:Fernando AiutiFernando Aiutia Department of Allergy and Clinical Immunology, University of Rome ‘La Sapienza’, andSearch for other works by this author on:
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155 - 160: Preparation for HIV Vaccine Efficacy TrialsByRodney Hoff;Rodney HoffEfficacy Trials Branch, Vaccine and Prevention Research Program, Division of AIDS, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Md., USASearch for other works by this author on:Dale N. LawrenceDale N. LawrenceEfficacy Trials Branch, Vaccine and Prevention Research Program, Division of AIDS, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Md., USASearch for other works by this author on:
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161 - 172: Strategies for the Achievement of Prophylactic Vaccination against HIVByMaurice R. HillemanMaurice R. HillemanMerck Institute for Therapeutic Research, Merck Research Laboratories, West Point, Pa., USASearch for other works by this author on:
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173 - 183: Functional Studies of Bispecific Antibodies Directed against HIV-1 and the Fcy I Receptor Type IByMiroslaw K. Gorny;Miroslaw K. Gornya New York University Medical Center, New York, N.Y.;Search for other works by this author on:Tibor Keler;Tibor Kelerb Medarex, Inc., Annandale, N.J.;Search for other works by this author on:Sherri Burda;Sherri Burdac Veterans Affairs Medical Center, New York, N.Y.;Search for other works by this author on:Constance Williams;Constance Williamsc Veterans Affairs Medical Center, New York, N.Y.;Search for other works by this author on:Jerome L. Gabriel;Jerome L. Gabrield Temple University School of Medicine, Philadelphia, Pa., andSearch for other works by this author on:William M. Mitchell;William M. Mitchelle Vanderbilt University School of Medicine, Nashville, Tenn., USASearch for other works by this author on:Yashwant M. Deo;Yashwant M. Deob Medarex, Inc., Annandale, N.J.;Search for other works by this author on:Susan Zolla-PaznerSusan Zolla-Paznera New York University Medical Center, New York, N.Y.;c Veterans Affairs Medical Center, New York, N.Y.;Search for other works by this author on:
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184 - 187: Conformation of the HIV-1 gp120 Envelope GlycoproteinByJoseph Sodroski;Joseph Sodroskia Division of Human Retrovirology, Dana-Farber Cancer Institute, Department of Pathology, Harvard Medical School, Boston, Mass.,Search for other works by this author on:Richard Wyatt;Richard Wyatta Division of Human Retrovirology, Dana-Farber Cancer Institute, Department of Pathology, Harvard Medical School, Boston, Mass.,Search for other works by this author on:Udy Olshevsky;Udy Olshevskya Division of Human Retrovirology, Dana-Farber Cancer Institute, Department of Pathology, Harvard Medical School, Boston, Mass.,Search for other works by this author on:Varda Olshevsky;Varda Olshevskya Division of Human Retrovirology, Dana-Farber Cancer Institute, Department of Pathology, Harvard Medical School, Boston, Mass.,Search for other works by this author on:John MooreJohn Mooreb Aaron Diamond AIDS Research Center, New York, N.Y., USASearch for other works by this author on:
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188 - 191: Some Novel Approaches to the Control of HIV and Select Aspects of HIV PathogenesisByRobert C. GalloRobert C. GalloLaboratory of Tumor Cell Biology, National Cancer Institute, National Institutes of Health, Bethesda, Md., USASearch for other works by this author on:
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192 - 197: TAR Decoys and Trans-Dominant gag Mutant for HIV-1 Gene TherapyByJulianna LisziewiczJulianna LisziewiczResearch Institute for Genetic and Human Therapy, Gaithersburg, Md., USA, and Pavia, ItalySearch for other works by this author on:
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198 - 204: Genetic Pharmacomodulation of Nucleoside Analogues and Gene Therapy for AIDS and CancerByNadia Guettari;Nadia GuettariLaboratoire de Biologie et Thérapeutique des Pathologies Immunitaires, CNRS ERS 107, Hôpital de la Pitié-Salpêtrière, Paris, FranceSearch for other works by this author on:Laurence Loubière;Laurence LoubièreLaboratoire de Biologie et Thérapeutique des Pathologies Immunitaires, CNRS ERS 107, Hôpital de la Pitié-Salpêtrière, Paris, FranceSearch for other works by this author on:Manuel Caruso;Manuel CarusoLaboratoire de Biologie et Thérapeutique des Pathologies Immunitaires, CNRS ERS 107, Hôpital de la Pitié-Salpêtrière, Paris, FranceSearch for other works by this author on:David KlatzmannDavid KlatzmannLaboratoire de Biologie et Thérapeutique des Pathologies Immunitaires, CNRS ERS 107, Hôpital de la Pitié-Salpêtrière, Paris, FranceSearch for other works by this author on:
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205 - 216: The HIV-1 Regulatory Genes tat and rev as Targets for Gene Therapy1ByAntonella Caputo;Antonella CaputoInstitute of Microbiology, University of Ferrara, School of Medicine, Ferrara, ItalySearch for other works by this author on:Cristina Rossi;Cristina RossiInstitute of Microbiology, University of Ferrara, School of Medicine, Ferrara, ItalySearch for other works by this author on:Pier Giorgio Balboni;Pier Giorgio BalboniInstitute of Microbiology, University of Ferrara, School of Medicine, Ferrara, ItalySearch for other works by this author on:Roberta Bozzini;Roberta BozziniInstitute of Microbiology, University of Ferrara, School of Medicine, Ferrara, ItalySearch for other works by this author on:Maria Pia Grossi;Maria Pia GrossiInstitute of Microbiology, University of Ferrara, School of Medicine, Ferrara, ItalySearch for other works by this author on:Monica Betti;Monica BettiInstitute of Microbiology, University of Ferrara, School of Medicine, Ferrara, ItalySearch for other works by this author on:Giuseppe Barbanti-BrodanoGiuseppe Barbanti-BrodanoInstitute of Microbiology, University of Ferrara, School of Medicine, Ferrara, ItalySearch for other works by this author on:
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217 - 225: A Replication-Deficient Human Immunodeficiency Virus-1 Genome as an Interference-Inducing ProvirusByMaurizio Federico;Maurizio Federicoa Laboratory of Virology, Istituto Superiore di Sanità, Rome,Search for other works by this author on:Filomena Nappi;Filomena Nappia Laboratory of Virology, Istituto Superiore di Sanità, Rome,Search for other works by this author on:Fulvio Mavilio;Fulvio Maviliob DIBIT-Istituto Scientifico, San Raffaele Hospital, Milan, ItalySearch for other works by this author on:Paola VeraniPaola Verania Laboratory of Virology, Istituto Superiore di Sanità, Rome,Search for other works by this author on:
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226 - 232: Development of Ribozyme Gene Therapy for HIV InfectionByFlossie Wong-StaalFlossie Wong-StaalUniversity of California-San Diego, La Jolla, Calif., USASearch for other works by this author on:
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233 - 239: Immune Reconstitution for HIV DiseaseBySandra H. BridgesSandra H. BridgesDivision of AIDS, National Institute of Allergy and Infectious Disease, National Institutes of Health, Bethesda, Md, USASearch for other works by this author on: