Innate Immunity: Resistance and Disease-Promoting Principles
Our understanding of the complex innate immune response is increasing rapidly. Its role in the protection against viral or bacterial pathogens is essential for the survival of an organism. However, it is equally important to avoid unregulated inflammation because innate immune responses can cause or promote chronic autoinflammatory diseases such as gout, atherosclerosis, type 2 diabetes or certain aspects of the metabolic syndrome. In this book leading international experts in the field of innate immunity share their findings, define the ‚state of the art‘ in this field and evaluate how insight into the molecular basis of these diseases could help in the design of new therapies. A tremendous amount of work on the innate immune response has been done over the last fifteen years, culminating in the 2011 Nobel Prize in Physiology/Medicine awarded for the discoveries of Toll genes in immunity in flies, membrane-bound Toll-like receptors in mammals, and dendritic cells as initiators of adaptive immunity.
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1 - 3: IntroductionByH. Wagner;H. WagneraInstitute for Medical Microbiology, Immunology and Hygiene, Technical University Munich, Munich, andSearch for other works by this author on:G. HartmannG. HartmannbDepartment for Clinical Pharmacology, University Clinics Bonn, Bonn, GermanySearch for other works by this author on:
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4 - 10: Innate Immunity, Inflammation and Colorectal CancerByKepeng Wang;Kepeng WangLaboratory of Gene Regulation and Signal Transduction, Department of Pharmacology and Pathology, School of Medicine, University of California, San Diego, La Jolla, Calif., USASearch for other works by this author on:Sergei Grivennikov;Sergei GrivennikovLaboratory of Gene Regulation and Signal Transduction, Department of Pharmacology and Pathology, School of Medicine, University of California, San Diego, La Jolla, Calif., USASearch for other works by this author on:Michael KarinMichael KarinLaboratory of Gene Regulation and Signal Transduction, Department of Pharmacology and Pathology, School of Medicine, University of California, San Diego, La Jolla, Calif., USASearch for other works by this author on:
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11 - 14: Immunobiology of C-Type Lectin ReceptorsBySusanne Roth;Susanne RothaInstitut für Klinische Chemie und Pathobiochemie, Klinikum rechts der Isar, Technische Universität München, Munich, andSearch for other works by this author on:Christina Thomas;Christina ThomasaInstitut für Klinische Chemie und Pathobiochemie, Klinikum rechts der Isar, Technische Universität München, Munich, andSearch for other works by this author on:Jürgen RulandJürgen RulandaInstitut für Klinische Chemie und Pathobiochemie, Klinikum rechts der Isar, Technische Universität München, Munich, andbLaboratory of Signaling in the Immune System, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, GermanySearch for other works by this author on:
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15 - 23: Mechanisms of IL-1β Maturation in NeutrophilsByArun K. Mankan;Arun K. MankanUnit for Clinical Biochemistry, Institute for Clinical Chemistry and Clinical Pharmacology, University Hospital, University of Bonn, Bonn, GermanySearch for other works by this author on:Veit HornungVeit HornungUnit for Clinical Biochemistry, Institute for Clinical Chemistry and Clinical Pharmacology, University Hospital, University of Bonn, Bonn, GermanySearch for other works by this author on:
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24 - 28: The Innate Immune System: Its Rediscovery before Toll Was DescribedByWalter G. Land;Walter G. LandGerman Academy of Transplantation Medicine, Munich, Former Institute for Surgical Research, University of Munich, Munich, GermanySearch for other works by this author on:Konrad MessmerKonrad MessmerGerman Academy of Transplantation Medicine, Munich, Former Institute for Surgical Research, University of Munich, Munich, GermanySearch for other works by this author on:
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29 - 34: Innate-Adaptive Immune Responses in Organ Ischemia/Reperfusion InjuryByHaofeng Ji;Haofeng JiDumont-UCLA Transplantation Center, Division of Liver and Pancreas Transplantation, Department of Surgery, David Geffen School of Medicine at UCLA, Los Angeles, Calif., USASearch for other works by this author on:Yuan Zhai;Yuan ZhaiDumont-UCLA Transplantation Center, Division of Liver and Pancreas Transplantation, Department of Surgery, David Geffen School of Medicine at UCLA, Los Angeles, Calif., USASearch for other works by this author on:Jerzy W. Kupiec-WeglinskiJerzy W. Kupiec-WeglinskiDumont-UCLA Transplantation Center, Division of Liver and Pancreas Transplantation, Department of Surgery, David Geffen School of Medicine at UCLA, Los Angeles, Calif., USASearch for other works by this author on:
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35 - 42: Tolerogenic Dendritic Cells in Transplantation: From Preclinical to Clinical ApplicationByAurélie Moreau;Aurélie MoreauITUN INSERM S1064, CHU Hôtel Dieu, Nantes, FranceSearch for other works by this author on:Maria-Cristina CuturiMaria-Cristina CuturiITUN INSERM S1064, CHU Hôtel Dieu, Nantes, FranceSearch for other works by this author on:
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43 - 47: Microbiota's Influence on ImmunityByKenya Honda;Kenya HondaDepartment of Immunology, Graduate School of Medicine, The University of Tokyo, Tokyo, JapanSearch for other works by this author on:Takeshi Tanoue;Takeshi TanoueDepartment of Immunology, Graduate School of Medicine, The University of Tokyo, Tokyo, JapanSearch for other works by this author on:Yuji Nagano;Yuji NaganoDepartment of Immunology, Graduate School of Medicine, The University of Tokyo, Tokyo, JapanSearch for other works by this author on:Koji AtarashiKoji AtarashiDepartment of Immunology, Graduate School of Medicine, The University of Tokyo, Tokyo, JapanSearch for other works by this author on:
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48 - 52: Inflammasomes and Mucosal Immune ResponseByEran Elinav;Eran ElinavaYale University School of Medicine, New Haven, Conn., andSearch for other works by this author on:Jorge Henao-Mejia;Jorge Henao-MejiaaYale University School of Medicine, New Haven, Conn., andSearch for other works by this author on:Richard A. FlavellRichard A. FlavellaYale University School of Medicine, New Haven, Conn., andbHoward Hughes Medical Institute, Chevy Chase, Md., USASearch for other works by this author on:
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53 - 58: Microbial Endocrinology: An Evolution-Based Shared Mechanism Determining Microbiota's Influence on Health and DiseaseByMark LyteMark LyteTexas Tech University Health Sciences Center, Abilene, Tex., USASearch for other works by this author on:
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59 - 72: Standing Guard: Innate Lymphoid Cells Promote Immunity and Tissue Homeostasis at Barrier SurfacesByLaurel A. Monticelli;Laurel A. MonticelliaDepartment of Microbiology and Institute for Immunology, Perelman School of Medicine, andSearch for other works by this author on:David ArtisDavid ArtisaDepartment of Microbiology and Institute for Immunology, Perelman School of Medicine, andbDepartment of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pa., USASearch for other works by this author on:
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73 - 79: miRNAs That Shape the Innate Immune System: Regulation through Toll-Like Receptor SignalingByAnne M. Curtis;Anne M. CurtisDepartment of Biochemistry and Immunology, Trinity Biomedical Science Institute, Trinity College Dublin, Dublin, IrelandSearch for other works by this author on:Luke A.J. O'NeillLuke A.J. O'NeillDepartment of Biochemistry and Immunology, Trinity Biomedical Science Institute, Trinity College Dublin, Dublin, IrelandSearch for other works by this author on:
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80 - 85: Type 2 Diabetes and Islet InflammationByMarc Y. DonathMarc Y. DonathClinic for Endocrinology, Diabetes and Metabolism, University Hospital Basel, Basel, SwitzerlandSearch for other works by this author on:
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86 - 90: The Innate Immune System in Alzheimer's DiseaseByHannes Beckert;Hannes BeckertCenter of Advanced European Studies and Research, Bonn, GermanySearch for other works by this author on:Annett HalleAnnett HalleCenter of Advanced European Studies and Research, Bonn, GermanySearch for other works by this author on:
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91 - 95: Role of Inflammasomes in ObesityByVishwa Deep DixitVishwa Deep DixitImmunobiology Laboratory, Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, La., USASearch for other works by this author on:
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96 - 102: Gut-Brain Communication in the Regulation of System MetabolismByTimo D. Müller;Timo D. MüllerInstitute for Diabetes and Obesity (IDO), Helmholtz Centre Munich, Department of Medicine, Technical University of Munich, Munich, Germany; Obesity Research Center, Department of Internal Medicine, University of Cincinnati, Cincinnati, Ohio, USASearch for other works by this author on:Paul T. Pfluger;Paul T. PflugerInstitute for Diabetes and Obesity (IDO), Helmholtz Centre Munich, Department of Medicine, Technical University of Munich, Munich, Germany; Obesity Research Center, Department of Internal Medicine, University of Cincinnati, Cincinnati, Ohio, USASearch for other works by this author on:Matthias H. TschöpMatthias H. TschöpInstitute for Diabetes and Obesity (IDO), Helmholtz Centre Munich, Department of Medicine, Technical University of Munich, Munich, Germany; Obesity Research Center, Department of Internal Medicine, University of Cincinnati, Cincinnati, Ohio, USASearch for other works by this author on:
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103 - 111: Metabolism and Innate Immunity: FOXO Regulation of Antimicrobial Peptides in DrosophilaByGerrit Loch;Gerrit LochaMolecular Developmental Biology andSearch for other works by this author on:Eva Jentgens;Eva JentgensaMolecular Developmental Biology andSearch for other works by this author on:Margret Bülow;Margret BülowaMolecular Developmental Biology andSearch for other works by this author on:Ingo Zinke;Ingo ZinkebMolecular Brain Physiology and Behavior, LIMES Institute, University of Bonn, Bonn, Germany;Search for other works by this author on:Tetsushi Mori;Tetsushi MoricCenter for Advanced Biomedical Science, Faculty of Science and Engineering, Waseda University, Tokyo, JapanSearch for other works by this author on:Sayaka Suzuki;Sayaka SuzukicCenter for Advanced Biomedical Science, Faculty of Science and Engineering, Waseda University, Tokyo, JapanSearch for other works by this author on:Haruko Takeyama;Haruko TakeyamacCenter for Advanced Biomedical Science, Faculty of Science and Engineering, Waseda University, Tokyo, JapanSearch for other works by this author on:Michael HochMichael HochaMolecular Developmental Biology andSearch for other works by this author on:
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112 - 119: Dendritic Cells Orchestrate Innate Immunity against Bacterial Kidney InfectionByAndré P. Tittel;André P. TittelInstitutes of Molecular Medicine and Experimental Immunology, Friedrich-Wilhelms-Universität Bonn, Bonn, GermanySearch for other works by this author on:Christoph Heuser;Christoph HeuserInstitutes of Molecular Medicine and Experimental Immunology, Friedrich-Wilhelms-Universität Bonn, Bonn, GermanySearch for other works by this author on:Natalio Garbi;Natalio GarbiInstitutes of Molecular Medicine and Experimental Immunology, Friedrich-Wilhelms-Universität Bonn, Bonn, GermanySearch for other works by this author on:Christian KurtsChristian KurtsInstitutes of Molecular Medicine and Experimental Immunology, Friedrich-Wilhelms-Universität Bonn, Bonn, GermanySearch for other works by this author on: