How Gut and Brain Control MetabolismAvailable to Purchase
Obesity is an epidemic problem not limited to Western society, but also in emerging industrial nations with large populations, especially in Asia. The connection between the gut and the brain is probably one of the most promising therapeutic targets for the treatment of obesity and metabolic syndrome. This book brings together reviews on the current understanding of how the gut and brain communicate in the regulation of metabolism. Individual chapters explore novel aspects of this interaction. A comprehensive update on the roles of smell and taste, the gut microbiome, and novel gut-derived neuropeptides in regulating metabolism via the brain is offered. Furthermore, the regulation of insulin sensitivity in the brain is discussed in detail. This overview of current findings is meant to spark new ideas and/or approaches, thus leading to much-needed new medical treatments. Physicians involved in the treatment of metabolic disease and scientists performing research in the fields of nutrition and obesity will find this book to be a valuable addition to their bookshelves.
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Table of Contents
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1 - 28: Hormonal Control of Metabolism by the Hypothalamus-Autonomic Nervous System-Liver AxisByAndries Kalsbeek;Andries KalsbeekaDepartment of Endocrinology and Metabolism, Academic Medical Center, University of Amsterdam, andbHypothalamic Integration Mechanisms, Netherlands Institute for Neuroscience, Amsterdam, The NetherlandsSearch for other works by this author on:Eveline Bruinstroop;Eveline BruinstroopaDepartment of Endocrinology and Metabolism, Academic Medical Center, University of Amsterdam, andSearch for other works by this author on:Chun-Xia Yi;Chun-Xia YibHypothalamic Integration Mechanisms, Netherlands Institute for Neuroscience, Amsterdam, The NetherlandsSearch for other works by this author on:Lars Klieverik;Lars KlieverikaDepartment of Endocrinology and Metabolism, Academic Medical Center, University of Amsterdam, andSearch for other works by this author on:Ji Liu;Ji LiuaDepartment of Endocrinology and Metabolism, Academic Medical Center, University of Amsterdam, andSearch for other works by this author on:Eric FliersEric FliersaDepartment of Endocrinology and Metabolism, Academic Medical Center, University of Amsterdam, andSearch for other works by this author on:
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29 - 49: The Blood-Brain Barrier as a Regulator of the Gut-Brain AxisByMarie Schaeffer;Marie SchaefferaInstitut de Génomique Fonctionnelle, UMR-5203, CNRS,bU661, INSERM, andcUMR-5203, Universities of Montpellier 1 & 2, Montpellier, France;Search for other works by this author on:David J. Hodson;David J. HodsonaInstitut de Génomique Fonctionnelle, UMR-5203, CNRS,bU661, INSERM, andcUMR-5203, Universities of Montpellier 1 & 2, Montpellier, France;dSection of Cell Biology, Division of Diabetes, Endocrinology and Metabolism, Department of Medicine, Imperial College London, London, UKSearch for other works by this author on:Patrice MollardPatrice MollardaInstitut de Génomique Fonctionnelle, UMR-5203, CNRS,bU661, INSERM, andcUMR-5203, Universities of Montpellier 1 & 2, Montpellier, France;Search for other works by this author on:
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50 - 58: The Brain Modulates Insulin Sensitivity in Multiple TissuesByEdwin T. Parlevliet;Edwin T. ParlevlietaDepartment of Medicine, Academic Medical Center, University of Amsterdam, Amsterdam,bDepartment of Endocrinology and Metabolic Diseases,cEinthoven Laboratory for Experimental Vascular Medicine, andSearch for other works by this author on:Claudia P. Coomans;Claudia P. CoomansdDepartment of Molecular Cell Biology, Leiden University Medical Center, Leiden, The NetherlandsSearch for other works by this author on:Patrick C.N. Rensen;Patrick C.N. RensenbDepartment of Endocrinology and Metabolic Diseases,cEinthoven Laboratory for Experimental Vascular Medicine, andSearch for other works by this author on:Johannes A. RomijnJohannes A. RomijnaDepartment of Medicine, Academic Medical Center, University of Amsterdam, Amsterdam,Search for other works by this author on:
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59 - 72: The Important Role of Sleep in MetabolismByGeorges Copinschi;Georges CopinschiaLaboratory of Physiology, Université Libre de Bruxelles (ULB) andSearch for other works by this author on:Rachel Leproult;Rachel LeproultbNeuropsychology and Functional Neuroimaging Research Unit, Center for Research in Cognition and Neurosciences and ULB Neuroscience Institute, ULB, Brussels, Belgium;Search for other works by this author on:Karine SpiegelKarine SpiegelcIntegrated Physiology and Physiology of Brain Arousal Systems, Lyon Neuroscience Research Center, INSERM U1028 - UMR 5292, Faculty of Medicine Lyon Est, Université Claude Bernard Lyon 1, Lyon, FranceSearch for other works by this author on:
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73 - 82: Metabolic Interplay between Gut Bacteria and Their HostByFrank Duca;Frank DucaaUMR1319, Micalis, INRA andbMicalis, AgroParisTech, Jouy-en-Josas, France;cToronto General Research Institute, University Health Network, Toronto, Ont., Canada;Search for other works by this author on:Philippe Gérard;Philippe GérardaUMR1319, Micalis, INRA andbMicalis, AgroParisTech, Jouy-en-Josas, France;Search for other works by this author on:Mihai Covasa;Mihai CovasaaUMR1319, Micalis, INRA andbMicalis, AgroParisTech, Jouy-en-Josas, France;dDepartment of Basic Medical Sciences, College of Osteopathic Medicine, Western University of Health Sciences, Pomona, Calif., USA;eDepartment of Human and Health Development, University of Suceava, Suceava, RomaniaSearch for other works by this author on:Patricia LepagePatricia LepageaUMR1319, Micalis, INRA andbMicalis, AgroParisTech, Jouy-en-Josas, France;Search for other works by this author on:
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83 - 92: The Brain-Stomach ConnectionByC. Folgueira;C. FolgueiraaGrupo Fisiopatologia Endocrina, Instituto de Investigación Sanitaria de Santiago de Compostela (IDIS), Complexo Hospitalario Universitario de Santiago (CHUS/SERGAS),cCIBER Fisiopatologia Obesidad y Nutricion (CB06/03), Instituto de Salud Carlos III, Santiago de Compostela, SpainSearch for other works by this author on:L.M. Seoane;L.M. SeoaneaGrupo Fisiopatologia Endocrina, Instituto de Investigación Sanitaria de Santiago de Compostela (IDIS), Complexo Hospitalario Universitario de Santiago (CHUS/SERGAS),cCIBER Fisiopatologia Obesidad y Nutricion (CB06/03), Instituto de Salud Carlos III, Santiago de Compostela, SpainSearch for other works by this author on:F.F. CasanuevaF.F. CasanuevabLaboratorio de Endocrinologia Molecular y Celular, IDIS, CHUS/SERGAS, andcCIBER Fisiopatologia Obesidad y Nutricion (CB06/03), Instituto de Salud Carlos III, Santiago de Compostela, SpainSearch for other works by this author on:
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93 - 106: Prader-Willi Syndrome as a Model of Human HyperphagiaByMaithe Tauber;Maithe TauberaCentre de référence du syndrome de Prader-Willi,bUnité d'Endocrinologie, Hôpital des Enfants, CHU de Toulouse,cCentre de Physiopathologie de Toulouse Purpan, INSERM UMR 1043/CNRS UMR 5282, Université Paul Sabatier, Toulouse, andSearch for other works by this author on:Gwenaelle Diene;Gwenaelle DieneaCentre de référence du syndrome de Prader-Willi,bUnité d'Endocrinologie, Hôpital des Enfants, CHU de Toulouse,Search for other works by this author on:Emmanuelle Mimoun;Emmanuelle MimounaCentre de référence du syndrome de Prader-Willi,bUnité d'Endocrinologie, Hôpital des Enfants, CHU de Toulouse,Search for other works by this author on:Sophie Çabal-Berthoumieu;Sophie Çabal-BerthoumieuaCentre de référence du syndrome de Prader-Willi,bUnité d'Endocrinologie, Hôpital des Enfants, CHU de Toulouse,Search for other works by this author on:Carine Mantoulan;Carine MantoulanaCentre de référence du syndrome de Prader-Willi,bUnité d'Endocrinologie, Hôpital des Enfants, CHU de Toulouse,Search for other works by this author on:Catherine Molinas;Catherine MolinasaCentre de référence du syndrome de Prader-Willi,bUnité d'Endocrinologie, Hôpital des Enfants, CHU de Toulouse,cCentre de Physiopathologie de Toulouse Purpan, INSERM UMR 1043/CNRS UMR 5282, Université Paul Sabatier, Toulouse, andSearch for other works by this author on:F. Muscatelli;F. MuscatellidInstitut de Neurobiologie de la Méditerranée (INMED), INSERM U901, Parc Scientifique de Luminy, Marseille, FranceSearch for other works by this author on:Jean Pierre SallesJean Pierre SallesaCentre de référence du syndrome de Prader-Willi,bUnité d'Endocrinologie, Hôpital des Enfants, CHU de Toulouse,cCentre de Physiopathologie de Toulouse Purpan, INSERM UMR 1043/CNRS UMR 5282, Université Paul Sabatier, Toulouse, andSearch for other works by this author on:
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107 - 122: Interactions between the Gut, the Brain and Brown Adipose Tissue FunctionByJohanna C. van den Beukel;Johanna C. van den BeukelDepartment of Internal Medicine, Erasmus MC, Rotterdam, The NetherlandsSearch for other works by this author on:Aldo GrefhorstAldo GrefhorstDepartment of Internal Medicine, Erasmus MC, Rotterdam, The NetherlandsSearch for other works by this author on:
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123 - 133: Gut Sweet Taste Receptors and Their Role in MetabolismByA.C. Meyer-Gerspach;A.C. Meyer-GerspachDepartment of Biomedicine and Division of Gastroenterology and Hepatology, University Hospital Basel, Basel, SwitzerlandSearch for other works by this author on:B. Wölnerhanssen;B. WölnerhanssenDepartment of Biomedicine and Division of Gastroenterology and Hepatology, University Hospital Basel, Basel, SwitzerlandSearch for other works by this author on:C. BeglingerC. BeglingerDepartment of Biomedicine and Division of Gastroenterology and Hepatology, University Hospital Basel, Basel, SwitzerlandSearch for other works by this author on:
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134 - 146: What Is the Role of Metabolic Hormones in Taste Buds of the TongueByHuan Cai;Huan CaiMetabolism Unit, Laboratory of Clinical Investigation, National Institute on Aging, National Institutes of Health, Baltimore, Md., USASearch for other works by this author on:Stuart Maudsley;Stuart MaudsleyMetabolism Unit, Laboratory of Clinical Investigation, National Institute on Aging, National Institutes of Health, Baltimore, Md., USASearch for other works by this author on:Bronwen MartinBronwen MartinMetabolism Unit, Laboratory of Clinical Investigation, National Institute on Aging, National Institutes of Health, Baltimore, Md., USASearch for other works by this author on:
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147 - 154: Protein PYY and Its Role in MetabolismBySamantha L. Price;Samantha L. PriceDivision of Diabetes, Endocrinology and Metabolism, Department of Medicine, Imperial College London, London, UKSearch for other works by this author on:Stephen R. BloomStephen R. BloomDivision of Diabetes, Endocrinology and Metabolism, Department of Medicine, Imperial College London, London, UKSearch for other works by this author on:
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155 - 162: Nutropioids Regulate Gut-Brain Circuitry Controlling Food IntakeByGilles MithieuxGilles MithieuxNational Institute of Health and Medical Research, U855, and University of Lyon, Lyon, and University Lyon 1, Villeurbanne, FranceSearch for other works by this author on:
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163 - 174: Should We Consider Des-Acyl Ghrelin as a Separate Hormone and If So, What Does It Do?ByPatric J.D. Delhanty;Patric J.D. DelhantyDepartment of Internal Medicine, Erasmus MC, Rotterdam, The NetherlandsSearch for other works by this author on:Sebastian J. Neggers;Sebastian J. NeggersDepartment of Internal Medicine, Erasmus MC, Rotterdam, The NetherlandsSearch for other works by this author on:Aart J. van der LelyAart J. van der LelyDepartment of Internal Medicine, Erasmus MC, Rotterdam, The NetherlandsSearch for other works by this author on:
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175 - 185: Obestatin: Is It Really Doing Something?ByLetizia Trovato;Letizia TrovatoDivision of Endocrinology, Diabetology and Metabolism, Department of Medical Sciences, University of Turin, Turin, ItalySearch for other works by this author on:Davide Gallo;Davide GalloDivision of Endocrinology, Diabetology and Metabolism, Department of Medical Sciences, University of Turin, Turin, ItalySearch for other works by this author on:Fabio Settanni;Fabio SettanniDivision of Endocrinology, Diabetology and Metabolism, Department of Medical Sciences, University of Turin, Turin, ItalySearch for other works by this author on:Iacopo Gesmundo;Iacopo GesmundoDivision of Endocrinology, Diabetology and Metabolism, Department of Medical Sciences, University of Turin, Turin, ItalySearch for other works by this author on:Ezio Ghigo;Ezio GhigoDivision of Endocrinology, Diabetology and Metabolism, Department of Medical Sciences, University of Turin, Turin, ItalySearch for other works by this author on:Riccarda GranataRiccarda GranataDivision of Endocrinology, Diabetology and Metabolism, Department of Medical Sciences, University of Turin, Turin, ItalySearch for other works by this author on: