Aging: Facts and Theories
Aging inspired a large number of theories trying to rationalize the aging process common to all living beings. In this publication the most important environmental and intrinsic mechanisms involved in the aging process and in its pathological consequences are reviewed. Furthermore theoretical and experimental evidence of the most important theoretical elements based on Darwinian evolution, cellular aging, role of cell membranes, free radicals and oxidative processes, receptor-mediated reactions, the extracellular matrix and immune functions as well as the most important environmental and intrinsic mechanisms involved in the aging process and in its pathological consequences are discussed. These presentations of theories and related experimental facts give a global overview of up to date concepts of the biology of the aging process and are of essential reading not only for specialists in this field but also for practitioners of scientific, medical, social and experimental sciences.
Download citation file:
Digital Version
Print Version
Table of Contents
-
1 - 7: The Commitment of Human Cells to SenescenceByRobin HollidayRobin HollidayAustralian Academy of Science, Canberra, AustraliaSearch for other works by this author on:
-
8 - 23: Evolutionary Theories of Aging Can Explain Why We AgeByEric Le BourgEric Le BourgCentre de Recherches sur la Cognition Animale, UMR CNRS 5169, Université Paul-Sabatier, Toulouse, FranceSearch for other works by this author on:
-
24 - 44: Control of Cell Replication during AgingByAlvaro Macieira-CoelhoAlvaro Macieira-CoelhoINSERM, Versailles, FranceSearch for other works by this author on:
-
45 - 61: Cell Senescence: Role in Aging and Age-Related DiseasesByJudith Campisi;Judith CampisiaBuck Institute for Research on Aging, Novato, Calif., USA;Search for other works by this author on:Ladislas RobertLadislas RobertbHotel Dieu Hospital, Paris V University, Paris, FranceSearch for other works by this author on:
-
62 - 85: Aging of Cell Membranes: Facts and TheoriesByImre Zs.-NagyImre Zs.-NagyFaculty of Medicine, Medical and Health Science Center, University of Debrecen, Debrecen, HungarySearch for other works by this author on:
-
86 - 107: Oxidative Stress, Mitochondrial Dysfunction and the Mitochondria Theory of AgingByYahui Kong;Yahui KongDepartment of Cell and Developmental Biology, University of Massachusetts Medical School, Worcester, Mass., USASearch for other works by this author on:Sally E. Trabucco;Sally E. TrabuccoDepartment of Cell and Developmental Biology, University of Massachusetts Medical School, Worcester, Mass., USASearch for other works by this author on:Hong ZhangHong ZhangDepartment of Cell and Developmental Biology, University of Massachusetts Medical School, Worcester, Mass., USASearch for other works by this author on:
-
108 - 141: Aging of Connective Tissues: Experimental Facts and Theoretical ConsiderationsByJ. Labat-Robert;J. Labat-RobertHotel-Dieu Hospital, Paris V University, Paris, FranceSearch for other works by this author on:L. RobertL. RobertHotel-Dieu Hospital, Paris V University, Paris, FranceSearch for other works by this author on:
-
142 - 162: Aging of Cell Communication: Loss of Receptor Function
-
163 - 176: On the Immunological Theory of AgingByTamas Fulop;Tamas FulopaResearch Center on Aging,bGeriatrics Division, Department of Medicine, andSearch for other works by this author on:Jacek M. Witkowski;Jacek M. WitkowskidDepartment of Pathophysiology, Medical University of Gdansk, Gdansk, Poland;Search for other works by this author on:Graham Pawelec;Graham PaweleceCenter for Medical Research, University of Tübingen, Tübingen, Germany;Search for other works by this author on:Cohen Alan;Cohen AlanaResearch Center on Aging,cDepartment of Family Medicine, University of Sherbrooke, Sherbrooke, Que., Canada;Search for other works by this author on:Anis LarbiAnis LarbifSingapore Immunology Network (SIgN), Biopolis, Agency for Science Technology and Research (A*STAR), Singapore, SingaporeSearch for other works by this author on:
-
177 - 186: Aging of the Brain, Dementias, Role of Infectious Proteins: Facts and TheoriesByFrédéric MorinetFrédéric MorinetGroupe Hospitalier Saint-Louis, Lariboisiére, Fernand Widal, Université Paris Diderot-Paris Sorbonne Cité, Paris, FranceSearch for other works by this author on:
-
187 - 197: Aging as AlterationByPaul-Antoine MiquelPaul-Antoine MiquelLaboratoire ERRAPHIS, Université de Toulouse 2/Le Mirail, Toulouse, FranceSearch for other works by this author on:
-
198 - 211: Longevity and Its Regulation: Centenarians and BeyondByL. Robert;L. RobertaHotel-Dieu Hospital, Paris V University, Paris, France;Search for other works by this author on:T. FulopT. FulopbResearch Center on Aging, Geriatrics Division, Department of Medicine, University of Sherbrooke, Sherbrooke, Que., CanadaSearch for other works by this author on: