Aging and Health - A Systems Biology Perspective
Aging is a major risk factor for chronic diseases, which in turn can provide information about the aging of a biological system. This publication serves as an introduction to systems biology and its application to biological aging. Key pathways and processes that impinge on aging are reviewed, and how they contribute to health and disease during aging is discussed. The evolution of this situation is analyzed, and the consequences for the study of genetic effects on aging are presented. Epigenetic programming of aging, as a continuation of development, creates an interface between the genome and the environment. New research into the gut microbiome describes how this interface may operate in practice with marked consequences for a variety of disorders. This analysis is bolstered by a view of the aging organism as a whole, with conclusions about the mechanisms underlying resilience of the organism to change, and is expanded with a discussion of circadian rhythms in aging. Finally, the book presents an outlook for the development of interventions to delay or to reverse the features of aging.
The publication is recommended to students, researchers as well as professionals dealing with public health and public policy related to an aging society.
Download citation file:
Print Version
Table of Contents
-
1 - 17: Introduction to the Theory of Aging NetworksByTarynn M. WittenTarynn M. WittenCenter for the Study of Biological Complexity, Virginia Commonwealth University, Richmond, Va., USASearch for other works by this author on:
-
18 - 34: Applications to Aging NetworksByChristopher Wimble;Christopher WimbleCenter for the Study of Biological Complexity, Virginia Commonwealth University, Richmond, Va., USASearch for other works by this author on:Tarynn M. WittenTarynn M. WittenCenter for the Study of Biological Complexity, Virginia Commonwealth University, Richmond, Va., USASearch for other works by this author on:
-
35 - 48: Computational Systems Biology for Aging ResearchByMark T. Mc Auley;Mark T. Mc AuleyaFaculty of Science and Engineering, Thornton Science Park, University of Chester, Chester, andSearch for other works by this author on:Kathleen M. MooneyKathleen M. MooneybFaculty of Health and Social Care, Edge Hill University, Ormskirk, UKSearch for other works by this author on:
-
49 - 62: How Does the Body Know How Old It Is? Introducing the Epigenetic Clock HypothesisByJoshua MitteldorfJoshua MitteldorfDepartment of EAPS, Massachusetts Institute of Technology, Cambridge, Mass., USASearch for other works by this author on:
-
63 - 73: The Great Evolutionary Divide: Two Genomic Systems Biologies of AgingByMichael R. Rose;Michael R. RoseDepartment of Ecology and Evolutionary Biology, University of California, Irvine, Calif., USASearch for other works by this author on:Larry G. Cabral;Larry G. CabralDepartment of Ecology and Evolutionary Biology, University of California, Irvine, Calif., USASearch for other works by this author on:Mark A. Philips;Mark A. PhilipsDepartment of Ecology and Evolutionary Biology, University of California, Irvine, Calif., USASearch for other works by this author on:Grant A. Rutledge;Grant A. RutledgeDepartment of Ecology and Evolutionary Biology, University of California, Irvine, Calif., USASearch for other works by this author on:Kevin H. Phung;Kevin H. PhungDepartment of Ecology and Evolutionary Biology, University of California, Irvine, Calif., USASearch for other works by this author on:Laurence D. Mueller;Laurence D. MuellerDepartment of Ecology and Evolutionary Biology, University of California, Irvine, Calif., USASearch for other works by this author on:Lee F. GreerLee F. GreerDepartment of Ecology and Evolutionary Biology, University of California, Irvine, Calif., USASearch for other works by this author on:
-
74 - 84: Development and Aging: Two Opposite but Complementary PhenomenaByBruno César Feltes;Bruno César FeltesLaboratory of Molecular and Computational Biology, Department of Molecular Biology and Biotechnology, Center of Biotechnology, Federal University of Rio Grande do Sul, Rio Grande do Sul, BrazilSearch for other works by this author on:Joice de Faria Poloni;Joice de Faria PoloniLaboratory of Molecular and Computational Biology, Department of Molecular Biology and Biotechnology, Center of Biotechnology, Federal University of Rio Grande do Sul, Rio Grande do Sul, BrazilSearch for other works by this author on:Diego BonattoDiego BonattoLaboratory of Molecular and Computational Biology, Department of Molecular Biology and Biotechnology, Center of Biotechnology, Federal University of Rio Grande do Sul, Rio Grande do Sul, BrazilSearch for other works by this author on:
-
85 - 98: Aging as a Process of Deficit Accumulation: Its Utility and OriginByArnold Mitnitski;Arnold MitnitskiaDepartments of Medicine andbMathematics and Statistics, Dalhousie University,Search for other works by this author on:Kenneth RockwoodKenneth RockwoodaDepartments of Medicine andcDivision of Geriatric Medicine, QEII Health Science Centre, Halifax, N.S., CanadaSearch for other works by this author on:
-
99 - 106: Low-Grade Systemic Inflammation Connects Aging, Metabolic Syndrome and Cardiovascular DiseaseByVerónica Guarner;Verónica GuarnerDepartment of Physiology, Instituto Nacional de Cardiologia ‘Ignacio Chávez', Mexico, MexicoSearch for other works by this author on:Maria Esther Rubio-RuizMaria Esther Rubio-RuizDepartment of Physiology, Instituto Nacional de Cardiologia ‘Ignacio Chávez', Mexico, MexicoSearch for other works by this author on:
-
107 - 127: Modulating mTOR in Aging and HealthBySimon C. Johnson;Simon C. JohnsonDepartment of Pathology, University of Washington, Seattle, Wash., USASearch for other works by this author on:Maya Sangesland;Maya SangeslandDepartment of Pathology, University of Washington, Seattle, Wash., USASearch for other works by this author on:Matt Kaeberlein;Matt KaeberleinDepartment of Pathology, University of Washington, Seattle, Wash., USASearch for other works by this author on:Peter S. RabinovitchPeter S. RabinovitchDepartment of Pathology, University of Washington, Seattle, Wash., USASearch for other works by this author on:
-
128 - 140: Melatonin and Circadian Oscillators in Aging - A Dynamic Approach to the Multiply Connected PlayersByRüdiger HardelandRüdiger HardelandJohann Friedrich Blumenbach Institute of Zoology and Anthropology, University of Göttingen, Göttingen, GermanySearch for other works by this author on:
-
141 - 154: Diet-Microbiota-Health Interactions in Older Subjects: Implications for Healthy AgingByD.B. Lynch;D.B. LynchaSchool of Microbiology andbAlimentary Pharmabiotic Centre, University College Cork, Cork, andSearch for other works by this author on:I.B. Jeffery;I.B. JefferyaSchool of Microbiology andbAlimentary Pharmabiotic Centre, University College Cork, Cork, andSearch for other works by this author on:E.M. O'Connor;E.M. O'ConnorcDepartment of Life Sciences, University of Limerick, Limerick, IrelandSearch for other works by this author on:P.W. O'TooleP.W. O'TooleaSchool of Microbiology andbAlimentary Pharmabiotic Centre, University College Cork, Cork, andSearch for other works by this author on:
-
155 - 176: Systems Biology Approaches in Aging ResearchByAnuradha Chauhan;Anuradha ChauhanbDepartment of Systems Biology and Bioinformatics, Institute of Computer Science, University of Rostock,Search for other works by this author on:Ulf W. Liebal;Ulf W. LiebalbDepartment of Systems Biology and Bioinformatics, Institute of Computer Science, University of Rostock,fInstitute of Physiology, Rostock University Medicine, Rostock, GermanySearch for other works by this author on:Julio Vera;Julio VeraaLaboratory of Systems Tumor Immunology, Department of Dermatology, University Hospital Erlangen and Friedrich-Alexander Universität Erlangen, Erlangen,Search for other works by this author on:Simone Baltrusch;Simone BaltruschcInstitute of Medical Biochemistry,Search for other works by this author on:Christian Junghanß;Christian JunghanßdDepartment of Hematology,Search for other works by this author on:Markus Tiedge;Markus TiedgecInstitute of Medical Biochemistry,Search for other works by this author on:Georg Fuellen;Georg FuelleneInstitute for Biostatistics and Informatics in Medicine and Ageing Research of Physiology,Search for other works by this author on:Olaf Wolkenhauer;Olaf WolkenhauerbDepartment of Systems Biology and Bioinformatics, Institute of Computer Science, University of Rostock,Search for other works by this author on:Rüdiger KöhlingRüdiger KöhlingfInstitute of Physiology, Rostock University Medicine, Rostock, GermanySearch for other works by this author on:
-
177 - 188: Conservative Growth Hormone/IGF-1 and mTOR Signaling Pathways as a Target for Aging and Cancer Prevention: Do We Really Have an Antiaging DrugByVladimir N. AnisimovVladimir N. AnisimovDepartment of Carcinogenesis and Oncogerontology, N.N. Petrov Research Institute of Oncology, St. Petersburg, RussiaSearch for other works by this author on: