Cell-Based Therapy for Retinal Degenerative Disease
In this volume, some of the leading authorities present their exploration of applications of stem cell therapy to the treatment of major causes of blindness, including degenerative diseases and glaucoma. The diagnostic approach to patients, general concepts of cell-based therapy, immunological considerations, approaches to cell delivery (including engineered scaffolds), combined cell and gene therapy, nanomedicine applications to cell therapy and regulatory issues pertaining to manufacture and production are all considered in detail. The book serves as an excellent introduction to a field that is now entering early-stage clinical trials and promises to operate at the leading edge of regenerative medicine. Retina specialists, general ophthalmologists as well as researchers will find here a wealth of information on the translational aspects of cell-based therapies. Further, business executives and students interested in understanding the potential applications of stem cell therapy to retinal degenerative disease and glaucoma will also find this book informative reading.
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Table of Contents
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1 - 32: Age-Related Macular Degeneration: Clinical Findings, Histopathology and Imaging TechniquesByMarco A. Zarbin;Marco A. ZarbinaRutgers New Jersey Medical School, Newark, N.J., andSearch for other works by this author on:Ricardo P. Casaroli-Marano;Ricardo P. Casaroli-MaranocDepartment of Surgery, School of Medicine and Instituto Clínic de Oftalmología, University of Barcelona, Barcelona, SpainSearch for other works by this author on:Philip J. RosenfeldPhilip J. RosenfeldbBascom Palmer Eye Institute, Miami, Fla., USA;Search for other works by this author on:
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33 - 43: General Pathophysiology in Retinal DegenerationByKatherine J. Wert;Katherine J. WertaBernard and Shirlee Brown Glaucoma Laboratory, Departments of Ophthalmology, Pathology and Cell Biology,bInstitute of Human Nutrition, College of Physicians and Surgeons,cEdward S. Harkness Eye Institute, Columbia University, andSearch for other works by this author on:Jonathan H. Lin;Jonathan H. LineShiley Eye Center, Department of Pathology, University of California San Diego, La Jolla, Calif., USASearch for other works by this author on:Stephen H. TsangStephen H. TsangaBernard and Shirlee Brown Glaucoma Laboratory, Departments of Ophthalmology, Pathology and Cell Biology,cEdward S. Harkness Eye Institute, Columbia University, anddNew York-Presbyterian Hospital/Columbia University Medical Center, New York, N.Y.,Search for other works by this author on:
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44 - 52: Juvenile-Onset Macular Degeneration and Allied DisordersByVictoria North;Victoria NorthbCollege of Physicians and Surgeons, Columbia University,Search for other works by this author on:Rony Gelman;Rony GelmanaDepartment of Ophthalmology, University of Southern California Eye Institute, University of Southern California, Los Angeles, Calif.,Search for other works by this author on:Stephen H. TsangStephen H. TsangcDepartment of Ophthalmology, anddBernard and Shirlee Brown Glaucoma Laboratory, Department of Pathology and Cell Biology, Edward S. Harkness Eye Institute, Columbia University, New York, N.Y., USASearch for other works by this author on:
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53 - 69: Diagnosis and Complementary ExaminationsByMoreno Menghini;Moreno MenghiniDepartment of Ophthalmology, University of California, San Francisco, Calif., USASearch for other works by this author on:Jacque L. DuncanJacque L. DuncanDepartment of Ophthalmology, University of California, San Francisco, Calif., USASearch for other works by this author on:
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70 - 80: Stem Cells for Retinal RepairByJeffrey Stern;Jeffrey SternNeural Stem Cell Institute, Rensselaer, N.Y., USASearch for other works by this author on:Sally TempleSally TempleNeural Stem Cell Institute, Rensselaer, N.Y., USASearch for other works by this author on:
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81 - 96: Differentiation of Pluripotent Stem Cells into Retinal Pigmented EpitheliumByRoxanne H. Croze;Roxanne H. CrozeCenter for Stem Cell Biology and Engineering, Center for the Study of Macular Degeneration, Neuroscience Research Institute, Department of Molecular, Cellular and Developmental Biology, University of California, Santa Barbara, Calif., USASearch for other works by this author on:Dennis O. CleggDennis O. CleggCenter for Stem Cell Biology and Engineering, Center for the Study of Macular Degeneration, Neuroscience Research Institute, Department of Molecular, Cellular and Developmental Biology, University of California, Santa Barbara, Calif., USASearch for other works by this author on:
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97 - 110: Neural Retinal Regeneration with Pluripotent Stem CellsByConor M. Ramsden;Conor M. RamsdenaThe London Project to Cure Blindness, Division of ORBIT, Institute of Ophthalmology, University College London,bNIHR Biomedical Research Centre at Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology, London, UK;Search for other works by this author on:Michael B. Powner;Michael B. PowneraThe London Project to Cure Blindness, Division of ORBIT, Institute of Ophthalmology, University College London,Search for other works by this author on:Amanda-Jayne F. Carr;Amanda-Jayne F. CarraThe London Project to Cure Blindness, Division of ORBIT, Institute of Ophthalmology, University College London,Search for other works by this author on:Matthew J.K. Smart;Matthew J.K. SmartaThe London Project to Cure Blindness, Division of ORBIT, Institute of Ophthalmology, University College London,Search for other works by this author on:Lyndon da Cruz;Lyndon da CruzaThe London Project to Cure Blindness, Division of ORBIT, Institute of Ophthalmology, University College London,bNIHR Biomedical Research Centre at Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology, London, UK;Search for other works by this author on:Peter J. CoffeyPeter J. CoffeyaThe London Project to Cure Blindness, Division of ORBIT, Institute of Ophthalmology, University College London,cCenter for Stem Cell Biology and Engineering, NRI, UC Santa Barbara, Santa Barbara, Calif., USASearch for other works by this author on:
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111 - 121: Stem Cells, Retinal Ganglion Cells and GlaucomaByValentin M. Sluch;Valentin M. SluchaOphthalmology, Wilmer Eye Institute,bBiochemistry, Cellular and Molecular Biology Graduate Program, Departments ofSearch for other works by this author on:Donald J. ZackDonald J. ZackaOphthalmology, Wilmer Eye Institute,cMolecular Biology and Genetics, anddNeuroscience,eInstitute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Md., USA;fInstitut de la Vision, Université Pierre et Marie Curie, Paris, FranceSearch for other works by this author on:
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122 - 132: Stem Cells: Immunology and ImmunomodulationByAseda Tena;Aseda TenaTransplantation Biology Research Center, Harvard Medical School and Massachusetts General Hospital, Boston, Mass., USASearch for other works by this author on:David H. SachsDavid H. SachsTransplantation Biology Research Center, Harvard Medical School and Massachusetts General Hospital, Boston, Mass., USASearch for other works by this author on:
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133 - 142: Biochemical Restoration of Aged Human Bruch's Membrane: Experimental Studies to Improve Retinal Pigment Epithelium Transplant Survival and DifferentiationByIlene K. Sugino;Ilene K. SuginoaInstitute of Ophthalmology and Visual Science, Rutgers New Jersey Medical School, Rutgers University, Newark, N.J.,Search for other works by this author on:Qian Sun;Qian SunaInstitute of Ophthalmology and Visual Science, Rutgers New Jersey Medical School, Rutgers University, Newark, N.J.,Search for other works by this author on:Noounanong Cheewatrakoolpong;Noounanong CheewatrakoolpongaInstitute of Ophthalmology and Visual Science, Rutgers New Jersey Medical School, Rutgers University, Newark, N.J.,Search for other works by this author on:Christopher Malcuit;Christopher MalcuitbDepartment of Biological Sciences, Kent State University, Kent, Ohio, USASearch for other works by this author on:Marco A. ZarbinMarco A. ZarbinaInstitute of Ophthalmology and Visual Science, Rutgers New Jersey Medical School, Rutgers University, Newark, N.J.,Search for other works by this author on:
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143 - 154: Approaches to Cell Delivery: Substrates and Scaffolds for Cell TherapyByJoydip Kundu;Joydip KunduaChemical Engineering, Northeastern University, andSearch for other works by this author on:Andrew Michaelson;Andrew MichaelsonaChemical Engineering, Northeastern University, andSearch for other works by this author on:Petr Baranov;Petr BaranovbSchepens Eye Research Institute, Harvard Medical School, Boston, Mass., USASearch for other works by this author on:Michael J. Young;Michael J. YoungbSchepens Eye Research Institute, Harvard Medical School, Boston, Mass., USASearch for other works by this author on:Rebecca L. CarrierRebecca L. CarrieraChemical Engineering, Northeastern University, andSearch for other works by this author on:
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155 - 166: Microdevice-Based Cell Therapy for Age-Related Macular DegenerationByBo Lu;Bo LuaElectrical Engineering, California Institute of Technology, Pasadena, Calif., andSearch for other works by this author on:Yu-Chong Tai;Yu-Chong TaiaElectrical Engineering, California Institute of Technology, Pasadena, Calif., andSearch for other works by this author on:Mark S. HumayunMark S. HumayunbDoheny Retina Institute, University of Southern California, Los Angeles, Calif., USASearch for other works by this author on:
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167 - 177: Cell and Gene TherapyByRajesh C. Rao;Rajesh C. RaoaDepartment of Pathology, University of Michigan Medical School, andbDepartment of Ophthalmology and Visual Sciences, W.K. Kellogg Eye Center, University of Michigan Medical School, Ann Arbor, Mich., USASearch for other works by this author on:David N. ZacksDavid N. ZacksbDepartment of Ophthalmology and Visual Sciences, W.K. Kellogg Eye Center, University of Michigan Medical School, Ann Arbor, Mich., USASearch for other works by this author on:
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178 - 188: Cellular Manufacturing for Clinical ApplicationsByJonathan Sheu;Jonathan SheuaInstitute for Regenerative Cures, University of California Davis School of Medicine, Sacramento, Calif., andSearch for other works by this author on:Henry Klassen;Henry KlassenbGavin Herbert Eye Institute and Stem Cell Research Center, University of California Irvine School of Medicine, Irvine, Calif., USASearch for other works by this author on:Gerhard BauerGerhard BaueraInstitute for Regenerative Cures, University of California Davis School of Medicine, Sacramento, Calif., andSearch for other works by this author on:
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189 - 200: Regulatory Issues in Cell-Based Therapy for Clinical PurposesByRicardo P. Casaroli-Marano;Ricardo P. Casaroli-MaranoaDepartment of Surgery, School of Medicine, University of Barcelona, andbTransplant Services Foundation, Hospital Clínic de Barcelona, Barcelona, SpainSearch for other works by this author on:Jaime Tabera;Jaime TaberabTransplant Services Foundation, Hospital Clínic de Barcelona, Barcelona, SpainSearch for other works by this author on:Anna Vilarrodona;Anna VilarrodonabTransplant Services Foundation, Hospital Clínic de Barcelona, Barcelona, SpainSearch for other works by this author on:Esteve TriasEsteve TriasbTransplant Services Foundation, Hospital Clínic de Barcelona, Barcelona, SpainSearch for other works by this author on: