Next-Generation Nutritional Biomarkers to Guide Better Health Care: 84th Nestlé Nutrition Institute Workshop, Lausanne, September 2014
There are only a few areas in human nutrition and metabolism where biomarkers are routinely used to predict health and functional outcome. For instance, of the four major nutritional deficiencies, only iron deficiency can be precisely diagnosed by employing biomarkers. They therefore play a limited role in research and decision making, and intervention strategies are still mostly targeted at the population level. What is needed at this stage are biomarkers that are predictive of later functional health and that stay stable from infancy to childhood and adult health. Moreover, individual variability must be considered, taking into account the complexity of foods, lifestyle, and metabolic processes that contribute to health or disease. These factors present significant challenges when it comes to personalizing dietary advice for healthy or diseased individuals.
This book focuses on the values and limitations of traditional nutritional biomarkers and on opportunities for new biomarkers. Contributions are divided into three parts: Methodologies with regard to global epidemiology; applications/end users, and future horizons. The main goal is to review recent developments and predict how exciting new technologies could be used to drive advances in nutrition-related health care.
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Table of Contents
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1 - 13: Systems-Level Nutrition Approaches to Define Phenotypes Resulting from Complex Gene-Environment InteractionsByJim KaputJim KaputSystems Nutrition and Health, Nestlé Institute of Health Sciences, Lausanne, SwitzerlandSearch for other works by this author on:
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15 - 23: Applications of Nutritional Biomarkers in Global Health SettingsByAndrew M. PrenticeAndrew M. PrenticeMRC International Nutrition Group, London School of Hygiene and Tropical Medicine, London, UKSearch for other works by this author on:
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25 - 33: Next-Generation Biomarkers of HealthByBen van Ommen;Ben van OmmenDepartment of Systems Biology, The Netherlands Organization for Applied Scientific Research (TNO), Zeist, The NetherlandsSearch for other works by this author on:Suzan WopereisSuzan WopereisDepartment of Systems Biology, The Netherlands Organization for Applied Scientific Research (TNO), Zeist, The NetherlandsSearch for other works by this author on:
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35 - 46: Bioinformatics: Novel Insights from Genomic InformationByRobert E.W. HancockRobert E.W. HancockCentre for Microbial Diseases and Immunity Research, University of British Columbia, Vancouver, BC, CanadaSearch for other works by this author on:
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49 - 58: Biomarkers in Pediatric Liver DiseaseByEirini Kyrana;Eirini KyranaPaediatric Liver, GI and Nutrition Centre, King's College Hospital, London, UKSearch for other works by this author on:Emer Fitzpatrick;Emer FitzpatrickPaediatric Liver, GI and Nutrition Centre, King's College Hospital, London, UKSearch for other works by this author on:Anil DhawanAnil DhawanPaediatric Liver, GI and Nutrition Centre, King's College Hospital, London, UKSearch for other works by this author on:
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59 - 69: Next-Generation Biomarkers for Iron StatusByHal DrakesmithHal DrakesmithMRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UKSearch for other works by this author on:
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71 - 80: The Search for Biomarkers of Long-Term Outcome after Preterm BirthByJames R.C. Parkinson;James R.C. ParkinsonSection of Neonatal Medicine, Department of Medicine, Imperial College London, London, UKSearch for other works by this author on:Matthew J. Hyde;Matthew J. HydeSection of Neonatal Medicine, Department of Medicine, Imperial College London, London, UKSearch for other works by this author on:Neena ModiNeena ModiSection of Neonatal Medicine, Department of Medicine, Imperial College London, London, UKSearch for other works by this author on:
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81 - 88: Beyond Cholesterol - New Cardiovascular BiomarkersByHarald ManggeHarald ManggeClinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, and BioTechMed-Graz, Graz, AustriaSearch for other works by this author on:
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91 - 102: Stratified Medicine: Maximizing Clinical Benefit by Biomarker-Driven Health CareBySharat SinghSharat SinghPrometheus Laboratories Inc., San Diego, Calif., USASearch for other works by this author on:
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103 - 110: The Gut Microbiome, Its Metabolome, and Their Relationship to Health and DiseaseByGary D. WuGary D. WuDivision of Gastroenterology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USASearch for other works by this author on:
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111 - 119: The Scientific Challenge of Expanding the Frontiers of NutritionBySerge Rezzi;Serge RezziNestlé Institute of Health Sciences, Lausanne, SwitzerlandSearch for other works by this author on:Soren Solari;Soren SolariNestlé Institute of Health Sciences, Lausanne, SwitzerlandSearch for other works by this author on:Nicolas Bouche;Nicolas BoucheNestlé Institute of Health Sciences, Lausanne, SwitzerlandSearch for other works by this author on:Emmanuel E. BaetgeEmmanuel E. BaetgeNestlé Institute of Health Sciences, Lausanne, SwitzerlandSearch for other works by this author on:
