Vitamin D in Clinical Medicine
Vitamin D deficiency is prevalent today not only among the elderly but pervasively throughout all ages of life.This is due, in part, to systemic diseases that affect vitamin D metabolism, to changes in lifestyle, such as insufficient exposure to sunlight, and to increased use of sunscreen. Apart from the obvious effects of vitamin D deficiency on skeletal metabolism, the problem is assuming even greater significance because observational and interventional studies have linked vitamin D deficiency to cardiovascular disease, cancer, and diabetes.
This book addresses a variety of important issues that have emerged from this fast-moving area of clinical medicine. The topics include assays of vitamin D and its binding protein, effects on aging and associated complications, primary and secondary states of altered parathyroid hormone secretion, vitamin D in the growing years of children and adolescents, nutritional requirements, and vitamin D as it relates to systemic disorders such as diabetes mellitus.
Vitamin D in Clinical Medicine aims to offer new insights, in an evidence-based way, on important issues related to vitamin D. It is written for general practitioners and internists, as well as for endocrinologists, nutritionists, pulmonologists, cardiologists, and oncologists.
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Table of Contents
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1 - 13: Physiology of the Calcium-Parathyroid Hormone-Vitamin D AxisByDavid Goltzman;David GoltzmanaDepartment of Medicine, McGill University and McGill University Health Centre, Montreal, QC, Canada;Search for other works by this author on:Michael Mannstadt;Michael MannstadtbEndocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA;Search for other works by this author on:Claudio MarcocciClaudio MarcoccicDepartment of Clinical and Experimental Medicine, University of Pisa, Pisa, ItalySearch for other works by this author on:
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14 - 30: Vitamin D AssaysByDaniel D. BikleDaniel D. BikleVA Medical Center and University of California San Francisco, San Francisco, CA, USASearch for other works by this author on:
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31 - 41: Vitamin D-Binding ProteinByTatiane Vilaça;Tatiane VilaçaaAcademic Unit of Bone Metabolism, University of Sheffield, Sheffield, UK;Search for other works by this author on:Marise Lazaretti-CastroMarise Lazaretti-CastrobDivision of Endocrinology, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, BrazilSearch for other works by this author on:
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42 - 65: New Concepts in Vitamin D Requirements for Children and Adolescents: A Controversy RevisitedByEmma M. Laing;Emma M. LaingDepartment of Foods and Nutrition, The University of Georgia, Athens, GA, USASearch for other works by this author on:Richard D. LewisRichard D. LewisDepartment of Foods and Nutrition, The University of Georgia, Athens, GA, USASearch for other works by this author on:
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66 - 71: Practical Issues in Vitamin D ReplacementByRobert A. AdlerRobert A. AdlerEndocrinology and Metabolism Section, McGuire Veterans Affairs Medical Center, Endocrine Division, Virginia Commonwealth University School of Medicine, Richmond, VA, USASearch for other works by this author on:
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72 - 88: Extra-Skeletal Effects of Vitamin DByRoger BouillonRoger BouillonClinical and Experimental Endocrinology, KU Leuven, Leuven, BelgiumSearch for other works by this author on:
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89 - 113: Hypercalcemic States Associated with Abnormalities of Vitamin D MetabolismByGlenville Jones;Glenville JonesaDepartment of Biomedical and Molecular Sciences, Queen's University, Kingston, ON, Canada;Search for other works by this author on:Karl-Peter SchlingmannKarl-Peter SchlingmannbDepartment of General Pediatrics, University Children's Hospital, Munster, GermanySearch for other works by this author on:
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114 - 124: Vitamin D and HypoparathyroidismByLeonardo C. Bandeira;Leonardo C. BandeiraMetabolic Bone Diseases Unit, Division of Endocrinology, Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, NY, USASearch for other works by this author on:Mishaela R. Rubin;Mishaela R. RubinMetabolic Bone Diseases Unit, Division of Endocrinology, Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, NY, USASearch for other works by this author on:Natalie E. Cusano;Natalie E. CusanoMetabolic Bone Diseases Unit, Division of Endocrinology, Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, NY, USASearch for other works by this author on:John P. BilezikianJohn P. BilezikianMetabolic Bone Diseases Unit, Division of Endocrinology, Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, NY, USASearch for other works by this author on:
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125 - 137: Vitamin D and Primary HyperparathyroidismByMarcella D. Walker;Marcella D. WalkeraDivision of Endocrinology, Department of Medicine, Columbia University, College of Physicians and Surgeons, New York, NY, USA;Search for other works by this author on:Jens BollerslevJens BollerslevbSection of Specialized Endocrinology, Oslo University Hospital, andcFaculty of Medicine, Oslo University, Oslo, NorwaySearch for other works by this author on:
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138 - 148: Vitamin D and Secondary Hyperparathyroid StatesByCristiana Cipriani;Cristiana CiprianiDepartment of Internal Medicine and Medical Disciplines, “Sapienza” University of Rome, Rome, ItalySearch for other works by this author on:Jessica Pepe;Jessica PepeDepartment of Internal Medicine and Medical Disciplines, “Sapienza” University of Rome, Rome, ItalySearch for other works by this author on:Luciano Colangelo;Luciano ColangeloDepartment of Internal Medicine and Medical Disciplines, “Sapienza” University of Rome, Rome, ItalySearch for other works by this author on:Salvatore MinisolaSalvatore MinisolaDepartment of Internal Medicine and Medical Disciplines, “Sapienza” University of Rome, Rome, ItalySearch for other works by this author on:
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149 - 160: Vitamin D and Glucocorticoid-Induced OsteoporosisByG. Mazziotti;G. MazziottibEndocrinology Unit, ASST, Carlo Poma, Mantua, andSearch for other works by this author on:A.M. Formenti;A.M. FormenticDepartment of Molecular and Translational Medicine, University of Brescia, Brescia, ItalySearch for other works by this author on:S. Frara;S. FraraaChair of Endocrinology, San Raffaele Vita-Salute University, Milan,Search for other works by this author on:M. Doga;M. DogaaChair of Endocrinology, San Raffaele Vita-Salute University, Milan,Search for other works by this author on:A. GiustinaA. GiustinaaChair of Endocrinology, San Raffaele Vita-Salute University, Milan,Search for other works by this author on:
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161 - 176: Vitamin D and Diabetes MellitusByErnesto Maddaloni;Ernesto MaddaloniaDepartment of Medicine, Unit of Endocrinology and Diabetes, andSearch for other works by this author on:Ilaria Cavallari;Ilaria CavallariaDepartment of Medicine, Unit of Endocrinology and Diabetes, andbDepartment of Cardiovascular Science, Campus Bio-Medico University of Rome, Rome, andSearch for other works by this author on:Nicola Napoli;Nicola NapoliaDepartment of Medicine, Unit of Endocrinology and Diabetes, andSearch for other works by this author on:Caterina ConteCaterina ContecInternal Medicine and Transplant Unit, San Raffaele Hospital, Milan, ItalySearch for other works by this author on:
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177 - 188: Vitamin D, Sarcopenia and AgingByTea Skaaby;Tea SkaabyaResearch Centre for Prevention and Health, Capital Region of Denmark, andSearch for other works by this author on:Betina H. Thuesen;Betina H. ThuesenaResearch Centre for Prevention and Health, Capital Region of Denmark, andSearch for other works by this author on:Allan LinnebergAllan LinnebergaResearch Centre for Prevention and Health, Capital Region of Denmark, andbDepartment of Clinical Experimental Research, Rigshospitalet, Glostrup, andcDepartment of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, DenmarkSearch for other works by this author on:
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189 - 201: Vitamin D Homeostasis and Diseases in PediatricsByMaria Luisa BianchiMaria Luisa BianchiExperimental Laboratory for Children's Bone Metabolism Research, Bone Metabolism Unit, Istituto Auxologico Italiano IRCCS, Milan, ItalySearch for other works by this author on: