Current Concepts in Movement Disorder Management
This book summarizes the current state of movement disorder management and the role of surgical therapies as an alternative to medication.
Following a chapter on the history of movement disorder surgery, leaders in their fields describe the pathophysiology, functional neuroanatomy, clinical presentation, and medical management of Parkinson’s disease, dystonia, and essential tremor. This is followed by chapters on the spectrum of movement disorder surgery itself, from the lesioning procedures of radiofrequency ablation, stereotactic radiosurgery, and high-frequency ultrasound to the modulatory procedures of “asleep”, image-guided deep brain stimulation (DBS) and “awake”, microelectrode-guided DBS. The final chapters focus on closed-loop DBS, drug-delivery, gene therapy, and other emerging neurosurgical therapies, highlighting long-standing experimental strategies that are reaching exciting phases of clinical translation.
This volume is a valuable tool for accessing the wide spectrum of concepts that currently define this dynamic field.
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Table of Contents
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1 - 12: The History of Movement Disorder Brain SurgeryByL. Dade Lunsford;L. Dade LunsfordThe Center for Image Guided Neurosurgery, University of Pittsburgh Medical Center, Pittsburgh, PA, USASearch for other works by this author on:Ajay NiranjanAjay NiranjanThe Center for Image Guided Neurosurgery, University of Pittsburgh Medical Center, Pittsburgh, PA, USASearch for other works by this author on:
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13 - 24: Pathophysiologic Basis of Movement DisordersByThomas WichmannThomas WichmannDepartment of Neurology, School of Medicine, Emory University, Atlanta, GA, USASearch for other works by this author on:
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25 - 40: Clinical Presentation and Prognosis of Common Movement DisordersByJennifer Han;Jennifer HanDepartment of Neurology, Movement Disorders Division, University of Pittsburgh Medical Center, Pittsburgh, PA, USASearch for other works by this author on:Samay JainSamay JainDepartment of Neurology, Movement Disorders Division, University of Pittsburgh Medical Center, Pittsburgh, PA, USASearch for other works by this author on:
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41 - 49: Medical Management of Movement DisordersByMarina Picillo;Marina PicilloMorton and Gloria Shulman Movement Disorders Clinic and the Edmond J. Safra Program in Parkinson's Disease, Toronto Western Hospital and Division of Neurology, University of Toronto, Toronto, ON, CanadaSearch for other works by this author on:Renato P. MunhozRenato P. MunhozMorton and Gloria Shulman Movement Disorders Clinic and the Edmond J. Safra Program in Parkinson's Disease, Toronto Western Hospital and Division of Neurology, University of Toronto, Toronto, ON, CanadaSearch for other works by this author on:
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50 - 61: Functional Anatomy of Basal Ganglia Circuits with the Cerebral Cortex and the CerebellumByAndreea C. Bostan;Andreea C. BostancCenter for the Neural Basis of Cognition and Systems Neuroscience Institute, University of Pittsburgh, Pittsburgh, PA, USASearch for other works by this author on:Richard P. Dum;Richard P. DumbDepartment of Neurobiology, andcCenter for the Neural Basis of Cognition and Systems Neuroscience Institute, University of Pittsburgh, Pittsburgh, PA, USASearch for other works by this author on:Peter L. StrickPeter L. StrickaUniversity of Pittsburgh Brain Institute,bDepartment of Neurobiology, andcCenter for the Neural Basis of Cognition and Systems Neuroscience Institute, University of Pittsburgh, Pittsburgh, PA, USASearch for other works by this author on:
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62 - 79: Diffusion Tensor Imaging of the Basal Ganglia for Functional Neurosurgery ApplicationsByFrancesco Sammartino;Francesco SammartinoaCenter for Neuromodulation, Department of Neurosurgery and Department of Neuroscience, Ohio State University, Columbus, OH, USA;Search for other works by this author on:Mojgan HodaieMojgan HodaiebDivision of Neurosurgery, Toronto Western Hospital and Department of Surgery, University of Toronto, Toronto, ON, CanadaSearch for other works by this author on:
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80 - 93: Patient Evaluation and Selection for Movement Disorders Surgery: The Changing Spectrum of IndicationsBySteffen Paschen;Steffen PaschenDepartment of Neurology, Christian-Albrechts-Universitat Kiel, Kiel, GermanySearch for other works by this author on:Günther DeuschlGünther DeuschlDepartment of Neurology, Christian-Albrechts-Universitat Kiel, Kiel, GermanySearch for other works by this author on:
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94 - 106: Image-Guided, Asleep Deep Brain StimulationByAndrew L. Ko;Andrew L. KoaDepartment of Neurological Surgery, University of Washington, Seattle, WA, andSearch for other works by this author on:Kim J. BurchielKim J. BurchielbDepartment of Neurological Surgery, Oregon Health and Sciences University, Portland, OR, USASearch for other works by this author on:
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107 - 119: Stereotactic Radiofrequency Lesioning for Movement DisordersByTakaomi Taira;Takaomi TairaDepartment of Neurosurgery, Tokyo Women's Medical University, Tokyo, JapanSearch for other works by this author on:Shiro Horisawa;Shiro HorisawaDepartment of Neurosurgery, Tokyo Women's Medical University, Tokyo, JapanSearch for other works by this author on:Nobuhiko Takeda;Nobuhiko TakedaDepartment of Neurosurgery, Tokyo Women's Medical University, Tokyo, JapanSearch for other works by this author on:Prajakta GhatePrajakta GhateDepartment of Neurosurgery, Tokyo Women's Medical University, Tokyo, JapanSearch for other works by this author on:
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120 - 134: Magnetic Resonance-Guided High Intensity Focused Ultrasound for Treating Movement DisordersByYoung Goo Kim;Young Goo KimDepartment of Neurosurgery, Yonsei University College of Medicine, Seoul, Republic of KoreaSearch for other works by this author on:Eun Jung Kweon;Eun Jung KweonDepartment of Neurosurgery, Yonsei University College of Medicine, Seoul, Republic of KoreaSearch for other works by this author on:Won Seok Chang;Won Seok ChangDepartment of Neurosurgery, Yonsei University College of Medicine, Seoul, Republic of KoreaSearch for other works by this author on:Hyun Ho Jung;Hyun Ho JungDepartment of Neurosurgery, Yonsei University College of Medicine, Seoul, Republic of KoreaSearch for other works by this author on:Jin Woo ChangJin Woo ChangDepartment of Neurosurgery, Yonsei University College of Medicine, Seoul, Republic of KoreaSearch for other works by this author on:
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135 - 148: Radiosurgical ThalamotomyByEdward A. Monaco III;Edward A. Monaco IIIDepartment of Neurological Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA, USASearch for other works by this author on:Samuel S. Shin;Samuel S. ShinDepartment of Neurological Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA, USASearch for other works by this author on:Ajay Niranjan;Ajay NiranjanDepartment of Neurological Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA, USASearch for other works by this author on:L. Dade LunsfordL. Dade LunsfordDepartment of Neurological Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA, USASearch for other works by this author on:
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149 - 157: Radiosurgical Pallidotomy for Parkinson's DiseaseByLeslie D. Cahan;Leslie D. CahanLos Robles Gamma Knife Center, Thousand Oaks CA and Swedish Hospital Gamma Knife Center, Seattle, WA, USASearch for other works by this author on:Ronald F. Young;Ronald F. YoungLos Robles Gamma Knife Center, Thousand Oaks CA and Swedish Hospital Gamma Knife Center, Seattle, WA, USASearch for other works by this author on:Francisco LiFrancisco LiLos Robles Gamma Knife Center, Thousand Oaks CA and Swedish Hospital Gamma Knife Center, Seattle, WA, USASearch for other works by this author on:
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158 - 167: Radiosurgical Subthalamic NucleotomyByJean Régis;Jean RégisaDepartment of Functional Neurosurgey, andSearch for other works by this author on:Romain Carron;Romain CarronaDepartment of Functional Neurosurgey, andSearch for other works by this author on:Tatiana WitjasTatiana WitjasbDepartment of Neurology, Timone University Hospital, Aix Marseille University, Marseille, FranceSearch for other works by this author on:
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168 - 186: Frameless Functional Stereotactic ApproachesByViktoras Palys;Viktoras PalysaDepartment of Neurosurgery, Medical College of Virginia Hospitals, Virginia Commonwealth University, andbThe Parkinson's Disease Research, Education and Care Center, Hunter Holmes McGuire Department of Veterans Affairs Medical Center, Richmond, VA, USASearch for other works by this author on:Kathryn L. HollowayKathryn L. HollowayaDepartment of Neurosurgery, Medical College of Virginia Hospitals, Virginia Commonwealth University, andbThe Parkinson's Disease Research, Education and Care Center, Hunter Holmes McGuire Department of Veterans Affairs Medical Center, Richmond, VA, USASearch for other works by this author on:
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187 - 197: Deep Brain Stimulation: Interventional and Intraoperative MRI ApproachesByPaul S. Larson;Paul S. LarsonaDepartment of Neurological Surgery, andSearch for other works by this author on:Philip A. Starr;Philip A. StarraDepartment of Neurological Surgery, andSearch for other works by this author on:Alastair J. MartinAlastair J. MartinbDepartment of Radiology, University of California, San Francisco, CA, USASearch for other works by this author on:
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198 - 206: Thalamic Deep Brain StimulationByBenjamin B. Whiting;Benjamin B. WhitingTemple University School of Medicine, Philadelphia, PA, Barrow Neurological Institute, Phoenix, AZ, and Allegheny Health Network, Pittsburgh, PA, USASearch for other works by this author on:Alexander C. Whiting;Alexander C. WhitingTemple University School of Medicine, Philadelphia, PA, Barrow Neurological Institute, Phoenix, AZ, and Allegheny Health Network, Pittsburgh, PA, USASearch for other works by this author on:Donald M. WhitingDonald M. WhitingTemple University School of Medicine, Philadelphia, PA, Barrow Neurological Institute, Phoenix, AZ, and Allegheny Health Network, Pittsburgh, PA, USASearch for other works by this author on:
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207 - 221: Deep Brain Stimulation of the Subthalamic Nucleus and Globus Pallidus for Parkinson's DiseaseByPhilip S. Lee;Philip S. LeeDepartment of Neurological Surgery, University of Pittsburgh, Pittsburgh, PA, USASearch for other works by this author on:Donald J. Crammond;Donald J. CrammondDepartment of Neurological Surgery, University of Pittsburgh, Pittsburgh, PA, USASearch for other works by this author on:R. Mark RichardsonR. Mark RichardsonDepartment of Neurological Surgery, University of Pittsburgh, Pittsburgh, PA, USASearch for other works by this author on:
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222 - 229: Current and Expected Advances in Deep Brain Stimulation for Movement DisordersByAusaf A. Bari;Ausaf A. BariaDepartment of Neurosurgery, University of California Los Angeles, Los Angeles, CA, USA;Search for other works by this author on:Jasmine Thum;Jasmine ThumaDepartment of Neurosurgery, University of California Los Angeles, Los Angeles, CA, USA;Search for other works by this author on:Diana Babayan;Diana BabayanaDepartment of Neurosurgery, University of California Los Angeles, Los Angeles, CA, USA;Search for other works by this author on:Andres M. LozanoAndres M. LozanobDepartment of Surgery, Division of Neurosurgery, University of Toronto, Toronto Western Hospital, Toronto,ON, CanadaSearch for other works by this author on:
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230 - 242: Adaptive Brain Stimulation for Movement DisordersByMartijn Beudel;Martijn BeudelaDepartment of Neurology, University Medical Centre Groningen, University of Groningen, Groningen, The Netherlands;Search for other works by this author on:Hayriye Cagnan;Hayriye CagnanbWellcome Trust Centre for Neuroimaging, andSearch for other works by this author on:Simon LittleSimon LittlecSobell Department of Motor Neuroscience and Movement Disorders, UCL Institute of Neurology, London, UKSearch for other works by this author on:
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243 - 252: Drug Delivery for Movement DisordersByNeil Barua;Neil BaruaFunctional Neurosurgery Research Group, University of Bristol, Learning and Research Building, Southmead Hospital, Bristol, UKSearch for other works by this author on:Steven GillSteven GillFunctional Neurosurgery Research Group, University of Bristol, Learning and Research Building, Southmead Hospital, Bristol, UKSearch for other works by this author on:
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253 - 264: Gene Therapy for Parkinson's DiseaseByVivek Sudhakar;Vivek SudhakarDepartment of Neurological Surgery, University of Pittsburgh, Pittsburgh, PA, USASearch for other works by this author on:R. Mark RichardsonR. Mark RichardsonDepartment of Neurological Surgery, University of Pittsburgh, Pittsburgh, PA, USASearch for other works by this author on: