In all vertebrate species examined thus far the production of new neurons in the central nervous system takes place not only during embryogenesis but also in adult life. However, although in mammals this so-called adult neurogenesis appears to be limited to a very few brain regions, in non-mammalian vertebrates new neurons are generated continuously in many regions of the adult central nervous system. This difference makes it particularly interesting to examine adult neurogenesis from a comparative point of view. Such an approach is likely not only to yield new insights into the evolution and function(s) of this phenomenon, but also to facilitate identification of central sites that, although quiescent in vivo, have retained their intrinsic potential to produce new cells during adulthood in mammals.

Keywords:
Adult neurogenesis, Cell proliferation, Stem cells, Comparative approach, Vertebrates
1.
Altman, J. (1963) Autoradiographic investigation of cell proliferation in the brains of rats and cats. Anat. Rec., 145: 573–591.
2.
Altman, J. (1969) Autoradiographic and histological studies of postnatal neurogenesis: IV. Cell proliferation and migration in the anterior forebrain, with special reference to persisting neurogenesis in the olfactory bulb. J. Comp. Neurol., 137: 433–458.
3.
Altman, J., and G.D. Das (1965) Autoradiographic and histological evidence of postnatal hippocampal neurogenesis in rats. J. Comp. Neurol., 124: 319–336.
4.
Bernocchi, G., E. Scherini, S. Giacometti, and V. Mareš (1990) Premitotic DNA synthesis in the brain of the adult frog (Rana esculenta L.): An autoradigraphic 3H-thymidine study. Anat. Rec., 228: 461–470.
5.
Burd, G.D., and F. Nottebohm (1985) Ultrastructural characterization of synaptic terminals formed on newly generated neurons in a song control nucleus of the adult canary forebrain. J. Comp. Neurol., 240: 143–152.
6.
Doetsch, F., and C. Scharff (2001) Challenges for brain repair: Insights from adult neurogenesis in birds and mammals. Brain Behav. Evol., 58: 306–322.
7.
Ekström, P., C.-M. Johnsson, and L.-M. Ohlin (2001) Ventricular proliferation zones in the brain of an adult teleost fish and their relation to neuromeres and migration (secondary matrix) zones. J. Comp. Neurol., 436: 92–110.
8.
Eriksson, P.S., E. Perfilieva, T. Björk-Eriksson, A.-M. Alborn, C. Nordborg, D.A. Peterson, and F.H. Gage (1998) Neurogenesis in the adult human hippocampus. Nat. Med., 4: 1313–1317.
9.
Font, E., E. Desfilis, M.M. Pérez-Cañellas, and J.M. García-Verdugo (2001) Neurogenesis and neuronal regeneration in the adult reptilian brain. Brain Behav. Evol., 58: 276–295.
10.
Goldman, S.A., and M.B. Luskin (1998) Strategies utilized by migrating neurons of the postnatal vertebrate forebrain. Trends Neurosci., 21:107–114.
11.
Goldman, S.A., and F. Nottebohm (1983) Neuronal production, migration, and differentiation in a vocal control nucleus of the adult female canary brain. Proc. Natl. Acad. Sci. USA, 80:2390–2394.
12.
Gould, E., P. Tanapat, B.S. McEwen, G. Flügge, and E. Fuchs (1998) Proliferation of granule cell precursors in the dentate gyrus of adult monkeys is diminished by stress. Proc. Natl. Acad. Sci. USA, 95: 3168–3171.
13.
Kirsche, W. (1967) Über postembryonale Matrixzonen im Gehirn verschiedener Vertebraten und deren Beziehung zur Hirnbauplanlehre. Z. mikrosk.-anat. Forsch., 77: 313–406.
14.
Kirschenbaum, B., M. Nedergaard, A. Preuss, K. Barami, R.A. Fraser, and S.A. Goldman (1994) In vitro neuronal production and differentiation by precursor cells derived from the adult human forebrain. Cereb. Cortex, 4: 576–589.
15.
Lavenex, P.B., P. Lavenex, and N.S. Clayton (2001) Comparative studies of postnatal neurogenesis and learning: a critical review. Avian Poultry Biol. Rev., 12: 103–125.
16.
Lois, C., and A. Alvarez-Buylla (1994) Long-distance neuronal migration in the adult mammalian brain. Science, 264: 1145–1148.
17.
Luskin, M.B. (1993) Restricted proliferation and migration of postnatally generated neurons derived from the forebrain subventricular zone. Neuron, 11: 173–189.
18.
Morshead, C.M., and D. van der Kooy (1992) Postmitotic death is the fate of constitutively proliferating cells in the subependymal layer of the adult mouse brain. J. Neurosci., 12: 249–256.
19.
Paton, J.A., and F.N. Nottebohm (1984) Neurons generated in the adult brain are recruited into functional circuits. Science, 225: 1046–1048.
20.
Paton, J.A., B.E. O’Loughlin, and F. Nottebohm (1985) Cells born in adult canary forebrain are local interneurons. J. Neurosci., 5: 3088–3093.
21.
Rakic, P. (1985) Limits of neurogenesis in primates. Science, 227: 1054–1056.
22.
Reh, T.A., and A.J. Fischer (2001) Stem cells in the vertebrate retina. Brain Behav. Evol., 58: 296–305.
23.
Reynolds, B.A., and S. Weiss (1992) Generation of neurons and astrocytes from isolated cells of the adult mammalian central nervous system. Science, 255: 1707–1710.
24.
Weiss, S., C. Dunne, J. Hewson, C. Wohl, M. Wheatly, A.C. Peterson, and B.A. Reynolds (1996) Multipotent CNS stem cells are present in the adult mammalian spinal cord and ventricular neuroaxis. J. Neurosci., 16: 7599–7609.
25.
Zupanc, G.K.H. (2001) Adult neurogenesis and neuronal regeneration in the central nervous system of teleost fish. Brain Behav. Evol., 58: 250–275.
26.
Zupanc, G.K.H., and I. Horschke (1995) Proliferation zones in the brain of adult gymnotiform fish: a quantitative mapping study. J. Comp. Neurol., 353: 213–233.
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2002
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