...(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Ear surgery Hearing loss Inner ear Middle ear Round window membrane Gene therapy National Institutes...

... to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Intratympanic drug delivery Glucocorticoids Triamcinolone acetonide Round window membrane Inner ear therapy Perilymph UKRI (UK Research and Innovation...

..., 2008]. IT steroid injection allows for the direct uptake of steroid across the round window membrane (RWM), resulting in higher achievable perilymph steroid levels and much lower systemic concentrations in both animals and humans [Parnes et al., 1999; Chandrasekhar et al., 2000; Bird et al., 2007...

... of this fully implantable device picks up ambient sounds, converts them into an electrical signal, amplifies the signal according to the user’s needs, and sends it to an electromechanical transducer. The transducer tip is customized with a prosthesis in order to be in contact with the round window membrane...

... with either dexamethasone or normal saline, was placed upon the round window membrane. Animals that did not receive beads acted as controls. Pure-tone auditory brainstem response thresholds were estimated before and after electrode insertion, and 1 and 4 weeks later. Selected cochlear histology was performed...

... and acoustic auditory stimulation. A prototype 16-mm multichannel array has been designed to facilitate placement of 22 electrodes without damage to intracochlear structures. The electrode array is suitable for insertion via the round window membrane (RWM) or a small cochleostomy. Aim: To evaluate...

... synaptic tinnitus. Local administration of caroverine on the round window membrane (RWM) could be a more effective means of administration to avoid systemic side/adverse effects. The present study investigates the pharmacokinetics of caroverine in the perilymph, cerebrospinal fluid (CSF) and plasma...

... careful consideration. Several different routes of delivery have been tested in our laboratory including infusion with osmotic minipump, direct microinjection into the cochlea and application of vector-transgene complex-soaked Gelfoam ® into the direct contact with the round window membrane. In our...