..., instructions or products referred to in the content or advertisements. Drug delivery Gentamicin Cochlea Inner ear Ototoxicity Perilymph Pharmacokinetics Guinea pig National Institutes of Health (NIH) 10.13039/100000002 Gentamicin is an aminoglycoside antibiotic in clinical use...

... and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Cochleostomy Perforation Cochlear implant Electrode Pharmacokinetics Drug distribution Computational modeling...

... to develop feasible and safe methods for the targeted delivery of drugs to specific regions in the inner ear. Recently developed methods for sampling perilymph from the cochlea have overcome major technical problems that have distorted previous pharmacokinetic studies of the ear. These measurements show...

...Stefan K. Plontke; Norbert Siedow; Raimund Wegener; Hans-Peter Zenner; Alec N. Salt Hypothesis: Cochlear fluid pharmacokinetics can be better represented by three-dimensional (3D) finite-element simulations of drug dispersal. Background: Local drug deliveries to the round window membrane...

... synaptic tinnitus. Local administration of caroverine on the round window membrane (RWM) could be a more effective means of administration to avoid systemic side/adverse effects. The present study investigates the pharmacokinetics of caroverine in the perilymph, cerebrospinal fluid (CSF) and plasma...

... actions and acute side effects of the drugs. It then details the pathophysiology of aminoglycoside ototoxicity including experimental and clinical observations, risk factors and incidence. Pharmacokinetics, cellular actions and our current understanding of the underlying molecular mechanisms...