... 25 03 2019 13 02 2020 5 5 2020 Cochlea Gentamicin toxicity GW9662 Hair cells Inner ear Organ of Corti Peroxisome proliferator-activated receptor γ Telmisartan All data are presented as means ± SDs. The statistical analysis was performed using Prism 7 (GraphPad...

... transporters in the cochlea. We performed immunohistochemistry and gene/protein expression analysis to characterize the expression pattern of the IR and glucose transporters in the mouse organ of Corti (OC). We also performed glucose uptake assays to explore the action of insulin and the effects...

... investigated the effects of brimonidine on auditory HCs that were also exposed to gentamicin, which is toxic to HCs. Organ of Corti explants were exposed to gentamicin in the presence or absence of brimonidine, and the α 2 -AR protein expression levels and Erk1/2 and Akt phosphorylation levels were determined...

... Hearing Organ of Corti Auditory brainstem response Activin has initially been discovered in the 1980s as an important regulator of reproduction, inducing follicle-stimulating hormone release from the pituitary gland. In recent years activin, a dimeric protein belonging to the transforming...

... internal structures by using OCT. We identified endolymphatic hydrops, strial atrophy and damage to the organ of Corti, evident as a distention of Reissner's membrane, thinning of the lateral wall and flattening of the organ of Corti, respectively. When specimens embedded in paraffin, sliced and stained...

... gradients and neurotransmission within the inner ear is supported by the extent of P2 receptor expression in this tissue, data which beg for intense functional study. ATP-gated ion channels Acetylcholine receptors Cochlea Vestibular system Hair cells Organ of Corti Spiral ganglion 12 11...

... in Mammalian Hair Cells Key Words Cochlea Organ of Corti Hair cells Cytoskelcton Actin Adhesion belt Abstract A monoclonal antibody (CAR) was raised by in vitro immu­ nisation to a component of the circumferential actin ring that is associated with the apical junctions encircling the cuticular plates...

.... Cisplatin Organ of Corti Stria vascularis Spiral ganglion Melanocortins ORG 2766 Ototoxicity Neuropathy cis -Dichlorodiammineplatinum-II (cisplatin) is one of the most potent antitumor agents available, but its use is hampered by severe toxic effects, including ototoxicity. The main...

...-time PCR analysis of cDNAs generated from unstimulated or IFN-γ-stimulated organ of Corti demonstrated no change in the transcription of the gene encoding FasL. In contrast, confocal microscopy revealed dramatic changes in the cellular distribution of FasL, consistent with movement from the endoplasmic...

... cochlear turns was observed. No other tissues in the cochlea exhibited P2X 7 -like immunolabelling. Cochlea Development Ontogeny Immunohistochemistry Rat Adenosine triphosphate Purinergic receptors P2X 7 receptor Organ of Corti Spiral ganglion Fig. 1 P2X 7 receptor subunit...

...-k3 cells derived from an immortalized cell line developed from the organ of Corti of transgenic mice. Administration of 50 µ M gentamicin significantly reduced cell proliferation and viability, as well as initiating morphological changes associated with apoptosis. Protein kinase C (PKC) α activity...

... and in vitro preparations of guinea pig and mouse inner ears, cellular structures within the intact organ of Corti can be visualized at high resolution. The approach thus offers a means to investigate detailed cellular events, e.g. structural reorganization following acoustic overstimulation. Confocal...

... comparison with histological changes in SGCs from corresponding cochlear loci. At each assessed location, an area of the organ of Corti containing 100 IHCs and 100 each three rows of OHCs was examined to determine the degree of damage. Following scanning electron microscopy (SEM) assessment of hair...