...David C. Hughes Mouse models have proved valuable tools in the analysis of human genetic disorders. The identification of the genes mutated in classical mouse mutants and the analysis of the phenotype of mutants following targeted gene disruption have provided some clarification of the development...

... larger than in OHCs at any given stage. In OHCs, they were initially non-inactivating but gained the partial inactivation characteristic of the K + current of neonatal mouse cochlear hair cells, I K,neo , by day 18 in the base and by P0 in the apex. In IHCs, there was little change, other than...

... Mouse Thyroxine Thyroid hormone T 4 Hearing Sound Auditory brain stem response Ear Development Cochlea Original Paper Audiol Neurootol 2004;9:88 106 DOI: 10.1159/000076000 Received: July 2, 2003 Accepted after revision: October 2, 2003 Hearing Loss in Athyroid Pax8 Knockout Mice and Effects...

... and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Inner ear development Hair cell Transcription factor Mouse The differentiation of hair cells (HCs...