... of genotype-phenotype correlations is beginning to emerge (Table 1). Given the prevalence of DFNB8/10 and the characterization of associated mutations, TMPRSS3 is an excellent potential target for gene therapy. However, developing these approaches requires a comprehensive understanding of the molecular...

...(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Ear surgery Hearing loss Inner ear Middle ear Round window membrane Gene therapy National Institutes...

..., as cessation of treatment results in resumed SGN degradation [Gillespie et al., 2003]. Sensorineural hearing loss Neurotrophic factors Spiral ganglion neurons Hair cells Round window Vestibular organs Cochlear implant Slow-release polymers Gene therapy Cell-based therapy Table 1...

... factor (BDNF) gene therapy on the survival of spiral ganglion neurons (SGNs) after elimination of inner hair cells in the mature guinea pig ear. Seven days after bilateral deafening, a 5-µl suspension of CNTF and/or BDNF adenovirus vectors was injected into the left scala tympani through the round window...

.... In contrast, DEX-treated ears were largely protected, and transduction of inner ear cells was readily apparent. These data demonstrate that immunosuppressive treatment can reduce the negative consequences of repeated adenovirus-mediated gene therapy. 23 01 2002 12 09 2002 17 3 2003 ©...

.... Cochlea Inner ear therapy Herpes simplex virus 1 Gene therapy Utriculus Amplicon vector Hair cells in the auditory and vestibular organ secrete neurotrophic factors that participate in the maintenance of spiral ganglion and hair cell survival during mechanical traumas or ototoxic conditions...

... of gene therapy for treating hereditary and environmental inner ear disease. We used this technology to compare the normal profile of genes expressed in the vestibular epithelium to those expressed after an ototoxic insult. RNA was collected from vestibular organs of 40 normal mouse inner ears and from...