Discriminant analysis (DA) and self-organizing feature maps (SOFM) were used to classify passively evoked auditory event-related potentials (ERP) P1, N1, P2 and N2. Responses from 16 children with severe behavioral auditory perception deficits, 16 children with marked behavioral auditory perception deficits, and 14 controls were examined. Eighteen ERP amplitude parameters were selected for examination of statistical differences between the groups. Different DA methods and SOFM configurations were trained to the values. SOFM had better classification results than DA methods. Subsequently, measures on another 37 subjects that were unknown for the trained SOFM were used to test the reliability of the system. With 10-dimensional vectors, reliable classifications were obtained that matched behavioral auditory perception deficits in 96%, implying central auditory processing disorder (CAPD). The results also support the assumption that CAPD includes a ‘non-peripheral’ auditory processing deficit.

1.
Alcaini M, Giard MH, Thévenet M, Pernier J: Two separate frontal components in the N1 wave of the human auditory evoked response. Psychophysiology 1994;31:611–615.
2.
Alexander JE, Bauer LO, Kuperman S, Morzorati S, O’Connor SJ, Rohrbaugh J, Porjesz B, Begleiter H, Polich J: Hemispheric differences for P300 amplitude from an auditory oddball task. Int J Psychophysiol 1996;21:189–196.
3.
Alexander JE, Polich J, Bloom FE, Bauer LO, Kuperman S, Rohrbaugh J, Morzorati S, O’Connor SJ, Porjesz B, Begleiter H: P300 from an auditory oddball task: Inter-laboratory consistency. Int J Psychophysiol 1994;17:35–46.
4.
Anderer P, Semlitsch HV, Saletu B: Multichannel auditory event-related brain potentials: Effects of normal aging on the scalp distribution of N1, P2, N2 and P300 latencies and amplitudes. Electroencephalogr Clin Neurophysiol 1996;99:458–472.
5.
Augustine LE, Damico JS: Attention deficit hyperactivity disorder: The scope of the problem. Semin Speech Lang 1995;16:243–258.
6.
Baxt WG: Application of artificial neural networks to clinical medicine. Lancet 1995;346:1135–1207.
7.
Byring R, Järvilehto T: Evoked potentials of schoolboys with spelling disabilities. Dev Med Child Neurol 1985;27:141–148.
8.
Chermak GD, Hall JW, Baran JA, Sloan C, Musiek FE: Diagnosis and management of CAPD and ADHD. Consensus Conference Annual Convention. American Speech-Language-Hearing Association, Boston, November 1997.
9.
Coyle S, Gordon E, Howson A, Meares R: The effects of age on auditory event-related potentials. Exp Aging Res 1991;17:103–111.
10.
Erwin E, Obermayer K, Schulten K: Self-organizing maps: Ordering, convergence properties and energy functions. Biol Cybern 1992;67:47–55.
11.
Esser G, Anderski C, Birken A, Breuer E, Cramer B, Eisermann E, Kulenkampff H, Schröer M, Schunicht R, Toro la Roche M: Auditive Wahrnehmungsstörungen und Fehlhörigkeit bei Kindern im Schulalter. Sprache Stimme Gehör 1987;11:10–16.
12.
Feldmann H: Dichotischer Diskriminationstest, eine neue Methode zur Diagnostik zentraler Hörstörungen. Arch Ohren Nasen Kehlkopfheilkd 1965;184:294–329.
13.
Fuchigami T, Okubo O, Fujita Y, Okuni M, Noguchi Y, Yamada T: Auditory event- related potentials and reaction time in children: Evaluation of cognitive development. Dev Med Child Neurol 1993;35:230–237.
14.
Gabor AJ, Leach RR, Dowla FU: Automated seizure detection using a self-organizing neural network. Electroencephalogr Clin Neurophysiol 1996;99:257–266.
15.
Garcia-Larrea L, Lukaszewicz AC, Mauguiere F: Revisiting the oddball paradigm: Non-target vs neutral stimuli and the evaluation of ERP attentional effects. Neuropsychologia 1992;30:723–741.
16.
Giard MH, Perrin F, Pernier J, Bouchet P: Brain generators implicated in the processing of auditory stimulus deviance: A topographic event-related study. Psychophysiology 1990;27:627–640.
17.
Grauel A, Becker W, Belli F: Proceedings in Artificial Intelligence. Sankt Augustin, Infix, 1997, vol 5.
18.
Hyde M: The N1 response and its applications. Audiol Neurootol 1997;2:281–307.
19.
Kohonen T: The self-organizing map. Proc IEEE ICASSP 1990;78:1464–1480.
20.
Kohonen T, Hynninen J, Kangas J, Laaksonen J: The self-organizing map program package, version 3.1. Available http://hpux.ask.uni-karlsruhe.de/hpux/NeuralNets/sompak-q.2.html, 1995a.
21.
Kohonen T, Hynninen J, Kangas J, Laaksonen J, Torkkola K: The learning vector quantization program package, version 3.1. Espoo (Finland), Helsinki University of Technology (HUT), 1995b.
22.
Kraus N, McGee TJ, Carrell TD, Zecker SG, Nicol TG, Koch DB: Auditory neurophysiologic responses and discrimination deficits in children with learning problems. Science 1996;273:971–973.
23.
Kraus N, McGee T, Ferre J, Hoeppner JA, Carrell T, Sharma A, Nicol T: Mismatch negativity in the neurophysiologic/behavioral evaluation of auditory processing deficits: A case study. Ear Hear 1993a;14:223–234.
24.
Kraus N, Micco AG, Koch DB, McGee T, Carrell T, Sharma A, Wiet RJ, Weingarten CZ: The mismatch negativity cortical evoked potential elicited by speech in cochlear-implant users. Hear Res 1993b;65:118–124.
25.
Kraus N, Ozdamar O, Stein L, Reed N: Absent auditory brain stem response: Peripheral hearing loss or brain stem dysfunction? Laryngoscope 1984;94:400–406.
26.
Lehtiö P, Kohonen T: Associative memory and pattern recognition. Med Biol 1978;56:110–116.
27.
Leppänen PHT, Lyytinen H: Auditory event-related potentials in the study of developmental language disorders. Audiol Neurootol 1997;2:308–340.
28.
Looney CG: Pattern Recognition Using Neural Networks – Theory and Algorithms for Engineers and Scientists. Oxford, Oxford University Press, 1997.
29.
de Lugt DR, Loewy DH: The effect of sleep on event related potentials with rapid rates of stimulus presentation. Electroencephalogr Clin Neurophysiol 1996;98:484–492.
30.
Merzenich MM, Schreiner C, Jenkins WM, Wang X: Neural mechanisms underlying temporal integration, segmentation and input sequence representation: Some implications for the origin of learning disabilities. Ann NY Academ Sci 1993;682:1–22.
31.
Näätänen R: Implications of ERP data for psychological theories of attention. Biol Psychol 1988;26:117–163.
32.
Näätänen R, Alho K: Mismatch negativity – The measure for central sound representation accuracy. Audiol Neurootol 1997;2:341–353.
33.
Näätänen R, Lehtokoski A, Lennes M, Cheour M, Huotilainen M, Iivonen A, Vainio M, Alku P, Ilmoniemi RJ, Luuk A, Allik J, Sinkkonen J, Alho K: Language-specific phoneme representations revealed by electric and magnetic brain responses. Nature 1997;385:432–434.
34.
Niemeyer W: BLDT: Bremer Lautdiskriminationstest. Bremen, Herbig, 1976.
35.
Pinkerton F, Watson DR, McClelland RJ: A neurophysiological study of children with reading, writing and spelling difficulties. Dev Med Child Neurol 1989;31:569–581.
36.
Polich J: Cognitive brain potentials. Current directions in psychological science. Curr Dir Psychol Sci 1993;2:175–179.
37.
Polich J: Meta-analysis of P300 normative aging studies (literature review). Psychophysiology 1996;33:334–353.
38.
Polich J, Eischen SE, Collins GE: P300 from a single auditory stimulus. Electroencephalogr Clin Neurophysiol 1994;92:253–261.
39.
Portin K, Kajola M, Salmelin R: Neural net identification of thumb movement using spectral characteristics of magnetic cortical rhythms. Electroencephalogr Clin Neurophysiol 1996;98:273–280.
40.
Ritter H: Self-organizing maps for internal representations. Psychol Res 1990;52:128–136.
41.
Ritter H, Martinetz T, Schulten K: Neuronale Netze, ed 2. Bonn, Addison-Wesley, 1991.
42.
Rose C, Schönweiler R, Tolloczko R, Ptok M: Zum Stellenwert der späten akustisch evozierten Potentiale (SAEP) in der Diagnostik zentraler Hörstörungen; in Gross M (ed): Aktuelle phoniatrisch-pädaudiologische Aspekte 1995. Berlin, Renate-Gross-Verlag, 1996, pp 173–174.
43.
Scherer A: Neuronale Netze – Grundlagen und Anwendungen. Braunschweig, Vieweg, 1997.
44.
Schröger E: The influence of stimulus intensity and inter-stimulus interval on the detection of pitch and loudness changes. Electroencephalogr Clin Neurophysiol 1996;100:517–526.
45.
Schröger E, Tervaniemi M, Wolff C, Näätänen RN: Preattentive periodicity detection in auditory patterns as governed by time and intensity information. Cogn Brain Res 1996;4:145–148.
46.
Schunicht R, Esser G: ERA-Befunde bei zentralen Hörstörungen. Arch Otorhinolaryngol 1974;206:217–224.
47.
Studdert-Kennedy M, Mody M: Auditory temporal perception deficits in the reading impaired: A critical review of the evidence. Psychonom Bull Rev 1995;2:508–514.
48.
Sugg MJ, Polich J: P300 from auditory stimuli: Intensity and frequency effects. Biol Psychol 1995;41:255–269.
49.
Tallal P, Stark RE, Mellits D: The relationship between auditory temporal analysis and receptive language development: Evidence from studies of developmental language disorder. Neuropsychologia 1985a;23:527–534.
50.
Tallal P, Stark RE, Mellits ED: Identification of language-impaired children on the basis of rapid perception and production skills. Brain Lang 1985b;25:314–322.
51.
Tonnquist-Uhlén I, Borg E, Persson HE, Spens KE: Topography of auditory evoked cortical potentials in children with severe language impairment: The N1 component. Electroencephalogr Clin Neurophysiol 1996;100:250–260.
52.
Uttenweiler V: Dichotischer Diskriminationstest für Kinder. Sprache Stimme Gehör 1980;4:107–111.
53.
Welte V: Der Mottier-Test, ein Prüfmaterial für die Lautdifferenzierungsfähigkeit und die auditive Merkfähigkeit. Sprache Stimme Gehör 1981;5:121–125.
54.
Wright BA, Lombardino LJ, King WM, Puranik CS, Leonard CM, Merzenich MM: Deficits in auditory temporal and spectral resolution in language-impaired children. Nature 1997;387:176–178.
55.
Zhang X, Tomblin JB: Can children with language impairment be accurately identified using temporal processing measures? A simulation study. Brain Lang 1998;65:395–403.
Copyright / Drug Dosage / Disclaimer
Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.
You do not currently have access to this content.