Direct intracochlear acoustic pressure recordings (from 20 to 20,000 Hz) are used to measure the middle-ear transfer functions (forward and reverse) and to better understand the cochlear mechanics in the guinea pig. In the forward direction, the middle-ear transfer function is strongly dependent on the frequency and presents a maximum of +30 dB at 1,000 Hz (bulla open). In the reverse direction, the middle-ear transfer function looks like an ideal reverse middle-ear pressure transformer with –35 dB gain and 0° phase lag from 20 to 8,000 Hz (bulla open, closed ear canal). Passive cochlear mechanics is studied with the help of intracochlear pressure measurements and differential cochlear microphonic potential recordings in the different turns.

Keywords:
Middle ear, Transfer function, Cochlear mechanics, Otoacoustic emission, Intracochlear pressure, Cochlear microphonic potential
1.
Dallos P, Cheatham MA: Travel time in the cochlea and its determination from CM data. J Acoust Soc Am 1971;49:1140–1143.
2.
Dancer A: Experimental look at cochlear mechanics. Audiology 1992;31:301–312.
3.
Dancer A, Franke R: Intracochlear sound pressure measurements in guinea pigs. Hear Res 1980;2:191–205.
4.
Décory L, Dancer A, Aran JM: Species differences and mechanisms of damage; in Dancer AL, Henderson D, Salvi R, Hamernik RP (eds): Noise-Induced Hearing Loss. St Louis, Mosby Year Book, 1991, pp 73–88.
5.
Franke R, Dancer A: Etude du potentiel microphonique cochléaire chez le cobaye en fonction des conditions expérimentales. Acustica 1983;52:160–168.
6.
Franke R, Dancer A, Buck K, Evrard G, Lenoir M: Phénomènes hydro-mécaniques cochléaires aux basses fréquences chez le cobaye. Acustica 1985;59:30–41.
7.
Kemp DT: Stimulated acoustic emissions from within the human auditory system. J Acoust Soc Am 1978;64:1386–1391.
8.
Kurokawa H, Goode RL: Sound pressure gain produced by the human middle ear. Arch Otolaryngol Head Neck Surg 1995;113:349–355.
9.
Magnan P: Propagation and Dissipation of the Acoustic Signal into the Inner Ear in Guinea Pigs; PhD thesis, University Montpellier-II, 1995.
10.
Magnan P, Avan P, Dancer A, Smurzynski J, Probst R: Reverse middle-ear transfer function in the guinea pig measured with cubic difference tones. Hear Res 1997;107:41–45.
11.
Nedzelnitsky V: Sound pressures in the basal turn of the cat cochlea. J Acoust Soc Am 1980;68:1676–1689.
12.
Nuttall AL, Dolan DF: Steady-state sinusoidal velocity responses of the basilar membrane in guinea pig. J Acoust Soc Am 1996;99:1556–1565.
13.
Probst R, Lonsbury-Martin BL, Martin GK: A review of otoacoustic emissions. J Acoust Soc Am 1991;89:2027–2067.
14.
Puria S, Peake WT, Rosowski JJ: Sound-pressure measurements in the cochlear vestibule of human-cadaver ears. J Acoust Soc Am 1997;101:2754–2770.
15.
Puria S, Rosowski JJ: Measurementof reverse transmission in the human middle ear: Preliminary results; in Lewis ER, Long GR, Lyon RF, Narins PM, Steele CR, Hecht-Poinar E (eds): Diversity in Auditory Mechanics. Singapore, World Scientific, 1997, pp 151–157.
16.
Rosowski JJ: Outer and middle ears; in Fay RR, Popper AN (eds): Comparative Hearing: Mammals Springer Handbook of Auditory Research. Berlin, Springer, 1994, pp 172–247.
17.
Ruggero MA, Rich NC, Recio A, Narayan SS, Robles L: Basilar-membrane responses to tones at the base of the chinchilla cochlea. J Acoust Soc Am 1997;101:2151–2163.
18.
Sellick PM, Patuzzi R, Johnstone BM: Measurement of basilar membrane motion in guinea pig using Mössbauer technique. J Acoust Soc Am 1982;72:131–141.
19.
Zwislocki JJ: Cochlear waves: Interaction between theory and experiments. J Acoust Soc Am 1974;55:578–583.
1999
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