Aims/Hypothesis: Idiopathic sudden sensorineural hearing loss (ISSNHL) represents an acute inner ear disorder with an overall incidence of 5–20/100000 individuals per year in western countries. No clear causes for this disease have been found so far, but cochlear ischemia has been hypothesized as one of the etiopathological mechanisms. The aim of our study was to assess the role of diabetes and traditional cardiovascular risk factors in the pathogenesis of ISSNHL. Materials/Methods: Case-control study of 141 patients (75 males/66 females) matched for age and gender. Cases were affected by ISSNHL, defined as a sudden hearing loss ≧30 dB, within 3 frequencies, developing over 72 h. The control group was composed of 271 sex- and age-matched subjects (142 males/129 females) who agreed to participate in this observational study and provided blood samples for laboratory investigations. Cardiovascular risk factors examined were: diabetes mellitus, smoking history, hypercholesterolemia, hypertriglyceridemia and hypertension. Results: On the univariate analysis, diabetes prevalence was higher in the ISSNHL group (15.6%) compared to controls (8.5%) (p = 0.03). Also hypercholesterolemia was significantly more frequent in the ISSNHL group compared to the control population. There were no statistically significant differences between the 2 populations concerning other cardiovascular risk factors. The risk of ISSNHL tended to increase as the number of cardiovascular risk factors increased (p for linear trend = 0.018). Conclusions: Our findings suggest that diabetes mellitus, hypercholesterolemia and a high burden of cardiovascular risk factors are associated with the risk of ISSNHL.

Keywords:
Idiopathic sudden sensorineural hearing loss, Cardiovascular risk factors, Diabetes mellitus
1.
Browning GG, Gatehouse S, Lowe GDO: Blood viscosity as a factor in sensorineural hearing impairment. Lancet 1986;1:121–123.
2.
Einer H, Tengborn L, Axelsson A, Edstrom S: Sudden sensorineural hearing loss and hemostatic mechanisms. Arch Otolaryngol Head Neck Surg 1994;120:536–540.
3.
Expert Committee on the Diagnosis and Classification of Diabetes Mellitus: Report of the Expert Committee on the Diagnosis and Classification of Diabetes Mellitus. Diabetes Care 1997;20:1183–1197.
4.
Frisina ST, Mapes F, Kim S, Frisina DR, Frisina RD: Characterization of hearing loss in aged type II diabetics. Hear Res 2006;211:103–113.
5.
Fukui M, Kitagawa Y, Nakamura N, Kadono M, Mogami S, Ohnishi M, Hirata C, Ichio N, Wada K, Kishimoto C, Okada H, Miyata H, Yoshikawa T: Idiopathic sudden hearing loss in patients with type 2 diabetes. Diabetes Res Clin Pract 2004;63:205–211.
6.
García Berrocal JRG, Ramírez-Camacho R, Portero F, Vargas JA: Role of viral and Myco plasma pneumoniae infection in idiopathic sudden sensorineural hearing loss. Acta Otolaryngol 2000;120:835–839.
7.
Haberkamp TJ, Tanyeri HM: Management of idiopathic sudden sensorineural hearing loss. Am J Otol 1999;20:587–595.
8.
Harmel AP: Treating diabetes: cardiovascular benefits of antidiabetes drugs. Am J Manag Care 2002;8(8 suppl):S219–S228; quiz S229–S232.
9.
Istituto Nazionale di Statistica. Annuariostatistico Italiano 2006. Cap. 3 Sanità e Salute. (http://www.istat.it/dati/catalogo/20061109_00/PDF/cap3.pdf).
10.
Lalanne MC, Doutremepuich C, Boj F, Traissac L, Quichaud F: Some hemostatic and hemorrheological disorders in auditory and vestibular impairments. Thromb Res 1992;66:787–791.
11.
Marcucci R, Alessandrello Liotta A, Cellai AP, Rogolino A, Berloco P, Leprini E, Pagnini P, Abbate R, Prisco D: Cardiovascular and thrombophilic risk factors for idiopathic sudden sensorineural hearing loss. J Thromb Haemost 2005;3:929–934.
12.
Mattox DE, Lyles CA: Idiopathic sudden sensorineural hearing loss. Am J Otol 1989;10:242–247.
13.
Merchant SN, Durand ML, Adams JC: Sudden deafness: is it viral? ORL J Otorhinolaryngol Relat Spec 2008;70:52–60.
14.
Mercier E, Quere I, Chabert R, Lallemant JG, Daures JP, Berlan J, Gris JP: The 20210A allele of the prothrombin gene is an independent risk factor for perception deafness in patients with venous thromboembolic antecedents. Blood 1999;93:3150–3152.
15.
Miller JM, Ren TY, Nuttall AL: Studies of inner ear blood flow in animals and human beings. Otolaryngol Head Neck Surg 1995;112:101–113. Review.
16.
Mom T, Avan P, Gilian L: Les surdités brusques idiopathiques. Rev Méd Interne 2002;23:292–307.
17.
Monfared A, Blevins NH, Cheung EL, Jung JC, Popelka G, Schnitzer MJ: In vivo imaging of mammalian cochlear blood flow using fluorescence microendoscopy. Otol Neurotol 2006;27:144–152.
18.
Nakashima T, Itoh A, Misawa H, Ohno Y: Clinico-epidemiologic features of sudden deafness diagnosed and treated at university hospitals in Japan. Otolaryngol Head Neck Surg 2000;123:593–597.
19.
Olzowy B, Osterkron D, Suckfüll M: The incidence of sensorineural sudden hearing loss is greater than previously presumed. MMW Fortschr Med 2005;147:37–38.
20.
Rust KR, Prazma J, Triana RJ, Michaelis OE 4th, Pillsbury HC: Inner ear damage secondary to diabetes mellitus. II. Changes in aging SHR/N-cp rats. Arch Otolaryngol Head Neck Surg 1992;118:397–400.
21.
Satar B, Ozkaptan Y, Surucu HS, Ozturk H: Ultrastructural effects of hypercholesterolemia on the cochlea. Otol Neurotol 2001;22:786–789.
22.
Suzuki K, KanekoM, Murai K: Influence of serum lipids on auditory function. Laryngoscope 2000;110:1736–1738.
23.
Yavuz E, Morawski K, Telischi FF, Ozdamar O, Delgado RE, Manns F, Parel JM: Simultaneous measurement of electrocochleography and cochlear blood flow during cochlear hypoxia in rabbits. J Neurosci Methods 2005;147:55–64.
24.
Yoshida Y, Yamauchi S, Shinkawa A, Horiuchi M, Sakai M: Immunological and virological study of sudden deafness. Auris Nasus Larynx 1996;23:63–68.
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2009
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