A 48-year-old man presented with sudden right ear tinnitus and showed no other otoneurologic signs or symptoms. Auditory brainstem response revealed prolonged III–V interpeak latencies from stimulating either ear. MRI revealed a small, circumscribed lesion of the left inferior colliculus, probably from an acute hemorrhage leading to a small cavernous malformation. Circumscribed lesions of the inferior colliculus are rare with no prior reports of contralateral tinnitus.

Keywords:
Tinnitus, Colliculus inferior, Hemorrhage, Brainstem, Auditory pathway, Cavernoma
1.
Aiba T, Tanaka R: Natural history of intracranial cavernous malformations. J Neurosurg 1995;83:56–59.
2.
Bähr M, Frotscher M: Neurologisch-topische Diagnostik. Stuttgart, Thieme, 2003, pp 176–183.
3.
Bertalanffy H, Benes L, Miyazawa T, Alberti O, Siegel AM, Sure U: Cerebral cavernomas in the adult. Review of the literature and analysis of 72 surgically treated patients. Neurosurg Rev 2002;25:1–53.
4.
Bolzani W, Rognone F, Savoldi F, Montalbetti L: Colliculus hemorrhage. Rev Neurol (Paris) 1996;152:548–551.
5.
Chen CH, Hwang WJ, Tsai TT, Lai ML: Midbrain hemorrhage presenting with trochlear nerve palsy. Zhonghua Yi Xue Za Zhi 2000;63:138–143.
6.
Cocito D, Amedeo G, Gallo G, Vischia F, De Lucchi R: Hematoma of the inferior colliculus: uncommon cause of trochlear nerve deficit and contralateral sensory hemisyndrome. Ital J Neurol Sci 1990;11:71–74.
7.
Demanez JP, Demanez L: Anatomophysiology of the central auditory nervous system: basic concepts. Acta Otorhinolaryngol Belg 2003;57:227–236.
8.
Durrant JD, Martin WH, Hirsch B, Schwegler J: 3 CLT ABR analyses in a human subject with unilateral extirpation of the inferior colliculus. Hear Res 1994;72:99–107.
9.
Faingold CL: Role of GABA abnormalities in the inferior colliculus pathophysiology-audiogenic seizures. Hear Res 2002;168:223–237.
10.
Fritschi JA, Reulen HJ, Spetzler RF, Zabramski JM: Cavernous malformations of the brain stem. A review of 139 cases. Acta Neurochir 1994;130:35–46.
11.
Ishihara K, Furutani R, Shiota J, Kawamura M: A case presenting with trochlear nerve palsy and segmental sensory disturbance due to circumscribed midbrain and upper pontine hemorrhage. Rinsho Shinkeigaku 2003;43:417–421.
12.
Johkura K, Matsumoto S, Hasegawa O, Kuroiwa Y: Defective auditory recognition after small hemorrhage in the inferior colliculi. J Neurol Sci 1998;161:91–96.
13.
Li Y, Evans MS, Faingold CL: Synaptic response patterns of neurons in the cortex of rat inferior colliculus. Hear Res 1999;137:15–28.
14.
Litovsky RY, Fligor BJ, Tramo MJ: Functional role of the human inferior colliculus in binaural hearing. Hear Res 2002;165:177–188.
15.
Liu Y, Li X, Ma C, Liu J, Lu H: Salicylate blocks L-type calcium channels in rat inferior colliculus neurons. Hear Res 2005;205:271–276.
16.
Musiek FE, Charette L, Morse D, Baran JA: Central deafness associated with midbrain lesion. J Am Acad Audiol 2004;15:133–151.
17.
Nieuwenhuys R, Voogd J, van Huijzen C: The Human Central Nervous System. Berlin, Springer, 1981, pp 117–120.
18.
Oliver DL: Ascending efferent projections of the superior olivary complex. Microsc Res Tech 2000;51:355–363.
19.
Porter RW, Detwiler PW, Spetzler RF, Lawton MT, Baskin JJ, Derksen PT, Zabramski JM: Cavernous malformations of the brainstem: experience with 100 patients. J Neurosurg 1999;90:50–58.
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2008
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