Although the name of the discoverer of salicylate ototoxicity is still debated, most authors have quoted Müller and his 1877 report. To the best of our knowledge, the true discoverer of the transient ototoxicity of salicylate was the Italian chemist Cesare Bertagnini who reported this evidence in 1855 in the journal Il Nuovo Cimento.

1.
Bertagnini C: Sulle alterazioni che alcuni acidi subiscono nell’organismo animale. Nuovo Cimento 1855;1:363–372.
2.
Buss CE: Über die Anwendung der Salicylsäure als Antipyreticum. Dtsch Arch Klin Med 1875;15:457–501.
3.
Cazals Y: Auditory sensori-neural alterations induced by salicylate. Prog Neurobiol 2000;62:583–631.
4.
Fürbringer, Schultze: Über die Wirkungsweisen der Natronsalicylate bei fieberhaften Krankheiten. Dtsch Arch Klin Med 1876;17:204.
5.
Hogg D: De l’usage therapeutique de l’acide salicilyque; Thèse de Paris, 213, 1877.
6.
Marson P, Pasero G: The Italian contributions to the history of salicylates. Reumatismo 2006;58:66–75.
7.
Müller G: Beitrag zur Wirkung des salicylsauren Natrons beim Diabetes mellitus. Berl Klin Wochenschr 1877;14:29–31.
8.
Piria R: Recherches sur la salicine et les produits qui en dérivent. Ann Chim Phys 1838;69:218–325.
9.
Schacht J, Hawkins JE: Sketches of otohistory. 11. Ototoxicity: drug-induced hearing loss. Audiol Neurotol 2006;11:1–6.
10.
Sée G: Etudes sur l’acide salicylique et les salicylates, traitement du rhumatisme aigu et chronique, de la goutte, et des diverses affections du système nerveux sensitif par le salicylates. Bull Acad Natl Med 1877;26:689–706.
11.
Stephens SD: Some historical aspects of ototoxicity. Br J Audiol 1982;16:76–80.
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