Age-related hearing impairment (ARHI) is the most common sensory impairment seen in the elderly. It is a complex disorder, with both environmental as well as genetic factors contributing to the impairment. The involvement of several environmental factors has been partially elucidated. A first step towards the identification of the genetic factors has been made, which will result in the identification of susceptibility genes, and will provide possible targets for the future treatment and/or prevention of ARHI. This paper aims to give a broad overview of the scientific findings related to ARHI, focusing mainly on environmental and genetic data in humans and in animal models. In addition, methods for the identification of contributing genetic factors as well as possible future therapeutic strategies are discussed.

Keywords:
Ageing, Hearing impairment, Presbycusis
1.
Antonelli AR, Bonfioli F, Garrubba V, et al: Audiological findings in elderly patients with chronic renal failure. Acta Otolaryngol Suppl 1990;476:54–68.
2.
Aran JM, Hiel H, Hayashida T: Noise, aminoglycosides, diuretics; in Dancer A, Henderson D, Salvi R, Hamernik R (eds): Noise-Induced Hearing Loss. St Louis, Mosby, 1992, pp 188–195.
3.
Ates NA, Unal M, Tamer L, Derici E, Karakas S, Ercan B, Pata YS, Akbas Y, Vayisoglu Y, Camdeviren H: Glutathione S-transferase gene polymorphisms in presbyacusis. Otol Neurotol 2005;26:392–397.
4.
Bai U, Seidman MD, Hinojosa R, et al: Mitochondrial DNA deletions associated with aging and possibly presbycusis: a human archival temporal bone study. Am J Otol 1997;18:449–453.
5.
Bao J, Lei D, Du Y, Ohlemiller KK, Beaudet AL, Role LW: Requirement of nicotinic acetylcholine receptor subunit beta2 in the maintenance of spiral ganglion neurons during ageing. J Neurosci 2005;25:3041–3045.
6.
Boettcher FA, Gratton MA, Bancroft BR, Spongr V: Interaction of noise and other agents: recent advances; in Henderson D, Salvi R, Hamernik R (eds): Noise-Induced Hearing Loss. St Louis, Mosby, 1992, pp 175–187.
7.
Bowers WJ, Chen X, Guo H, et al: Neurotrophin-3 transduction attenuates cisplatin spiral ganglion neuron ototoxicity in the cochlea. Mol Ther 2002;6:12–18.
8.
Brant LJ, Gordon-Salant S, Pearson JD, Klein LL, Morrell CH, Metter EJ, Fozard JL: Risk factors related to age-associated hearing loss in speech frequencies. J Am Acad Audiol 1996;7:152–160.
9.
Chang SJ, Chen CJ, Lien CH, et al: Hearing loss in workers exposed to toluene and noise. Environ Health Perspect 2006;114:1283–1286.
10.
Chen Y, Huang WG, Zha DJ, et al: Aspirin attenuates gentamicin ototoxicity: from the laboratory to the clinic. Hear Res 2007;226:178–182.
11.
Christensen K, Frederiksen H, Hoffman HJ: Genetic and environmental influences on self-reported reduced hearing in the old and oldest old. J Am Geriatr Soc 2001;49:1512–1517.
12.
Clark WW: Noise exposure from leisure activities: a review. J Acoust Soc Am 1991;90:175–181.
13.
Clark K, Sowers MR, Wallace RB, et al: Age-related hearing loss and bone mass in a population of rural women aged 60 to 85 years. Ann Epidemiol 1995;5:8–14.
14.
Coling DE, Yu KC, Somand D, et al: Effect of SOD1 overexpression on age- and noise-related hearing loss. Free Radic Biol Med 2003;34:873–880.
15.
Corso JF: Support for Corso’s hearing loss model. Relating aging and noise exposure. Audiology 1992;31:162–167.
16.
Cruickshanks KJ, Klein R, Klein BE, et al: Cigarette smoking and hearing loss: the epidemiology of hearing loss study. JAMA 1998a;279:1715–1719.
17.
Cruickshanks KJ, Tweed TS, Wiley TL, et al: The 5-year incidence and progression of hearing loss: the epidemiology of hearing loss study. Arch Otolaryngol Head Neck Surg 2003;129:1041–1046.
18.
Cruickshanks KJ, Wiley TL, Tweed TS, et al: Prevalence of hearing loss in older adults in Beaver Dam, Wisconsin. The Epidemiology of Hearing Loss Study. Am J Epidemiol 1998b;148:879–886.
19.
Dai P, Yang W, Jiang S, Gu R, Yuan H, Han D, Guo W, Cao J: Correlation of cochlear blood supply with mitochondrial DNA common deletion in presbyacusis. Acta Otolaryngol 2004;124:130–136.
20.
Dalton DS, Cruickshanks KJ, Klein BE, et al: The impact of hearing loss on quality of life in older adults. Gerontologist 2003;43:661–668.
21.
Danielidis V, Tsimpiris N, Balatsouras DG, et al: Short-term pathophysiologic changes and histopathologic findings of the auditory pathway after closed head injury, using a rabbit model. Audiol Neurootol 2007;12:145–154.
22.
Davis AC: The prevalence of hearing impairment and reported hearing disability among adults in Great Britain. Int J Epidemiol 1989;18:911–917.
23.
Davis AC: Epidemiological profile of hearing impairments: the scale and nature of the problem with special reference to elderly. Acta Otolaryngol Suppl 1991;476:23–31.
24.
Davis A: Prevalence of hearing impairment; in Davis A (ed): Hearing in Adults. London, Whurr Publishers Ltd, 1994, pp 43–321.
25.
Desai M, Pratt LA, Lentzner H, Robinson KN: Trends in vision and hearing amongst older Americans. Aging Trends 2001;2:1–8.
26.
DeStefano AL, Gates GA, Heard-Costa N, et al: Genome-wide linkage analysis to presbycusis in the Framingham Heart Study. Arch Otolaryngol Head Neck Surg 2003;129:285–289.
27.
Driscoll DP, Royster LH: Comparisons between the median hearing threshold levels for an unscreened black nonindustrial noise exposed population (NINEP) and four presbycusis data bases. Am Ind Hyg Assoc J 1984;45:577–593.
28.
Emmerich E, Richter F, Reinhold U, et al: Effects of industrial noise exposure on distortion product otoacoustic emissions (DPOAEs) and hair cell loss of the cochlea – Long-term experiments in awake guinea pigs. Hear Res 2000;148:9–17.
29.
Erway LC, Shiau YW, Davis RR, et al: Genetics of age-related hearing loss in mice. 3. Susceptibility of inbred and F1 hybrid strains to noise-induced hearing loss. Hear Res 1996;93:181–187.
30.
Erway LC, Willott JF, Archer JR, et al: Genetics of age-related hearing loss in mice. 1. Inbred and F1 hybrid strains. Hear Res 1993;65:125–132.
31.
Evans P, Halliwell B: Free radicals and hearing. Cause, consequence, and criteria. Ann NY Acad Sci 1999;884:19–40.
32.
Feldmann H: Sudden hearing loss with delayed onset following head trauma. Acta Otolaryngol 1987;103:379–383.
33.
Fischel-Ghodsian N, Bykhovskaya Y, Taylor K, et al: Temporal bone analysis of patients with presbycusis reveals high frequency of mitochondrial mutations. Hear Res 1997;110:147–154.
34.
Fitzgerald DC: Head trauma: hearing loss and dizziness. J Trauma 1996;40:488–496.
35.
Flock A, Flock B, Fridberger A, et al: Supporting cells contribute to control of hearing sensitivity. J Neurosci 1999;19:4498–4507.
36.
Fransen E, Van Laer L, Lemkens N, et al: A novel Z-score-based method to analyze candidate genes for age-related hearing impairment. Ear Hear 2004;25:133–141.
37.
Frisina ST, Mapes F, Kim S, et al: Characterization of hearing loss in aged type II diabetics. Hear Res 2006;211:103–113.
38.
Fuente A, McPherson B: Organic solvents and hearing loss: the challenge for audiology. Int J Audiol 2006;45:367–381.
39.
Fuente A, McPherson B, Munoz V, et al: Assessment of central auditory processing in a group of workers exposed to solvents. Acta Otolaryngol 2006;126:1188–1194.
40.
Fuortes LJ, Tang S, Pomrehn P, et al: Prospective evaluation of associations between hearing sensitivity and selected cardiovascular risk factors. Am J Ind Med 1995;28:275–280.
41.
Garringer HJ, Pankratz ND, Nichols WC, et al: Hearing impairment susceptibility in elderly men and the DFNA18 locus. Arch Otolaryngol Head Neck Surg 2006;132:506–510.
42.
Gates GA, Cobb JL, D’Agostino RB, et al: The relation of hearing in the elderly to the presence of cardiovascular disease and cardiovascular risk factors. Arch Otolaryngol Head Neck Surg 1993;119:156–161.
43.
Gates GA, Couropmitree NN, Myers RH: Genetic associations in age-related hearing thresholds. Arch Otolaryngol Head Neck Surg 1999;125:654–659.
44.
Gates GA, Mills JH: Presbycusis. Lancet 2005;366:1111–1120.
45.
Gates GA, Schmid P, Kujawa SG, et al: Longitudinal threshold changes in older men with audiometric notches. Hear Res 2000;141:220–228.
46.
Gratton MA, Vazquez AE: Age-related hearing loss: current research. Curr Opin Otolaryngol Head Neck Surg 2003;11:367–371.
47.
Guimaraes P, Frisina ST, Mapes F, et al: Progestin negatively affects hearing in aged women. Proc Natl Acad Sci USA 2006;103:14246–14249.
48.
Guimaraes P, Zhu X, Cannon T, et al: Sex differences in distortion product otoacoustic emissions as a function of age in CBA mice. Hear Res 2004;192:83–89.
49.
Hederstierna C, Hultcrantz M, Collins A, et al: Hearing in women at menopause. Prevalence of hearing loss, audiometric configuration and relation to hormone replacement therapy. Acta Otolaryngol 2007;127:149–155.
50.
Heine C, Browning CJ: Communication and psychosocial consequences of sensory loss in older adults: overview and rehabilitation directions. Disabil Rehabil 2002;24:763–773.
51.
Helzner EP, Cauley JA, Pratt SR, et al: Hearing sensitivity and bone mineral density in older adults: the Health, Aging and Body Composition Study. Osteoporos Int 2005;16:1675–1682.
52.
Henry KR: Males lose hearing earlier in mouse models of late-onset age-related hearing loss; females lose hearing earlier in mouse models of early-onset hearing loss. Hear Res 2004;190:141–148.
53.
Houston DK, Johnson MA, Nozza RJ, et al: Age-related hearing loss, vitamin B-12, and folate in elderly women. Am J Clin Nutr 1999;69:564–571.
54.
Hu Z, Ulfendahl M: Cell replacement therapy in the inner ear. Stem Cells Dev 2006;15:449–459.
55.
Huang T, Cheng AG, Stupak H, et al: Oxidative stress-induced apoptosis of cochlear sensory cells: otoprotective strategies. Int J Dev Neurosci 2000;18:259–270.
56.
Huang ZW, Luo Y, Wu Z, et al: Paradoxical enhancement of active cochlear mechanics in long-term administration of salicylate. J Neurophysiol 2005;93:2053–2061.
57.
Hultcrantz M, Simonoska R, Stenberg AE: Estrogen and hearing: a summary of recent investigations. Acta Otolaryngol 2006;126:10–14.
58.
International Organization of Standardization: Acoustics – Threshold of Hearing by Air Conduction as a Function of Age and Sex for Otologically Normal Persons. Geneva, International Organization of Standardization, 2000, ISO 7029.
59.
Ito J, Kojima K, Kawaguchi S: Survival of neural stem cells in the cochlea. Acta Otolaryngol 2001;121:140–142.
60.
Itoh A, Nakashima T, Arao H, et al: Smoking and drinking habits as risk factors for hearing loss in the elderly: epidemiological study of subjects undergoing routine health checks in Aichi, Japan. Public Health 2001;115:192–196.
61.
Iwai H, Lee S, Inaba M, et al: Prevention of accelerated presbycusis by bone marrow transplantation in senescence-accelerated mice. Bone Marrow Transplant 2001;28:323–328.
62.
Iwai H, Lee S, Inaba M, et al: Correlation between accelerated presbycusis and decreased immune functions. Exp Gerontol 2003;38:319–325.
63.
Iwai H, Tomoda K, Sugiura K, et al: T cells infiltrating from the systemic circulation proliferate in the endolymphatic sac. Ann Otol Rhinol Laryngol 1999;108:1146–1150.
64.
Izumikawa M, Minoda R, Kawamoto K, et al: Auditory hair cell replacement and hearing improvement by Atoh1 gene therapy in deaf mammals. Nat Med 2005;11:271–276.
65.
Janssen GM, Maassen JA, van Den Ouweland JM: The diabetes-associated 3243 mutation in the mitochondrial tRNA(Leu(UUR)) gene causes severe mitochondrial dysfunction without a strong decrease in protein synthesis rate. J Biol Chem 1999;274:29744–29748.
66.
Jarvis JF, Van Heerden HG: The acuity of hearing in the Kalahari Bushmen. A pilot survey. J Laryngol Otol 1967;81:63–68.
67.
Jiang H, Talaska AE, Schacht J, et al: Oxidative imbalance in the aging inner ear. Neurobiol Aging, 2006, E-pub ahead of print.
68.
Johnson AC, Nylen PR: Effect of industrial solvents on hearing. Occup Med 1995;10:623–640.
69.
Johnson KR, Erway LC, Cook SA, et al: A major gene affecting age-related hearing loss in C57BL/6J mice. Hear Res 1997;114:83–92.
70.
Johnson KR, Zheng QY: Ahl2, a second locus affecting age-related hearing loss in mice. Genomics 2002;80:461–464.
71.
Johnson KR, Zheng QY, Erway LC: A major gene affecting age-related hearing loss is common to at least ten inbred strains of mice. Genomics 2000;70:171–180.
72.
Kakarlapudi V, Sawyer R, Staecker H: The effect of diabetes on sensorineural hearing loss. Otol Neurotol 2003;24:382–386.
73.
Karlsson KK, Harris JR, Svartengren M: Description and primary results from an audiometric study of male twins. Ear Hear 1997;18:114–120.
74.
Keithley EM, Canto C, Zheng QY, et al: Age-related hearing loss and the ahl locus in mice. Hear Res 2004;188:21–28.
75.
Kermany MH, Parker LL, Guo YK, et al: Identification of 17 hearing impaired mouse strains in the TMGC ENU-mutagenesis screen. Hear Res 2006;220:76–86.
76.
Kujawa SG, Liberman MC: Acceleration of age-related hearing loss by early noise exposure: evidence of a misspent youth. J Neurosci 2006;26:2115–2123.
77.
Kujoth GC, Hiona A, Pugh TD, et al: Mitochondrial DNA mutations, oxidative stress, and apoptosis in mammalian aging. Science 2005;309:481–484.
78.
Kurien M, Thomas K, Bhanu TS: Hearing threshold in patients with diabetes mellitus. J Laryngol 1989;103:164–168.
79.
Lalwani AK, Jero J, Mhatre AN: Current issues in cochlear gene transfer. Audiol Neurootol 2002;7:146–151.
80.
Lautermann J, Crann SA, McLaren J, et al: Glutathione-dependent antioxidant systems in the mammalian inner ear: effects of aging, ototoxic drugs and noise. Hear Res 1997;114:75–82.
81.
Le T, Keithley EM: Effects of antioxidants on the aging inner ear. Hear Res 2007;226:194–202.
82.
Lee FS, Matthews LJ, Dubno JR, et al: Longitudinal study of pure-tone thresholds in older persons. Ear Hear 2005;26:1–11.
83.
Lee FS, Matthews LJ, Mills JH, et al: Analysis of blood chemistry and hearing levels in a sample of older persons. Ear Hear 1998;19:180–190.
84.
Lefebvre PP, Staecker H, Van de Water T, et al: Pharmacologic treatment of inner ear: from basic science to the patient. Acta Otorhinolaryngol Belg 2002;56:45–49.
85.
Li HS: Genetic influences on susceptibility of the auditory system to aging and environmental factors. Scand Audiol Suppl 1992;36:1–39.
86.
Li HS, Borg E: Age-related loss of auditory sensitivity in two mouse genotypes. Acta Otolaryngol 1991;111:827–834.
87.
Ludvig J, Miner B, Eisenberg MJ: Smoking cessation in patients with coronary artery disease. Am Heart J 2005;149:565–572.
88.
Lutman ME, Spencer HS: Occupational noise and demographic factors in hearing. Acta Otolaryngol Suppl 1990;476:74–84.
89.
Malgrange B, Rigo JM, Coucke P, et al: Identification of factors that maintain mammalian outer hair cells in adult organ of Corti explants. Hear Res 2002;170:48–58.
90.
McFadden SL, Ding D, Burkard RF, et al: Cu/Zn SOD deficiency potentiates hearing loss and cochlear pathology in aged 129,CD-1 mice. J Comp Neurol 1999a;413:101–112.
91.
McFadden SL, Ding D, Reaume AG, et al: Age-related cochlear hair cell loss is enhanced in mice lacking copper/zinc superoxide dismutase. Neurobiol Aging 1999b;20:1–8.
92.
McFadden SL, Ding D, Salvi R: Anatomical, metabolic and genetic aspects of age-related hearing loss in mice. Audiology 2001;40:313–321.
93.
Mellstrom D, Rundgren A, Jagenburg R, et al: Tobacco smoking, ageing and health among the elderly: a longitudinal population study of 70-year-old men and an age cohort comparison. Age Ageing 1982;11:45–58.
94.
Mills JH, Matthews LJ, Lee FS, et al: Gender-specific effects of drugs on hearing levels of older persons. Ann NY Acad Sci 1999;884:381–388.
95.
Montpetit A, Nelis M, Laflamme P, et al: An evaluation of the performance of tag SNPs derived from HapMap in a Caucasian population. PLoS Genet 2006;2:e27.
96.
Morata TC, Johnson AC, Nylen P, et al: Audiometric findings in workers exposed to low levels of styrene and noise. J Occup Environ Med 2002;44:806–814.
97.
Morita Y, Hirokawa S, Kikkawa Y, et al: Fine mapping of Ahl3 affecting both age-related and noise-induced hearing loss. Biochem Biophys Res Commun 2007;355:117–121.
98.
Mulroy MJ, Henry WR, McNeil PL: Noise-induced transient microlesions in the cell membranes of auditory hair cells. Hear Res 1998;115:93–100.
99.
Nemoto M, Morita Y, Mishima Y, et al: Ahl3, a third locus on mouse chromosome 17 affecting age-related hearing loss. Biochem Biophys Res Commun 2004;324:1283–1288.
100.
Noben-Trauth K, Zheng QY, Johnson KR: Association of cadherin 23 with polygenic inheritance and genetic modification of sensorineural hearing loss. Nat Genet 2003;35:21–23.
101.
Nomura K, Nakao M, Morimoto T: Effect of smoking on hearing loss: quality assessment and meta-analysis. Prev Med 2005;40:138–144.
102.
Ohlemiller KK: Age-related hearing loss: the status of Schuknecht’s typology. Curr Opin Otolaryngol Head Neck Surg 2004;12:439–443.
103.
Ohlemiller KK: Contributions of mouse models to understanding of age- and noise-related hearing loss. Brain Res 2006;1091:89–102.
104.
Ohlemiller KK, Gagnon PM: Cellular correlates of progressive hearing loss in 129S6/SvEv mice. J Comp Neurol 2004;469:377–390.
105.
Ohlemiller KK, Wright JS, Heidbreder AF: Vulnerability to noise-induced hearing loss in ‘middle-aged’ and young adult mice: a dose-response approach in CBA, C57BL, and BALB inbred strains. Hear Res 2000;149:239–247.
106.
Page GP, Amos CI: Comparison of linkage-disequilibrium methods for localization of genes influencing quantitative traits in humans. Am J Hum Genet 1999;64:1194–1205.
107.
Pearson JD, Morrell CH, Gordon-Salant S, et al: Gender differences in a longitudinal study of age-associated hearing loss. J Acoust Soc Am 1995;97:1196–1205.
108.
Picciotti P, Torsello A, Wolf FI, et al: Age-dependent modifications of expression level of VEGF and its receptors in the inner ear. Exp Gerontol 2004;39:1253–1258.
109.
Poortinga W: The prevalence and clustering of four major lifestyle risk factors in an English adult population. Prev Med 2007;44:124–128.
110.
Pujol R, Puel JL: Excitotoxicity, synaptic repair, and functional recovery in the mammalian cochlea: a review of recent findings. Ann NY Acad Sci 1999;884:249–254.
111.
Purchase-Helzner EL, Cauley JA, Faulkner KA, et al: Hearing sensitivity and the risk of incident falls and fracture in older women: the study of osteoporotic fractures. Ann Epidemiol 2004;14:311–318.
112.
Rivolta MN, Li H, Heller S: Generation of inner ear cell types from embryonic stem cells. Methods Mol Biol 2006;330:71–92.
113.
Rosen S, Bergman M, Plester D, et al: Presbycusis study of a relatively noise-free population in the Sudan. Ann Otol Rhinol Laryngol 1962;71:727–743.
114.
Rosenhall U, Sixt E, Sundh V, Svanborg A: Correlations between presbyacusis and extrinsic noxious factors. Audiology 1993;32:234–243.
115.
Rybak LP: Hearing: the effect of chemicals. Otolaryngol Head Neck Surg 1992;106:677–686.
116.
Rybak LP, Whitworth CA, Mukherjea D, et al: Mechanisms of cisplatin-induced ototoxicity and prevention. Hear Res 2007;226:157–167.
117.
Schacht J: Aminoglycoside ototoxicity: prevention in sight? Otolaryngol Head Neck Surg 1998;118:674–677.
118.
Schuknecht HF, Gacek MR: Cochlear pathology in presbycusis. Ann Otol Rhinol Laryngol 1993;102:1–16.
119.
Seidman MD: Effects of dietary restriction and antioxidants on presbyacusis. Laryngoscope 2000;110:727–738.
120.
Seidman MD, Ahmad N, Bai U: Molecular mechanisms of age-related hearing loss. Ageing Res Rev 2002a;1:331–343.
121.
Seidman MD, Bai U, Khan MJ, et al: Association of mitochondrial DNA deletions and cochlear pathology: a molecular biologic tool. Laryngoscope 1996;106:777–783.
122.
Seidman MD, Bai U, Khan MJ, et al: Mitochondrial DNA deletions associated with aging and presbyacusis. Arch Otolaryngol Head Neck Surg 1997;123:1039–1045.
123.
Seidman MD, Khan MJ, Bai U, et al: Biologic activity of mitochondrial metabolites on aging and age-related hearing loss. Am J Otol 2000;21:161–167.
124.
Seidman MD, Khan MJ, Tang WX, et al: Influence of lecithin on mitochondrial DNA and age-related hearing loss. Otolaryngol Head Neck Surg 2002b;127:138–144.
125.
Selimoglu E: Aminoglycoside-induced ototoxicity. Curr Pharm Des 2007;13:119–126.
126.
Sixt E, Rosenhall U: Presbyacusis related to socioeconomic factors and state of health. Scand Audiol 1997;26:133–140.
127.
Sliwinska-Kowalska M, Zamyslowska-Szmytke E, Szymczak W, et al: Effects of coexposure to noise and mixture of organic solvents on hearing in dockyard workers. J Occup Environ Med 2004;46:30–38.
128.
Sowers MR, Clark MK, Jannausch ML, et al: Body size, estrogen use and thiazide diuretic use affect 5-year radial bone loss in postmenopausal women. Osteoporos Int 1993;3:314–321.
129.
Stypulkowski PH: Mechanisms of salicylate ototoxicity. Hear Res 1990;46:113–145.
130.
Sweet RJ, Price JM, Henry KR: Dietary restriction and presbyacusis: periods of restriction and auditory threshold losses in the CBA/J mouse. Audiology 1988;27:305–312.
131.
Tabor HK, Risch NJ, Myers RM: Candidate-gene approaches for studying complex genetic traits: practical considerations. Nat Rev Genet 2002;3:391–397.
132.
Tadros SF, D’Souza M, Zettel ML, et al: Serotonin 2B receptor: upregulated with age and hearing loss in mouse auditory system. Neurobiol Aging 2007a;28:1112–1123.
133.
Tadros SF, D’Souza M, Zettel ML, et al: Glutamate-related gene expression changes with age in the mouse auditory midbrain. Brain Res 2007b;1127:1–9.
134.
Tadros SF, Frisina ST, Mapes F, et al: Higher serum aldosterone correlates with lower hearing thresholds: a possible protective hormone against presbycusis. Hear Res 2005;209:10–18.
135.
Torre P 3rd, Cruickshanks KJ, Klein BE, et al: The association between cardiovascular disease and cochlear function in older adults. J Speech Lang Hear Res 2005;48:473–481.
136.
Torre P 3rd, Mattison JA, Fowler CG, et al: Assessment of auditory function in rhesus monkeys (Macaca mulatta): effects of age and calorie restriction. Neurobiol Aging 2004;25:945–954.
137.
Trifunovic A, Wredenberg A, Falkenberg M, et al: Premature ageing in mice expressing defective mitochondrial DNA polymerase. Nature 2004;429:417–423.
138.
Unal M, Tamer L, Dogruer ZN, et al: N-acetyltransferase 2 gene polymorphism and presbycusis. Laryngoscope 2005;115:2238–2241.
139.
Van Eyken E, Van Laer L, Fransen E, et al: KCNQ4: a gene for age-related hearing impairment? Hum Mutat 2006;27:1007–1016.
140.
Van Laer L, DeStefano AL, Myers RH, et al: Is DFNA5 a susceptibility gene for age-related hearing impairment? Eur J Hum Genet 2002;10:883–886.
141.
Vaughan N, James K, McDermott D, et al: A 5-year prospective study of diabetes and hearing loss in a veteran population. Otol Neurotol 2006;27:37–43.
142.
Wallace DC: Mitochondrial DNA in aging and disease. Sci Am 1997;277:40–47.
143.
Wang J, Dib M, Lenoir M, et al: Riluzole rescues cochlear sensory cells from acoustic trauma in the guinea-pig. Neuroscience 2002;111:635–648.
144.
Wannamethee SG, Shaper AG: Alcohol, coronary heart disease and stroke: an examination of the J-shaped curve. Neuroepidemiology 1998;17:288–295.
145.
Willer CJ, Scott LJ, Bonnycastle LL, et al: Tag SNP selection for Finnish individuals based on the CEPH Utah HapMap database. Genet Epidemiol 2006;30:180–190.
146.
Willott JF, Erway LC, Archer JR, et al: Genetics of age-related hearing loss in mice. 2. Strain differences and effects of caloric restriction on cochlear pathology and evoked response thresholds. Hear Res 1995;88:143–155.
147.
Willott JF, Turner JG, Carlson S, et al: The BALB/c mouse as an animal model for progressive sensorineural hearing loss. Hear Res 1998;115:162–174.
148.
Yamasoba T, Nuttall AL, Harris C, et al: Role of glutathione in protection against noise-induced hearing loss. Brain Res 1998;784:82–90.
149.
Zhang X, Han D, Ding D, et al: Cochlear mitochondrial DNA3867bp deletion in aged mice. Chin Med J (Engl) 2002;115:1390–1393.
150.
Zheng QY, Johnson KR: Hearing loss associated with the modifier of deaf waddler (mdfw) locus corresponds with age-related hearing loss in 12 inbred strains of mice. Hear Res 2001;154:45–53.
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