Auditory brainstem response (ABR) reflects activation of the neural generators along the ascending auditory pathway when a sound is heard. In this study, we explored the relationship between brainstem encoding of click and speech signals in normal-learning children and in those with language-based learning problems. To that end, ABR was recorded from both types of stimuli. We found that the normal pattern of correlation between click- and speech-evoked ABRs was disrupted when speech-evoked ABRs were delayed. Thus, delayed responses to speech were not indicative of clinically abnormal responses to clicks. We conclude that these two responses reflect largely separate neural processes and that only processes involved in encoding complex signals such as speech are impaired in children with learning problems.

1.
Ahissar M, Protopapas A, Reid M, Merzenich MM: Auditory processing parallels reading abilities in adults. Proc Natl Acad Sci USA 2000;97:6832–6837.
2.
Amitay S, Ahissar M, Nelken I: Auditory processing deficits in reading disabled adults. J Assoc Res Otolaryngol 2002;3:302–320.
3.
Baldeweg T, Richardson A, Watkins S, Foale C, Gruzelier J: Impaired auditory frequency discrimination in dyslexia detected with mismatch evoked potentials. Ann Neurol 1999;45:495–503.
4.
Banai K, Ahissar M: Poor frequency discrimination probes dyslexics with particularly impaired working memory. Audiol Neurotol 2004;9:328–340.
5.
Banai K, Nicol T, Zecker SG, Kraus N: Brainstem timing: implications for cortical processing and literacy. J Neurosci 2005;25:9850–9857.
6.
Brandt J, Rosen JJ: Auditory phonemic perception in dyslexia: categorical identification and discrimination of stop consonants. Brain Lang 1980;9:324–337.
7.
Brown L, Sherbenou R, Johnsen S: Test of Nonverbal Intelligence, ed 3. Austin, PRO-ED, 1997.
8.
Cunningham J, Nicol T, Zecker SG, Kraus N: Neurobiologic responses to speech in noise in children with learning problems: deficits and strategies for improvements. Clin Neurophysiol 2001;112:758–767.
9.
Gorga M, Abbas P, Worthington D: Stimulus calibration in ABR measurements; in Jacobson J (ed): The Auditory Brainstem Response. San Diego, College-Hill Press, 1985, pp 49–62.
10.
Gorga MP, Kaminski JR, Beauchaine KA, Jesteadt W, Neeley ST: Auditory brainstem responses from children three months to three years of age. II. Normal patterns of response. J Speech Hear Res 1989;50:346–350.
11.
Grøntved A, Walter B, Gronborg A: Auditory brain stem responses in dyslexic and normal children. A perspective clinical investigation. Scand Audiol 1988a;17:53–54.
12.
Grøntved A, Walter B, Gronborg A: Normal ABR’s in dyslexic children. Acta Otolaryngol Suppl 1988b;449:171–173.
13.
Hall J: Handbook of Auditory Evoked Responses. Needham Heights, Allyn and Bacon, 1992.
14.
Heim S, Keil A: Large-scale neural correlates of developmental dyslexia. Eur Child Adolesc Psychiatry 2004;13:125–140.
15.
Hood LJ: Clinical applications of the auditory brainstem response. San Diego, Singular, 1998.
16.
Jacobson J: The Auditory Brainstem Response. San Diego, College-Hill Press, 1985.
17.
Jerger S, Martin RC, Jerger J: Specific auditory perceptual dysfunction in a learning disabled child. Ear Hear 1987;8:78–86.
18.
Jirsa RE: Maximum length sequences-auditory brainstem responses from children with auditory processing disorders. J Am Acad Audiol 2001;12:155–164.
19.
Johnson KL, Nicol T, Kraus N: The brainstem response to speech: a biological marker of auditory processing. Ear Hear 2005;26:424–434.
20.
Johnson KL, Nicol TG, Zecker SG, Wright BA, Kraus N: Brainstem timing in learning impaired children with excessive auditory backward masking (abstract). Assoc Res Otolaryngol 2004;27:118.
21.
Josey A: Auditory brainstem response in site of lesion testing; in Katz J (ed): Handbook of Clinical Audiology. Baltimore, Williams and Wilkins, 1985, pp 534–548.
22.
King C, Warrier CM, Hayes E, Kraus N: Deficits in auditory brainstem pathway encoding of speech sounds in children with learning problems. Neurosci Lett 2002;319:111–115.
23.
Klatt D: Software for cascade/parallel formant synthesizer. J Acoust Soc Am 1980;67:971–975.
24.
Krishnan A: Human frequency-following responses: representation of steady-state synthetic vowels. Hear Res 2002;166:192–201.
25.
Kraus N, McGee TJ, Carrell TD, Zecker SG, Nicol TG, Koch DB: Auditory neurophysiologic responses and discrimination deficits in children with learning problems. Science 1996;273:971–973.
26.
Kraus N, Nicol T: Brainstem origins for cortical ‘what’ and ‘where’ pathways in the auditory system. Trends Neurosci 2005;28:176–181.
27.
Lachmann T, Berti S, Kujala T, Schroger E: Diagnostic subgroups of developmental dyslexia have different deficits in neural processing of tones and phonemes. Int J Psychophysiol 2005;56:105–120.
28.
Lauter JL, Wood SB: Auditory-brainstem synchronicity in dyslexia measured using the REPs/ABR protocol. Ann N Y Acad Sci 1993;682:377–379.
29.
Marler JA, Champlin CA: Sensory processing of backward-masking signals in children with language-learning impairment as assessed with the auditory brainstem response. J Speech Lang Hear Res 2005;48:189–203.
30.
Mason SM, Mellor DH: Brain-stem, middle latency and late cortical evoked potentials in children with speech and language disorders. Electroencephalogr Clin Neurophysiol 1984;59:297–309.
31.
McAnally KI, Stein JF: Scalp potentials evoked by amplitude-modulated tones in dyslexia. J Speech Hear Res 1997;40:939–945.
32.
Menell P, McAnally KI, Stein JF: Psychophysical sensitivity and physiological response to amplitude modulation in adult dyslexic listeners. J Speech Lang Hear Res 1999;42:797–803.
33.
Møller A, Jannetta P: Neural generators of the auditory brainstem response; in Jacobson J (ed): The Auditory Brainstem Response. San Diego, College-Hill Press, 1985, pp 13–32.
34.
Musiek FE: Auditory evoked responses in site-of-lesion assessment; in Rintelmann WF (ed): Hearing Assessment. Austin, PRO-ED, 1991, pp 383–427.
35.
Nagarajan S, Mahncke H, Salz T, Tallal P, Roberts T, Merzenich M: Cortical auditory signal processing in poor readers. Proc Natl Acad Sci USA 1999;96:6483–6488.
36.
Paul I, Bott C, Heim S, Eulitz C, Elbert T: Reduced hemispheric asymmetry of the auditory N260m in dyslexia. Neuropsychologia 2006;44:785–794.
37.
Purdy S, Kelly A, Davies M: Auditory brainstem response, middle latency response, and late cortical evoked potentials in children with learning disabilities. J Am Acad Audiol 2002;13:367–382.
38.
Ramus F, Rosen S, Dakin SC, Day BL, Castellote JM, White S, et al: Theories of developmental dyslexia: insights from a multiple case study of dyslexic adults. Brain 2003;126:841–865.
39.
Russo N, Nicol T, Musacchia G, Kraus N: Brainstem responses to speech syllables. Clin Neurophysiol 2004;115:2021–2030.
40.
Starr A, Don M: Brainstem potentials evoked by acoustic stimuli; in Picton TW (ed): Handbook of Electroencepholography and Clinical Neurophysiology. Amsterdam, Elsevier, 1988, pp 97–150.
41.
Tait CA, Roush J, Johns J: Normal ABR’s in children classified as learning disabled. J Aud Res 1983;23:56–62.
42.
Tallal P: Auditory temporal perception, phonics, and reading disabilities in children. Brain Lang 1980;9:182–198.
43.
Torgesen JK: Learning disabilities: Historical and conceptual issues; in Wong BYL (ed): Learning about Learning Disabilities. San Diego, Academic Press, 1991.
44.
Wagner R, Torgesen J, Rashotte C: Comprehensive Test of Phonological Processing. Austin, PRO-ED, 1999.
45.
Wible B, Nicol T, Kraus N: Abnormal neural encoding of repeated speech stimuli in noise in children with learning problems. Clin Neurophysiol 2002;113:485–494.
46.
Wible B, Nicol T, Kraus N: Atypical brainstem representation of onset and formant structure of speech sounds in children with language-based learning problems. Biol Psychol 2004;67:299–317.
47.
Wible B, Nicol T, Kraus N: Correlation between brainstem and cortical auditory processes in normal and language-impaired children. Brain 2005;128:417–423.
48.
Wilkinson G: Wide Range Achievement Test-3. Wilmington, Jastak, 1993.
49.
Woodcock R, Johnson M: Woodcock-Johnson Psycho-Educational Battery-Revised. Allen, DLM Teach Resources, 1989.
50.
Wright BA, Lombardino LJ, King WM, Puranik CS, Leonard CM, Merzenich MM: Deficits in auditory temporal and spectral resolution in language-impaired children. Nature 1997;387:176–178.
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